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CASP8 and FADD-like apoptosis regulator is a protein that in humans is encoded by the CFLAR gene. Also called c-FLIP (FLICE-like inhibitory protein).
The analysis highlights Overview, Related Topics and Entities as prominent areas in the source structure around CFLAR.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around CFLAR shows recurring relationship patterns in the source. For example, CFLAR → apoptotic process, CD95 death-inducing signaling complex, cellular response to dexamethasone stimulus, cellular response to epidermal growth factor stimulus, cellular response to estradiol stimulus, cellular response to hypoxia, cellular response to insulin stimulus, cellular response to nitric oxide, cysteine-type endopeptidase activity, cysteine-type endopeptidase activity involved in apoptotic process, cysteine-type endopeptidase activity involved in execution phase of apoptosis, cysteine-type peptidase activity, cytoplasm, cytosol, death receptor binding, death-inducing signaling complex, enzyme activator activity, execution phase of apoptosis, membrane raft, negative regulation of apoptotic process Another extracted example is CFLAR → aortic valve, apex of heart, ascending aorta, blood, bone marrow cell, ciliary body, epithelium of colon, gastrocnemius muscle, granulocyte, lateral recess, left ventricle, proximal tubule, right auricle of heart, right kidney, right lung, right lung lobe, thymus, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
bp human gene chr band protein apoptosis chromosome location casp8 regulator mouse c-flip external pdb uniprot o15519 fadd-like search 176
TTTA extracted 126 structured relationships around CFLAR. Examples in this analysis include CFLAR → Aliases → CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP and CFLAR → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3H11, 3H13, 2N5R. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| CFLAR | Aliases | CFLAR, CASH, CASP8AP1, CLARP, Casper, FLAME, FLAME-1, FLAME1, FLIP, I-FLICE, MRIT, c-FLIP, c-FLIPL, c-FLIPR, c-FLIPS, CASP8 and FADD like apoptosis regulator, cFLIP | 1.00 | infobox |
| CFLAR | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3H11, 3H13, 2N5R | 1.00 | infobox |
| CFLAR | Band | 2q33.1 | 1.00 | infobox |
| CFLAR | Band | 1 C1.3|1 29.16 cM | 1.00 | infobox |
| CFLAR | Bgee | right lung | 1.00 | infobox |
| CFLAR | Bgee | apex of heart | 1.00 | infobox |
| CFLAR | Bgee | upper lobe of left lung | 1.00 | infobox |
| CFLAR | Bgee | right auricle of heart | 1.00 | infobox |
| CFLAR | Bgee | left ventricle | 1.00 | infobox |
| CFLAR | Bgee | epithelium of colon | 1.00 | infobox |
| CFLAR | Bgee | blood | 1.00 | infobox |
| CFLAR | Bgee | granulocyte | 1.00 | infobox |
| CFLAR | Bgee | gastrocnemius muscle | 1.00 | infobox |
| CFLAR | Bgee | bone marrow cell | 1.00 | infobox |
| CFLAR | Bgee | right kidney | 1.00 | infobox |
| CFLAR | Bgee | ascending aorta | 1.00 | infobox |
| CFLAR | Bgee | aortic valve | 1.00 | infobox |
| CFLAR | Bgee | proximal tubule | 1.00 | infobox |
| CFLAR | Bgee | right lung lobe | 1.00 | infobox |
| CFLAR | Bgee | ciliary body | 1.00 | infobox |
| CFLAR | Bgee | thymus | 1.00 | infobox |
| CFLAR | Bgee | lateral recess | 1.00 | infobox |
| CFLAR | BioGPS | More reference expression data | 1.00 | infobox |
| CFLAR | Chr. | Chromosome 2 (human) | 1.00 | infobox |
| CFLAR | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| CFLAR | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| CFLAR | End | 201,176,687 bp | 1.00 | infobox |
| CFLAR | End | 58,798,043 bp | 1.00 | infobox |
| CFLAR | Ensembl | ENSG00000003402 | 1.00 | infobox |
| CFLAR | Entrez | 8837 | 1.00 | infobox |
The concept neighborhoods around CFLAR bring nearby vocabulary together. In this analysis, examples include Gene, Search and Location. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
Bridges highlight paths between different parts of the CFLAR map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around CFLAR to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Related Topics & Entities, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — CFLAR · EN edition · Analysis: TopicsToTalkAbout