Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

P53: Function, Regulation & Role in disease

p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

P53 topic overview

The analysis highlights Function, Regulation and Role in disease as prominent areas in the source structure around P53. 4 topics appear in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
269
Source areas
9
Connected nodes
282
Extracted relationships
598
Concept neighborhoods
38
Bridge connections
282

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 101 topics
Function · 45 topics
Regulation · 35 topics
Discovery · 22 topics
Role in disease · 21 topics
Overview · 16 topics
Structure · 14 topics
Tetramerization · 12 topics
Gene · 7 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL,…
Band
17p13.1 · 11 B3|11 42.83 cM
Bgee
ventricular zone · ganglionic eminence · tendon of biceps brachii · monocyte · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Structure

Tetramerization

Function

Regulation

Role in disease

Discovery

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How P53 connects Entity context

The extracted context around P53 shows recurring relationship patterns in the source. For example, P53 → apoptotic process, ATP binding, autophagy, B cell lineage commitment, base-excision repair, bone marrow development, cardiac septum morphogenesis, cell cycle, cell differentiation, cell population proliferation, cellular response to actinomycin D, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to UV, cellular response to UV-C, central nervous system development, cerebellum development Another extracted example is P53 → AIMP2, ANKRD2, APTX, ATF3, ATM, ATR, AURKA, BAK1, BARD1, BLM, BRCA1, BRCA2, BRCC3, BRE, CCNG1, CDC14A, CDC14B, Cdk1, CDK7, CEBPZ. Use these groups to spot repeated connection types before inspecting the individual relationships.

P53

Top relations

Gene ontology · 197
P53 → apoptotic process, ATP binding, autophagy, B cell lineage commitment, base-excision repair, bone marrow development, cardiac septum morphogenesis, cell cycle, cell differentiation, cell population proliferation, cellular response to actinomycin D, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to UV, cellular response to UV-C, central nervous system development, cerebellum development
related to Interactions · 108
P53 → AIMP2, ANKRD2, APTX, ATF3, ATM, ATR, AURKA, BAK1, BARD1, BLM, BRCA1, BRCA2, BRCC3, BRE, CCNG1, CDC14A, CDC14B, Cdk1, CDK7, CEBPZ
related to External links · 37
P53 → Archived, Cell Biology, Cytogenetics, DNA, DS, GeneCardsp53 News, GeneReviews/NCBI/NIH/UW, Genetics, George Pantziarka TP53 Trust, HaematologyTP53 Gene, Human P53, IARC, IMCB, Institute, Knowledgebase, Lane Group, Li-Fraumeni Syndrome, Li-Fraumeni SyndromeTUMOR PROTEIN, Living LFS, Lyon
related to Discovery · 25
P53 → Academy, Arnold Levine, Cancer Institute, Center, David, David Givol, Imperial Cancer Research Fund, It, Lane, Lionel Crawford, Lloyd Old, Memorial Sloan Kettering Cancer, Moshe Oren, New Jersey, Peter Chumakov, Princeton University/UMDNJ, Science, Sciences, SV40, The
related to Stress-responsive kinases · 20
P53 → Additional, ATM, ATR, CAK, CDK-activating, CDK7, CHK1, CHK2, DNA, DNA-PK, ERK1/2, JNK1, Kinases, MAPK, MAT1, One, PRPK, Ser15, Ser33, TP53RK
Bgee · 18
P53 → blastocyst, embryo, epiblast, ganglionic eminence, genital tubercle, granulocyte, lip, monocyte, rectum, skin of abdomen, skin of leg, smooth muscle tissue, somite, stromal cell of endometrium, tail of embryo, tendon of biceps brachii, ventricular zone, yolk sac
RNA expression pattern · 18
P53 → blastocyst, embryo, epiblast, ganglionic eminence, genital tubercle, granulocyte, lip, monocyte, rectum, skin of abdomen, skin of leg, smooth muscle tissue, somite, stromal cell of endometrium, tail of embryo, tendon of biceps brachii, ventricular zone, yolk sac
related to Structure · 14
P53 → AD1, AD2, An, C-terminal, DBD, DNA, DNA-binding, LMO3, MAPK, N-terminus, NLS, OD, TAD, The
related to Tetramerization · 14
P53 → Arg337, Asp352, Each, Gly334, Helix, Ile332, Leu330, Leu344, Phe328, Phe338, Phe341, The, This, V-shaped
related to Deubiquitination · 11
P53 → After DNA, DUB, DUBs, HAUSP, In, It, MDM2, Several, USP10, USP42, USP7

