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DNA repair

DNA repair is a collection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome. A weakened capacity for DNA repair is a risk factor for the development of cancer. DNA is constantly modified in cells, by internal metabolic by-products, and by external ionizing radiation, ultraviolet light, and medicines…

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Overview

DNA damage

Mechanisms

Global response to DNA damage

Aging

Medicine and DNA repair modulation

Cancer

Epigenetic alterations due to DNA repair

Evolution

Technology

Advanced semantic analysis

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Map overview Semantic statistics

DNA repair

Nodes349
Edges348
Triples265
Avg. degree1.99
Density0.005731
Components1

How this topic connects Entity context

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DNA repair

Top relations

related to External links · 33
DNA repair → Ade CM, Bibcode, Brazilian Journal, CR, December, Deininger PL, Derbes RS, DNA, DNA RepairSegmental ProgeriaHakem, DNA-damage, Double Strand Break DNA, February, From, Genetics, Heavy Metal Exposure Influences, Human DNA, Human DNA Repair Genes3D, Institute DNA Repair LecturesA, Media, Menck CF
related to Translesion synthesis · 33
DNA repair → After, AP, Ashis Basu, At, DNA, Escherichia, For, From, Hoogsteen, However, Human DNA, II, In, It, IV, Me, Paromita Raychaudhury, PCNA, Pol, Polymerase
related to Double-strand breaks · 28
DNA repair → ADP-ribose, B-cell, Besides, DNA, DNA Ligase IV, Double-strand, DSBs, FEN1, G2, HR, If, In, In NHEJ, LIG3, Loss, MMEJ, MRE11, NHEJ, PARP1, Poly
related to Initial steps · 20
DNA repair → About, ADP, ADP-ribose, ALC1, ATP, Chromatin, DNA, DNA-based, DSBs, In, JNK, Jun N-terminal, MRE11, Next, PAR, PARP1, SIRT6, The, This, To
related to Cancer · 15
DNA repair → Because, BRCA1, BRCA2, Cancer, Cells, DNA, Hereditary, HNPCC, In, Inherited, Many, Modern, NHEJ, The, There
related to Repair of oxidative DNA damage can alter epigenetic markers · 12
DNA repair → CpG, DNA, However, In, In HeLa, OGG1, OHdG, OHdGs, Oxidized, Oxoguanine, The, There
has effect · 11
DNA repair → DNA, Experimental, For, Furthermore, However, In, NER, NHEJ, Of, The, These
related to DNA repair defects in cancer · 10
DNA repair → ATM, DNA, Early, Humans, In, Li-Fraumeni, Replication, RNA, ROS, Studies
related to Eukaryotic transcriptional responses to DNA damage · 10
DNA repair → An, DNA, Eukaryotic, Exposure, In, Saccharomyces, Similarities, Such, The, Yeast Rev1
related to Frequencies of epimutations in DNA repair genes · 9
DNA repair → Deficiencies, DNA, Five, For, In, MGMT, MLH1, PMS2, Similarly

Important terminology Word statistics

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Important terminology

dna repair damage cell cells cancer genes mutations double-strand response genome proteins mechanisms mutation gene chromatin also homologous breaks epigenetic

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
DNA repairis acollection of processes by which a cell identifies and corrects damage to the DNA molecules that encode its genome0.90text
DNA repairis arisk factor for the development of cancer0.90text
attack by reactive oxygen species produced from normal metabolic byproductsinstance ofendogenous damage0.80text
that created by radioactive decay or in cosmic rays causes breaks in DNA strandsinstance ofThe damage caused by free radicals is called indirect DNA damage.Ionizing radiation0.80text
vinyl chlorideinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
hydrogen peroxideinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
and environmental chemicals such as polycyclic aromatic hydrocarbons found in smokeinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
sootinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
tar create a huge diversity of DNA adducts- ethanoatesinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
oxidized basesinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
alkylated phosphodiestersinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text
crosslinking of DNAinstance ofhence a possibility of an adaptive response cannot be ruled out.Industrial chemicals0.80text

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