PTK2

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PTK2 topic overview

The analysis highlights Interactions, Function and Structure as prominent areas in the source structure around PTK2.

Related topics: 75
Source areas: 8
Connected nodes: 83
Extracted relationships: 182
Related term clusters: 19
Bridge connections: 83

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 27 topics

Function · 19 topics

Structure · 8 topics

Regulation · 7 topics

As a drug target · 6 topics

Overview · 4 topics

Clinical significance · 2 topics

Role in apoptosis · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2: ↗
Aliases: PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…
Available structures: Available structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…
Band: 8q24.3 · 15 D3|15 33.94 cM
Bgee: ovary · testicle · antenna · gut · left lung lobe
BioGPS: 37233/ More reference expression data

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

PTK2

4Protein · Gene · Focal adhesion

5Non-receptor tyrosine kinase · Extracellular matrix · Tyrosine kinase

7Integrin · Growth factor · Mitogenic

11Oncogene · Src (gene) · Cytoplasmic

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation

Role in apoptosis

Structure

Clinical significance

As a drug target

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How PTK2 connects Entity context

The extracted context around PTK2 shows recurring relationship patterns in the source. For example, PTK2 → actin binding, adherens junction, angiogenesis, apical plasma membrane, ATP binding, axon guidance, blood vessel development, cell cortex, cell differentiation, cell junction, cell motility, cellular response to transforming growth factor beta stimulus, central nervous system neuron axonogenesis, cytoplasm, cytoskeleton, cytosol, dendritic spine, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway Another extracted example is PTK2 → BCAR1, BMX, CD61, CRK, DCC, FYN, GIT1, Grb2, GRB7, IRS1, ITGB5, JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 91

PTK2 → actin binding, adherens junction, angiogenesis, apical plasma membrane, ATP binding, axon guidance, blood vessel development, cell cortex, cell differentiation, cell junction, cell motility, cellular response to transforming growth factor beta stimulus, central nervous system neuron axonogenesis, cytoplasm, cytoskeleton, cytosol, dendritic spine, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway

related to Interactions · 29

PTK2 → BCAR1, BMX, CD61, CRK, DCC, FYN, GIT1, Grb2, GRB7, IRS1, ITGB5, JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN

Bgee · 14

PTK2 → antenna, dentate gyrus of hippocampal formation granule cell, dermis, Gonadal ridge, gut, human fetus, left lung lobe, mandibular prominence, maxillary prominence, medullary collecting duct, ovary, prefrontal cortex, tail of embryo, testicle

RNA expression pattern · 14

related to Function · 4

PTK2 → FAK, FERM, PYK2, The PTK2

Band · 2

PTK2 → 15 D3|15 33.94 cM, 8q24.3

Chr. · 2

PTK2 → Chromosome 15 (mouse), Chromosome 2 (human)

End · 2

PTK2 → 19,437,259 bp, 73,423,280 bp

2.7.10.2 · 1

PTK2 → ↗

Aliases · 1

PTK2 → PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fak kinase focal domain protein adhesion tyrosine human cell band bp gene cells chr shown activity integrin adhesions chromosome also

PTK2 relationships Subject–Predicate–Object triples

TTTA extracted 182 structured relationships around PTK2. Examples in this analysis include PTK2 → 2.7.10.2 → ↗ and PTK2 → Aliases → PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
PTK2	2.7.10.2	↗	1.00	infobox
PTK2	Aliases	PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…	1.00	infobox
PTK2	Available structures	Available structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…	1.00	infobox
PTK2	Band	8q24.3	1.00	infobox
PTK2	Band	15 D3\|15 33.94 cM	1.00	infobox
PTK2	Bgee	ovary	1.00	infobox
PTK2	Bgee	testicle	1.00	infobox
PTK2	Bgee	antenna	1.00	infobox
PTK2	Bgee	gut	1.00	infobox
PTK2	Bgee	left lung lobe	1.00	infobox
PTK2	Bgee	Gonadal ridge	1.00	infobox
PTK2	Bgee	dermis	1.00	infobox
PTK2	Bgee	medullary collecting duct	1.00	infobox
PTK2	Bgee	tail of embryo	1.00	infobox
PTK2	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
PTK2	Bgee	mandibular prominence	1.00	infobox
PTK2	Bgee	human fetus	1.00	infobox
PTK2	Bgee	maxillary prominence	1.00	infobox
PTK2	Bgee	prefrontal cortex	1.00	infobox
PTK2	BioGPS	37233/ More reference expression data	1.00	infobox
PTK2	Chr.	Chromosome 2 (human)	1.00	infobox
PTK2	Chr.	Chromosome 15 (mouse)	1.00	infobox
PTK2	Databases	NCBI: entry, entry; OMA: entry	1.00	infobox
PTK2	End	19,437,259 bp	1.00	infobox
PTK2	End	73,423,280 bp	1.00	infobox
PTK2	Ensembl	ENSG00000169398 FBgn0020440	1.00	infobox
PTK2	Entrez	5747,37233 5747,37233	1.00	infobox
PTK2	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.10.2↗↗↗↗	1.00	infobox
PTK2	External IDs	OMIM: 600758; MGI: 95481; GeneCards: PTK2	1.00	infobox
PTK2	Gene location (Human)	Gene location (Human)Chr.Chromosome 2 (human)Band8q24.3Start19,430,659 bpEnd19,437,259 bp	1.00	infobox

