BARD1

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BARD1 topic overview

The analysis highlights Applications, Function and Interactions as prominent areas in the source structure around BARD1.

Related topics: 55
Source areas: 4
Connected nodes: 59
Extracted relationships: 155
Concept neighborhoods: 21
Bridge connections: 59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 35 topics

Interactions · 13 topics

Overview · 6 topics

Applications · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27: ↗
Aliases: BARD1, BRCA1 associated RING domain 1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 2NTE, 2R1Z, 3C5R, 3FA2
Band: 2q35 · 1|1 C3
Bgee: secondary oocyte · nipple · testicle · gonad · Achilles tendon
BioGPS: More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

BRCA1
In vivo
N-terminal
In vitro
C-terminal
Cysteine
Cell growth
Tumor suppressor
Protooncogenes Protooncogene
Polycomb
Ankyrin repeats Ankyrin repeat
Breast Breast cancer
Ovarian Ovarian cancer
Uterine cancers Uterine cancer
Missense mutations
Genotoxic
Apoptosis
P53
Lysine
ADP-ribose
PARP1
Ubiquitin ligase
RNA polymerase II
RAD51
DNA double-strand breaks DNA damage (naturally occurring)
Homologous recombinational Homologous recombination
Mediator complex Mediator (coactivator)
BRCA2
PALB2
53BP1
Non-homologous end joining
Double-strand break repair Double-strand break repair model
Methylation
H4K20 H4K20me
Chromatin

Interactions

Interact Protein-protein interaction
AURKB Aurora B kinase
BCL3
BRCC3
BRE BRE (gene)
CSTF1
CSTF2
EWSR1 Ewing sarcoma breakpoint region 1
FANCD2
H2AFX
NPM1
TACC1
UBE2D1

Applications

Cancer cell

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BARD1 connects Entity context

The extracted context around BARD1 shows recurring relationship patterns in the source. For example, BARD1 → BRCA1-A complex, BRCA1-BARD1 complex, cellular response to DNA damage stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA double-strand break processing, DNA repair, DNA replication, double-strand break repair via nonhomologous end joining, kinase binding, metal ion binding, negative regulation of apoptotic process, negative regulation of mRNA 3'-end processing, negative regulation of protein export from nucleus, nuclear speck, nucleoplasm, nucleus, positive regulation of apoptotic process, positive regulation of protein catabolic process, protein binding Another extracted example is BARD1 → Achilles tendon, bone marrow, buccal mucosa cell, epiblast, gonad, human penis, male urethra, morula, mucosa of pharynx, nipple, saphenous vein, secondary oocyte, spermatocyte, tail of embryo, testicle, urethra, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 32

BARD1 → BRCA1-A complex, BRCA1-BARD1 complex, cellular response to DNA damage stimulus, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA double-strand break processing, DNA repair, DNA replication, double-strand break repair via nonhomologous end joining, kinase binding, metal ion binding, negative regulation of apoptotic process, negative regulation of mRNA 3'-end processing, negative regulation of protein export from nucleus, nuclear speck, nucleoplasm, nucleus, positive regulation of apoptotic process, positive regulation of protein catabolic process, protein binding

Bgee · 18

BARD1 → Achilles tendon, bone marrow, buccal mucosa cell, epiblast, gonad, human penis, male urethra, morula, mucosa of pharynx, nipple, saphenous vein, secondary oocyte, spermatocyte, tail of embryo, testicle, urethra, ventricular zone, zygote

RNA expression pattern · 18

related to Function · 15

BARD1 → BARD1's, BARD1's BRCT, BRCA1, C-terminal BRCT, C645R, Most, Mutations, N-terminal RING, S761N, The BARD1, The BARD1-BRCA1, The BARD1/BRCA1, The RING, Three, V695L

related to Interactions · 15

BARD1 → AURKB, BCL3, BRCA1, BRCA2, BRCC3, BRE, CSTF1, CSTF2, EWSR1, FANCD2, H2AFX, NPM1, P53, RAD51, TACC1

related to DNA repair · 12

BARD1 → Additionally, BRCA1/BARD1, BRCA2, DNA, H4K20, H4K20me0-mediated, H4K20me2, However, It, PALB2, RAD51, Specifically

has application · 9

BARD1 → ADP-ribose, BARD1 BRCT, BRCA1/BARD1, DNA, If, Inhibiting, K619, One, This

related to External links · 8

BARD1 → BRCA1-associated RING, Human BARD1, Overview, PDB, PDBe-KB, Q99728, UCSC Genome Browser, UniProt