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tp53 gene human dna cancer cell protein also mdm2 mutations isoforms cells damage p21 tumor activation stem apoptosis role repair

P53 relationships Subject–Predicate–Object triples

TTTA extracted 598 structured relationships around P53. Examples in this analysis include P53 → Aliases → TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53 and P53 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
P53AliasesTP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p531.00infobox
P53Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL,…1.00infobox
P53Band17p13.11.00infobox
P53Band11 B3|11 42.83 cM1.00infobox
P53Bgeeventricular zone1.00infobox
P53Bgeeganglionic eminence1.00infobox
P53Bgeetendon of biceps brachii1.00infobox
P53Bgeemonocyte1.00infobox
P53Bgeestromal cell of endometrium1.00infobox
P53Bgeeskin of abdomen1.00infobox
P53Bgeerectum1.00infobox
P53Bgeegranulocyte1.00infobox
P53Bgeeskin of leg1.00infobox
P53Bgeesmooth muscle tissue1.00infobox
P53Bgeetail of embryo1.00infobox
P53Bgeegenital tubercle1.00infobox
P53Bgeeembryo1.00infobox
P53Bgeeepiblast1.00infobox
P53Bgeeyolk sac1.00infobox
P53Bgeelip1.00infobox
P53Bgeeblastocyst1.00infobox
P53Bgeesomite1.00infobox
P53BioGPSMore reference expression data1.00infobox
P53Chr.Chromosome 17 (human)1.00infobox
P53Chr.Chromosome 11 (mouse)1.00infobox
P53DatabasesNCBI: entry; OMA: entry1.00infobox
P53End7,687,538 bp1.00infobox
P53End69,482,699 bp1.00infobox
P53EnsemblENSG000001415101.00infobox
P53Entrez71571.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around P53 bring nearby vocabulary together. In this analysis, examples include Dna, Mdm2 and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • P53
    • Dna
    • Mdm2
    • Protein
    • Activation
    • Cells
    • Levels
    • Human
    • Stem
    • Response
    • Cell
    • Regulation
    • P21
  • p53
    • Dna
    • Mdm2
    • Protein
    • Activation
    • Cells
    • Levels
    • Human
    • Stem
    • Response
    • Cell
    • Regulation
    • P21
  • transcription factor
    • Genes
    • Domain
    • Binding
    • Repair
    • Response
    • Tumor
    • Dna
    • Bp
    • Differentiation
    • Gene
    • Including
    • Expression
  • tumor suppressor gene
    • Tp53
    • Human
    • Tumor
    • Bp
    • Proteins
    • Tumors
    • Mutations
    • Protein
    • Expression
    • Function
    • Role
    • Isoforms
  • gene expression
    • Tp53
    • Human
    • Differentiation
    • Tumor
    • Regulation
    • Bp
    • Proteins
    • Tumors
    • Mutations
    • P21
    • Protein
    • Expression
  • protein domains
    • Genes
    • Activation
    • Transcription
    • Function
    • Regulation
    • Dna
    • P21
    • Repair
    • Tumor
    • Tp53
    • Gene
    • Stem
  • apoptosis
    • Cell
    • Cycle
    • Damage
    • Repair
    • Response
    • Cellular
    • Dna
    • Bp
    • Differentiation
    • Proteins
    • Transcription
    • Including
  • dna repair
    • Damage
    • Repair
    • Binding
    • Cycle
    • Response
    • Regulation
    • Apoptosis
    • Role
    • P53
    • Activation
    • Tp53
    • Cell

Connections between topic areas Semantic bridges

For P53, one of the stronger structural bridges in this analysis connects P53 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
P53 — Interactions · splits 181 ⟂ 102
P53 — Function · splits 237 ⟂ 46
P53 — Regulation · splits 247 ⟂ 36
P53 — Discovery · splits 260 ⟂ 23
P53 — Role in disease · splits 261 ⟂ 22
P53 — Overview · splits 266 ⟂ 17
P53 — Structure · splits 268 ⟂ 15
P53 — Tetramerization · splits 270 ⟂ 13
P53 — Gene · splits 275 ⟂ 8

Map overview Semantic statistics

P53

Nodes283
Edges282
Triples598
Avg. degree1.99
Density0.007067
Components1

Source & methodology

TTTA analyzes the structure around P53 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Regulation & Role in disease, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — P53 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.