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PTK2: Interactions, Function & As a drug target

PTK2 protein tyrosine kinase 2 (PTK2), also known as focal adhesion kinase (FAK), is a protein that, in humans, is encoded by the PTK2 gene. PTK2 is a focal adhesion-associated protein kinase involved in cellular adhesion (how cells stick to each other and their surroundings) and spreading processes (how cells move around). It has been shown that when…

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PTK2 topic overview

The analysis highlights Interactions, Function and As a drug target as prominent areas in the source structure around PTK2.

Related topics
82
Source areas
8
Connected nodes
90
Extracted relationships
208
Concept neighborhoods
19
Bridge connections
90

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 27 topics
Function · 19 topics
As a drug target · 13 topics
Structure · 8 topics
Regulation · 7 topics
Overview · 4 topics
Clinical significance · 2 topics
Role in apoptosis · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2
↗
Aliases
PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…
Available structures
Available structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…
Band
8q24.3 · 15 D3|15 33.94 cM
Bgee
ovary · testicle · antenna · gut · left lung lobe
BioGPS
37233/ More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Regulation

Role in apoptosis

Structure

Clinical significance

As a drug target

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PTK2 connects Entity context

The extracted context around PTK2 shows recurring relationship patterns in the source. For example, PTK2 → actin binding, adherens junction, angiogenesis, apical plasma membrane, ATP binding, axon guidance, blood vessel development, cell cortex, cell differentiation, cell junction, cell motility, cellular response to transforming growth factor beta stimulus, central nervous system neuron axonogenesis, cytoplasm, cytoskeleton, cytosol, dendritic spine, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway Another extracted example is PTK2 → BCAR1, BMX, CD61, CRK, DCC, FYN, GIT1, Grb2, GRB7, IRS1, ITGB5, JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN. Use these groups to spot repeated connection types before inspecting the individual relationships.

PTK2

Top relations

Gene ontology · 91
PTK2 → actin binding, adherens junction, angiogenesis, apical plasma membrane, ATP binding, axon guidance, blood vessel development, cell cortex, cell differentiation, cell junction, cell motility, cellular response to transforming growth factor beta stimulus, central nervous system neuron axonogenesis, cytoplasm, cytoskeleton, cytosol, dendritic spine, endothelial cell migration, ephrin receptor signaling pathway, epidermal growth factor receptor signaling pathway
related to Interactions · 29
PTK2 → BCAR1, BMX, CD61, CRK, DCC, FYN, GIT1, Grb2, GRB7, IRS1, ITGB5, JAK2, MAPK8IP3, NCK1, NCK2, NEDD9, NEO1, P53, PIK3R1, PTEN
related to External links · 22
PTK2 → Archived, August, Breaking, Cancer Research UK, Cell Migration Gateway Archived, DR Nick Peel, FAKFAK Info, Human Focal, MBInfo, Medicine Medical Subject Headings, MeSH, Mouse Focal, National Library, Overview, P34152, PDB, PDBe-KB, Q05397, Science, UniProt
Bgee · 14
PTK2 → antenna, dentate gyrus of hippocampal formation granule cell, dermis, Gonadal ridge, gut, human fetus, left lung lobe, mandibular prominence, maxillary prominence, medullary collecting duct, ovary, prefrontal cortex, tail of embryo, testicle
RNA expression pattern · 14
PTK2 → antenna, dentate gyrus of hippocampal formation granule cell, dermis, Gonadal ridge, gut, human fetus, left lung lobe, mandibular prominence, maxillary prominence, medullary collecting duct, ovary, prefrontal cortex, tail of embryo, testicle
related to Function · 8
PTK2 → At, FAK, FERM, It, PYK2, The, The PTK2, With
Band · 2
PTK2 → 15 D3|15 33.94 cM, 8q24.3
Chr. · 2
PTK2 → Chromosome 15 (mouse), Chromosome 2 (human)
End · 2
PTK2 → 19,437,259 bp, 73,423,280 bp
2.7.10.2 · 1
PTK2 → ↗

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

fak kinase focal domain protein adhesion tyrosine human cell band bp gene cells chr shown activity integrin adhesions chromosome also

