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DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.
The analysis highlights Standards, Interactions and In other species as prominent areas in the source structure around TOP2A.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TOP2A shows recurring relationship patterns in the source. For example, TOP2A → apoptotic chromosome condensation, ATP binding, ATP-dependent activity, acting on DNA, cellular response to DNA damage stimulus, centriole, chromatin binding, chromosome condensation, chromosome segregation, condensed chromosome, cytoplasm, DNA binding, DNA binding, bending, DNA ligation, DNA metabolic process, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, DNA topological change, embryonic cleavage, enzyme binding Another extracted example is TOP2A → bone marrow, bone marrow cell, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, left testis, mandibular prominence, maxillary prominence, primitive streak, right testis, secondary oocyte, somite, tail of embryo, testicle, tibiofemoral joint, trabecular bone, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene dna enzyme human topoisomerase bp chromosome 17 chr band ii activity location iiα two encoding also mouse ataxia-telangiectasia topological
TTTA extracted 121 structured relationships around TOP2A. Examples in this analysis include TOP2A → 5.6.2.2 → ↗ and TOP2A → Aliases → TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TOP2A | 5.6.2.2 | ↗ | 1.00 | infobox |
| TOP2A | Aliases | TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha | 1.00 | infobox |
| TOP2A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXM, 1ZXN, 4FM9, 4R1F | 1.00 | infobox |
| TOP2A | Band | 17q21.2 | 1.00 | infobox |
| TOP2A | Band | 11 D|11 62.91 cM | 1.00 | infobox |
| TOP2A | Bgee | ventricular zone | 1.00 | infobox |
| TOP2A | Bgee | ganglionic eminence | 1.00 | infobox |
| TOP2A | Bgee | secondary oocyte | 1.00 | infobox |
| TOP2A | Bgee | right testis | 1.00 | infobox |
| TOP2A | Bgee | left testis | 1.00 | infobox |
| TOP2A | Bgee | bone marrow | 1.00 | infobox |
| TOP2A | Bgee | trabecular bone | 1.00 | infobox |
| TOP2A | Bgee | gonad | 1.00 | infobox |
| TOP2A | Bgee | bone marrow cell | 1.00 | infobox |
| TOP2A | Bgee | testicle | 1.00 | infobox |
| TOP2A | Bgee | genital tubercle | 1.00 | infobox |
| TOP2A | Bgee | tail of embryo | 1.00 | infobox |
| TOP2A | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| TOP2A | Bgee | maxillary prominence | 1.00 | infobox |
| TOP2A | Bgee | primitive streak | 1.00 | infobox |
| TOP2A | Bgee | mandibular prominence | 1.00 | infobox |
| TOP2A | Bgee | epiblast | 1.00 | infobox |
| TOP2A | Bgee | tibiofemoral joint | 1.00 | infobox |
| TOP2A | Bgee | somite | 1.00 | infobox |
| TOP2A | BioGPS | n/a | 1.00 | infobox |
| TOP2A | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| TOP2A | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| TOP2A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TOP2A | End | 40,417,896 bp | 1.00 | infobox |
| TOP2A | End | 98,915,015 bp | 1.00 | infobox |
The concept neighborhoods around TOP2A bring nearby vocabulary together. In this analysis, examples include Search, Species and Activity. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TOP2A, one of the stronger structural bridges in this analysis connects TOP2A with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TOP2A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Interactions & In other species, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TOP2A · EN edition · Analysis: TopicsToTalkAbout