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DNA topoisomerase 2-beta is an enzyme used in DNA transcription that in humans is encoded by the TOP2B gene on chromosome 3.
The analysis highlights Standards, Function and Interactions as prominent areas in the source structure around TOP2B.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TOP2B shows recurring relationship patterns in the source. For example, TOP2B → ATP binding, axonogenesis, chromatin binding, cytoplasm, cytosol, DNA binding, DNA metabolic process, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, DNA topological change, enzyme binding, forebrain development, heterochromatin, histone deacetylase binding, isomerase activity, metal ion binding, mitotic DNA integrity checkpoint signaling, neuron migration, nucleolus, nucleoplasm Another extracted example is TOP2B → abdominal wall, Achilles tendon, cerebellar cortex, cerebellar hemisphere, condyle, dermis, endothelial cell, epithelium of colon, ganglionic eminence, genital tubercle, lobe of cerebellum, medial ganglionic eminence, rectum, retinal pigment epithelium, right hemisphere of cerebellum, tail of embryo, thymus, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna gene enzyme transcription chromosome bp double-strand breaks topoisomerase chr human band genes activity cell location learning promoter repair mouse
TTTA extracted 117 structured relationships around TOP2B. Examples in this analysis include TOP2B → 5.6.2.2 → ↗ and TOP2B → Aliases → TOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TOP2B | 5.6.2.2 | ↗ | 1.00 | infobox |
| TOP2B | Aliases | TOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU | 1.00 | infobox |
| TOP2B | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QX3, 4G0U, 4G0V, 4G0W, 4J3N | 1.00 | infobox |
| TOP2B | Band | 3p24.2 | 1.00 | infobox |
| TOP2B | Band | 14|14 A1 | 1.00 | infobox |
| TOP2B | Bgee | ganglionic eminence | 1.00 | infobox |
| TOP2B | Bgee | ventricular zone | 1.00 | infobox |
| TOP2B | Bgee | endothelial cell | 1.00 | infobox |
| TOP2B | Bgee | Achilles tendon | 1.00 | infobox |
| TOP2B | Bgee | cerebellar cortex | 1.00 | infobox |
| TOP2B | Bgee | cerebellar hemisphere | 1.00 | infobox |
| TOP2B | Bgee | right hemisphere of cerebellum | 1.00 | infobox |
| TOP2B | Bgee | retinal pigment epithelium | 1.00 | infobox |
| TOP2B | Bgee | epithelium of colon | 1.00 | infobox |
| TOP2B | Bgee | rectum | 1.00 | infobox |
| TOP2B | Bgee | tail of embryo | 1.00 | infobox |
| TOP2B | Bgee | medial ganglionic eminence | 1.00 | infobox |
| TOP2B | Bgee | genital tubercle | 1.00 | infobox |
| TOP2B | Bgee | thymus | 1.00 | infobox |
| TOP2B | Bgee | abdominal wall | 1.00 | infobox |
| TOP2B | Bgee | dermis | 1.00 | infobox |
| TOP2B | Bgee | condyle | 1.00 | infobox |
| TOP2B | Bgee | lobe of cerebellum | 1.00 | infobox |
| TOP2B | BioGPS | More reference expression data | 1.00 | infobox |
| TOP2B | Chr. | Chromosome 3 (human) | 1.00 | infobox |
| TOP2B | Chr. | Chromosome 14 (mouse) | 1.00 | infobox |
| TOP2B | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TOP2B | End | 25,664,907 bp | 1.00 | infobox |
| TOP2B | End | 6,104,584 bp | 1.00 | infobox |
| TOP2B | Ensembl | ENSG00000077097 | 1.00 | infobox |
The concept neighborhoods around TOP2B bring nearby vocabulary together. In this analysis, examples include Double-strand, Transcription and Breaks. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TOP2B, one of the stronger structural bridges in this analysis connects TOP2B with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TOP2B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TOP2B · EN edition · Analysis: TopicsToTalkAbout