Related concept clusters Related term clusters

The concept neighborhoods around PTK2 bring nearby vocabulary together. In this analysis, examples include Tyrosine, Gene and Adhesion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

PTK2
- Tyrosine
- Gene
- Adhesion
- Kinase
- Human
- Cellular
- Involved
- Location
- Regulation
- Also
- Chromosome
- Focal
ptk2
- Tyrosine
- Gene
- Adhesion
- Kinase
- Human
- Cellular
- Involved
- Location
- Regulation
- Also
- Chromosome
- Focal
protein
- Tyrosine
- Ptk2
- Adhesion
- Kinase
- Focal
- Gene
- Cells
- Human
- Fak
- Cell
- Cellular
- Involved
gene
- Location
- Chromosome
- Bp
- Chr
- Ptk2
- Human
- Mouse
- Regulation
- Tyrosine
- Function
- Protein
- Activity
focal adhesion
- Adhesion
- Focal
- Adhesions
- Kinase
- Protein
- Ptk2
- Pdb
- Uniprot
- Gene
- Cells
- Human
- Actin
kinase
- Adhesion
- Tyrosine
- Protein
- Focal
- Ptk2
- Activity
- Fak
- Human
- Domain
- Cell
- Cellular
- Pdb
cytosolic protein tyrosine kinase
- Tyrosine
- Ptk2
- Adhesion
- Kinase
- Protein
- Focal
- Gene
- Cells
- Activity
- Human
- Fak
- Domain
tyrosine kinase
- Adhesion
- Tyrosine
- Protein
- Focal
- Ptk2
- Activity
- Fak
- Human
- Domain
- Cell
- Cellular
- Pdb

Connections between topic areas Semantic bridges

For PTK2, one of the stronger structural bridges in this analysis connects PTK2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

PTK2 — Interactions · splits 56 ⟂ 28

PTK2 — Function · splits 64 ⟂ 20

PTK2 — Structure · splits 75 ⟂ 9

PTK2 — Regulation · splits 76 ⟂ 8

PTK2 — As a drug target · splits 77 ⟂ 7

PTK2 — Overview · splits 79 ⟂ 5

PTK2 — Role in apoptosis · splits 81 ⟂ 3

PTK2 — Clinical significance · splits 81 ⟂ 3

Map overview Semantic statistics

PTK2

Nodes84

Edges83

Triples182

Avg. degree1.98

Density0.02381

Components1

Source & methodology

TTTA analyzes the structure around PTK2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PTK2 · EN edition · Analysis: TopicsToTalkAbout

PTK2: Interactions, Function & Structure

PTK2 topic overview

What this topic covers Research coverage

Key facts & relationships

Start with your topic. Discover where to go next.

Questions to explore

Explore all related topics Closing gaps

Overview

Function

Regulation

Role in apoptosis

Structure

Clinical significance

As a drug target

Interactions

For the semantics nerds

Advanced semantic analysis

How PTK2 connects Entity context

PTK2

Top relations

Important terminology

Important terminology

PTK2 relationships Subject–Predicate–Object triples

Related concept clusters Related term clusters

Connections between topic areas Semantic bridges

Map overview Semantic statistics

PTK2

Source & methodology