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Signal transducer and activator of transcription 3 (STAT3) is a transcription factor which in humans is encoded by the STAT3 gene. It is a member of the STAT protein family.
The analysis highlights Function, Interactions and Ligands as prominent areas in the source structure around STAT3.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around STAT3 shows recurring relationship patterns in the source. For example, STAT3 → acute-phase response, ageing, astrocyte differentiation, CCR5 chemokine receptor binding, cell population proliferation, cellular response to cytokine stimulus, cellular response to hormone stimulus, cellular response to leptin stimulus, cellular response to organic cyclic compound, chromatin DNA binding, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, eating behavior, energy homeostasis Another extracted example is STAT3 → ankle, ankle joint, beta cell, decidua, epithelium of colon, epithelium of stomach, granulocyte, lactiferous duct, left lung, lower lobe of lung, nipple, pericardium, right lung lobe, right ventricle, skin of external ear, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung, upper lobe of lung, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
human bp gene protein chr band factor activator transcription chromosome 17 expression cell cells signal transducer external mouse response growth
TTTA extracted 203 structured relationships around STAT3. Examples in this analysis include STAT3 → Aliases → STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1 and STAT3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AX3. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| STAT3 | Aliases | STAT3, ADMIO, APRF, HIES, signal transducer and activator of transcription 3, ADMIO1 | 1.00 | infobox |
| STAT3 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AX3 | 1.00 | infobox |
| STAT3 | Band | 17q21.2 | 1.00 | infobox |
| STAT3 | Band | 11 D|11 63.82 cM | 1.00 | infobox |
| STAT3 | Bgee | beta cell | 1.00 | infobox |
| STAT3 | Bgee | pericardium | 1.00 | infobox |
| STAT3 | Bgee | lower lobe of lung | 1.00 | infobox |
| STAT3 | Bgee | lactiferous duct | 1.00 | infobox |
| STAT3 | Bgee | nipple | 1.00 | infobox |
| STAT3 | Bgee | right ventricle | 1.00 | infobox |
| STAT3 | Bgee | upper lobe of lung | 1.00 | infobox |
| STAT3 | Bgee | upper lobe of left lung | 1.00 | infobox |
| STAT3 | Bgee | vena cava | 1.00 | infobox |
| STAT3 | Bgee | epithelium of colon | 1.00 | infobox |
| STAT3 | Bgee | right lung lobe | 1.00 | infobox |
| STAT3 | Bgee | ankle | 1.00 | infobox |
| STAT3 | Bgee | granulocyte | 1.00 | infobox |
| STAT3 | Bgee | left lung | 1.00 | infobox |
| STAT3 | Bgee | decidua | 1.00 | infobox |
| STAT3 | Bgee | epithelium of stomach | 1.00 | infobox |
| STAT3 | Bgee | ankle joint | 1.00 | infobox |
| STAT3 | Bgee | stroma of bone marrow | 1.00 | infobox |
| STAT3 | Bgee | skin of external ear | 1.00 | infobox |
| STAT3 | Bgee | tibiofemoral joint | 1.00 | infobox |
| STAT3 | BioGPS | More reference expression data | 1.00 | infobox |
| STAT3 | Chr. | Chromosome 17 (human) | 1.00 | infobox |
| STAT3 | Chr. | Chromosome 11 (mouse) | 1.00 | infobox |
| STAT3 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| STAT3 | End | 42,388,568 bp | 1.00 | infobox |
| STAT3 | End | 100,830,366 bp | 1.00 | infobox |
The concept neighborhoods around STAT3 bring nearby vocabulary together. In this analysis, examples include Cell, Cells and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For STAT3, one of the stronger structural bridges in this analysis connects STAT3 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around STAT3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Ligands, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — STAT3 · EN edition · Analysis: TopicsToTalkAbout