Prohibitin

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Prohibitin topic overview

The analysis highlights Regions, Interactions and Discovery as prominent areas in the source structure around Prohibitin.

Related topics: 35
Source areas: 6
Connected nodes: 41
Extracted relationships: 161
Concept neighborhoods: 13
Bridge connections: 41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 11 topics

Discovery · 8 topics

Function · 6 topics

Clinical significance · 4 topics

Drugs that bind to prohibitin · 3 topics

Overview · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: PHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LU7
Band: 17q21.33 · 11 59.01 cM|11 D
Bgee: mucosa of transverse colon · rectum · islet of Langerhans · right auricle of heart · apex of heart
BioGPS: More reference expression data
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Function

Inner mitochondrial membrane
Respiratory chain
Cell nucleus
Transcriptional Transcription (genetics)
Transcription factors Transcription factor
Nuclear receptors Nuclear receptor

Clinical significance

Interactions

Interact Protein-protein interaction
ANXA2 Annexin A2
C-Raf
E2F1
HDAC1
P53
RB1 Retinoblastoma protein
RBL1 Retinoblastoma-like protein 1
RBL2 Retinoblastoma-like protein 2
SMARCA2
SMARCA4

Drugs that bind to prohibitin

Aurilide Aurilide?action=edit&redlink=1
Fluorizoline Fluorizoline?action=edit&redlink=1
Rocaglamide A Rocaglamide

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Prohibitin connects Entity context

The extracted context around Prohibitin shows recurring relationship patterns in the source. For example, Prohibitin → animal organ regeneration, cell surface, cellular response to interleukin-6, complement component C3a binding, complement component C3b binding, cytoplasm, DNA biosynthetic process, DNA-binding transcription factor activity, RNA polymerase II-specific, early endosome, enzyme binding, extracellular exosome, extrinsic component of mitochondrial outer membrane, extrinsic component of presynaptic active zone membrane, GABA-ergic synapse, glutamatergic synapse, histone deacetylase binding, histone deacetylation, integral component of plasma membrane, membrane, mitochondrial calcium ion transmembrane transport Another extracted example is Prohibitin → apex of heart, dentate gyrus of hippocampal formation granule cell, embryo, internal carotid artery, islet of Langerhans, left adrenal gland, left ventricle, minor salivary glands, mucosa of transverse colon, muscle of thigh, neural layer of retina, proximal tubule, rectum, right adrenal gland, right auricle of heart, right kidney, ventricular zone, yolk sac. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 60

Prohibitin → animal organ regeneration, cell surface, cellular response to interleukin-6, complement component C3a binding, complement component C3b binding, cytoplasm, DNA biosynthetic process, DNA-binding transcription factor activity, RNA polymerase II-specific, early endosome, enzyme binding, extracellular exosome, extrinsic component of mitochondrial outer membrane, extrinsic component of presynaptic active zone membrane, GABA-ergic synapse, glutamatergic synapse, histone deacetylase binding, histone deacetylation, integral component of plasma membrane, membrane, mitochondrial calcium ion transmembrane transport

Bgee · 18

Prohibitin → apex of heart, dentate gyrus of hippocampal formation granule cell, embryo, internal carotid artery, islet of Langerhans, left adrenal gland, left ventricle, minor salivary glands, mucosa of transverse colon, muscle of thigh, neural layer of retina, proximal tubule, rectum, right adrenal gland, right auricle of heart, right kidney, ventricular zone, yolk sac

RNA expression pattern · 18

related to Drugs that bind to prohibitin · 10

Prohibitin → AurilideFluorizolineRocaglamide, Bacillus, Colorado, Cry, In, Leptinotarsa, PF2, PHB, Prohibitinn, Zabrotes

related to Discovery · 9

Prohibitin → BRCA1, However, Mutations, PHB, Prohibitins, PSA, RNA, The, This

related to Interactions · 8

Prohibitin → ANXA2C-Raf, E2F1, HDAC1, P53, RB1, RBL1, RBL2, SMARCA2

related to Clinical significance · 6

Prohibitin → Chikungunya Virus, CHIKV, Dengue Virus, DENV-2, Human, Little

related to Mitochondrial function and morphology · 6

Prohibitin → PHB, Phb1, Phb2, Prohibitins, Recently, The

Band · 2

Prohibitin → 11 59.01 cM|11 D, 17q21.33

Chr. · 2

Prohibitin → Chromosome 11 (mouse), Chromosome 17 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene phb human bp prohibitins protein chr band chromosome phb1 activity function 17 mitochondrial also cell receptor location region plants

