Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

BRCA2: History & Products

BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

BRCA2 topic overview

The analysis highlights History and Products as prominent areas in the source structure around BRCA2.

Related topics
112
Source areas
11
Connected nodes
123
Extracted relationships
277
Concept neighborhoods
35
Bridge connections
123

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Domain architecture · 28 topics
Overview · 20 topics
Interactions · 19 topics
Clinical significance · 10 topics
Function · 7 topics
History · 7 topics
Meiosis · 7 topics
BRCA2 expression in cancer · 6 topics
Epigenetic control · 3 topics
Patents, enforcement, litigation, and controversy · 3 topics
Neurogenesis · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 3EU7
Band
13q13.1 · 5 G3|5 89.52 cM
Bgee
testicle · secondary oocyte · ventricular zone · gonad · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

History

Meiosis

Neurogenesis

Epigenetic control

BRCA2 expression in cancer

Interactions

Domain architecture

Patents, enforcement, litigation, and controversy

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BRCA2 connects Entity context

The extracted context around BRCA2 shows recurring relationship patterns in the source. For example, BRCA2 → brain development, BRCA2-MAGE-D1 complex, cell cycle, cell population proliferation, cellular response to DNA damage stimulus, centrosome, centrosome duplication, chordate embryonic development, chromosome organization, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA recombination, DNA repair, DNA synthesis involved in double-strand break repair via homologous recombination, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere Another extracted example is BRCA2 → Achilles tendon, ankle joint, bone marrow cell, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, mandibular prominence, maxillary prominence, primary oocyte, secondary oocyte, seminiferous tubule, stromal cell of endometrium, tail of embryo, testicle, trabecular bone, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

BRCA2

Top relations

Gene ontology · 64
BRCA2 → brain development, BRCA2-MAGE-D1 complex, cell cycle, cell population proliferation, cellular response to DNA damage stimulus, centrosome, centrosome duplication, chordate embryonic development, chromosome organization, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA recombination, DNA repair, DNA synthesis involved in double-strand break repair via homologous recombination, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere
Bgee · 19
BRCA2 → Achilles tendon, ankle joint, bone marrow cell, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, mandibular prominence, maxillary prominence, primary oocyte, secondary oocyte, seminiferous tubule, stromal cell of endometrium, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BRCA2 → Achilles tendon, ankle joint, bone marrow cell, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, mandibular prominence, maxillary prominence, primary oocyte, secondary oocyte, seminiferous tubule, stromal cell of endometrium, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
related to Interactions · 19
BRCA2 → BARD1, BCCIP, BRCA1, BRCC3, BRE, BUB1B, C11orf30, CREBBP, FANCD2, FANCG, FLNA, HMG20B, P53, PALB2, PCAF, PLK1, RAD51, RPA1, SHFM1
related to BRCA2 expression in cancer · 18
BRCA2 → At, BCDX2, DNA, Figure, In, RAD51, RAD51B, RAD51C, RAD51D, RAD51L1, RAD51L2, RAD51L3, Recombinational, Some, Table, The BCDX2, This, XRCC2
related to history · 17
BRCA2 → Ashkenazi Jewish, Cancer Research, Center, Development Limited Partnership, Endo Recherche, HSC Research, In, Inc, Kenneth Offit, London, Memorial Sloan Kettering Cancer, Myriad Genetics, Pennsylvania, The, The BRCA2, The Institute, University
related to Patents, enforcement, litigation, and controversy · 16
BRCA2 → Association, BRCA1, CEO, Environmental Health Sciences, Europe, Molecular Pathology, Myriad, Myriad Genetics, National Institute, NIEHS, Peter Meldrum, The, This, University, US, Utah
related to Clinical significance · 15
BRCA2 → An, As, BRCA1, BRCA2-associated, Certain, DNA, Fanconi, Major, Patients, People, Researchers, The, There, This, Women
related to Meiosis · 14
BRCA2 → Arabidopsis, AtBRCA2, AtDMC1, AtRAD51, AtZYP1, Caenorhabditis, DNA, Drosophila, Furthermore, Homologs, In, It, Thus AtBRCA2, Ustilago
related to Function · 13
BRCA2 → Although, BRCA1, BRCA1-PALB2-BRCA2, By, DNA, Double, Figure, MRE11-dependent, PALB2, Partner, RAD51, The, These

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna cancer gene protein breast repair brca1 mutations genes human also rad51 meiosis homologous myriad mutation domain found strand chromosome

