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BRCA1

Breast cancer type 1 susceptibility protein is a protein that in humans is encoded by the BRCA1 (/ˌbrækəˈwʌn/) gene. Orthologs are common in other vertebrate species, whereas invertebrate genomes may encode a more distantly related gene. BRCA1 is a caretaker gene (responsible for repairing DNA), a type of tumor suppressor gene.

Protein structure, Function and mechanism & Interactions

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2.3.2.27
Aliases
BRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD,…
Band
17q21.31 · 11 65.18 cM|11 D
Bgee
ventricular zone · testicle · gonad · ganglionic eminence · secondary oocyte
BioGPS
More reference expression data

Topics to explore

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Overview

Discovery

Gene

Protein structure

Function and mechanism

Mutations and cancer risk

Low expression of BRCA1 in breast and ovarian cancers

Germ-line mutations and founder effect

Female fertility

Patents, enforcement, litigation, and controversy

Interactions

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Map overview Semantic statistics

BRCA1

Nodes190
Edges189
Triples351
Avg. degree1.99
Density0.010526
Components1

How this topic connects Entity context

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BRCA1

Top relations

Gene ontology · 92
BRCA1 → androgen receptor binding, androgen receptor signaling pathway, apoptotic process, BRCA1-A complex, BRCA1-BARD1 complex, cell cycle, cellular response to DNA damage stimulus, cellular response to indole-3-methanol, cellular response to tumor necrosis factor, centrosome cycle, chordate embryonic development, chromosome, chromosome segregation, condensed chromosome, condensed nuclear chromosome, cytoplasm, damaged DNA binding, DNA binding, DNA damage response, signal transduction by p53 class mediator resulting in transcription of p21 class mediator, DNA double-strand break processing
related to Patents, enforcement, litigation, and controversy · 33
BRCA1 → According, Association, August, BRCA2, Canada, CEO, Development Limited Partnership, Endo Recherche, Environmental Health Sciences, Europe, European-wide, For, Genetic Medicine, HSC Research, In, In Australia, Inc, Molecular Pathology, Myriad, Myriad Genetics
Bgee · 19
BRCA1 → bone marrow cell, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, lumbar spinal ganglion, mandibular prominence, maxillary prominence, primary oocyte, primitive streak, secondary oocyte, stromal cell of endometrium, sural nerve, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
RNA expression pattern · 19
BRCA1 → bone marrow cell, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, genital tubercle, gonad, lumbar spinal ganglion, mandibular prominence, maxillary prominence, primary oocyte, primitive streak, secondary oocyte, stromal cell of endometrium, sural nerve, tail of embryo, testicle, trabecular bone, ventricular zone, zygote
related to Zinc RING finger domain · 19
BRCA1 → Additional, BARD1, BRCA1-BARD1, BRCA2, DNA, E3, It, Lys-48-linked, RING, The, The BARD1/BRCA1, The BRCA1 RING, The RING, These, This, This RING, Ubiquitin, Ubiquitination, Zn
related to Function and mechanism · 14
BRCA1 → Ashkenazim, By, Complementation Group, DNA, Double-strand, FA-S, Fanconi Anemia, In, RAD51, Sometimes, The, The BRCA2, These, When
related to Germ-line mutations and founder effect · 12
BRCA1 → Additional, All, Analysis, Ashkenazi Jewish, Ashkenazi Jews, BRCA1-related, Examples, Given, In, Jewish, Table, Three
related to MicroRNA repression of BRCA1 in breast cancers · 12
BRCA1 → All, Breast, DNA, ER, HER2, In, Invasive, MicroRNA, PR, There, These, Thus
related to Cancer chemotherapy · 11
BRCA1 → Among, At, DNA, High BRCA1, Non-small, NSCLC, Patients, Persons, The, This, Thus
related to Discovery · 10
BRCA1 → After, Environmental Health Sciences, Mary-Claire King's, Myriad Genetics, National Institute, NIEHS, The, UC Berkeley, University, Utah

Important terminology Word statistics

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Important terminology

dna cancer protein breast mutations repair gene ovarian also expression brca2 may damage mutation myriad cancers double-strand domain proteins role

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
BRCA12.3.2.271.00infobox
BRCA1AliasesBRCA1, breast cancer 1, early onset, BRCAI, BRCC1, BROVCA1, IRIS, PNCA4, PPP1R53, PSCP, RNF53, FANCS, breast cancer 1, DNA repair associated, BRCA1 DNA repair associated, Genes1.00infobox
BRCA1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JM7, 1JNX, 1N5O, 1OQA, 1T15, 1T29, 1T2U, 1T2V, 1Y98, 2ING, 3COJ, 3K0H, 3K0K, 3K15, 3PXA, 3PXB, 3PXC, 3PXD,…1.00infobox
BRCA1Band17q21.311.00infobox
BRCA1Band11 65.18 cM|11 D1.00infobox
BRCA1Bgeeventricular zone1.00infobox
BRCA1Bgeetesticle1.00infobox
BRCA1Bgeegonad1.00infobox
BRCA1Bgeeganglionic eminence1.00infobox
BRCA1Bgeesecondary oocyte1.00infobox
BRCA1Bgeebone marrow cell1.00infobox
BRCA1Bgeesural nerve1.00infobox
BRCA1Bgeetrabecular bone1.00infobox
BRCA1Bgeestromal cell of endometrium1.00infobox
BRCA1Bgeeepithelium of colon1.00infobox
BRCA1Bgeeprimary oocyte1.00infobox
BRCA1Bgeezygote1.00infobox
BRCA1Bgeegenital tubercle1.00infobox
BRCA1Bgeetail of embryo1.00infobox
BRCA1Bgeeprimitive streak1.00infobox
BRCA1Bgeelumbar spinal ganglion1.00infobox
BRCA1Bgeemaxillary prominence1.00infobox
BRCA1Bgeefetal liver hematopoietic progenitor cell1.00infobox
BRCA1Bgeemandibular prominence1.00infobox
BRCA1BioGPSMore reference expression data1.00infobox
BRCA1Chr.Chromosome 17 (human)1.00infobox
BRCA1Chr.Chromosome 11 (mouse)1.00infobox
BRCA1DatabasesNCBI: entry; OMA: entry1.00infobox
BRCA1End43,170,245 bp1.00infobox
BRCA1End101,442,781 bp1.00infobox

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