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TOP2B

DNA topoisomerase 2-beta is an enzyme used in DNA transcription that in humans is encoded by the TOP2B gene on chromosome 3.

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Function

33 related topics

Interactions

7 related topics

In other species

1 related topics

Overview

4 related topics

Key facts & relationships

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5.6.2.2
Aliases
TOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QX3, 4G0U, 4G0V, 4G0W, 4J3N
Band
3p24.2 · 14|14 A1
Bgee
ganglionic eminence · ventricular zone · endothelial cell · Achilles tendon · cerebellar cortex
BioGPS
More reference expression data

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Overview

Function

Interactions

In other species

Advanced semantic analysis

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Map overview Semantic statistics

TOP2B

Nodes50
Edges49
Triples117
Avg. degree1.96
Density0.04
Components1

How this topic connects Entity context

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TOP2B

Top relations

Gene ontology · 31
TOP2B → ATP binding, axonogenesis, chromatin binding, cytoplasm, cytosol, DNA binding, DNA metabolic process, DNA topoisomerase activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) activity, DNA topological change, enzyme binding, forebrain development, heterochromatin, histone deacetylase binding, isomerase activity, metal ion binding, mitotic DNA integrity checkpoint signaling, neuron migration, nucleolus, nucleoplasm
Bgee · 18
TOP2B → abdominal wall, Achilles tendon, cerebellar cortex, cerebellar hemisphere, condyle, dermis, endothelial cell, epithelium of colon, ganglionic eminence, genital tubercle, lobe of cerebellum, medial ganglionic eminence, rectum, retinal pigment epithelium, right hemisphere of cerebellum, tail of embryo, thymus, ventricular zone
RNA expression pattern · 18
TOP2B → abdominal wall, Achilles tendon, cerebellar cortex, cerebellar hemisphere, condyle, dermis, endothelial cell, epithelium of colon, ganglionic eminence, genital tubercle, lobe of cerebellum, medial ganglionic eminence, rectum, retinal pigment epithelium, right hemisphere of cerebellum, tail of embryo, thymus, ventricular zone
related to Neuronal activity · 11
TOP2B → Activation, DNA, During, IEG, IEGs, Repair, Such, The, This, TOP2B-induced, When
related to Interactions · 6
TOP2B → BAZ1B, CD3, HDAC1, Histone, P53, Small
related to Other TOP2B and DNA interactions · 4
TOP2B → DNA, Interactions, Specifically, These
Band · 2
TOP2B → 14|14 A1, 3p24.2
Chr. · 2
TOP2B → Chromosome 14 (mouse), Chromosome 3 (human)
End · 2
TOP2B → 25,664,907 bp, 6,104,584 bp
5.6.2.2 · 1
TOP2B → ↗

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Important terminology

dna gene enzyme transcription chromosome bp double-strand breaks topoisomerase chr human band genes activity cell location learning promoter repair mouse

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TOP2B5.6.2.21.00infobox
TOP2BAliasesTOP2B, TOPIIB, top2beta, topoisomerase (DNA) II beta, DNA topoisomerase II beta, BILU1.00infobox
TOP2BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3QX3, 4G0U, 4G0V, 4G0W, 4J3N1.00infobox
TOP2BBand3p24.21.00infobox
TOP2BBand14|14 A11.00infobox
TOP2BBgeeganglionic eminence1.00infobox
TOP2BBgeeventricular zone1.00infobox
TOP2BBgeeendothelial cell1.00infobox
TOP2BBgeeAchilles tendon1.00infobox
TOP2BBgeecerebellar cortex1.00infobox
TOP2BBgeecerebellar hemisphere1.00infobox
TOP2BBgeeright hemisphere of cerebellum1.00infobox
TOP2BBgeeretinal pigment epithelium1.00infobox
TOP2BBgeeepithelium of colon1.00infobox
TOP2BBgeerectum1.00infobox
TOP2BBgeetail of embryo1.00infobox
TOP2BBgeemedial ganglionic eminence1.00infobox
TOP2BBgeegenital tubercle1.00infobox
TOP2BBgeethymus1.00infobox
TOP2BBgeeabdominal wall1.00infobox
TOP2BBgeedermis1.00infobox
TOP2BBgeecondyle1.00infobox
TOP2BBgeelobe of cerebellum1.00infobox
TOP2BBioGPSMore reference expression data1.00infobox
TOP2BChr.Chromosome 3 (human)1.00infobox
TOP2BChr.Chromosome 14 (mouse)1.00infobox
TOP2BDatabasesNCBI: entry; OMA: entry1.00infobox
TOP2BEnd25,664,907 bp1.00infobox
TOP2BEnd6,104,584 bp1.00infobox
TOP2BEnsemblENSG000000770971.00infobox

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