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Mdm2: Interactions, Structure and function & E3 ligase activity

Mouse double minute 2 homolog (MDM2) also known as E3 ubiquitin-protein ligase Mdm2 is a protein that in humans is encoded by the MDM2 gene. Mdm2 is an important negative regulator of the p53 tumor suppressor. Mdm2 protein functions both as an E3 ubiquitin ligase that recognizes the N-terminal trans-activation domain (TAD) of the p53 tumor suppressor and…

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Mdm2 topic overview

The analysis highlights Interactions, Structure and function and E3 ligase activity as prominent areas in the source structure around Mdm2.

Related topics
66
Source areas
6
Connected nodes
72
Extracted relationships
253
Concept neighborhoods
18
Bridge connections
72

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 33 topics
Structure and function · 10 topics
E3 ligase activity · 8 topics
Discovery and expression in tumor cells · 5 topics
Overview · 5 topics
Regulation · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27
↗
Aliases
MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS,…
Band
12q15 · 10 D2|10 66.32 cM
Bgee
Achilles tendon · ventricular zone · right uterine tube · olfactory zone of nasal mucosa · sural nerve
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery and expression in tumor cells

E3 ligase activity

Structure and function

Regulation

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mdm2 connects Entity context

The extracted context around Mdm2 shows recurring relationship patterns in the source. For example, Mdm2 → 5S rRNA binding, amyloid fibril formation, atrial septum development, atrioventricular valve morphogenesis, blood vessel development, blood vessel remodeling, cardiac septum morphogenesis, cellular response to actinomycin D, cellular response to alkaloid, cellular response to antibiotic, cellular response to estrogen stimulus, cellular response to gamma radiation, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to peptide hormone stimulus, cellular response to UV-C, cellular response to vitamin B1 Another extracted example is Mdm2 → ABL1, ARRB1, ARRB2, CCNG1, CTBP1, CTBP2, DAXX, DHFR, EP300, ERICH3, FKBP3, FOXO4, GNL3, HDAC1, HIF1A, HTATIP, IGF1R, MDM4, NUMB, P16. Use these groups to spot repeated connection types before inspecting the individual relationships.

Mdm2

Top relations

Gene ontology · 102
Mdm2 → 5S rRNA binding, amyloid fibril formation, atrial septum development, atrioventricular valve morphogenesis, blood vessel development, blood vessel remodeling, cardiac septum morphogenesis, cellular response to actinomycin D, cellular response to alkaloid, cellular response to antibiotic, cellular response to estrogen stimulus, cellular response to gamma radiation, cellular response to growth factor stimulus, cellular response to hydrogen peroxide, cellular response to hypoxia, cellular response to organic cyclic compound, cellular response to organic substance, cellular response to peptide hormone stimulus, cellular response to UV-C, cellular response to vitamin B1
related to Interactions · 32
Mdm2 → ABL1, ARRB1, ARRB2, CCNG1, CTBP1, CTBP2, DAXX, DHFR, EP300, ERICH3, FKBP3, FOXO4, GNL3, HDAC1, HIF1A, HTATIP, IGF1R, MDM4, NUMB, P16
Bgee · 20
Mdm2 → Achilles tendon, aortic valve, ascending aorta, epithelium of colon, epithelium of nasopharynx, ganglionic eminence, gastrula, granulocyte, muscle of thigh, olfactory zone of nasal mucosa, right lobe of liver, right uterine tube, secondary oocyte, seminiferous tubule, spermatid, spermatocyte, stromal cell of endometrium, sural nerve, ventricular zone, zygote
RNA expression pattern · 20
Mdm2 → Achilles tendon, aortic valve, ascending aorta, epithelium of colon, epithelium of nasopharynx, ganglionic eminence, gastrula, granulocyte, muscle of thigh, olfactory zone of nasal mucosa, right lobe of liver, right uterine tube, secondary oocyte, seminiferous tubule, spermatid, spermatocyte, stromal cell of endometrium, sural nerve, ventricular zone, zygote
related to Structure and function · 16
Mdm2 → Another, C-terminal RING, Cis3-His2-Cis3, E3, In, Mdm2 RING, N-terminal, P-loop, RING, RNA, The, The Mdm2, The RING, These, This, Walker
related to Regulation · 9
Mdm2 → Additionally, ARF, Following DNA, HIPK2, Inhibitors, MDM2-p53, One, The, There
related to Discovery and expression in tumor cells · 8
Mdm2 → An, DM, Further, Hdm2, Mdm4, MdmX, Ras, The
related to E3 ligase activity · 7
Mdm2 → C-terminus, DNA, E3, In, Several, The E3, This
related to Mdm2 p53-independent role · 6
Mdm2 → DNA, Mdm2-induced, Nbs1, Nbs1-binding, Regardless, These
is a · 5
Mdm2 → important negative regulator of the p53 tumor suppressor, negative regulator of the p53 tumor suppressor protein, p53 responsive gene, p53 tumor suppressor, protein that in humans is encoded by the MDM2 gene

