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BRCA2

BRCA2 and BRCA2 (/ˌbrækəˈtuː/) are human genes and their protein products, respectively. The official symbol (BRCA2, italic for the gene, nonitalic for the protein) and the official name (originally breast cancer 2; currently BRCA2, DNA repair associated) are maintained by the HUGO Gene Nomenclature Committee. One alternative symbol, FANCD1, recognizes…

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Aliases
BRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 3EU7
Band
13q13.1 · 5 G3|5 89.52 cM
Bgee
testicle · secondary oocyte · ventricular zone · gonad · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 13 (human) · Chromosome 5 (mouse)

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Overview

Function

Clinical significance

History

Meiosis

Neurogenesis

Epigenetic control

BRCA2 expression in cancer

Interactions

Domain architecture

Patents, enforcement, litigation, and controversy

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Map overview Semantic statistics

BRCA2

Nodes124
Edges123
Triples277
Avg. degree1.98
Density0.016129
Components1

How this topic connects Entity context

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BRCA2

Top relations

Gene ontology · 64
BRCA2 → brain development, BRCA2-MAGE-D1 complex, cell cycle, cell population proliferation, cellular response to DNA damage stimulus, centrosome, centrosome duplication, chordate embryonic development, chromosome organization, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA recombination, DNA repair, DNA synthesis involved in double-strand break repair via homologous recombination, double-strand break repair, double-strand break repair via homologous recombination, establishment of protein localization to telomere
Bgee · 19
BRCA2 → Achilles tendon, ankle joint, bone marrow cell, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, mandibular prominence, maxillary prominence, primary oocyte, secondary oocyte, seminiferous tubule, stromal cell of endometrium, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BRCA2 → Achilles tendon, ankle joint, bone marrow cell, epiblast, ganglionic eminence, genital tubercle, gonad, granulocyte, mandibular prominence, maxillary prominence, primary oocyte, secondary oocyte, seminiferous tubule, stromal cell of endometrium, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
related to Interactions · 19
BRCA2 → BARD1, BCCIP, BRCA1, BRCC3, BRE, BUB1B, C11orf30, CREBBP, FANCD2, FANCG, FLNA, HMG20B, P53, PALB2, PCAF, PLK1, RAD51, RPA1, SHFM1
related to BRCA2 expression in cancer · 18
BRCA2 → At, BCDX2, DNA, Figure, In, RAD51, RAD51B, RAD51C, RAD51D, RAD51L1, RAD51L2, RAD51L3, Recombinational, Some, Table, The BCDX2, This, XRCC2
related to history · 17
BRCA2 → Ashkenazi Jewish, Cancer Research, Center, Development Limited Partnership, Endo Recherche, HSC Research, In, Inc, Kenneth Offit, London, Memorial Sloan Kettering Cancer, Myriad Genetics, Pennsylvania, The, The BRCA2, The Institute, University
related to Patents, enforcement, litigation, and controversy · 16
BRCA2 → Association, BRCA1, CEO, Environmental Health Sciences, Europe, Molecular Pathology, Myriad, Myriad Genetics, National Institute, NIEHS, Peter Meldrum, The, This, University, US, Utah
related to Clinical significance · 15
BRCA2 → An, As, BRCA1, BRCA2-associated, Certain, DNA, Fanconi, Major, Patients, People, Researchers, The, There, This, Women
related to Meiosis · 14
BRCA2 → Arabidopsis, AtBRCA2, AtDMC1, AtRAD51, AtZYP1, Caenorhabditis, DNA, Drosophila, Furthermore, Homologs, In, It, Thus AtBRCA2, Ustilago
related to Function · 13
BRCA2 → Although, BRCA1, BRCA1-PALB2-BRCA2, By, DNA, Double, Figure, MRE11-dependent, PALB2, Partner, RAD51, The, These

Important terminology Word statistics

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Important terminology

dna cancer gene protein breast repair brca1 mutations genes human also rad51 meiosis homologous myriad mutation domain found strand chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BRCA2AliasesBRCA2, BRCC2, BROVCA2, FACD, FAD, FAD1, FANCD, FANCD1, GLM3, PNCA2, XRCC11, breast cancer 2, DNA repair associated, breast cancer 2, early onset, BRCA2 DNA repair associated, Genes1.00infobox
BRCA2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 3EU71.00infobox
BRCA2Band13q13.11.00infobox
BRCA2Band5 G3|5 89.52 cM1.00infobox
BRCA2Bgeetesticle1.00infobox
BRCA2Bgeesecondary oocyte1.00infobox
BRCA2Bgeeventricular zone1.00infobox
BRCA2Bgeegonad1.00infobox
BRCA2Bgeeganglionic eminence1.00infobox
BRCA2Bgeegranulocyte1.00infobox
BRCA2Bgeebone marrow cell1.00infobox
BRCA2Bgeetrabecular bone1.00infobox
BRCA2Bgeestromal cell of endometrium1.00infobox
BRCA2BgeeAchilles tendon1.00infobox
BRCA2Bgeeprimary oocyte1.00infobox
BRCA2Bgeezygote1.00infobox
BRCA2Bgeetail of embryo1.00infobox
BRCA2Bgeeepiblast1.00infobox
BRCA2Bgeeseminiferous tubule1.00infobox
BRCA2Bgeemaxillary prominence1.00infobox
BRCA2Bgeegenital tubercle1.00infobox
BRCA2Bgeeankle joint1.00infobox
BRCA2Bgeemandibular prominence1.00infobox
BRCA2BioGPSMore reference expression data1.00infobox
BRCA2Chr.Chromosome 13 (human)1.00infobox
BRCA2Chr.Chromosome 5 (mouse)1.00infobox
BRCA2DatabasesNCBI: entry; OMA: entry1.00infobox
BRCA2End32,400,268 bp1.00infobox
BRCA2End150,493,794 bp1.00infobox
BRCA2EnsemblENSG000001396181.00infobox

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