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Bcl-2 homologous antagonist killer

Bcl-2 homologous antagonist/killer is a protein which in humans is encoded by the BAK1 gene on chromosome 6. It belongs to the BCL2 protein family. BCL2 family members form oligomers or heterodimers and act as anti- or pro-apoptotic regulators that are involved in a wide variety of cellular activities. This protein localizes to mitochondria, and…

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Interactions

5 related topics

Clinical significance

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Function

1 related topics

Overview

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Aliases
BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Band
6p21.31
Bgee
mucosa of transverse colon · granulocyte · left adrenal gland · left adrenal cortex · right adrenal gland
BioGPS
More reference expression data
Chr.
Chromosome 6 (human)

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Overview

Function

Clinical significance

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Bcl-2 homologous antagonist killer

Nodes20
Edges19
Triples117
Avg. degree1.9
Density0.1
Components1

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Bcl-2 homologous antagonist killer

Top relations

Gene ontology · 78
Bcl-2 homologous antagonist killer → activation of cysteine-type endopeptidase activity, activation of cysteine-type endopeptidase activity involved in apoptotic process, activation of cysteine-type endopeptidase activity involved in apoptotic process by cytochrome c, ageing, animal organ regeneration, apoptotic process, apoptotic process involved in blood vessel morphogenesis, apoptotic signaling pathway, B cell apoptotic process, B cell homeostasis, B cell negative selection, BAK complex, BH domain binding, blood vessel remodeling, brain development, cell population proliferation, cellular response to mechanical stimulus, cellular response to UV, chaperone binding, cytosol
Bgee · 10
Bcl-2 homologous antagonist killer → apex of heart, duodenum, granulocyte, left adrenal cortex, left adrenal gland, monocyte, mucosa of transverse colon, rectum, right adrenal cortex, right adrenal gland
RNA expression pattern · 10
Bcl-2 homologous antagonist killer → apex of heart, duodenum, granulocyte, left adrenal cortex, left adrenal gland, monocyte, mucosa of transverse colon, rectum, right adrenal cortex, right adrenal gland
Aliases · 1
Bcl-2 homologous antagonist killer → BAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 1
Available structures · 1
Bcl-2 homologous antagonist killer → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI
Band · 1
Bcl-2 homologous antagonist killer → 6p21.31
BioGPS · 1
Bcl-2 homologous antagonist killer → More reference expression data
Chr. · 1
Bcl-2 homologous antagonist killer → Chromosome 6 (human)
Databases · 1
Bcl-2 homologous antagonist killer → NCBI: entry; OMA: entry
End · 1
Bcl-2 homologous antagonist killer → 33,580,293 bp

Important terminology Word statistics

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Important terminology

bak1 protein gene chromosome bcl2 human bcl-2 pro-apoptotic family mitochondria membrane involved mitochondrial bp form bak cells cellular release cytochrome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Bcl-2 homologous antagonist killerAliasesBAK1, BAK, BAK-LIKE, BCL2L7, CDN1, BCL2 antagonist/killer 11.00infobox
Bcl-2 homologous antagonist killerAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5AJK, 1BXL, 2IMS, 2IMT, 2JBY, 2JCN, 2LP8, 2M5B, 2XPX, 3I1H, 3QBR, 4D2L, 4U2U, 4U2V, 4UF1, 5FMK, 5FMI1.00infobox
Bcl-2 homologous antagonist killerBand6p21.311.00infobox
Bcl-2 homologous antagonist killerBgeemucosa of transverse colon1.00infobox
Bcl-2 homologous antagonist killerBgeegranulocyte1.00infobox
Bcl-2 homologous antagonist killerBgeeleft adrenal gland1.00infobox
Bcl-2 homologous antagonist killerBgeeleft adrenal cortex1.00infobox
Bcl-2 homologous antagonist killerBgeeright adrenal gland1.00infobox
Bcl-2 homologous antagonist killerBgeemonocyte1.00infobox
Bcl-2 homologous antagonist killerBgeeapex of heart1.00infobox
Bcl-2 homologous antagonist killerBgeeduodenum1.00infobox
Bcl-2 homologous antagonist killerBgeeright adrenal cortex1.00infobox
Bcl-2 homologous antagonist killerBgeerectum1.00infobox
Bcl-2 homologous antagonist killerBioGPSMore reference expression data1.00infobox
Bcl-2 homologous antagonist killerChr.Chromosome 6 (human)1.00infobox
Bcl-2 homologous antagonist killerDatabasesNCBI: entry; OMA: entry1.00infobox
Bcl-2 homologous antagonist killerEnd33,580,293 bp1.00infobox
Bcl-2 homologous antagonist killerEnsemblENSG000000301101.00infobox
Bcl-2 homologous antagonist killerEntrez5781.00infobox
Bcl-2 homologous antagonist killerExternal IDsOMIM: 600516; MGI: 1097161; GeneCards: BAK11.00infobox
Bcl-2 homologous antagonist killerGene location (Human)Gene location (Human)Chr.Chromosome 6 (human)Band6p21.31Start33,572,547 bpEnd33,580,293 bp1.00infobox
Bcl-2 homologous antagonist killerGene ontologytransmembrane transporter binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologymetal ion binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyidentical protein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein homodimerization activity1.00infobox
Bcl-2 homologous antagonist killerGene ontologymolecular function1.00infobox
Bcl-2 homologous antagonist killerGene ontologyheat shock protein binding1.00infobox
Bcl-2 homologous antagonist killerGene ontologyprotein heterodimerization activity1.00infobox
Bcl-2 homologous antagonist killerGene ontologychaperone binding1.00infobox

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