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TP53BP2

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

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Aliases
TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV
Band
1q41 · 1 H5|1 84.93 cM
Bgee
ventricular zone · ganglionic eminence · caudate nucleus · putamen · external globus pallidus
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

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TP53BP2

Nodes63
Edges62
Triples99
Avg. degree1.97
Density0.031746
Components1

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TP53BP2

Top relations

Gene ontology · 22
TP53BP2 → apoptotic process, cell cycle, cell junction, cytoplasm, cytosol, identical protein binding, intrinsic apoptotic signaling pathway by p53 class mediator, mitochondrion, negative regulation of cell cycle, NF-kappaB binding, nucleoplasm, nucleus, p53 binding, perinuclear region of cytoplasm, positive regulation of execution phase of apoptosis, positive regulation of neuron death, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, protein binding, regulation of apoptotic process, regulation of signal transduction by p53 class mediator
Bgee · 20
TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct
RNA expression pattern · 20
TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct
related to Expression · 4
TP53BP2 → ASPP2, ASPP2/53BP2, Northern-blot, The
Band · 2
TP53BP2 → 1 H5|1 84.93 cM, 1q41
Chr. · 2
TP53BP2 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
TP53BP2 → 182,289,997 bp, 223,845,954 bp
Aliases · 1
TP53BP2 → TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Available structures · 1
TP53BP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV
BioGPS · 1
TP53BP2 → More reference expression data

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Important terminology

aspp2 p53 binding human apoptosis gene protein expression bp family domain chr band chromosome sh3 aspp1 ankyrin repeats known found

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TP53BP2AliasesTP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 21.00infobox
TP53BP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV1.00infobox
TP53BP2Band1q411.00infobox
TP53BP2Band1 H5|1 84.93 cM1.00infobox
TP53BP2Bgeeventricular zone1.00infobox
TP53BP2Bgeeganglionic eminence1.00infobox
TP53BP2Bgeecaudate nucleus1.00infobox
TP53BP2Bgeeputamen1.00infobox
TP53BP2Bgeeexternal globus pallidus1.00infobox
TP53BP2Bgeenucleus accumbens1.00infobox
TP53BP2Bgeeamygdala1.00infobox
TP53BP2Bgeeretinal pigment epithelium1.00infobox
TP53BP2Bgeepars reticulata1.00infobox
TP53BP2Bgeeepithelium of colon1.00infobox
TP53BP2Bgeegenital tubercle1.00infobox
TP53BP2Bgeetail of embryo1.00infobox
TP53BP2Bgeevestibular membrane of cochlear duct1.00infobox
TP53BP2Bgeehand1.00infobox
TP53BP2Bgeesuperior cervical ganglion1.00infobox
TP53BP2Bgeeglomerulus1.00infobox
TP53BP2Bgeeotolith organ1.00infobox
TP53BP2Bgeeutricle1.00infobox
TP53BP2Bgeelumbar subsegment of spinal cord1.00infobox
TP53BP2Bgeehuman kidney1.00infobox
TP53BP2BioGPSMore reference expression data1.00infobox
TP53BP2Chr.Chromosome 1 (human)1.00infobox
TP53BP2Chr.Chromosome 1 (mouse)1.00infobox
TP53BP2DatabasesNCBI: entry; OMA: entry1.00infobox
TP53BP2End223,845,954 bp1.00infobox
TP53BP2End182,289,997 bp1.00infobox

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