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SMARCA4: Products, Interactions & Function

Transcription activator BRG1 also known as ATP-dependent chromatin remodeler SMARCA4 is a protein that in humans is encoded by the SMARCA4 gene.

Language: English [EN]
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SMARCA4 topic overview

The analysis highlights Products, Interactions and Function as prominent areas in the source structure around SMARCA4.

Related topics
43
Source areas
4
Connected nodes
47
Extracted relationships
151
Concept neighborhoods
10
Bridge connections
47

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 24 topics
Function · 14 topics
Clinical significance · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a,…
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GRC, 2H60, 3UVD, 5DKD, 5EA1
Band
19p13.2 · 9 A3|9 7.84 cM
Bgee
ganglionic eminence · tendon of biceps brachii · ventricular zone · amniotic fluid · epithelium of nasopharynx
BioGPS
More reference expression data
Chr.
Chromosome 19 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SMARCA4 connects Entity context

The extracted context around SMARCA4 shows recurring relationship patterns in the source. For example, SMARCA4 → androgen receptor binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, beta-catenin-TCF complex assembly, chromatin organization, chromatin remodeling, DNA binding, DNA polymerase binding, extracellular space, helicase activity, histone binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, interleukin-7-mediated signaling pathway, lysine-acetylated histone binding, membrane, nBAF complex, negative regulation of androgen receptor signaling pathway, negative regulation of cell growth Another extracted example is SMARCA4 → ACTL6A, ARID1A, ARID1B, BRCA1, CBX5, CCNE1, CREBBP, CTNNB1, ESR1, FANCA, HSP90B1, ING1, Myc, NR3C1, P53, PHB, POLR2A, SIN3A, SMARCB1, SMARCC1. Use these groups to spot repeated connection types before inspecting the individual relationships.

SMARCA4

Top relations

Gene ontology · 56
SMARCA4 → androgen receptor binding, ATP binding, ATP-dependent activity, acting on DNA, ATPase activity, beta-catenin-TCF complex assembly, chromatin organization, chromatin remodeling, DNA binding, DNA polymerase binding, extracellular space, helicase activity, histone binding, hydrolase activity, hydrolase activity, acting on acid anhydrides, interleukin-7-mediated signaling pathway, lysine-acetylated histone binding, membrane, nBAF complex, negative regulation of androgen receptor signaling pathway, negative regulation of cell growth
related to Interactions · 23
SMARCA4 → ACTL6A, ARID1A, ARID1B, BRCA1, CBX5, CCNE1, CREBBP, CTNNB1, ESR1, FANCA, HSP90B1, ING1, Myc, NR3C1, P53, PHB, POLR2A, SIN3A, SMARCB1, SMARCC1
Bgee · 19
SMARCA4 → amniotic fluid, endothelial cell, epithelium of nasopharynx, ganglionic eminence, Gonadal ridge, hand, internal carotid artery, mandibular prominence, maxillary prominence, middle temporal gyrus, otic vesicle, primary visual cortex, right hemisphere of cerebellum, Rostral migratory stream, somite, sural nerve, tail of embryo, tendon of biceps brachii, ventricular zone
RNA expression pattern · 19
SMARCA4 → amniotic fluid, endothelial cell, epithelium of nasopharynx, ganglionic eminence, Gonadal ridge, hand, internal carotid artery, mandibular prominence, maxillary prominence, middle temporal gyrus, otic vesicle, primary visual cortex, right hemisphere of cerebellum, Rostral migratory stream, somite, sural nerve, tail of embryo, tendon of biceps brachii, ventricular zone
related to Clinical significance · 8
SMARCA4 → ATP, ATPase, BRG1, DNA-binding, In, Later, Mutations, These
Band · 2
SMARCA4 → 19p13.2, 9 A3|9 7.84 cM
Chr. · 2
SMARCA4 → Chromosome 19 (human), Chromosome 9 (mouse)
End · 2
SMARCA4 → 11,065,395 bp, 21,615,526 bp
Aliases · 1
SMARCA4 → SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a,…
Available structures · 1
SMARCA4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GRC, 2H60, 3UVD, 5DKD, 5EA1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

brg1 chromatin gene bp human chr band protein atpase development cancer mutations chromosome 19 transcription swi snf expression cell atp-dependent

