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Genome instability

Genome instability (also genetic instability or genomic instability) refers to a high frequency of mutations within the genome of a cellular lineage. These mutations can include changes in nucleic acid sequences, chromosomal rearrangements or aneuploidy. Genome instability does occur in bacteria. In multicellular organisms genome instability is central…

Applications, In cancer & In neuronal and neuromuscular disease

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Overview

Usual genome situation

Causes of genome instability

In neuronal and neuromuscular disease

In cancer

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Map overview Semantic statistics

Genome instability

Nodes89
Edges88
Triples51
Avg. degree1.98
Density0.022472
Components1

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Genome instability

Top relations

related to In neuronal and neuromuscular disease · 13
Genome instability → Alzheimer's, Cockayne's, DNA, Down's, Five, Four, Friedreich's, Huntington's, Nijmegen, Of, Overall, Parkinson's, Six
related to In cancer · 11
Genome instability → An, Any, DNA, During, Genetic, Genome, In, It, Losing, Situations, The
related to Usual genome situation · 5
Genome instability → In, List, Sometimes, The, Usually

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Important terminology

dna genome repair mutations instability replication cancer epigenetic breaks cells also leading damage genes mutation occur caused genetic high gene

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
amyotrophic lateral sclerosis or the neuromuscular disease myotonic dystrophy.The sources of genome instability have only recently begun to be elucidatedinstance ofand in humans it is also a factor in some neurodegenerative diseases0.80text
tightly wound chromatin with bound proteinsinstance ofThe replisome must be able to navigate obstacles0.80text
singleinstance ofThe replisome must be able to navigate obstacles0.80text
double stranded breaks which can lead to the stalling of the replication forkinstance ofThe replisome must be able to navigate obstacles0.80text
DNA polymerase or DNA ligase can lead to impairment of replicationinstance ofMutations of proteins0.80text
lead to spontaneous chromosomal exchangesinstance ofMutations of proteins0.80text
Tel1instance ofProteins0.80text
Mec1instance ofProteins0.80text
UV damageinstance ofG1 and G2 checkpoints exist to check for transient DNA damage which could be caused by mutagens0.80text
in the aforementioned checkpoint arrestinstance ofThe cells that arrested were able to survive due to the increased time in S/G2 phase allowing for DNA repair enzymes to function fully.Fragile SitesThere are hotspots in the gen…0.80text
fragile X intellectual disability syndromeinstance ofRare fragile sites can lead to genetic disease0.80text
myotonic dystrophyinstance ofRare fragile sites can lead to genetic disease0.80text

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