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RAD51

DNA repair protein RAD51 homolog 1 is a protein encoded by the gene RAD51. The enzyme encoded by this gene is a member of the RAD51 protein family which assists in repair of DNA double strand breaks. RAD51 family members are homologous to the bacterial RecA, Archaeal RadA, and yeast Rad51. The protein is highly conserved in most eukaryotes, from yeast to…

Movements, MicroRNA control of RAD51 expression & Interactions

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Aliases
RAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 1B22
Band
15q15.1
Bgee
gonad · buccal mucosa cell · ventricular zone · embryo · ganglionic eminence
BioGPS
More reference expression data
Chr.
Chromosome 15 (human)

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Overview

Family

Function

RAD51 expression in cancer

Role in double-strand break repair

Meiosis

Chemotherapy and aging

MicroRNA control of RAD51 expression

Pathology

Interactions

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Map overview Semantic statistics

RAD51

Nodes79
Edges78
Triples178
Avg. degree1.97
Density0.025316
Components1

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RAD51

Top relations

Gene ontology · 58
RAD51 → ATP binding, ATP-dependent activity, acting on DNA, cellular response to camptothecin, cellular response to DNA damage stimulus, cellular response to ionizing radiation, chromatin, chromatin binding, chromosome, chromosome organization involved in meiotic cell cycle, condensed chromosome, condensed nuclear chromosome, cytoplasm, cytoskeleton, cytosol, DNA binding, DNA metabolic process, DNA polymerase binding, DNA recombinase assembly, DNA recombination, DNA repair
related to Interactions · 12
RAD51 → Abl, Ataxia, BARD1, Bloom, BRCA1, BRCA2, BRCC3, BRE, DMC1, P53RAD52, RAD54, RAD54B
Bgee · 10
RAD51 → bone marrow cell, buccal mucosa cell, embryo, ganglionic eminence, gonad, left testis, mucosa of transverse colon, right testis, testicle, ventricular zone
RNA expression pattern · 10
RAD51 → bone marrow cell, buccal mucosa cell, embryo, ganglionic eminence, gonad, left testis, mucosa of transverse colon, right testis, testicle, ventricular zone
related to Cancer · 10
RAD51 → BRCA2, DNA, DNA-binding, In, Loss, PALB2, Several, Table, The, This
related to Family · 10
RAD51 → All, DMC1, DMC1/Lim15, In, Rad51L1/B, Rad51L2/C, Rad51L3/D, RecA-like NTPases, XRCC2, XRCC3
related to MicroRNA control of RAD51 expression · 7
RAD51 → At, For, Further, If, In, Some, TNBC
related to Fanconi anemia · 6
RAD51 → DNA, FA, FA-like, Fanconi, Rad51-mediated, This
related to Role in double-strand break repair · 6
RAD51 → DNA, DNA2, Double-strand, DSB, Figure, In
related to Chemotherapy and aging · 5
RAD51 → DNA, In, Rad51's, Survival, The Rad51-induced

Important terminology Word statistics

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Important terminology

dna repair homologous protein recombination expression gene brca2 damage strand paralogs increased cancer cancers role dmc1 complex family human function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RAD51AliasesRAD51, BRCC5, FANCR, HHsRad51, HsT16930, MRMV2, RAD51A, RECA, RAD51 recombinase1.00infobox
RAD51Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1N0W, 1B221.00infobox
RAD51Band15q15.11.00infobox
RAD51Bgeegonad1.00infobox
RAD51Bgeebuccal mucosa cell1.00infobox
RAD51Bgeeventricular zone1.00infobox
RAD51Bgeeembryo1.00infobox
RAD51Bgeeganglionic eminence1.00infobox
RAD51Bgeeleft testis1.00infobox
RAD51Bgeeright testis1.00infobox
RAD51Bgeemucosa of transverse colon1.00infobox
RAD51Bgeetesticle1.00infobox
RAD51Bgeebone marrow cell1.00infobox
RAD51BioGPSMore reference expression data1.00infobox
RAD51Chr.Chromosome 15 (human)1.00infobox
RAD51DatabasesNCBI: entry; OMA: entry1.00infobox
RAD51End40,732,340 bp1.00infobox
RAD51EnsemblENSG000000511801.00infobox
RAD51Entrez58881.00infobox
RAD51External IDsOMIM: 179617; MGI: 97890; GeneCards: RAD511.00infobox
RAD51Gene location (Human)Gene location (Human)Chr.Chromosome 15 (human)Band15q15.1Start40,694,774 bpEnd40,732,340 bp1.00infobox
RAD51Gene ontologynucleotide binding1.00infobox
RAD51Gene ontologyDNA binding1.00infobox
RAD51Gene ontologyATP-dependent activity, acting on DNA1.00infobox
RAD51Gene ontologyDNA strand exchange activity1.00infobox
RAD51Gene ontologyDNA polymerase binding1.00infobox
RAD51Gene ontologyprotein C-terminus binding1.00infobox
RAD51Gene ontologyprotein binding1.00infobox
RAD51Gene ontologyfour-way junction DNA binding1.00infobox
RAD51Gene ontologyidentical protein binding1.00infobox

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