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RAD51: Movements, MicroRNA control of RAD51 expression & Interactions

DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA, and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to…

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RAD51 topic overview

The analysis highlights Movements, MicroRNA control of RAD51 expression and Interactions as prominent areas in the source structure around RAD51.

Related topics
68
Source areas
10
Connected nodes
78
Extracted relationships
178
Concept neighborhoods
31
Bridge connections
78

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 11 topics
MicroRNA control of RAD51 expression · 11 topics
Overview · 9 topics
Family · 7 topics
Function · 7 topics
Role in double-strand break repair · 7 topics
Pathology · 6 topics
Meiosis · 5 topics
Chemotherapy and aging · 4 topics
RAD51 expression in cancer · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
RAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 1B22
Band
15q15.1
Bgee
gonad · buccal mucosa cell · ventricular zone · embryo · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 15 (human)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Family

Function

RAD51 expression in cancer

Role in double-strand break repair

Meiosis

Chemotherapy and aging

MicroRNA control of RAD51 expression

Pathology

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RAD51 connects Entity context

The extracted context around RAD51 shows recurring relationship patterns in the source. For example, RAD51 → ATP binding, ATP-dependent activity, acting on DNA, cellular response to camptothecin, cellular response to DNA damage stimulus, cellular response to ionizing radiation, chromatin, chromatin binding, chromosome, chromosome organization involved in meiotic cell cycle, condensed chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA metabolic process, DNA polymerase binding, DNA recombinase assembly, DNA recombination, DNA repair Another extracted example is RAD51 → Abl, Ataxia, BARD1, Bloom, BRCA1, BRCA2, BRCC3, BRE, DMC1, P53RAD52, RAD54, RAD54B. Use these groups to spot repeated connection types before inspecting the individual relationships.

RAD51

Top relations

Gene ontology · 58
RAD51 → ATP binding, ATP-dependent activity, acting on DNA, cellular response to camptothecin, cellular response to DNA damage stimulus, cellular response to ionizing radiation, chromatin, chromatin binding, chromosome, chromosome organization involved in meiotic cell cycle, condensed chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA metabolic process, DNA polymerase binding, DNA recombinase assembly, DNA recombination, DNA repair
related to Interactions · 12
RAD51 → Abl, Ataxia, BARD1, Bloom, BRCA1, BRCA2, BRCC3, BRE, DMC1, P53RAD52, RAD54, RAD54B
Bgee · 10
RAD51 → bone marrow cell, buccal mucosa cell, embryo, ganglionic eminence, gonad, left testis, mucosa of transverse colon, right testis, testicle, ventricular zone
RNA expression pattern · 10
RAD51 → bone marrow cell, buccal mucosa cell, embryo, ganglionic eminence, gonad, left testis, mucosa of transverse colon, right testis, testicle, ventricular zone
related to Cancer · 10
RAD51 → BRCA2, DNA, DNA-binding, In, Loss, PALB2, Several, Table, The, This
related to Family · 10
RAD51 → All, DMC1, DMC1/Lim15, In, Rad51L1/B, Rad51L2/C, Rad51L3/D, RecA-like NTPases, XRCC2, XRCC3
related to MicroRNA control of RAD51 expression · 7
RAD51 → At, For, Further, If, In, Some, TNBC
related to Fanconi anemia · 6
RAD51 → DNA, FA, FA-like, Fanconi, Rad51-mediated, This
related to Role in double-strand break repair · 6
RAD51 → DNA, DNA2, Double-strand, DSB, Figure, In
related to Chemotherapy and aging · 5
RAD51 → DNA, In, Rad51's, Survival, The Rad51-induced

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

dna repair homologous protein recombination expression gene brca2 damage strand paralogs increased cancer cancers role dmc1 complex family human function

