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BRCA1: Protein structure, Function and mechanism & Interactions

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (/ˌbrækəˈwʌn/) gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. BRCA1 is a caretaker gene (responsible for repairing DNA), a type of tumor suppressor gene.

Language: English [EN]
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BRCA1 topic overview

The analysis highlights Protein structure, Function and mechanism and Interactions as prominent areas in the source structure around BRCA1.

Related topics
178
Source areas
11
Connected nodes
189
Extracted relationships
351
Concept neighborhoods
42
Bridge connections
189

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 59 topics
Overview · 26 topics
Function and mechanism · 25 topics
Protein structure · 25 topics
Low expression of BRCA1 in breast and ovarian cancers · 17 topics
Mutations and cancer risk · 17 topics
Patents, enforcement, litigation, and controversy · 4 topics
Discovery · 2 topics
Female fertility · 1 topics
Gene · 1 topics
Germ-line mutations and founder effect · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.3.2.27
↗
Aliases
BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD,…
Band
17q21.31 · 11 65.18 cM|11 D
Bgee
ventricular zone · testicle · gonad · ganglionic eminence · secondary oocyte
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Gene

Protein structure

Function and mechanism

Mutations and cancer risk

Low expression of BRCA1 in breast and ovarian cancers

Germ-line mutations and founder effect

Female fertility

Patents, enforcement, litigation, and controversy

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How BRCA1 connects Entity context

The extracted context around BRCA1 shows recurring relationship patterns in the source. For example, BRCA1 → androgen receptor binding, androgen receptor signaling pathway, apoptotic process, BRCA1-A complex, BRCA1-BARD1 complex, cell cycle, cellular response to DNA damage stimulus, cellular response to indole-3-methanol, cellular response to tumor necrosis factor, centrosome cycle, chordate embryonic development, chromosome, chromosome segregation, condensed chromosome, condensed nuclear chromosome, cytoplasm, damaged DNA binding, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA double-strand break processing Another extracted example is BRCA1 → According, Association, August, BRCA2, Canada, CEO, Development Limited Partnership, Endo Recherche, Environmental Health Sciences, Europe, European-wide, For, Genetic Medicine, HSC Research, In, In Australia, Inc, Molecular Pathology, Myriad, Myriad Genetics. Use these groups to spot repeated connection types before inspecting the individual relationships.

BRCA1

Top relations

Gene ontology · 92
BRCA1 → androgen receptor binding, androgen receptor signaling pathway, apoptotic process, BRCA1-A complex, BRCA1-BARD1 complex, cell cycle, cellular response to DNA damage stimulus, cellular response to indole-3-methanol, cellular response to tumor necrosis factor, centrosome cycle, chordate embryonic development, chromosome, chromosome segregation, condensed chromosome, condensed nuclear chromosome, cytoplasm, damaged DNA binding, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA double-strand break processing
related to Patents, enforcement, litigation, and controversy · 33
BRCA1 → According, Association, August, BRCA2, Canada, CEO, Development Limited Partnership, Endo Recherche, Environmental Health Sciences, Europe, European-wide, For, Genetic Medicine, HSC Research, In, In Australia, Inc, Molecular Pathology, Myriad, Myriad Genetics
Bgee · 19
BRCA1 → bone marrow cell, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, lumbar spinal ganglion, mandibular prominence, maxillary prominence, primary oocyte, primitive streak, secondary oocyte, stromal cell of endometrium, sural nerve, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BRCA1 → bone marrow cell, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, lumbar spinal ganglion, mandibular prominence, maxillary prominence, primary oocyte, primitive streak, secondary oocyte, stromal cell of endometrium, sural nerve, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
related to Zinc RING finger domain · 19
BRCA1 → Additional, BARD1, BRCA1-BARD1, BRCA2, DNA, E3, It, Lys-48-linked, RING, The, The BARD1/BRCA1, The BRCA1 RING, The RING, These, This, This RING, Ubiquitin, Ubiquitination, Zn
related to Function and mechanism · 14
BRCA1 → Ashkenazim, By, Complementation Group, DNA, Double-strand, FA-S, Fanconi Anemia, In, RAD51, Sometimes, The, The BRCA2, These, When
related to Germ-line mutations and founder effect · 12
BRCA1 → Additional, All, Analysis, Ashkenazi Jewish, Ashkenazi Jews, BRCA1-related, Examples, Given, In, Jewish, Table, Three
related to MicroRNA repression of BRCA1 in breast cancers · 12
BRCA1 → All, Breast, DNA, ER, HER2, In, Invasive, MicroRNA, PR, There, These, Thus
related to Cancer chemotherapy · 11
BRCA1 → Among, At, DNA, High BRCA1, Non-small, NSCLC, Patients, Persons, The, This, Thus
related to Discovery · 10
BRCA1 → After, Environmental Health Sciences, Mary-Claire King's, Myriad Genetics, National Institute, NIEHS, The, UC Berkeley, University, Utah