PTK2 relationships Subject–Predicate–Object triples

TTTA extracted 208 structured relationships around PTK2. Examples in this analysis include PTK2 → 2.7.10.2 → ↗ and PTK2 → Aliases → PTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PTK22.7.10.2↗1.00infobox
PTK2AliasesPTK2, FADK, FAK, FAK1, FRNK, PPP1R71, p125FAK, pp125FAK, protein tyrosine kinase 2, Fak, Focal adhesion kinase, Dmel_CG10023, FAK65D, ptk2, DFAK, Fak56, DFak56, Dmel\CG10023, pF…1.00infobox
PTK2Available structuresAvailable structuresPDBOrtholog search: H0YB16 PDBe H0YB16 RCSB List of PDB id codes4Q9S, 1K04, 1K05, 1MP8, 1OW6, 1OW7, 1OW8, 2ETM, 2IJM, 3B71, 3BZ3, 3PXK, 3S9O, 4EBV, 4EBW, 4GU…1.00infobox
PTK2Band8q24.31.00infobox
PTK2Band15 D3|15 33.94 cM1.00infobox
PTK2Bgeeovary1.00infobox
PTK2Bgeetesticle1.00infobox
PTK2Bgeeantenna1.00infobox
PTK2Bgeegut1.00infobox
PTK2Bgeeleft lung lobe1.00infobox
PTK2BgeeGonadal ridge1.00infobox
PTK2Bgeedermis1.00infobox
PTK2Bgeemedullary collecting duct1.00infobox
PTK2Bgeetail of embryo1.00infobox
PTK2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PTK2Bgeemandibular prominence1.00infobox
PTK2Bgeehuman fetus1.00infobox
PTK2Bgeemaxillary prominence1.00infobox
PTK2Bgeeprefrontal cortex1.00infobox
PTK2BioGPS37233/ More reference expression data1.00infobox
PTK2Chr.Chromosome 2 (human)1.00infobox
PTK2Chr.Chromosome 15 (mouse)1.00infobox
PTK2DatabasesNCBI: entry, entry; OMA: entry1.00infobox
PTK2End19,437,259 bp1.00infobox
PTK2End73,423,280 bp1.00infobox
PTK2EnsemblENSG00000169398 FBgn00204401.00infobox
PTK2Entrez5747,37233 5747,372331.00infobox
PTK2Enzyme activityEnzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.10.2↗↗↗↗1.00infobox
PTK2External IDsOMIM: 600758; MGI: 95481; GeneCards: PTK21.00infobox
PTK2Gene location (Human)Gene location (Human)Chr.Chromosome 2 (human)Band8q24.3Start19,430,659 bpEnd19,437,259 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PTK2 bring nearby vocabulary together. In this analysis, examples include Tyrosine, Gene and Adhesion. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PTK2
    • Tyrosine
    • Gene
    • Adhesion
    • Kinase
    • Human
    • Cellular
    • Involved
    • Location
    • Regulation
    • Also
    • Chromosome
    • Focal
  • ptk2
    • Tyrosine
    • Gene
    • Adhesion
    • Kinase
    • Human
    • Cellular
    • Involved
    • Location
    • Regulation
    • Also
    • Chromosome
    • Focal
  • protein
    • Tyrosine
    • Ptk2
    • Adhesion
    • Kinase
    • Focal
    • Gene
    • Cells
    • Human
    • Fak
    • Cell
    • Cellular
    • Involved
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Ptk2
    • Human
    • Mouse
    • Regulation
    • Tyrosine
    • Function
    • Protein
    • Activity
  • focal adhesion
    • Adhesion
    • Focal
    • Adhesions
    • Kinase
    • Protein
    • Ptk2
    • Pdb
    • Uniprot
    • Gene
    • Cells
    • Human
    • Actin
  • kinase
    • Adhesion
    • Tyrosine
    • Protein
    • Focal
    • Ptk2
    • Activity
    • Fak
    • Human
    • Domain
    • Cell
    • Cellular
    • Pdb
  • cytosolic protein tyrosine kinase
    • Tyrosine
    • Ptk2
    • Adhesion
    • Kinase
    • Protein
    • Focal
    • Gene
    • Cells
    • Activity
    • Human
    • Fak
    • Domain
  • tyrosine kinase
    • Adhesion
    • Tyrosine
    • Protein
    • Focal
    • Ptk2
    • Activity
    • Fak
    • Human
    • Domain
    • Cell
    • Cellular
    • Pdb

Connections between topic areas Semantic bridges

For PTK2, one of the stronger structural bridges in this analysis connects PTK2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PTK2 — Interactions · splits 63 ⟂ 28
PTK2 — Function · splits 71 ⟂ 20
PTK2 — As a drug target · splits 77 ⟂ 14
PTK2 — Structure · splits 82 ⟂ 9
PTK2 — Regulation · splits 83 ⟂ 8
PTK2 — Overview · splits 86 ⟂ 5
PTK2 — Role in apoptosis · splits 88 ⟂ 3
PTK2 — Clinical significance · splits 88 ⟂ 3

Map overview Semantic statistics

PTK2

Nodes91
Edges90
Triples208
Avg. degree1.98
Density0.021978
Components1

Source & methodology

TTTA analyzes the structure around PTK2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & As a drug target, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PTK2 · EN edition · Analysis: TopicsToTalkAbout

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