Cyclin-dependent kinase 4

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around Cyclin-dependent kinase 4. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Interactions

Interact CDC37 CDKN1B CDKN2B CDKN2C

13 related topics

Clinical significance

Ribociclib US FDA Estrogen receptor HER2

4 related topics

Overview

Enzyme Gene Cyclin-dependent kinase Serine/threonine kinases Cell cycle

13 related topics

Function

Retinoblastoma gene Retinoblastoma (RB) protein family including RB1 E2F

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.11.22: ↗
Aliases: CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK
Band: 12q14.1
Bgee: ganglionic eminence · ventricular zone · stromal cell of endometrium · right adrenal gland · right ovary
BioGPS: More reference expression data

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Enzyme
Gene
Cyclin-dependent kinase
Serine/threonine kinases Serine/threonine kinase
Cell cycle
G1/S transition
Phosphorylation Protein phosphorylation
E2F1
S-phase
Cyclins Cyclin
Cyclin D
Cyclin kinase inhibitors Cyclin-dependent kinase inhibitor protein
Therapeutic target Drug target

Function

Retinoblastoma gene
Retinoblastoma (RB) protein family including RB1 Retinoblastoma protein
E2F

Clinical significance

Interactions

Interact Protein-protein interaction
CDC37
CDKN1B
CDKN2B
CDKN2C
CEBPA
CCND1 Cyclin D1
CCND3 Cyclin D3
DBNL Drebrin-like
MyoD
P16 P16 (gene)
PCNA
SERTAD1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes38

Edges37

Triples116

Avg. degree1.95

Density0.052632

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

Cyclin-dependent kinase 4

Top relations

Gene ontology · 63

Cyclin-dependent kinase 4 → adipose tissue development, animal organ regeneration, ATP binding, bicellular tight junction, cell cycle, cell division, cellular response to insulin stimulus, cellular response to interleukin-4, cellular response to ionomycin, cellular response to lipopolysaccharide, cellular response to phorbol 13-acetate 12-myristate, chromatin, circadian rhythm, cyclin binding, cyclin D2-CDK4 complex, cyclin-dependent protein kinase holoenzyme complex, cyclin-dependent protein serine/threonine kinase activity, cyclin-dependent protein serine/threonine kinase regulator activity, cytoplasm, cytosol

related to Interactions · 12

Cyclin-dependent kinase 4 → CCND1, CCND3, CDC37, CDKN1B, CDKN2B, CDKN2C, CEBPA, Cyclin-dependent, DBNL, MyoD, P16, PCNA

Bgee · 10

Cyclin-dependent kinase 4 → ganglionic eminence, left adrenal cortex, left adrenal gland, left ovary, right adrenal cortex, right adrenal gland, right ovary, smooth muscle tissue, stromal cell of endometrium, ventricular zone

RNA expression pattern · 10

2.7.11.22 · 1

Cyclin-dependent kinase 4 → ↗

Aliases · 1

Cyclin-dependent kinase 4 → CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4

Available structures · 1

Cyclin-dependent kinase 4 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK

Band · 1

Cyclin-dependent kinase 4 → 12q14.1

BioGPS · 1

Cyclin-dependent kinase 4 → More reference expression data

Chr. · 1

Cyclin-dependent kinase 4 → Chromosome 12 (human)

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cdk4 cell rb kinase cyclin g1 cycle gene protein proteins inhibitors cyclin-dependent progression cancer complex transition human phosphorylation role activity

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Cyclin-dependent kinase 4	2.7.11.22	↗	1.00	infobox
Cyclin-dependent kinase 4	Aliases	CDK4, CMM3, PSK-J3, cyclin-dependent kinase 4, cyclin dependent kinase 4	1.00	infobox
Cyclin-dependent kinase 4	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2W96, 2W99, 2W9F, 2W9Z, 3G33, 5FWL, 5FWM, 5FWK	1.00	infobox
Cyclin-dependent kinase 4	Band	12q14.1	1.00	infobox
Cyclin-dependent kinase 4	Bgee	ganglionic eminence	1.00	infobox
Cyclin-dependent kinase 4	Bgee	ventricular zone	1.00	infobox
Cyclin-dependent kinase 4	Bgee	stromal cell of endometrium	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right adrenal gland	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right ovary	1.00	infobox
Cyclin-dependent kinase 4	Bgee	smooth muscle tissue	1.00	infobox
Cyclin-dependent kinase 4	Bgee	right adrenal cortex	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left ovary	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left adrenal gland	1.00	infobox
Cyclin-dependent kinase 4	Bgee	left adrenal cortex	1.00	infobox
Cyclin-dependent kinase 4	BioGPS	More reference expression data	1.00	infobox
Cyclin-dependent kinase 4	Chr.	Chromosome 12 (human)	1.00	infobox
Cyclin-dependent kinase 4	Databases	NCBI: entry; OMA: entry	1.00	infobox
Cyclin-dependent kinase 4	End	57,756,013 bp	1.00	infobox
Cyclin-dependent kinase 4	Ensembl	ENSG00000135446	1.00	infobox
Cyclin-dependent kinase 4	Entrez	1019	1.00	infobox
Cyclin-dependent kinase 4	Enzyme activity	Enzyme activityEC #BRENDAExPASyKEGGMetaCyc2.7.11.22↗↗↗↗	1.00	infobox
Cyclin-dependent kinase 4	External IDs	OMIM: 123829; MGI: 88357; GeneCards: CDK4	1.00	infobox
Cyclin-dependent kinase 4	Gene location (Human)	Gene location (Human)Chr.Chromosome 12 (human)Band12q14.1Start57,747,727 bpEnd57,756,013 bp	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	transferase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	nucleotide binding	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein serine/threonine kinase activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	cyclin-dependent protein serine/threonine kinase regulator activity	1.00	infobox
Cyclin-dependent kinase 4	Gene ontology	protein binding	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3