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p53 protein domain also tumor ligase ubiquitin e3 human bp gene function activity negative chr band dna mouse levels degradation

Mdm2 relationships Subject–Predicate–Object triples

TTTA extracted 253 structured relationships around Mdm2. Examples in this analysis include Mdm2 → 2.3.2.27 → ↗ and Mdm2 → Aliases → MDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Mdm22.3.2.27↗1.00infobox
Mdm2AliasesMDM2, ACTFS, HDMX, hdm2, MDM2 proto-oncogene, LSKB1.00infobox
Mdm2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1RV1, 1T4E, 1T4F, 1YCR, 1Z1M, 2AXI, 2C6A, 2C6B, 2FOP, 2GV2, 2HDP, 2LZG, 2M86, 2MPS, 2RUH, 2VJE, 2VJF, 3EQS,…1.00infobox
Mdm2Band12q151.00infobox
Mdm2Band10 D2|10 66.32 cM1.00infobox
Mdm2BgeeAchilles tendon1.00infobox
Mdm2Bgeeventricular zone1.00infobox
Mdm2Bgeeright uterine tube1.00infobox
Mdm2Bgeeolfactory zone of nasal mucosa1.00infobox
Mdm2Bgeesural nerve1.00infobox
Mdm2Bgeeepithelium of colon1.00infobox
Mdm2Bgeeepithelium of nasopharynx1.00infobox
Mdm2Bgeestromal cell of endometrium1.00infobox
Mdm2Bgeeright lobe of liver1.00infobox
Mdm2Bgeeganglionic eminence1.00infobox
Mdm2Bgeezygote1.00infobox
Mdm2Bgeegastrula1.00infobox
Mdm2Bgeeseminiferous tubule1.00infobox
Mdm2Bgeespermatocyte1.00infobox
Mdm2Bgeegranulocyte1.00infobox
Mdm2Bgeespermatid1.00infobox
Mdm2Bgeeaortic valve1.00infobox
Mdm2Bgeesecondary oocyte1.00infobox
Mdm2Bgeeascending aorta1.00infobox
Mdm2Bgeemuscle of thigh1.00infobox
Mdm2BioGPSMore reference expression data1.00infobox
Mdm2Chr.Chromosome 12 (human)1.00infobox
Mdm2Chr.Chromosome 10 (mouse)1.00infobox
Mdm2DatabasesNCBI: entry; OMA: entry1.00infobox
Mdm2End68,845,544 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mdm2 bring nearby vocabulary together. In this analysis, examples include P53, Protein and Domain. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Mdm2
    • P53
    • Protein
    • Domain
    • Also
    • Ligase
    • E3
    • Tumor
    • Ubiquitin
    • Degradation
    • Levels
    • Negative
    • Function
  • mdm2
    • P53
    • Protein
    • Domain
    • Also
    • Ligase
    • E3
    • Tumor
    • Ubiquitin
    • Degradation
    • Levels
    • Negative
    • Function
  • protein
    • Function
    • Ubiquitin
    • N-terminal
    • Ubiquitination
    • Contains
    • Interaction
    • Phosphorylation
    • Several
    • Suppressor
    • Transcription
    • Zinc
    • Activity
  • gene
    • Location
    • Mouse
    • Chromosome
    • Bp
    • Chr
    • Human
    • Expression
    • Ubiquitination
    • Ligase
    • Band
    • Regulation
    • Transcription
  • p53
    • Protein
    • Dna
    • Degradation
    • Domain
    • Tumor
    • Ubiquitin
    • Suppressor
    • Target
    • Transcription
    • Activity
    • Levels
    • Function
  • e3 ubiquitin ligase
    • Ligase
    • Ubiquitin
    • Activity
    • Gene
    • Tumor
    • Expression
    • Location
    • Mouse
    • Suppressor
    • Ubiquitination
    • Chromosome
    • P53
  • zinc finger
    • Binding
    • Domain
    • Ring
    • Residues
    • Function
    • Expression
    • Location
    • Mouse
    • Ubiquitination
    • Band
    • Chromosome
    • Contains
  • zinc
    • Binding
    • Domain
    • Ring
    • Residues
    • Function
    • Expression
    • Location
    • Mouse
    • Ubiquitination
    • Band
    • Chromosome
    • Contains

Connections between topic areas Semantic bridges

For Mdm2, one of the stronger structural bridges in this analysis connects Mdm2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Mdm2 — Interactions · splits 39 ⟂ 34
Mdm2 — Structure and function · splits 62 ⟂ 11
Mdm2 — E3 ligase activity · splits 64 ⟂ 9
Mdm2 — Overview · splits 67 ⟂ 6
Mdm2 — Discovery and expression in tumor cells · splits 67 ⟂ 6
Mdm2 — Regulation · splits 67 ⟂ 6

Map overview Semantic statistics

Mdm2

Nodes73
Edges72
Triples253
Avg. degree1.97
Density0.027397
Components1

Source & methodology

TTTA analyzes the structure around Mdm2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Structure and function & E3 ligase activity, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mdm2 · EN edition · Analysis: TopicsToTalkAbout

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