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PCAF

P300/CBP-associated factor (PCAF), also known as K(lysine) acetyltransferase 2B (KAT2B), is a human gene and transcriptional coactivator associated with p53.

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Interactions

15 related topics

Function

6 related topics

Structure

3 related topics

Targets

2 related topics

Key facts & relationships

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2.3.1.48
2.3.1.57
Aliases
KAT2B, CAF, P/CAF, PCAF, lysine acetyltransferase 2B
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CM0, 1JM4, 1N72, 1WUG, 1WUM, 1ZS5, 2RNW, 2RNX, 3GG3, 4NSQ, 5FE2, 5FE4, 5FDZ, 5FE8, 5FE5, 5FE1, 5FE7, 5FE9,…
Band
3p24.3 · 17 C|17 27.86 cM
Bgee
external globus pallidus · trabecular bone · buccal mucosa cell · corpus callosum · Achilles tendon

Topics to explore

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Overview

Structure

Function

Regulation

Protein interactions

  • ATF Activating transcription factor

Targets

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

PCAF

Nodes39
Edges38
Triples161
Avg. degree1.95
Density0.051282
Components1

How this topic connects Entity context

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PCAF

Top relations

Gene ontology · 58
PCAF → A band, acetyltransferase activity, actomyosin, acyltransferase activity, cell cycle, cellular response to insulin stimulus, centrosome, chromatin binding, chromatin remodeling, cyclin-dependent protein serine/threonine kinase inhibitor activity, cytoplasm, cytoskeleton, development of the heart, diamine N-acetyltransferase activity, epigenetic maintenance of chromatin in transcription-competent conformation, histone acetylation, histone acetyltransferase activity, histone acetyltransferase complex, histone deacetylase binding, histone H3 acetylation
Bgee · 20
PCAF → Achilles tendon, amniotic fluid, ankle, buccal mucosa cell, corpus callosum, Epithelium of choroid plexus, extensor digitorum longus muscle, external globus pallidus, gastrula, iris, nasal epithelium, olfactory epithelium, pars compacta, pars reticulata, retinal pigment epithelium, seminal vesicula, Skeletal muscle tissue of rectus abdominis, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct
RNA expression pattern · 20
PCAF → Achilles tendon, amniotic fluid, ankle, buccal mucosa cell, corpus callosum, Epithelium of choroid plexus, extensor digitorum longus muscle, external globus pallidus, gastrula, iris, nasal epithelium, olfactory epithelium, pars compacta, pars reticulata, retinal pigment epithelium, seminal vesicula, Skeletal muscle tissue of rectus abdominis, subthalamic nucleus, trabecular bone, vestibular membrane of cochlear duct
related to Interactions · 14
PCAF → BRCA2, CREBBP, CTNNB1, EVI1, HNF1A, IRF1, IRF2, KLF13, Mdm2Myc, NCOA1, POLR2A, RBPJ, TCF3, TRRAP
related to External links · 4
PCAF → Medicine Medical Subject Headings, MeSH, National Library, NURSAC105
related to Function · 4
PCAF → CBP, E1A, It, The
related to Targets · 4
PCAF → Fli1, Hdm2, PCAF's, There
related to Protein interactions · 3
PCAF → ATF, ATF4, For
related to Regulation · 3
PCAF → Acetylation, HDAC3, The
Band · 2
PCAF → 17 C|17 27.86 cM, 3p24.3

Important terminology Word statistics

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Important terminology

acetyltransferase activity human bp gene p300 chr band protein chromosome also kat2b location lysine external transcription acetylation p53 regulation cbp

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PCAF2.3.1.481.00infobox
PCAF2.3.1.571.00infobox
PCAFAliasesKAT2B, CAF, P/CAF, PCAF, lysine acetyltransferase 2B1.00infobox
PCAFAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CM0, 1JM4, 1N72, 1WUG, 1WUM, 1ZS5, 2RNW, 2RNX, 3GG3, 4NSQ, 5FE2, 5FE4, 5FDZ, 5FE8, 5FE5, 5FE1, 5FE7, 5FE9,…1.00infobox
PCAFBand3p24.31.00infobox
PCAFBand17 C|17 27.86 cM1.00infobox
PCAFBgeeexternal globus pallidus1.00infobox
PCAFBgeetrabecular bone1.00infobox
PCAFBgeebuccal mucosa cell1.00infobox
PCAFBgeecorpus callosum1.00infobox
PCAFBgeeAchilles tendon1.00infobox
PCAFBgeesubthalamic nucleus1.00infobox
PCAFBgeepars reticulata1.00infobox
PCAFBgeeamniotic fluid1.00infobox
PCAFBgeeSkeletal muscle tissue of rectus abdominis1.00infobox
PCAFBgeepars compacta1.00infobox
PCAFBgeeretinal pigment epithelium1.00infobox
PCAFBgeenasal epithelium1.00infobox
PCAFBgeeolfactory epithelium1.00infobox
PCAFBgeeEpithelium of choroid plexus1.00infobox
PCAFBgeeiris1.00infobox
PCAFBgeeseminal vesicula1.00infobox
PCAFBgeevestibular membrane of cochlear duct1.00infobox
PCAFBgeegastrula1.00infobox
PCAFBgeeextensor digitorum longus muscle1.00infobox
PCAFBgeeankle1.00infobox
PCAFBioGPSMore reference expression data1.00infobox
PCAFChr.Chromosome 3 (human)1.00infobox
PCAFChr.Chromosome 17 (mouse)1.00infobox
PCAFDatabasesNCBI: entry; OMA: entry1.00infobox

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