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EP300

Histone acetyltransferase p300 also known as p300 HAT or E1A-associated protein p300 (where E1A = adenovirus early region 1A) also known as EP300 or p300 is an enzyme that, in humans, is encoded by the EP300 gene. It functions as histone acetyltransferase that regulates transcription of genes via chromatin remodeling by allowing histone proteins to wrap…

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2.3.1.48
Aliases
EP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT3
Band
22q13.2 · 15|15 E1
Bgee
epithelium of colon · bone marrow cell · lower lobe of lung · tonsil · testicle
BioGPS
More reference expression data

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Map overview Semantic statistics

EP300

Nodes103
Edges102
Triples236
Avg. degree1.98
Density0.019417
Components1

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EP300

Top relations

Gene ontology · 95
EP300 → acetyltransferase activity, acyltransferase activity, androgen receptor binding, animal organ morphogenesis, apoptotic process, B cell differentiation, beta-catenin binding, beta-catenin-TCF complex assembly, cell cycle, cellular response to UV, chromatin binding, chromatin DNA binding, chromosome, circadian rhythm, cytoplasm, cytosol, damaged DNA binding, development of the heart, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in cell cycle arrest
related to Interactions · 57
EP300 → BCL3, BRCA1, CDX2, CEBPB, CITED1, CITED2, DDX5, DTX1, EID1, ELK1, ESR1, FEN1, GPS2, HIF1A, HNF1A, HNRPU, ING4, ING5, IRF2, LEF1
Bgee · 20
EP300 → bone marrow cell, corpus callosum, epithelium of colon, gastrula, genital tubercle, granulocyte, hand, lower lobe of lung, mesenteric lymph nodes, monocyte, parietal pleura, secondary oocyte, spleen, submandibular gland, tail of embryo, testicle, tonsil, ventricular zone, visceral pleura, zygote
RNA expression pattern · 20
EP300 → bone marrow cell, corpus callosum, epithelium of colon, gastrula, genital tubercle, granulocyte, hand, lower lobe of lung, mesenteric lymph nodes, monocyte, parietal pleura, secondary oocyte, spleen, submandibular gland, tail of embryo, testicle, tonsil, ventricular zone, visceral pleura, zygote
related to Clinical significance · 10
EP300 → Although, AML, Another, Chromosomal, For, Mutations, Rubinstein-Taybi, Some, These, This
related to External links · 8
EP300 → GeneReviews/NCBI/NIH/UW, Medicine, Medicine Medical Subject Headings, MeSH, National Library, NURSAC54FactorBookP300 This, Rubinstein-Taybi SyndromeGeneCardEP300, United States National Library
Band · 2
EP300 → 15|15 E1, 22q13.2
Chr. · 2
EP300 → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
EP300 → 41,180,077 bp, 81,536,278 bp
2.3.1.48 · 1
EP300 → ↗

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Important terminology

gene p300 protein chromosome human 22 mutations transcription bp binding chr band histone development cancer acetyltransferase enzyme cells cell function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EP3002.3.1.481.00infobox
EP300AliasesEP300, KAT3B, RSTS2, p300, E1A binding protein p300, MKHK21.00infobox
EP300Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1L3E, 1P4Q, 2K8F, 2MH0, 2MZD, 3BIY, 3I3J, 3IO2, 3P57, 3T92, 4BHW, 4PZR, 4PZS, 4PZT, 5BT31.00infobox
EP300Band22q13.21.00infobox
EP300Band15|15 E11.00infobox
EP300Bgeeepithelium of colon1.00infobox
EP300Bgeebone marrow cell1.00infobox
EP300Bgeelower lobe of lung1.00infobox
EP300Bgeetonsil1.00infobox
EP300Bgeetesticle1.00infobox
EP300Bgeevisceral pleura1.00infobox
EP300Bgeeventricular zone1.00infobox
EP300Bgeeparietal pleura1.00infobox
EP300Bgeecorpus callosum1.00infobox
EP300Bgeemonocyte1.00infobox
EP300Bgeetail of embryo1.00infobox
EP300Bgeegenital tubercle1.00infobox
EP300Bgeegastrula1.00infobox
EP300Bgeezygote1.00infobox
EP300Bgeegranulocyte1.00infobox
EP300Bgeemesenteric lymph nodes1.00infobox
EP300Bgeehand1.00infobox
EP300Bgeesubmandibular gland1.00infobox
EP300Bgeespleen1.00infobox
EP300Bgeesecondary oocyte1.00infobox
EP300BioGPSMore reference expression data1.00infobox
EP300Chr.Chromosome 22 (human)1.00infobox
EP300Chr.Chromosome 15 (mouse)1.00infobox
EP300DatabasesNCBI: entry; OMA: entry1.00infobox
EP300End41,180,077 bp1.00infobox

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