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EP300: Regions & Products

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap…

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EP300 topic overview

The analysis highlights Regions and Products as prominent areas in the source structure around EP300.

Related topics
97
Source areas
5
Connected nodes
102
Extracted relationships
236
Concept neighborhoods
20
Bridge connections
102

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 58 topics
Overview · 13 topics
Clinical significance · 11 topics
Mechanism · 10 topics
Function · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.1.48
↗
Aliases
EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3
Band
22q13.2 · 15|15 E1
Bgee
epithelium of colon · bone marrow cell · lower lobe of lung · tonsil · testicle
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Mechanism

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How EP300 connects Entity context

The extracted context around EP300 shows recurring relationship patterns in the source. For example, EP300 → acetyltransferase activity, acyltransferase activity, androgen receptor binding, animal organ morphogenesis, apoptotic process, B cell differentiation, beta-catenin binding, beta-catenin-TCF complex assembly, cell cycle, cellular response to UV, chromatin binding, chromatin DNA binding, chromosome, circadian rhythm, cytoplasm, cytosol, damaged DNA binding, development of the heart, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest Another extracted example is EP300 → BCL3, BRCA1, CDX2, CEBPB, CITED1, CITED2, DDX5, DTX1, EID1, ELK1, ESR1, FEN1, GPS2, HIF1A, HNF1A, HNRPU, ING4, ING5, IRF2, LEF1. Use these groups to spot repeated connection types before inspecting the individual relationships.

EP300

Top relations

Gene ontology · 95
EP300 → acetyltransferase activity, acyltransferase activity, androgen receptor binding, animal organ morphogenesis, apoptotic process, B cell differentiation, beta-catenin binding, beta-catenin-TCF complex assembly, cell cycle, cellular response to UV, chromatin binding, chromatin DNA binding, chromosome, circadian rhythm, cytoplasm, cytosol, damaged DNA binding, development of the heart, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
related to Interactions · 57
EP300 → BCL3, BRCA1, CDX2, CEBPB, CITED1, CITED2, DDX5, DTX1, EID1, ELK1, ESR1, FEN1, GPS2, HIF1A, HNF1A, HNRPU, ING4, ING5, IRF2, LEF1
Bgee · 20
EP300 → bone marrow cell, corpus callosum, epithelium of colon, gastrula, genital tubercle, granulocyte, hand, lower lobe of lung, mesenteric lymph nodes, monocyte, parietal pleura, secondary oocyte, spleen, submandibular gland, tail of embryo, testicle, tonsil, ventricular zone, visceral pleura, zygote
RNA expression pattern · 20
EP300 → bone marrow cell, corpus callosum, epithelium of colon, gastrula, genital tubercle, granulocyte, hand, lower lobe of lung, mesenteric lymph nodes, monocyte, parietal pleura, secondary oocyte, spleen, submandibular gland, tail of embryo, testicle, tonsil, ventricular zone, visceral pleura, zygote
related to Clinical significance · 10
EP300 → Although, AML, Another, Chromosomal, For, Mutations, Rubinstein-Taybi, Some, These, This
related to External links · 8
EP300 → GeneReviews/NCBI/NIH/UW, Medicine, Medicine Medical Subject Headings, MeSH, National Library, NURSAC54FactorBookP300 This, Rubinstein-Taybi SyndromeGeneCardEP300, United States National Library
Band · 2
EP300 → 15|15 E1, 22q13.2
Chr. · 2
EP300 → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
EP300 → 41,180,077 bp, 81,536,278 bp
2.3.1.48 · 1
EP300 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene p300 protein chromosome human 22 mutations transcription bp binding chr band histone development cancer acetyltransferase enzyme cells cell function

EP300 relationships Subject–Predicate–Object triples

TTTA extracted 236 structured relationships around EP300. Examples in this analysis include EP300 → 2.3.1.48 → ↗ and EP300 → Aliases → EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
EP3002.3.1.48↗1.00infobox
EP300AliasesEP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK21.00infobox
EP300Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT31.00infobox
EP300Band22q13.21.00infobox
EP300Band15|15 E11.00infobox
EP300Bgeeepithelium of colon1.00infobox
EP300Bgeebone marrow cell1.00infobox
EP300Bgeelower lobe of lung1.00infobox
EP300Bgeetonsil1.00infobox
EP300Bgeetesticle1.00infobox
EP300Bgeevisceral pleura1.00infobox
EP300Bgeeventricular zone1.00infobox
EP300Bgeeparietal pleura1.00infobox
EP300Bgeecorpus callosum1.00infobox
EP300Bgeemonocyte1.00infobox
EP300Bgeetail of embryo1.00infobox
EP300Bgeegenital tubercle1.00infobox
EP300Bgeegastrula1.00infobox
EP300Bgeezygote1.00infobox
EP300Bgeegranulocyte1.00infobox
EP300Bgeemesenteric lymph nodes1.00infobox
EP300Bgeehand1.00infobox
EP300Bgeesubmandibular gland1.00infobox
EP300Bgeespleen1.00infobox
EP300Bgeesecondary oocyte1.00infobox
EP300BioGPSMore reference expression data1.00infobox
EP300Chr.Chromosome 22 (human)1.00infobox
EP300Chr.Chromosome 15 (mouse)1.00infobox
EP300DatabasesNCBI: entry; OMA: entry1.00infobox
EP300End41,180,077 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around EP300 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • EP300
    • Gene
    • Protein
    • Human
    • Chromosome
    • Mutations
    • Development
    • P300
    • Region
    • Tumors
    • Binding
    • Enzyme
    • Hat
  • ep300
    • Gene
    • Protein
    • Human
    • Chromosome
    • Mutations
    • Development
    • P300
    • Region
    • Tumors
    • Binding
    • Enzyme
    • Hat
  • gene
    • Protein
    • Chromosome
    • Mutations
    • P300
    • Human
    • Location
    • Region
    • One
    • Bp
    • Chr
    • Development
    • Binding
  • histone acetyltransferase
    • Histone
    • Chromatin
    • Dna
    • Functions
    • Hat
    • Region
    • Transcription
    • Adenovirus
    • Cellular
    • E1a
    • E1a-associated
    • Mouse
  • chromatin remodeling
    • Dna
    • Functions
    • Histone
    • Transcription
    • Cellular
    • Mouse
    • Cell
    • Factor
    • Hat
    • Location
    • P53
    • Region
  • histone
    • Chromatin
    • Dna
    • Functions
    • Hat
    • Region
    • Transcription
    • Adenovirus
    • Cellular
    • E1a
    • E1a-associated
    • Mouse
    • Also
  • cell growth
    • Functions
    • Cellular
    • Chromatin
    • Dna
    • Mouse
    • Enzyme
    • Factor
    • Hat
    • Histone
    • Location
    • P53
    • Region
  • chromosome 22
    • Human
    • Bp
    • Chr
    • Location
    • Band
    • Gene
    • Ep300
    • Binding
    • Mouse
    • Region
    • Function
    • Protein

Connections between topic areas Semantic bridges

For EP300, one of the stronger structural bridges in this analysis connects EP300 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
EP300 — Interactions · splits 44 ⟂ 59
EP300 — Overview · splits 89 ⟂ 14
EP300 — Clinical significance · splits 91 ⟂ 12
EP300 — Mechanism · splits 92 ⟂ 11
EP300 — Function · splits 97 ⟂ 6

Map overview Semantic statistics

EP300

Nodes103
Edges102
Triples236
Avg. degree1.98
Density0.019417
Components1

Source & methodology

TTTA analyzes the structure around EP300 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — EP300 · EN edition · Analysis: TopicsToTalkAbout

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