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Apoptosis-stimulating of p53 protein 2 (ASPP2) also known as Bcl2-binding protein (Bbp) and tumor suppressor p53-binding protein 2 (p53BP2) is a protein that in humans is encoded by the TP53BP2 gene. Multiple transcript variants encoding different isoforms have been found for this gene.
The analysis highlights Members and Standards as prominent areas in the source structure around TP53BP2.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TP53BP2 shows recurring relationship patterns in the source. For example, TP53BP2 → apoptotic process, cell cycle, cell junction, cytoplasm, cytosol, identical protein binding, intrinsic apoptotic signaling pathway by p53 class mediator, mitochondrion, negative regulation of cell cycle, NF-kappaB binding, nucleoplasm, nucleus, p53 binding, perinuclear region of cytoplasm, positive regulation of execution phase of apoptosis, positive regulation of neuron death, positive regulation of protein insertion into mitochondrial membrane involved in apoptotic signaling pathway, protein binding, regulation of apoptotic process, regulation of signal transduction by p53 class mediator Another extracted example is TP53BP2 → amygdala, caudate nucleus, epithelium of colon, external globus pallidus, ganglionic eminence, genital tubercle, glomerulus, hand, human kidney, lumbar subsegment of spinal cord, nucleus accumbens, otolith organ, pars reticulata, putamen, retinal pigment epithelium, superior cervical ganglion, tail of embryo, utricle, ventricular zone, vestibular membrane of cochlear duct. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
aspp2 p53 binding human apoptosis gene protein expression bp family domain chr band chromosome sh3 aspp1 ankyrin repeats known found
TTTA extracted 99 structured relationships around TP53BP2. Examples in this analysis include TP53BP2 → Aliases → TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2 and TP53BP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TP53BP2 | Aliases | TP53BP2, 53BP2, ASPP2, BBP, P53BP2, PPP1R13A, tumor protein p53 binding protein 2 | 1.00 | infobox |
| TP53BP2 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1YCS, 2UWQ, 4A63, 4IRV | 1.00 | infobox |
| TP53BP2 | Band | 1q41 | 1.00 | infobox |
| TP53BP2 | Band | 1 H5|1 84.93 cM | 1.00 | infobox |
| TP53BP2 | Bgee | ventricular zone | 1.00 | infobox |
| TP53BP2 | Bgee | ganglionic eminence | 1.00 | infobox |
| TP53BP2 | Bgee | caudate nucleus | 1.00 | infobox |
| TP53BP2 | Bgee | putamen | 1.00 | infobox |
| TP53BP2 | Bgee | external globus pallidus | 1.00 | infobox |
| TP53BP2 | Bgee | nucleus accumbens | 1.00 | infobox |
| TP53BP2 | Bgee | amygdala | 1.00 | infobox |
| TP53BP2 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| TP53BP2 | Bgee | pars reticulata | 1.00 | infobox |
| TP53BP2 | Bgee | epithelium of colon | 1.00 | infobox |
| TP53BP2 | Bgee | genital tubercle | 1.00 | infobox |
| TP53BP2 | Bgee | tail of embryo | 1.00 | infobox |
| TP53BP2 | Bgee | vestibular membrane of cochlear duct | 1.00 | infobox |
| TP53BP2 | Bgee | hand | 1.00 | infobox |
| TP53BP2 | Bgee | superior cervical ganglion | 1.00 | infobox |
| TP53BP2 | Bgee | glomerulus | 1.00 | infobox |
| TP53BP2 | Bgee | otolith organ | 1.00 | infobox |
| TP53BP2 | Bgee | utricle | 1.00 | infobox |
| TP53BP2 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| TP53BP2 | Bgee | human kidney | 1.00 | infobox |
| TP53BP2 | BioGPS | More reference expression data | 1.00 | infobox |
| TP53BP2 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| TP53BP2 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| TP53BP2 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TP53BP2 | End | 223,845,954 bp | 1.00 | infobox |
| TP53BP2 | End | 182,289,997 bp | 1.00 | infobox |
The concept neighborhoods around TP53BP2 bring nearby vocabulary together. In this analysis, examples include Chromosome, Function and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TP53BP2, one of the stronger structural bridges in this analysis connects TP53BP2 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TP53BP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TP53BP2 · EN edition · Analysis: TopicsToTalkAbout