Cyclin-dependent kinase 2

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Interactions

Interact BRCA1 CDK2AP1 CDKN3 CEBPA

14 related topics

Inhibitors

CDKN1A CDKN1B Neointima Restenosis

4 related topics

Overview

Enzyme Gene Protein Cyclin-dependent kinase Ser/Thr protein kinases

13 related topics

Dispensability in normally functioning tissue

G1 phase S phase Meiosis

3 related topics

Key facts & relationships

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2.7.11.22: ↗
Aliases: CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII,…
Band: 12q13.2 · 10|10 D3
Bgee: ventricular zone · ganglionic eminence · left uterine tube · gastric mucosa · stromal cell of endometrium
BioGPS: More reference expression data

Topics to explore

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Overview

Enzyme
Gene
Protein
Cyclin-dependent kinase
Ser/Thr protein kinases Serine/threonine-specific protein kinase
S. cerevisiae Saccharomyces cerevisiae
Cdc28
S. pombe Schizosaccharomyces pombe
Cdk1
Cell cycle
Cyclin E
Phosphorylation
G1-S transition

Dispensability in normally functioning tissue

Mechanism of activation

Cyclins Cyclin
Activation loop

Role in DNA replication

Cdk2/Cyclin E Cyclin E/Cdk2
Phase transition
Retinoblastoma Retinoblastoma protein

Inhibitors

Gene regulation

Melanocytic Melanocyte
Microphthalmia-associated transcription factor

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Nodes49

Edges48

Triples158

Avg. degree1.96

Density0.040816

Components1

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Cyclin-dependent kinase 2

Top relations

Gene ontology · 60

Cyclin-dependent kinase 2 → anaphase-promoting complex-dependent catabolic process, ATP binding, Cajal body, cell cycle, cell division, cellular response to DNA damage stimulus, cellular response to nitric oxide, centriole replication, centrosome, centrosome duplication, condensed chromosome, cyclin A1-CDK2 complex, cyclin A2-CDK2 complex, cyclin binding, cyclin E1-CDK2 complex, cyclin E2-CDK2 complex, cyclin-dependent protein kinase activity, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cytoplasm

related to Mechanism of activation · 22

Cyclin-dependent kinase 2 → Activation, Asp, ATP, C-helix, C-lobe, C-terminus, Cdk1, Cdk2, Cyclin-dependent, Due, Finally, Glu, Hydrophobic, Lys, N-lobe, N-terminus, PSTAIRE-helix, Recent, The, This

Bgee · 19

Cyclin-dependent kinase 2 → abdominal wall, blastocyst, epiblast, epithelium of colon, ganglionic eminence, gastric mucosa, granulocyte, left ovary, left uterine tube, maxillary prominence, right lung, skin of abdomen, skin of leg, spermatocyte, stromal cell of endometrium, thymus, tibiofemoral joint, ventricular zone, yolk sac

RNA expression pattern · 19

related to Interactions · 13

Cyclin-dependent kinase 2 → BRCA1, CDK2AP1, CDKN1BCDKN3, CEBPA, Cyclin A1, Cyclin E1, Cyclin-dependent, Flap, ORC1L, P21, PPM1B, PPP2CA, Retinoblastoma-like

Band · 2

Cyclin-dependent kinase 2 → 10|10 D3, 12q13.2

Chr. · 2

Cyclin-dependent kinase 2 → Chromosome 10 (mouse), Chromosome 12 (human)

End · 2

Cyclin-dependent kinase 2 → 128,540,900 bp, 55,972,789 bp

2.7.11.22 · 1

Cyclin-dependent kinase 2 → ↗

Aliases · 1

Cyclin-dependent kinase 2 → CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2

Important terminology Word statistics

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Important terminology

cdk2 cyclin gene cell kinase protein binding phase cells cyclin-dependent cycle also site activity inhibitors human bp g1 complex dna

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Cyclin-dependent kinase 2	2.7.11.22	↗	1.00	infobox
Cyclin-dependent kinase 2	Aliases	CDK2, cyclin-dependent kinase 2, A630093N05Rik, CDKN2, p33(CDK2), cyclin dependent kinase 2	1.00	infobox
Cyclin-dependent kinase 2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1AQ1, 1B38, 1B39, 1BUH, 1CKP, 1DI8, 1DM2, 1E1V, 1E1X, 1E9H, 1F5Q, 1FIN, 1FQ1, 1FVT, 1FVV, 1G5S, 1GIH, 1GII,…	1.00	infobox
Cyclin-dependent kinase 2	Band	12q13.2	1.00	infobox
Cyclin-dependent kinase 2	Band	10\|10 D3	1.00	infobox
Cyclin-dependent kinase 2	Bgee	ventricular zone	1.00	infobox
Cyclin-dependent kinase 2	Bgee	ganglionic eminence	1.00	infobox
Cyclin-dependent kinase 2	Bgee	left uterine tube	1.00	infobox
Cyclin-dependent kinase 2	Bgee	gastric mucosa	1.00	infobox
Cyclin-dependent kinase 2	Bgee	stromal cell of endometrium	1.00	infobox
Cyclin-dependent kinase 2	Bgee	skin of abdomen	1.00	infobox
Cyclin-dependent kinase 2	Bgee	left ovary	1.00	infobox
Cyclin-dependent kinase 2	Bgee	skin of leg	1.00	infobox
Cyclin-dependent kinase 2	Bgee	right lung	1.00	infobox
Cyclin-dependent kinase 2	Bgee	epithelium of colon	1.00	infobox
Cyclin-dependent kinase 2	Bgee	spermatocyte	1.00	infobox
Cyclin-dependent kinase 2	Bgee	granulocyte	1.00	infobox
Cyclin-dependent kinase 2	Bgee	thymus	1.00	infobox
Cyclin-dependent kinase 2	Bgee	yolk sac	1.00	infobox
Cyclin-dependent kinase 2	Bgee	tibiofemoral joint	1.00	infobox
Cyclin-dependent kinase 2	Bgee	epiblast	1.00	infobox
Cyclin-dependent kinase 2	Bgee	abdominal wall	1.00	infobox
Cyclin-dependent kinase 2	Bgee	maxillary prominence	1.00	infobox
Cyclin-dependent kinase 2	Bgee	blastocyst	1.00	infobox
Cyclin-dependent kinase 2	BioGPS	More reference expression data	1.00	infobox
Cyclin-dependent kinase 2	Chr.	Chromosome 12 (human)	1.00	infobox
Cyclin-dependent kinase 2	Chr.	Chromosome 10 (mouse)	1.00	infobox
Cyclin-dependent kinase 2	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cyclin-dependent kinase 2	End	55,972,789 bp	1.00	infobox
Cyclin-dependent kinase 2	End	128,540,900 bp	1.00	infobox

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