Band · 2

BARD1 → 1|1 C3, 2q35

Chr. · 2

BARD1 → Chromosome 1 (mouse), Chromosome 2 (human)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

brca1 dna human protein ring repair bp domain heterodimer gene chr band damage tumor brct chromosome location function cancer sites

BARD1 relationships Subject–Predicate–Object triples

TTTA extracted 155 structured relationships around BARD1. Examples in this analysis include BARD1 → 2.3.2.27 → ↗ and BARD1 → Aliases → BARD1, BRCA1 associated RING domain 1. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
BARD1	2.3.2.27	↗	1.00	infobox
BARD1	Aliases	BARD1, BRCA1 associated RING domain 1	1.00	infobox
BARD1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 2NTE, 2R1Z, 3C5R, 3FA2	1.00	infobox
BARD1	Band	2q35	1.00	infobox
BARD1	Band	1\|1 C3	1.00	infobox
BARD1	Bgee	secondary oocyte	1.00	infobox
BARD1	Bgee	nipple	1.00	infobox
BARD1	Bgee	testicle	1.00	infobox
BARD1	Bgee	gonad	1.00	infobox
BARD1	Bgee	Achilles tendon	1.00	infobox
BARD1	Bgee	saphenous vein	1.00	infobox
BARD1	Bgee	buccal mucosa cell	1.00	infobox
BARD1	Bgee	human penis	1.00	infobox
BARD1	Bgee	mucosa of pharynx	1.00	infobox
BARD1	Bgee	bone marrow	1.00	infobox
BARD1	Bgee	zygote	1.00	infobox
BARD1	Bgee	urethra	1.00	infobox
BARD1	Bgee	spermatocyte	1.00	infobox
BARD1	Bgee	male urethra	1.00	infobox
BARD1	Bgee	tail of embryo	1.00	infobox
BARD1	Bgee	ventricular zone	1.00	infobox
BARD1	Bgee	epiblast	1.00	infobox
BARD1	Bgee	morula	1.00	infobox
BARD1	BioGPS	More reference expression data	1.00	infobox
BARD1	Chr.	Chromosome 2 (human)	1.00	infobox
BARD1	Chr.	Chromosome 1 (mouse)	1.00	infobox
BARD1	Databases	NCBI: entry; OMA: entry	1.00	infobox
BARD1	End	214,809,683 bp	1.00	infobox
BARD1	End	71,142,305 bp	1.00	infobox
BARD1	Ensembl	ENSG00000138376	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BARD1 bring nearby vocabulary together. In this analysis, examples include Brca1, Dna and Heterodimer. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

BARD1
- Brca1
- Dna
- Heterodimer
- Repair
- Protein
- Sites
- Damage
- Tumor
- Ring
- Function
- Brct
- Gene
bard1
- Brca1
- Dna
- Heterodimer
- Repair
- Protein
- Sites
- Damage
- Tumor
- Ring
- Function
- Brct
- Gene
protein
- Function
- Ankyrin
- Q99728
- Uniprot
- Ring
- Double-strand
- Tandem
- Bard1
- Gene
- Human
- Repair
- Mouse
gene
- Location
- Human
- Chromosome
- Bp
- Chr
- Mouse
- End
- Band
- Function
- External
- Protein
- Ring
ring finger domain
- Ring
- Brct
- Pdb
- Protein
- Gene
- Human
- External
- Bard1
- Ankyrin
- Q99728
- Uniprot
- Brca1
brct domain
- Ring
- Brct
- Domain
- Lysine
- Pdb
- Tandem
- Protein
- Gene
- Human
- External
- Bard1
- Ankyrin
brca1
- Dna
- Heterodimer
- Repair
- Sites
- Damage
- Tumor
- Binding
- Complex
- Double-strand
- P53
- Function
- Proteins
cell growth
- Damage
- Tumor
- Mouse
- Q99728
- Uniprot
- Repair
- Binding
- Complex
- Double-strand
- End
- P53
- Chromosome

Connections between topic areas Semantic bridges

For BARD1, one of the stronger structural bridges in this analysis connects BARD1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

BARD1 — Function · splits 24 ⟂ 36

BARD1 — Interactions · splits 46 ⟂ 14

BARD1 — Overview · splits 53 ⟂ 7

Map overview Semantic statistics

BARD1

Nodes60

Edges59

Triples155

Avg. degree1.97

Density0.033333

Components1

Source & methodology

TTTA analyzes the structure around BARD1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BARD1 · EN edition · Analysis: TopicsToTalkAbout