SMARCA4 relationships Subject–Predicate–Object triples

TTTA extracted 151 structured relationships around SMARCA4. Examples in this analysis include SMARCA4 → Aliases → SMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a,… and SMARCA4 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GRC, 2H60, 3UVD, 5DKD, 5EA1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SMARCA4AliasesSMARCA4, BAF190, BAF190A, BRG1, MRD16, RTPS2, SNF2, SNF2L4, SNF2LB, SWI2, hSNF2b, CSS4, SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfamily a,…1.00infobox
SMARCA4Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2GRC, 2H60, 3UVD, 5DKD, 5EA11.00infobox
SMARCA4Band19p13.21.00infobox
SMARCA4Band9 A3|9 7.84 cM1.00infobox
SMARCA4Bgeeganglionic eminence1.00infobox
SMARCA4Bgeetendon of biceps brachii1.00infobox
SMARCA4Bgeeventricular zone1.00infobox
SMARCA4Bgeeamniotic fluid1.00infobox
SMARCA4Bgeeepithelium of nasopharynx1.00infobox
SMARCA4Bgeesural nerve1.00infobox
SMARCA4Bgeemiddle temporal gyrus1.00infobox
SMARCA4Bgeeprimary visual cortex1.00infobox
SMARCA4Bgeeendothelial cell1.00infobox
SMARCA4Bgeeright hemisphere of cerebellum1.00infobox
SMARCA4BgeeRostral migratory stream1.00infobox
SMARCA4Bgeeotic vesicle1.00infobox
SMARCA4Bgeehand1.00infobox
SMARCA4Bgeemandibular prominence1.00infobox
SMARCA4Bgeesomite1.00infobox
SMARCA4Bgeetail of embryo1.00infobox
SMARCA4Bgeeinternal carotid artery1.00infobox
SMARCA4BgeeGonadal ridge1.00infobox
SMARCA4Bgeemaxillary prominence1.00infobox
SMARCA4BioGPSMore reference expression data1.00infobox
SMARCA4Chr.Chromosome 19 (human)1.00infobox
SMARCA4Chr.Chromosome 9 (mouse)1.00infobox
SMARCA4DatabasesNCBI: entry; OMA: entry1.00infobox
SMARCA4End11,065,395 bp1.00infobox
SMARCA4End21,615,526 bp1.00infobox
SMARCA4EnsemblENSG000001276161.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SMARCA4 bring nearby vocabulary together. In this analysis, examples include Search, Gene and Encoded. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • SMARCA4
    • Search
    • Gene
    • Encoded
    • Function
    • Location
    • Remodeling
    • Snf
    • Swi
    • Chromosome
    • Protein
    • Transcription
    • Atpase
  • smarca4
    • Search
    • Gene
    • Encoded
    • Function
    • Location
    • Remodeling
    • Snf
    • Swi
    • Chromosome
    • Protein
    • Transcription
    • Atpase
  • gene
    • Human
    • Location
    • Cell
    • Chromosome
    • Bp
    • Chr
    • Smarca4
    • A3
    • End
    • Mouse
    • Search
    • Function
  • atpase
    • Remodeling
    • Transcription
    • Chromatin
    • Smarca4
    • Cancer
    • Mutations
    • End
    • Mouse
    • Search
    • Encoded
    • Function
    • Functional
  • chromatin
    • Smarca4
    • Encoded
    • Function
    • Remodeling
    • Snf
    • Swi
    • Protein
    • Transcription
    • Atpase
    • Gene
    • Search
    • Location
  • atp-dependent chromatin remodeling
    • Encoded
    • Protein
    • Remodeling
    • Snf
    • Swi
    • Smarca4
    • Transcription
    • Chromatin
    • Function
    • Gene
    • Atpase
    • A3
  • protein
    • Encoded
    • Remodeling
    • Snf
    • Swi
    • Expression
    • Transcription
    • Smarca4
    • Gene
    • A3
    • End
    • Mouse
    • Search
  • function
    • Search
    • Location
    • Snf
    • Swi
    • Chromosome
    • Bp
    • Chr
    • Human
    • Smarca4
    • Gene
    • A3
    • End

Connections between topic areas Semantic bridges

For SMARCA4, one of the stronger structural bridges in this analysis connects SMARCA4 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SMARCA4Interactions · splits 23 ⟂ 25
SMARCA4Function · splits 33 ⟂ 15
SMARCA4Clinical significance · splits 44 ⟂ 4
SMARCA4Overview · splits 45 ⟂ 3

Map overview Semantic statistics

SMARCA4

Nodes48
Edges47
Triples151
Avg. degree1.96
Density0.041667
Components1

Source & methodology

TTTA analyzes the structure around SMARCA4 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SMARCA4 · EN edition · Analysis: TopicsToTalkAbout

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