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PTK2

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when…

Interactions, Function & As a drug target

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2.7.10.2
↗
Aliases
PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…
Available structures
Available structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…
Band
8q24.3 · 15 D3|15 33.94 cM
Bgee
ovary · testicle · antenna · gut · left lung lobe
BioGPS
37233/ More reference expression data

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Function

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Role in apoptosis

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Clinical significance

As a drug target

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PTK2

Nodes91
Edges90
Triples208
Avg. degree1.98
Density0.021978
Components1

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PTK2

Top relations

Gene ontology · 91
PTK2 → actin binding, adherens junction, angiogenesis, apical plasma membrane, ATP binding, axon guidance, blood vessel development, cell cortex, cell differentiation, cell junction, cell motility, cellular response to transforming growth factor beta stimulus, central nervous system neuron axonogenesis, cytoplasm, cytoskeleton, cytosol, dendritic spine, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway
related to Interactions · 29
PTK2 → BCAR1, BMX, CD61, CRK, DCC, FYN, GIT1, Grb2, GRB7, IRS1, ITGB5, JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN
related to External links · 22
PTK2 → Archived, August, Breaking, Cancer Research UK, Cell Migration Gateway Archived, DR Nick Peel, FAKFAK Info, Human Focal, MBInfo, Medicine Medical Subject Headings, MeSH, Mouse Focal, National Library, Overview, P34152, PDB, PDBe-KB, Q05397, Science, UniProt
Bgee · 14
PTK2 → antenna, dentate gyrus of hippocampal formation granule cell, dermis, Gonadal ridge, gut, human fetus, left lung lobe, mandibular prominence, maxillary prominence, medullary collecting duct, ovary, prefrontal cortex, tail of embryo, testicle
RNA expression pattern · 14
PTK2 → antenna, dentate gyrus of hippocampal formation granule cell, dermis, Gonadal ridge, gut, human fetus, left lung lobe, mandibular prominence, maxillary prominence, medullary collecting duct, ovary, prefrontal cortex, tail of embryo, testicle
related to Function · 8
PTK2 → At, FAK, FERM, It, PYK2, The, The PTK2, With
Band · 2
PTK2 → 15 D3|15 33.94 cM, 8q24.3
Chr. · 2
PTK2 → Chromosome 15 (mouse), Chromosome 2 (human)
End · 2
PTK2 → 19,437,259 bp, 73,423,280 bp
2.7.10.2 · 1
PTK2 → ↗

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Important terminology

fak kinase focal domain protein adhesion tyrosine human cell band bp gene cells chr shown activity integrin adhesions chromosome also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PTK22.7.10.2↗1.00infobox
PTK2AliasesPTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…1.00infobox
PTK2Available structuresAvailable structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…1.00infobox
PTK2Band8q24.31.00infobox
PTK2Band15 D3|15 33.94 cM1.00infobox
PTK2Bgeeovary1.00infobox
PTK2Bgeetesticle1.00infobox
PTK2Bgeeantenna1.00infobox
PTK2Bgeegut1.00infobox
PTK2Bgeeleft lung lobe1.00infobox
PTK2BgeeGonadal ridge1.00infobox
PTK2Bgeedermis1.00infobox
PTK2Bgeemedullary collecting duct1.00infobox
PTK2Bgeetail of embryo1.00infobox
PTK2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PTK2Bgeemandibular prominence1.00infobox
PTK2Bgeehuman fetus1.00infobox
PTK2Bgeemaxillary prominence1.00infobox
PTK2Bgeeprefrontal cortex1.00infobox
PTK2BioGPS37233/ More reference expression data1.00infobox
PTK2Chr.Chromosome 2 (human)1.00infobox
PTK2Chr.Chromosome 15 (mouse)1.00infobox
PTK2DatabasesNCBI: entry, entry; OMA: entry1.00infobox
PTK2End19,437,259 bp1.00infobox
PTK2End73,423,280 bp1.00infobox
PTK2EnsemblENSG00000169398 FBgn00204401.00infobox
PTK2Entrez5747,37233 5747,372331.00infobox
PTK2Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.10.2↗↗↗↗1.00infobox
PTK2External IDsOMIM: 600758; MGI: 95481; GeneCards: PTK21.00infobox
PTK2Gene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band8q24.3Start19,430,659 bpEnd19,437,259 bp1.00infobox

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