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Prohibitin

Prohibitin, also known as PHB, is a protein that in humans is encoded by the PHB gene. The Phb gene has also been described in animals, fungi, plants, and unicellular eukaryotes. Prohibitins are divided in two classes, termed Type-I and Type-II prohibitins, based on their similarity to yeast PHB1 and PHB2, respectively. Each organism has at least one…

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Aliases
PHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LU7
Band
17q21.33 · 11 59.01 cM|11 D
Bgee
mucosa of transverse colon · rectum · islet of Langerhans · right auricle of heart · apex of heart
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Function

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Interactions

Drugs that bind to prohibitin

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Prohibitin

Nodes42
Edges41
Triples161
Avg. degree1.95
Density0.047619
Components1

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Prohibitin

Top relations

Gene ontology · 60
Prohibitin → animal organ regeneration, cell surface, cellular response to interleukin-6, complement component C3a binding, complement component C3b binding, cytoplasm, DNA biosynthetic process, DNA-binding transcription factor activity, RNA polymerase II-specific, early endosome, enzyme binding, extracellular exosome, extrinsic component of mitochondrial outer membrane, extrinsic component of presynaptic active zone membrane, GABA-ergic synapse, glutamatergic synapse, histone deacetylase binding, histone deacetylation, integral component of plasma membrane, membrane, mitochondrial calcium ion transmembrane transport
Bgee · 18
Prohibitin → apex of heart, dentate gyrus of hippocampal formation granule cell, embryo, internal carotid artery, islet of Langerhans, left adrenal gland, left ventricle, minor salivary glands, mucosa of transverse colon, muscle of thigh, neural layer of retina, proximal tubule, rectum, right adrenal gland, right auricle of heart, right kidney, ventricular zone, yolk sac
RNA expression pattern · 18
Prohibitin → apex of heart, dentate gyrus of hippocampal formation granule cell, embryo, internal carotid artery, islet of Langerhans, left adrenal gland, left ventricle, minor salivary glands, mucosa of transverse colon, muscle of thigh, neural layer of retina, proximal tubule, rectum, right adrenal gland, right auricle of heart, right kidney, ventricular zone, yolk sac
related to Drugs that bind to prohibitin · 10
Prohibitin → AurilideFluorizolineRocaglamide, Bacillus, Colorado, Cry, In, Leptinotarsa, PF2, PHB, Prohibitinn, Zabrotes
related to Discovery · 9
Prohibitin → BRCA1, However, Mutations, PHB, Prohibitins, PSA, RNA, The, This
related to Interactions · 8
Prohibitin → ANXA2C-Raf, E2F1, HDAC1, P53, RB1, RBL1, RBL2, SMARCA2
related to Clinical significance · 6
Prohibitin → Chikungunya Virus, CHIKV, Dengue Virus, DENV-2, Human, Little
related to Mitochondrial function and morphology · 6
Prohibitin → PHB, Phb1, Phb2, Prohibitins, Recently, The
Band · 2
Prohibitin → 11 59.01 cM|11 D, 17q21.33
Chr. · 2
Prohibitin → Chromosome 11 (mouse), Chromosome 17 (human)

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Important terminology

gene phb human bp prohibitins protein chr band chromosome phb1 activity function 17 mitochondrial also cell receptor location region plants

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ProhibitinAliasesPHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 11.00infobox
ProhibitinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LU71.00infobox
ProhibitinBand17q21.331.00infobox
ProhibitinBand11 59.01 cM|11 D1.00infobox
ProhibitinBgeemucosa of transverse colon1.00infobox
ProhibitinBgeerectum1.00infobox
ProhibitinBgeeislet of Langerhans1.00infobox
ProhibitinBgeeright auricle of heart1.00infobox
ProhibitinBgeeapex of heart1.00infobox
ProhibitinBgeeminor salivary glands1.00infobox
ProhibitinBgeemuscle of thigh1.00infobox
ProhibitinBgeeright adrenal gland1.00infobox
ProhibitinBgeeleft ventricle1.00infobox
ProhibitinBgeeleft adrenal gland1.00infobox
ProhibitinBgeeyolk sac1.00infobox
ProhibitinBgeeright kidney1.00infobox
ProhibitinBgeeembryo1.00infobox
ProhibitinBgeedentate gyrus of hippocampal formation granule cell1.00infobox
ProhibitinBgeeneural layer of retina1.00infobox
ProhibitinBgeeproximal tubule1.00infobox
ProhibitinBgeeventricular zone1.00infobox
ProhibitinBgeeinternal carotid artery1.00infobox
ProhibitinBioGPSMore reference expression data1.00infobox
ProhibitinChr.Chromosome 17 (human)1.00infobox
ProhibitinChr.Chromosome 11 (mouse)1.00infobox
ProhibitinDatabasesNCBI: entry; OMA: entry1.00infobox
ProhibitinEnd49,414,905 bp1.00infobox
ProhibitinEnd95,571,599 bp1.00infobox
ProhibitinEnsemblENSG000001670851.00infobox
ProhibitinEntrez52451.00infobox

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