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Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.
The analysis highlights DNA repair, Interactions and Clinical significance as prominent areas in the source structure around TP53BP1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TP53BP1 shows recurring relationship patterns in the source. For example, TP53BP1 → cellular response to DNA damage stimulus, cellular response to X-ray, chromosome, chromosome, centromeric region, cytoplasm, damaged DNA binding, DNA binding, DNA damage checkpoint signaling, DNA repair, DNA repair complex, double-strand break repair via nonhomologous end joining, histone binding, kinetochore, methylated histone binding, negative regulation of double-strand break repair via homologous recombination, nuclear body, nucleoplasm, nucleus, p53 binding, positive regulation of DNA-binding transcription factor activity Another extracted example is TP53BP1 → Achilles tendon, anterior pituitary, aortic valve, ascending aorta, ciliary body, condyle, fossa, ganglionic eminence, gonad, middle temporal gyrus, pituitary gland, primary oocyte, renal corpuscle, right uterine tube, Rostral migratory stream, secondary oocyte, stromal cell of endometrium, substantia nigra, sural nerve, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
53bp1 bp chr human chromosome band 15 gene protein repair nhej dna end location p53 dsbs mouse double-strand process tumor
TTTA extracted 97 structured relationships around TP53BP1. Examples in this analysis include TP53BP1 → Aliases → TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1 and TP53BP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TP53BP1 | Aliases | TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1 | 1.00 | infobox |
| TP53BP1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG | 1.00 | infobox |
| TP53BP1 | Band | 15q15.3 | 1.00 | infobox |
| TP53BP1 | Band | 2|2 E5 | 1.00 | infobox |
| TP53BP1 | Bgee | pituitary gland | 1.00 | infobox |
| TP53BP1 | Bgee | anterior pituitary | 1.00 | infobox |
| TP53BP1 | Bgee | gonad | 1.00 | infobox |
| TP53BP1 | Bgee | ventricular zone | 1.00 | infobox |
| TP53BP1 | Bgee | stromal cell of endometrium | 1.00 | infobox |
| TP53BP1 | Bgee | Achilles tendon | 1.00 | infobox |
| TP53BP1 | Bgee | right uterine tube | 1.00 | infobox |
| TP53BP1 | Bgee | ganglionic eminence | 1.00 | infobox |
| TP53BP1 | Bgee | middle temporal gyrus | 1.00 | infobox |
| TP53BP1 | Bgee | sural nerve | 1.00 | infobox |
| TP53BP1 | Bgee | primary oocyte | 1.00 | infobox |
| TP53BP1 | Bgee | ascending aorta | 1.00 | infobox |
| TP53BP1 | Bgee | substantia nigra | 1.00 | infobox |
| TP53BP1 | Bgee | secondary oocyte | 1.00 | infobox |
| TP53BP1 | Bgee | ciliary body | 1.00 | infobox |
| TP53BP1 | Bgee | fossa | 1.00 | infobox |
| TP53BP1 | Bgee | renal corpuscle | 1.00 | infobox |
| TP53BP1 | Bgee | Rostral migratory stream | 1.00 | infobox |
| TP53BP1 | Bgee | aortic valve | 1.00 | infobox |
| TP53BP1 | Bgee | condyle | 1.00 | infobox |
| TP53BP1 | BioGPS | More reference expression data | 1.00 | infobox |
| TP53BP1 | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| TP53BP1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| TP53BP1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TP53BP1 | End | 43,510,728 bp | 1.00 | infobox |
| TP53BP1 | End | 121,101,888 bp | 1.00 | infobox |
The concept neighborhoods around TP53BP1 bring nearby vocabulary together. In this analysis, examples include Gene, Binding and Search. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TP53BP1, one of the stronger structural bridges in this analysis connects TP53BP1 with DNA repair. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TP53BP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as DNA repair, Interactions & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TP53BP1 · EN edition · Analysis: TopicsToTalkAbout