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TOP2A

DNA topoisomerase IIα is a human enzyme encoded by the TOP2A gene.

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7 related topics

In other species

1 related topics

Overview

2 related topics

Key facts & relationships

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5.6.2.2
Aliases
TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXM, 1ZXN, 4FM9, 4R1F
Band
17q21.2 · 11 D|11 62.91 cM
Bgee
ventricular zone · ganglionic eminence · secondary oocyte · right testis · left testis
BioGPS
n/a

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Overview

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In other species

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Map overview Semantic statistics

TOP2A

Nodes14
Edges13
Triples121
Avg. degree1.86
Density0.142857
Components1

How this topic connects Entity context

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TOP2A

Top relations

Gene ontology · 52
TOP2A → apoptotic chromosome condensation, ATP binding, ATP-dependent activity, acting on DNA, cellular response to DNA damage stimulus, centriole, chromatin binding, chromosome condensation, chromosome segregation, condensed chromosome, cytoplasm, DNA binding, DNA binding, bending, DNA ligation, DNA metabolic process, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, DNA topological change, embryonic cleavage, enzyme binding
Bgee · 19
TOP2A → bone marrow, bone marrow cell, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, left testis, mandibular prominence, maxillary prominence, primitive streak, right testis, secondary oocyte, somite, tail of embryo, testicle, tibiofemoral joint, trabecular bone, ventricular zone
RNA expression pattern · 19
TOP2A → bone marrow, bone marrow cell, epiblast, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, left testis, mandibular prominence, maxillary prominence, primitive streak, right testis, secondary oocyte, somite, tail of embryo, testicle, tibiofemoral joint, trabecular bone, ventricular zone
related to Interactions · 6
TOP2A → CDC5L, HDAC1, P53, Small, SMURF2, TOPBP1
Band · 2
TOP2A → 11 D|11 62.91 cM, 17q21.2
Chr. · 2
TOP2A → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
TOP2A → 40,417,896 bp, 98,915,015 bp
5.6.2.2 · 1
TOP2A → ↗
Aliases · 1
TOP2A → TOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha
Available structures · 1
TOP2A → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXM, 1ZXN, 4FM9, 4R1F

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Important terminology

gene dna enzyme human topoisomerase bp chromosome 17 chr band ii activity location iiα two encoding also mouse ataxia-telangiectasia topological

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TOP2A5.6.2.21.00infobox
TOP2AAliasesTOP2A, TOP2, TP2A, topoisomerase (DNA) II alpha, DNA topoisomerase II alpha, TOPIIA, TOP2alpha1.00infobox
TOP2AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1ZXM, 1ZXN, 4FM9, 4R1F1.00infobox
TOP2ABand17q21.21.00infobox
TOP2ABand11 D|11 62.91 cM1.00infobox
TOP2ABgeeventricular zone1.00infobox
TOP2ABgeeganglionic eminence1.00infobox
TOP2ABgeesecondary oocyte1.00infobox
TOP2ABgeeright testis1.00infobox
TOP2ABgeeleft testis1.00infobox
TOP2ABgeebone marrow1.00infobox
TOP2ABgeetrabecular bone1.00infobox
TOP2ABgeegonad1.00infobox
TOP2ABgeebone marrow cell1.00infobox
TOP2ABgeetesticle1.00infobox
TOP2ABgeegenital tubercle1.00infobox
TOP2ABgeetail of embryo1.00infobox
TOP2ABgeefetal liver hematopoietic progenitor cell1.00infobox
TOP2ABgeemaxillary prominence1.00infobox
TOP2ABgeeprimitive streak1.00infobox
TOP2ABgeemandibular prominence1.00infobox
TOP2ABgeeepiblast1.00infobox
TOP2ABgeetibiofemoral joint1.00infobox
TOP2ABgeesomite1.00infobox
TOP2ABioGPSn/a1.00infobox
TOP2AChr.Chromosome 17 (human)1.00infobox
TOP2AChr.Chromosome 11 (mouse)1.00infobox
TOP2ADatabasesNCBI: entry; OMA: entry1.00infobox
TOP2AEnd40,417,896 bp1.00infobox
TOP2AEnd98,915,015 bp1.00infobox

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