STAT3

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Function

Cytokines Growth factors Janus kinases Transcription activator Interferons

20 related topics

Interactions

Interact AR EGFR ELP2 EP300

24 related topics

Ligands

Napabucasin Niclosamide Nicotinamide Acetylcysteine Stattic

6 related topics

Clinical significance

Hyperimmunoglobulin E syndrome Gain-of-function mutations Glioblastoma

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AX3
Band: 17q21.2 · 11 D|11 63.82 cM
Bgee: beta cell · pericardium · lower lobe of lung · lactiferous duct · nipple
BioGPS: More reference expression data
Chr.: Chromosome 17 (human) · Chromosome 11 (mouse)

Topics to explore

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Overview

Function

Cytokines
Growth factors
Janus kinases Janus kinase
Transcription activator Transcription activators
Interferons Interferon
Epidermal growth factor
Interleukin (IL-)5 Interleukin 5
IL-6 Interleukin 6
Mitogen-activated protein kinases
C-src Src (gene)
Cell growth
Apoptosis
Embryos Embryo
Embryonic stem cells Embryonic stem cell
LIF Leukemia inhibitory factor
Murine Mouse
Undifferentiated Cellular differentiation
TH17 T helper 17 cell
Autoimmune diseases Autoimmune disease
COVID-19

Clinical significance

Interactions

Interact Protein-protein interaction
AR Androgen receptor
EGFR Epidermal growth factor receptor
ELP2
EP300
HIF1A
JAK1 Janus kinase 1
JUN C-jun
KHDRBS1
KPNA4
MTOR Mammalian target of rapamycin
MYOD1 MyoD
NCOA1 Nuclear receptor coactivator 1
NDUFA13
NFKB1
NR3C1 Glucocorticoid receptor
PML Promyelocytic leukemia protein
RAC1
RELA
RET RET proto-oncogene
RPA2
STAT1
Stathmin
TRIP10

Ligands

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes62

Edges61

Triples203

Avg. degree1.97

Density0.032258

Components1

How this topic connects Entity context

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STAT3

Top relations

Gene ontology · 115

STAT3 → acute-phase response, ageing, astrocyte differentiation, CCR5 chemokine receptor binding, cell population proliferation, cellular response to cytokine stimulus, cellular response to hormone stimulus, cellular response to leptin stimulus, cellular response to organic cyclic compound, chromatin DNA binding, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, eating behavior, energy homeostasis

Bgee · 20

STAT3 → ankle, ankle joint, beta cell, decidua, epithelium of colon, epithelium of stomach, granulocyte, lactiferous duct, left lung, lower lobe of lung, nipple, pericardium, right lung lobe, right ventricle, skin of external ear, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung, upper lobe of lung, vena cava

RNA expression pattern · 20

related to Function · 16

STAT3 → Additionally, EGF, ESC, ESCs, IL, IL-6, In, Indeed, It, JAK, Janus, LIF, MAPK, Specifically, STAT, STAT3-deficient

related to Clinical significance · 3

STAT3 → Gain-of-function, It, Loss-of-function

Band · 2

STAT3 → 11 D|11 63.82 cM, 17q21.2

Chr. · 2

STAT3 → Chromosome 11 (mouse), Chromosome 17 (human)

End · 2

STAT3 → 100,830,366 bp, 42,388,568 bp

Aliases · 1

STAT3 → STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1

Available structures · 1

STAT3 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AX3

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene protein chr band factor activator transcription chromosome 17 expression cell cells signal transducer external mouse response growth

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
STAT3	Aliases	STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1	1.00	infobox
STAT3	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AX3	1.00	infobox
STAT3	Band	17q21.2	1.00	infobox
STAT3	Band	11 D\|11 63.82 cM	1.00	infobox
STAT3	Bgee	beta cell	1.00	infobox
STAT3	Bgee	pericardium	1.00	infobox
STAT3	Bgee	lower lobe of lung	1.00	infobox
STAT3	Bgee	lactiferous duct	1.00	infobox
STAT3	Bgee	nipple	1.00	infobox
STAT3	Bgee	right ventricle	1.00	infobox
STAT3	Bgee	upper lobe of lung	1.00	infobox
STAT3	Bgee	upper lobe of left lung	1.00	infobox
STAT3	Bgee	vena cava	1.00	infobox
STAT3	Bgee	epithelium of colon	1.00	infobox
STAT3	Bgee	right lung lobe	1.00	infobox
STAT3	Bgee	ankle	1.00	infobox
STAT3	Bgee	granulocyte	1.00	infobox
STAT3	Bgee	left lung	1.00	infobox
STAT3	Bgee	decidua	1.00	infobox
STAT3	Bgee	epithelium of stomach	1.00	infobox
STAT3	Bgee	ankle joint	1.00	infobox
STAT3	Bgee	stroma of bone marrow	1.00	infobox
STAT3	Bgee	skin of external ear	1.00	infobox
STAT3	Bgee	tibiofemoral joint	1.00	infobox
STAT3	BioGPS	More reference expression data	1.00	infobox
STAT3	Chr.	Chromosome 17 (human)	1.00	infobox
STAT3	Chr.	Chromosome 11 (mouse)	1.00	infobox
STAT3	Databases	NCBI: entry; OMA: entry	1.00	infobox
STAT3	End	42,388,568 bp	1.00	infobox
STAT3	End	100,830,366 bp	1.00	infobox

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