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Explore the main themes, entities and connections around Mdm2. Start with the topic map, then use the sections below for research and deeper semantic analysis.
Explore this topic
Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Interactions
33 related topics
Structure and function
10 related topics
E3 ligase activity
8 related topics
Discovery and expression in tumor cells
5 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- 2.3.2.27
- ↗
- Aliases
- MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS,…
- Band
- 12q15 · 10 D2|10 66.32 cM
- Bgee
- Achilles tendon · ventricular zone · right uterine tube · olfactory zone of nasal mucosa · sural nerve
- BioGPS
- More reference expression data
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Protein
- Gene
- P53
- E3 ubiquitin ligase Ubiquitin ligase
- N-terminal
Discovery and expression in tumor cells
- Double minute
- Oncogene
- Ras Ras (protein)
- Nude mice
- Tumor
E3 ligase activity
Structure and function
- Amino acids
- Structural domains Structural domain
- X-ray crystallography
- Phosphorylation
- Zinc finger
- C-terminal
- Zinc
- Walker A or P-loop Walker motifs
- Nucleotide
- RNA
Regulation
Interactions
- Interact Protein-protein interaction
- ABL1 Abl gene
- ARRB1 Arrestin beta 1
- ARRB2 Arrestin beta 2
- CCNG1
- CTBP1
- CTBP2
- DAXX Death associated protein 6
- DHFR Dihydrofolate reductase
- EP300
- ERICH3 C1orf173
- FKBP3
- FOXO4
- GNL3
- HDAC1
- HIF1A
- HTATIP
- IGF1R Insulin-like growth factor 1 receptor
- MDM4
- NUMB NUMB (gene)
- P16 P16 (gene)
- P73
- PCAF
- PSMD10
- PSME3
- RPL5 Ribosomal protein L5
- RPL11
- PML Promyelocytic leukemia protein
- RPL26
- RRM2B
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.Mdm2
Nodes73
Edges72
Triples253
Avg. degree1.97
Density0.027397
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
Mdm2
Top relations
Gene ontology · 102
Mdm2 → 5S rRNA binding, amyloid fibril formation, atrial septum development, atrioventricular valve morphogenesis, blood vessel development, blood vessel remodeling, cardiac septum morphogenesis, cellular response to actinomycin D, cellular response to alkaloid, cellular response to antibiotic, cellular response to estrogen stimulus, cellular response to gamma radiation, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to peptide hormone stimulus, cellular response to UV-C, cellular response to vitamin B1
related to Interactions · 32
Mdm2 → ABL1, ARRB1, ARRB2, CCNG1, CTBP1, CTBP2, DAXX, DHFR, EP300, ERICH3, FKBP3, FOXO4, GNL3, HDAC1, HIF1A, HTATIP, IGF1R, MDM4, NUMB, P16
Bgee · 20
Mdm2 → Achilles tendon, aortic valve, ascending aorta, epithelium of colon, epithelium of nasopharynx, ganglionic eminence, gastrula, granulocyte, muscle of thigh, olfactory zone of nasal mucosa, right lobe of liver, right uterine tube, secondary oocyte, seminiferous tubule, spermatid, spermatocyte, stromal cell of endometrium, sural nerve, ventricular zone, zygote
RNA expression pattern · 20
Mdm2 → Achilles tendon, aortic valve, ascending aorta, epithelium of colon, epithelium of nasopharynx, ganglionic eminence, gastrula, granulocyte, muscle of thigh, olfactory zone of nasal mucosa, right lobe of liver, right uterine tube, secondary oocyte, seminiferous tubule, spermatid, spermatocyte, stromal cell of endometrium, sural nerve, ventricular zone, zygote
related to Structure and function · 16
Mdm2 → Another, C-terminal RING, Cis3-His2-Cis3, E3, In, Mdm2 RING, N-terminal, P-loop, RING, RNA, The, The Mdm2, The RING, These, This, Walker
related to Regulation · 9
Mdm2 → Additionally, ARF, Following DNA, HIPK2, Inhibitors, MDM2-p53, One, The, There
related to Discovery and expression in tumor cells · 8
Mdm2 → An, DM, Further, Hdm2, Mdm4, MdmX, Ras, The
related to E3 ligase activity · 7
Mdm2 → C-terminus, DNA, E3, In, Several, The E3, This
related to Mdm2 p53-independent role · 6
Mdm2 → DNA, Mdm2-induced, Nbs1, Nbs1-binding, Regardless, These
is a · 5
Mdm2 → important negative regulator of the p53 tumor suppressor, negative regulator of the p53 tumor suppressor protein, p53 responsive gene, p53 tumor suppressor, protein that in humans is encoded by the MDM2 gene
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
p53 protein domain also tumor ligase ubiquitin e3 human bp gene function activity negative chr band dna mouse levels degradation
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Mdm2 | 2.3.2.27 | ↗ | 1.00 | infobox |
| Mdm2 | Aliases | MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB | 1.00 | infobox |
| Mdm2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS,… | 1.00 | infobox |
| Mdm2 | Band | 12q15 | 1.00 | infobox |
| Mdm2 | Band | 10 D2|10 66.32 cM | 1.00 | infobox |
| Mdm2 | Bgee | Achilles tendon | 1.00 | infobox |
| Mdm2 | Bgee | ventricular zone | 1.00 | infobox |
| Mdm2 | Bgee | right uterine tube | 1.00 | infobox |
| Mdm2 | Bgee | olfactory zone of nasal mucosa | 1.00 | infobox |
| Mdm2 | Bgee | sural nerve | 1.00 | infobox |
| Mdm2 | Bgee | epithelium of colon | 1.00 | infobox |
| Mdm2 | Bgee | epithelium of nasopharynx | 1.00 | infobox |
| Mdm2 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| Mdm2 | Bgee | right lobe of liver | 1.00 | infobox |
| Mdm2 | Bgee | ganglionic eminence | 1.00 | infobox |
| Mdm2 | Bgee | zygote | 1.00 | infobox |
| Mdm2 | Bgee | gastrula | 1.00 | infobox |
| Mdm2 | Bgee | seminiferous tubule | 1.00 | infobox |
| Mdm2 | Bgee | spermatocyte | 1.00 | infobox |
| Mdm2 | Bgee | granulocyte | 1.00 | infobox |
| Mdm2 | Bgee | spermatid | 1.00 | infobox |
| Mdm2 | Bgee | aortic valve | 1.00 | infobox |
| Mdm2 | Bgee | secondary oocyte | 1.00 | infobox |
| Mdm2 | Bgee | ascending aorta | 1.00 | infobox |
| Mdm2 | Bgee | muscle of thigh | 1.00 | infobox |
| Mdm2 | BioGPS | More reference expression data | 1.00 | infobox |
| Mdm2 | Chr. | Chromosome 12 (human) | 1.00 | infobox |
| Mdm2 | Chr. | Chromosome 10 (mouse) | 1.00 | infobox |
| Mdm2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Mdm2 | End | 68,845,544 bp | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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