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TP53BP1

Tumor suppressor p53-binding protein 1 also known as p53-binding protein 1 or 53BP1 is a protein that in humans is encoded by the TP53BP1 gene.

DNA repair, Interactions & Clinical significance

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Aliases
TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG
Band
15q15.3 · 2|2 E5
Bgee
pituitary gland · anterior pituitary · gonad · ventricular zone · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 15 (human) · Chromosome 2 (mouse)

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Overview

Clinical significance

DNA repair

Interactions

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Map overview Semantic statistics

TP53BP1

Nodes22
Edges21
Triples97
Avg. degree1.91
Density0.090909
Components1

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TP53BP1

Top relations

Gene ontology · 34
TP53BP1 → cellular response to DNA damage stimulus, cellular response to X-ray, chromosome, chromosome, centromeric region, cytoplasm, damaged DNA binding, DNA binding, DNA damage checkpoint signaling, DNA repair, DNA repair complex, double-strand break repair via nonhomologous end joining, histone binding, kinetochore, methylated histone binding, negative regulation of double-strand break repair via homologous recombination, nuclear body, nucleoplasm, nucleus, p53 binding, positive regulation of DNA-binding transcription factor activity
Bgee · 20
TP53BP1 → Achilles tendon, anterior pituitary, aortic valve, ascending aorta, ciliary body, condyle, fossa, ganglionic eminence, gonad, middle temporal gyrus, pituitary gland, primary oocyte, renal corpuscle, right uterine tube, Rostral migratory stream, secondary oocyte, stromal cell of endometrium, substantia nigra, sural nerve, ventricular zone
RNA expression pattern · 20
TP53BP1 → Achilles tendon, anterior pituitary, aortic valve, ascending aorta, ciliary body, condyle, fossa, ganglionic eminence, gonad, middle temporal gyrus, pituitary gland, primary oocyte, renal corpuscle, right uterine tube, Rostral migratory stream, secondary oocyte, stromal cell of endometrium, substantia nigra, sural nerve, ventricular zone
Band · 2
TP53BP1 → 15q15.3, 2|2 E5
Chr. · 2
TP53BP1 → Chromosome 15 (human), Chromosome 2 (mouse)
End · 2
TP53BP1 → 121,101,888 bp, 43,510,728 bp
Aliases · 1
TP53BP1 → TP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 1
Available structures · 1
TP53BP1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG
BioGPS · 1
TP53BP1 → More reference expression data
Databases · 1
TP53BP1 → NCBI: entry; OMA: entry

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Important terminology

53bp1 bp chr human chromosome band 15 gene protein repair nhej dna end location p53 dsbs mouse double-strand process tumor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TP53BP1AliasesTP53BP1, 53BP1, p202, p53BP1, TP53, TDRD30, tumor protein p53 binding protein 11.00infobox
TP53BP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GZH, 1KZY, 1XNI, 2G3R, 2IG0, 2LVM, 2MWO, 2MWP, 3LGF, 3LGL, 3LH0, 4CRI, 4RG2, 4X34, 5ECG1.00infobox
TP53BP1Band15q15.31.00infobox
TP53BP1Band2|2 E51.00infobox
TP53BP1Bgeepituitary gland1.00infobox
TP53BP1Bgeeanterior pituitary1.00infobox
TP53BP1Bgeegonad1.00infobox
TP53BP1Bgeeventricular zone1.00infobox
TP53BP1Bgeestromal cell of endometrium1.00infobox
TP53BP1BgeeAchilles tendon1.00infobox
TP53BP1Bgeeright uterine tube1.00infobox
TP53BP1Bgeeganglionic eminence1.00infobox
TP53BP1Bgeemiddle temporal gyrus1.00infobox
TP53BP1Bgeesural nerve1.00infobox
TP53BP1Bgeeprimary oocyte1.00infobox
TP53BP1Bgeeascending aorta1.00infobox
TP53BP1Bgeesubstantia nigra1.00infobox
TP53BP1Bgeesecondary oocyte1.00infobox
TP53BP1Bgeeciliary body1.00infobox
TP53BP1Bgeefossa1.00infobox
TP53BP1Bgeerenal corpuscle1.00infobox
TP53BP1BgeeRostral migratory stream1.00infobox
TP53BP1Bgeeaortic valve1.00infobox
TP53BP1Bgeecondyle1.00infobox
TP53BP1BioGPSMore reference expression data1.00infobox
TP53BP1Chr.Chromosome 15 (human)1.00infobox
TP53BP1Chr.Chromosome 2 (mouse)1.00infobox
TP53BP1DatabasesNCBI: entry; OMA: entry1.00infobox
TP53BP1End43,510,728 bp1.00infobox
TP53BP1End121,101,888 bp1.00infobox

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