Prohibitin relationships Subject–Predicate–Object triples

TTTA extracted 161 structured relationships around Prohibitin. Examples in this analysis include Prohibitin → Aliases → PHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 1 and Prohibitin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LU7. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Prohibitin	Aliases	PHB1, prohibitin, HEL-S-54e, HEL-215, PHB, prohibitin 1	1.00	infobox
Prohibitin	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1LU7	1.00	infobox
Prohibitin	Band	17q21.33	1.00	infobox
Prohibitin	Band	11 59.01 cM\|11 D	1.00	infobox
Prohibitin	Bgee	mucosa of transverse colon	1.00	infobox
Prohibitin	Bgee	rectum	1.00	infobox
Prohibitin	Bgee	islet of Langerhans	1.00	infobox
Prohibitin	Bgee	right auricle of heart	1.00	infobox
Prohibitin	Bgee	apex of heart	1.00	infobox
Prohibitin	Bgee	minor salivary glands	1.00	infobox
Prohibitin	Bgee	muscle of thigh	1.00	infobox
Prohibitin	Bgee	right adrenal gland	1.00	infobox
Prohibitin	Bgee	left ventricle	1.00	infobox
Prohibitin	Bgee	left adrenal gland	1.00	infobox
Prohibitin	Bgee	yolk sac	1.00	infobox
Prohibitin	Bgee	right kidney	1.00	infobox
Prohibitin	Bgee	embryo	1.00	infobox
Prohibitin	Bgee	dentate gyrus of hippocampal formation granule cell	1.00	infobox
Prohibitin	Bgee	neural layer of retina	1.00	infobox
Prohibitin	Bgee	proximal tubule	1.00	infobox
Prohibitin	Bgee	ventricular zone	1.00	infobox
Prohibitin	Bgee	internal carotid artery	1.00	infobox
Prohibitin	BioGPS	More reference expression data	1.00	infobox
Prohibitin	Chr.	Chromosome 17 (human)	1.00	infobox
Prohibitin	Chr.	Chromosome 11 (mouse)	1.00	infobox
Prohibitin	Databases	NCBI: entry; OMA: entry	1.00	infobox
Prohibitin	End	49,414,905 bp	1.00	infobox
Prohibitin	End	95,571,599 bp	1.00	infobox
Prohibitin	Ensembl	ENSG00000167085	1.00	infobox
Prohibitin	Entrez	5245	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Prohibitin bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Human. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

gene
- Chromosome
- Phb
- Location
- Human
- Prohibitin
- Bp
- Chr
- Activity
- Protein
- End
- Mouse
- Search
function
- Mitochondrial
- Search
- Cells
- Location
- May
- Transcription
- Phb1
- Bp
- Chr
- Chromosome
- Prohibitins
- Human
Prohibitin
- Gene
- Protein
- Human
- Region
- Chromosome
- Expressed
- Organism
- Search
- Two
- 3'
- Location
- Negative
prohibitin
- Gene
- Protein
- Human
- Region
- Chromosome
- Expressed
- Organism
- Search
- Two
- 3'
- Location
- Negative
cell proliferation
- Negative
- Proliferation
- Transcription
- Prohibitins
- Human
- Chromosome
- Activity
- Search
- End
- Expressed
- Mouse
- Plants
cell nucleus
- Negative
- Proliferation
- Transcription
- Prohibitins
- Human
- Chromosome
- Activity
- End
- Expressed
- Mouse
- Search
- Gene
drugs that bind to prohibitin
- Gene
- Protein
- Human
- Region
- Chromosome
- Expressed
- Organism
- Search
- Two
- 3'
- Location
- Negative
inner mitochondrial membrane
- Phb1
- Search
- Location
- Prohibitins
- End
- Expressed
- Human
- Mouse
- Phb2
- Phb
- May
- Negative

Connections between topic areas Semantic bridges

For Prohibitin, one of the stronger structural bridges in this analysis connects Prohibitin with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Prohibitin — Interactions · splits 30 ⟂ 12

Prohibitin — Discovery · splits 33 ⟂ 9

Prohibitin — Function · splits 35 ⟂ 7

Prohibitin — Clinical significance · splits 37 ⟂ 5

Prohibitin — Overview · splits 38 ⟂ 4

Prohibitin — Drugs that bind to prohibitin · splits 38 ⟂ 4

Map overview Semantic statistics

Prohibitin

Nodes42

Edges41

Triples161

Avg. degree1.95

Density0.047619

Components1

Source & methodology

TTTA analyzes the structure around Prohibitin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Interactions & Discovery, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Prohibitin · EN edition · Analysis: TopicsToTalkAbout