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna cancer protein breast mutations repair gene ovarian also expression brca2 may damage mutation myriad cancers double-strand domain proteins role

BRCA1 relationships Subject–Predicate–Object triples

TTTA extracted 351 structured relationships around BRCA1. Examples in this analysis include BRCA1 → 2.3.2.27 → ↗ and BRCA1 → Aliases → BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
BRCA12.3.2.27↗1.00infobox
BRCA1AliasesBRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes1.00infobox
BRCA1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD,…1.00infobox
BRCA1Band17q21.311.00infobox
BRCA1Band11 65.18 cM|11 D1.00infobox
BRCA1Bgeeventricular zone1.00infobox
BRCA1Bgeetesticle1.00infobox
BRCA1Bgeegonad1.00infobox
BRCA1Bgeeganglionic eminence1.00infobox
BRCA1Bgeesecondary oocyte1.00infobox
BRCA1Bgeebone marrow cell1.00infobox
BRCA1Bgeesural nerve1.00infobox
BRCA1Bgeetrabecular bone1.00infobox
BRCA1Bgeestromal cell of endometrium1.00infobox
BRCA1Bgeeepithelium of colon1.00infobox
BRCA1Bgeeprimary oocyte1.00infobox
BRCA1Bgeezygote1.00infobox
BRCA1Bgeegenital tubercle1.00infobox
BRCA1Bgeetail of embryo1.00infobox
BRCA1Bgeeprimitive streak1.00infobox
BRCA1Bgeelumbar spinal ganglion1.00infobox
BRCA1Bgeemaxillary prominence1.00infobox
BRCA1Bgeefetal liver hematopoietic progenitor cell1.00infobox
BRCA1Bgeemandibular prominence1.00infobox
BRCA1BioGPSMore reference expression data1.00infobox
BRCA1Chr.Chromosome 17 (human)1.00infobox
BRCA1Chr.Chromosome 11 (mouse)1.00infobox
BRCA1DatabasesNCBI: entry; OMA: entry1.00infobox
BRCA1End43,170,245 bp1.00infobox
BRCA1End101,442,781 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around BRCA1 bring nearby vocabulary together. In this analysis, examples include Cancer, Dna and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • BRCA1
    • Cancer
    • Dna
    • Expression
    • Breast
    • Protein
    • Mutations
    • Repair
    • Gene
    • Ovarian
    • Brca2
    • Cancers
    • Also
  • brca1
    • Cancer
    • Dna
    • Expression
    • Breast
    • Protein
    • Mutations
    • Repair
    • Gene
    • Ovarian
    • Brca2
    • Cancers
    • Also
  • gene
    • Risk
    • Mutations
    • Ovarian
    • Tumor
    • Function
    • Genetics
    • Human
    • Myriad
    • Expression
    • Brca2
    • Protein
    • Also
  • caretaker gene
    • Risk
    • Mutations
    • Ovarian
    • Tumor
    • Function
    • Genetics
    • Human
    • Myriad
    • Expression
    • Brca2
    • Protein
    • Also
  • dna
    • Repair
    • Damage
    • Double-strand
    • Breaks
    • Role
    • Protein
    • Cells
    • May
    • Mutations
    • Also
    • Complex
    • Brca2
  • tumor suppressor gene
    • Risk
    • Mutations
    • Complex
    • Ovarian
    • Gene
    • Tumor
    • Expression
    • Function
    • Genetics
    • Human
    • Myriad
    • Damage
  • brca2
    • Breast
    • Cancer
    • Patents
    • Risk
    • Proteins
    • Mutations
    • Genes
    • Genetics
    • Ovarian
    • Gene
    • Dna
    • Myriad
  • breast
    • Cancer
    • Risk
    • Ovarian
    • Cancers
    • Brca2
    • Gene
    • Brca1
    • Expression
    • Mutations
    • Proteins
    • Mutation
    • Protein

Connections between topic areas Semantic bridges

For BRCA1, one of the stronger structural bridges in this analysis connects BRCA1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
BRCA1 — Interactions · splits 130 ⟂ 60
BRCA1 — Overview · splits 163 ⟂ 27
BRCA1 — Protein structure · splits 164 ⟂ 26
BRCA1 — Function and mechanism · splits 164 ⟂ 26
BRCA1 — Mutations and cancer risk · splits 172 ⟂ 18
BRCA1 — Low expression of BRCA1 in breast and ovarian cancers · splits 172 ⟂ 18
BRCA1 — Patents, enforcement, litigation, and controversy · splits 185 ⟂ 5
BRCA1 — Discovery · splits 187 ⟂ 3

Map overview Semantic statistics

BRCA1

Nodes190
Edges189
Triples351
Avg. degree1.99
Density0.010526
Components1

Source & methodology

TTTA analyzes the structure around BRCA1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Protein structure, Function and mechanism & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — BRCA1 · EN edition · Analysis: TopicsToTalkAbout

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