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BARD1

BRCA1-associated RING domain protein 1 is a protein that in humans is encoded by the BARD1 gene. The human BARD1 protein is 777 amino acids long and contains a RING finger domain (residues 46-90), four ankyrin repeats (residues 420-555), and a tandem BRCT domain (residues 568-777).

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Function

35 related topics

Interactions

13 related topics

Applications

1 related topics

Overview

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Key facts & relationships

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2.3.2.27
Aliases
BARD1, BRCA1 associated RING domain 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 2NTE, 2R1Z, 3C5R, 3FA2
Band
2q35 · 1|1 C3
Bgee
secondary oocyte · nipple · testicle · gonad · Achilles tendon
BioGPS
More reference expression data

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Overview

Function

Interactions

Applications

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Map overview Semantic statistics

BARD1

Nodes60
Edges59
Triples155
Avg. degree1.97
Density0.033333
Components1

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BARD1

Top relations

Gene ontology · 32
BARD1 → BRCA1-A complex, BRCA1-BARD1 complex, cellular response to DNA damage stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA double-strand break processing, DNA repair, DNA replication, double-strand break repair via nonhomologous end joining, kinase binding, metal ion binding, negative regulation of apoptotic process, negative regulation of mRNA 3'-end processing, negative regulation of protein export from nucleus, nuclear speck, nucleoplasm, nucleus, positive regulation of apoptotic process, positive regulation of protein catabolic process, protein binding
Bgee · 18
BARD1 → Achilles tendon, bone marrow, buccal mucosa cell, epiblast, gonad, human penis, male urethra, morula, mucosa of pharynx, nipple, saphenous vein, secondary oocyte, spermatocyte, tail of embryo, testicle, urethra, ventricular zone, zygote
RNA expression pattern · 18
BARD1 → Achilles tendon, bone marrow, buccal mucosa cell, epiblast, gonad, human penis, male urethra, morula, mucosa of pharynx, nipple, saphenous vein, secondary oocyte, spermatocyte, tail of embryo, testicle, urethra, ventricular zone, zygote
related to Function · 15
BARD1 → BARD1's, BARD1's BRCT, BRCA1, C-terminal BRCT, C645R, Most, Mutations, N-terminal RING, S761N, The BARD1, The BARD1-BRCA1, The BARD1/BRCA1, The RING, Three, V695L
related to Interactions · 15
BARD1 → AURKB, BCL3, BRCA1, BRCA2, BRCC3, BRE, CSTF1, CSTF2, EWSR1, FANCD2, H2AFX, NPM1, P53, RAD51, TACC1
related to DNA repair · 12
BARD1 → Additionally, BRCA1/BARD1, BRCA2, DNA, H4K20, H4K20me0-mediated, H4K20me2, However, It, PALB2, RAD51, Specifically
has application · 9
BARD1 → ADP-ribose, BARD1 BRCT, BRCA1/BARD1, DNA, If, Inhibiting, K619, One, This
related to External links · 8
BARD1 → BRCA1-associated RING, Human BARD1, Overview, PDB, PDBe-KB, Q99728, UCSC Genome Browser, UniProt
Band · 2
BARD1 → 1|1 C3, 2q35
Chr. · 2
BARD1 → Chromosome 1 (mouse), Chromosome 2 (human)

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Important terminology

brca1 dna human protein ring repair bp domain heterodimer gene chr band damage tumor brct chromosome location function cancer sites

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BARD12.3.2.271.00infobox
BARD1AliasesBARD1, BRCA1 associated RING domain 11.00infobox
BARD1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 2NTE, 2R1Z, 3C5R, 3FA21.00infobox
BARD1Band2q351.00infobox
BARD1Band1|1 C31.00infobox
BARD1Bgeesecondary oocyte1.00infobox
BARD1Bgeenipple1.00infobox
BARD1Bgeetesticle1.00infobox
BARD1Bgeegonad1.00infobox
BARD1BgeeAchilles tendon1.00infobox
BARD1Bgeesaphenous vein1.00infobox
BARD1Bgeebuccal mucosa cell1.00infobox
BARD1Bgeehuman penis1.00infobox
BARD1Bgeemucosa of pharynx1.00infobox
BARD1Bgeebone marrow1.00infobox
BARD1Bgeezygote1.00infobox
BARD1Bgeeurethra1.00infobox
BARD1Bgeespermatocyte1.00infobox
BARD1Bgeemale urethra1.00infobox
BARD1Bgeetail of embryo1.00infobox
BARD1Bgeeventricular zone1.00infobox
BARD1Bgeeepiblast1.00infobox
BARD1Bgeemorula1.00infobox
BARD1BioGPSMore reference expression data1.00infobox
BARD1Chr.Chromosome 2 (human)1.00infobox
BARD1Chr.Chromosome 1 (mouse)1.00infobox
BARD1DatabasesNCBI: entry; OMA: entry1.00infobox
BARD1End214,809,683 bp1.00infobox
BARD1End71,142,305 bp1.00infobox
BARD1EnsemblENSG000001383761.00infobox

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