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TP53BP2: Members & Standards

Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.

Language: English [EN]
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TP53BP2 topic overview

The analysis highlights Members and Standards as prominent areas in the source structure around TP53BP2.

Related topics
54
Source areas
8
Connected nodes
62
Extracted relationships
99
Concept neighborhoods
23
Bridge connections
62

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 21 topics
Function · 9 topics
Binding partners · 5 topics
Expression · 5 topics
Structure · 5 topics
Family members · 4 topics
Nomenclature · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV
Band
1q41 · 1 H5|1 84.93 cM
Bgee
ventricular zone · ganglionic eminence · caudate nucleus · putamen · external globus pallidus
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Nomenclature

Function

Structure

Family members

Binding partners

Expression

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TP53BP2 connects Entity context

The extracted context around TP53BP2 shows recurring relationship patterns in the source. For example, TP53BP2 → apoptotic process, cell cycle, cell junction, cytoplasm, cytosol, identical protein binding, intrinsic apoptotic signaling pathway by p53 class mediator, mitochondrion, negative regulation of cell cycle, NF-kappaB binding, nucleoplasm, nucleus, p53 binding, perinuclear region of cytoplasm, positive regulation of execution phase of apoptosis, positive regulation of neuron death, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, protein binding, regulation of apoptotic process, regulation of signal transduction by p53 class mediator Another extracted example is TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.

TP53BP2

Top relations

Gene ontology · 22
TP53BP2 → apoptotic process, cell cycle, cell junction, cytoplasm, cytosol, identical protein binding, intrinsic apoptotic signaling pathway by p53 class mediator, mitochondrion, negative regulation of cell cycle, NF-kappaB binding, nucleoplasm, nucleus, p53 binding, perinuclear region of cytoplasm, positive regulation of execution phase of apoptosis, positive regulation of neuron death, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, protein binding, regulation of apoptotic process, regulation of signal transduction by p53 class mediator
Bgee · 20
TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct
RNA expression pattern · 20
TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct
related to Expression · 4
TP53BP2 → ASPP2, ASPP2/53BP2, Northern-blot, The
Band · 2
TP53BP2 → 1 H5|1 84.93 cM, 1q41
Chr. · 2
TP53BP2 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
TP53BP2 → 182,289,997 bp, 223,845,954 bp
Aliases · 1
TP53BP2 → TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2
Available structures · 1
TP53BP2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV
BioGPS · 1
TP53BP2 → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

aspp2 p53 binding human apoptosis gene protein expression bp family domain chr band chromosome sh3 aspp1 ankyrin repeats known found

TP53BP2 relationships Subject–Predicate–Object triples

TTTA extracted 99 structured relationships around TP53BP2. Examples in this analysis include TP53BP2 → Aliases → TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2 and TP53BP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TP53BP2AliasesTP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 21.00infobox
TP53BP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV1.00infobox
TP53BP2Band1q411.00infobox
TP53BP2Band1 H5|1 84.93 cM1.00infobox
TP53BP2Bgeeventricular zone1.00infobox
TP53BP2Bgeeganglionic eminence1.00infobox
TP53BP2Bgeecaudate nucleus1.00infobox
TP53BP2Bgeeputamen1.00infobox
TP53BP2Bgeeexternal globus pallidus1.00infobox
TP53BP2Bgeenucleus accumbens1.00infobox
TP53BP2Bgeeamygdala1.00infobox
TP53BP2Bgeeretinal pigment epithelium1.00infobox
TP53BP2Bgeepars reticulata1.00infobox
TP53BP2Bgeeepithelium of colon1.00infobox
TP53BP2Bgeegenital tubercle1.00infobox
TP53BP2Bgeetail of embryo1.00infobox
TP53BP2Bgeevestibular membrane of cochlear duct1.00infobox
TP53BP2Bgeehand1.00infobox
TP53BP2Bgeesuperior cervical ganglion1.00infobox
TP53BP2Bgeeglomerulus1.00infobox
TP53BP2Bgeeotolith organ1.00infobox
TP53BP2Bgeeutricle1.00infobox
TP53BP2Bgeelumbar subsegment of spinal cord1.00infobox
TP53BP2Bgeehuman kidney1.00infobox
TP53BP2BioGPSMore reference expression data1.00infobox
TP53BP2Chr.Chromosome 1 (human)1.00infobox
TP53BP2Chr.Chromosome 1 (mouse)1.00infobox
TP53BP2DatabasesNCBI: entry; OMA: entry1.00infobox
TP53BP2End223,845,954 bp1.00infobox
TP53BP2End182,289,997 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TP53BP2 bring nearby vocabulary together. In this analysis, examples include Chromosome, Function and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TP53BP2
    • Chromosome
    • Function
    • Location
    • Tumor
    • 53bp2
    • Expression
    • Partners
    • Bp
    • Chr
    • Binding
    • Cytoplasm
    • Mouse
  • tp53bp2
    • Chromosome
    • Function
    • Location
    • Tumor
    • 53bp2
    • Expression
    • Partners
    • Bp
    • Chr
    • Binding
    • Cytoplasm
    • Mouse
  • protein
    • Tp53bp2
    • 53bp2
    • Chromosome
    • Binding
    • Domain
    • P53bp2
    • Sh3
    • Function
    • Location
    • Tumor
    • Expression
    • Partners
  • gene
    • Tp53bp2
    • Chromosome
    • Location
    • Protein
    • Bp
    • Chr
    • Mouse
    • P53bp2
    • Function
    • Tumor
    • Expression
    • 53bp2
  • p53
    • Protein
    • Binding
    • Aspp2
    • Human
    • Domain
    • Sh3
    • Tumor
    • 53bp2
    • Tp53bp2
    • Ankyrin
    • Repeats
    • Gene
  • apoptosis
    • Regulation
    • Cell
    • Expression
    • Cycle
    • Aspp2
    • P53
    • Domain
    • Protein
    • Sh3
    • Family
    • Cytoplasm
    • Mouse
  • virus core protein
    • Tp53bp2
    • 53bp2
    • Chromosome
    • Binding
    • Domain
    • P53bp2
    • Sh3
    • Function
    • Location
    • Tumor
    • Expression
    • Partners
  • chromosome 1
    • Bp
    • Location
    • Gene
    • Band
    • Tp53bp2
    • Human
    • Mouse
    • Protein
    • Function
    • Expression
    • Partners
    • Cytoplasm

Connections between topic areas Semantic bridges

For TP53BP2, one of the stronger structural bridges in this analysis connects TP53BP2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TP53BP2Clinical significance · splits 41 ⟂ 22
TP53BP2Function · splits 53 ⟂ 10
TP53BP2Structure · splits 57 ⟂ 6
TP53BP2Binding partners · splits 57 ⟂ 6
TP53BP2Expression · splits 57 ⟂ 6
TP53BP2Family members · splits 58 ⟂ 5
TP53BP2Nomenclature · splits 59 ⟂ 4
TP53BP2Overview · splits 60 ⟂ 3

Map overview Semantic statistics

TP53BP2

Nodes63
Edges62
Triples99
Avg. degree1.97
Density0.031746
Components1

Source & methodology

TTTA analyzes the structure around TP53BP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TP53BP2 · EN edition · Analysis: TopicsToTalkAbout

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