BRCA2 relationships Subject–Predicate–Object triples

TTTA extracted 277 structured relationships around BRCA2. Examples in this analysis include BRCA2 → Aliases → BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes and BRCA2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 3EU7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BRCA2AliasesBRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes1.00infobox
BRCA2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 3EU71.00infobox
BRCA2Band13q13.11.00infobox
BRCA2Band5 G3|5 89.52 cM1.00infobox
BRCA2Bgeetesticle1.00infobox
BRCA2Bgeesecondary oocyte1.00infobox
BRCA2Bgeeventricular zone1.00infobox
BRCA2Bgeegonad1.00infobox
BRCA2Bgeeganglionic eminence1.00infobox
BRCA2Bgeegranulocyte1.00infobox
BRCA2Bgeebone marrow cell1.00infobox
BRCA2Bgeetrabecular bone1.00infobox
BRCA2Bgeestromal cell of endometrium1.00infobox
BRCA2BgeeAchilles tendon1.00infobox
BRCA2Bgeeprimary oocyte1.00infobox
BRCA2Bgeezygote1.00infobox
BRCA2Bgeetail of embryo1.00infobox
BRCA2Bgeeepiblast1.00infobox
BRCA2Bgeeseminiferous tubule1.00infobox
BRCA2Bgeemaxillary prominence1.00infobox
BRCA2Bgeegenital tubercle1.00infobox
BRCA2Bgeeankle joint1.00infobox
BRCA2Bgeemandibular prominence1.00infobox
BRCA2BioGPSMore reference expression data1.00infobox
BRCA2Chr.Chromosome 13 (human)1.00infobox
BRCA2Chr.Chromosome 5 (mouse)1.00infobox
BRCA2DatabasesNCBI: entry; OMA: entry1.00infobox
BRCA2End32,400,268 bp1.00infobox
BRCA2End150,493,794 bp1.00infobox
BRCA2EnsemblENSG000001396181.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BRCA2 bring nearby vocabulary together. In this analysis, examples include Dna, Gene and Cancer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BRCA2
    • Dna
    • Gene
    • Cancer
    • Mutations
    • Protein
    • Brca1
    • Breast
    • Repair
    • Mutation
    • Genes
    • Also
    • Function
  • brca2
    • Dna
    • Gene
    • Cancer
    • Mutations
    • Protein
    • Brca1
    • Breast
    • Repair
    • Mutation
    • Genes
    • Also
    • Function
  • genes
    • Brca1
    • Function
    • Expression
    • Human
    • Repair
    • Bp
    • Chr
    • Patents
    • Breast
    • Chromosome
    • See
    • Dna
  • hugo gene nomenclature committee
    • Cancer
    • Breast
    • Human
    • Mutations
    • Protein
    • Chromosome
    • Ovarian
    • Brca1
    • Bp
    • Chr
    • Risk
    • Function
  • tumor suppressor gene
    • Cancer
    • Breast
    • Human
    • Mutations
    • Protein
    • Chromosome
    • Ovarian
    • Brca1
    • Bp
    • Chr
    • Risk
    • Function
  • caretaker gene
    • Cancer
    • Breast
    • Human
    • Mutations
    • Protein
    • Chromosome
    • Ovarian
    • Brca1
    • Bp
    • Chr
    • Risk
    • Function
  • brca1
    • Breast
    • Genes
    • Patents
    • Brca2
    • Genetics
    • Cancer
    • Myriad
    • Gene
    • Mutation
    • Dna
    • Mutations
    • Repair
  • breast
    • Cancer
    • Ovarian
    • Gene
    • Mutation
    • Risk
    • Brca1
    • Found
    • Mutations
    • Genes
    • Also
    • Dna
    • Repair

Connections between topic areas Semantic bridges

For BRCA2, one of the stronger structural bridges in this analysis connects BRCA2 with Domain architecture. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BRCA2Domain architecture · splits 95 ⟂ 29
BRCA2Overview · splits 103 ⟂ 21
BRCA2Interactions · splits 104 ⟂ 20
BRCA2Clinical significance · splits 113 ⟂ 11
BRCA2Function · splits 116 ⟂ 8
BRCA2History · splits 116 ⟂ 8
BRCA2Meiosis · splits 116 ⟂ 8
BRCA2BRCA2 expression in cancer · splits 117 ⟂ 7
BRCA2Epigenetic control · splits 120 ⟂ 4
BRCA2Patents, enforcement, litigation, and controversy · splits 120 ⟂ 4
BRCA2Neurogenesis · splits 121 ⟂ 3

Map overview Semantic statistics

BRCA2

Nodes124
Edges123
Triples277
Avg. degree1.98
Density0.016129
Components1

Source & methodology

TTTA analyzes the structure around BRCA2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BRCA2 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.