RAD51 relationships Subject–Predicate–Object triples

TTTA extracted 178 structured relationships around RAD51. Examples in this analysis include RAD51 → Aliases → RAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase and RAD51 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 1B22. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RAD51AliasesRAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase1.00infobox
RAD51Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 1B221.00infobox
RAD51Band15q15.11.00infobox
RAD51Bgeegonad1.00infobox
RAD51Bgeebuccal mucosa cell1.00infobox
RAD51Bgeeventricular zone1.00infobox
RAD51Bgeeembryo1.00infobox
RAD51Bgeeganglionic eminence1.00infobox
RAD51Bgeeleft testis1.00infobox
RAD51Bgeeright testis1.00infobox
RAD51Bgeemucosa of transverse colon1.00infobox
RAD51Bgeetesticle1.00infobox
RAD51Bgeebone marrow cell1.00infobox
RAD51BioGPSMore reference expression data1.00infobox
RAD51Chr.Chromosome 15 (human)1.00infobox
RAD51DatabasesNCBI: entry; OMA: entry1.00infobox
RAD51End40,732,340 bp1.00infobox
RAD51EnsemblENSG000000511801.00infobox
RAD51Entrez58881.00infobox
RAD51External IDsOMIM: 179617; MGI: 97890; GeneCards: RAD511.00infobox
RAD51Gene location (Human)Gene location (Human)Chr.Chromosome 15 (human)Band15q15.1Start40,694,774 bpEnd40,732,340 bp1.00infobox
RAD51Gene ontologynucleotide binding1.00infobox
RAD51Gene ontologyDNA binding1.00infobox
RAD51Gene ontologyATP-dependent activity, acting on DNA1.00infobox
RAD51Gene ontologyDNA strand exchange activity1.00infobox
RAD51Gene ontologyDNA polymerase binding1.00infobox
RAD51Gene ontologyprotein C-terminus binding1.00infobox
RAD51Gene ontologyprotein binding1.00infobox
RAD51Gene ontologyfour-way junction DNA binding1.00infobox
RAD51Gene ontologyidentical protein binding1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RAD51 bring nearby vocabulary together. In this analysis, examples include Expression, Homologous and Repair. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • RAD51
    • Expression
    • Homologous
    • Repair
    • Recombination
    • Complex
    • Gene
    • Damage
    • Increased
    • Cancer
    • Strand
    • Dmc1
    • Identified
  • rad51
    • Expression
    • Homologous
    • Repair
    • Recombination
    • Complex
    • Gene
    • Damage
    • Increased
    • Cancer
    • Strand
    • Dmc1
    • Identified
  • gene
    • Bp
    • Chromosome
    • Protein
    • Double-strand
    • Family
    • Human
    • Break
    • Function
    • Recombinase
    • Repair
    • Cancer
    • Strand
  • dna double strand breaks
    • Repair
    • Damage
    • Homologous
    • Protein
    • Rad51
    • Strand
    • Recombination
    • Recombinational
    • Ssdna
    • Increased
    • Role
    • Break
  • homologous
    • Recombination
    • Repair
    • Recombinational
    • Strand
    • Break
    • Rad51
    • Role
    • Double-strand
    • Two
    • Protein
    • Brca2
    • Damage
  • homologous recombination
    • Recombination
    • Repair
    • Recombinational
    • Strand
    • Break
    • Rad51
    • Role
    • Paralogs
    • Double-strand
    • Two
    • Protein
    • Brca2
  • frequencies of epimutations in dna repair genes in cancers
    • Repair
    • Homologous
    • Recombinational
    • Damage
    • Role
    • Strand
    • Break
    • See
    • Recombination
    • Protein
    • Double-strand
    • Expression
  • rad51 nucleoprotein filament
    • Expression
    • Homologous
    • Repair
    • Recombination
    • Complex
    • Gene
    • Damage
    • Increased
    • Cancer
    • Strand
    • Dmc1
    • Identified

Connections between topic areas Semantic bridges

For RAD51, one of the stronger structural bridges in this analysis connects RAD51 with MicroRNA control of RAD51 expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RAD51MicroRNA control of RAD51 expression · splits 67 ⟂ 12
RAD51Interactions · splits 67 ⟂ 12
RAD51Overview · splits 69 ⟂ 10
RAD51Family · splits 71 ⟂ 8
RAD51Function · splits 71 ⟂ 8
RAD51Role in double-strand break repair · splits 71 ⟂ 8
RAD51Pathology · splits 72 ⟂ 7
RAD51Meiosis · splits 73 ⟂ 6
RAD51Chemotherapy and aging · splits 74 ⟂ 5

Map overview Semantic statistics

RAD51

Nodes79
Edges78
Triples178
Avg. degree1.97
Density0.025316
Components1

Source & methodology

TTTA analyzes the structure around RAD51 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Movements, MicroRNA control of RAD51 expression & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RAD51 · EN edition · Analysis: TopicsToTalkAbout

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