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USP7: Applications, Function & Binding partners

Ubiquitin-specific-processing protease 7 (USP7), also known as ubiquitin carboxyl-terminal hydrolase 7 or herpesvirus-associated ubiquitin-specific protease (HAUSP), is an enzyme that in humans is encoded by the USP7 gene.

Language: English [EN]
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USP7 topic overview

The analysis highlights Applications, Function and Binding partners as prominent areas in the source structure around USP7.

Related topics
33
Source areas
6
Connected nodes
39
Extracted relationships
158
Concept neighborhoods
15
Bridge connections
39

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 11 topics
Binding partners · 6 topics
Clinical significance · 6 topics
Association with herpesviruses · 5 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.4.19.12
Aliases
USP7, HAUSP, TEF1, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific peptidase 7, HAFOUS
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NB8, 1NBF, 1YY6, 1YZE, 2F1W, 2F1X, 2F1Y, 2F1Z, 2FOJ, 2FOO, 2FOP, 2KVR, 2XXN, 2YLM, 3MQR, 3MQS, 4JJQ, 4KG9,…
Band
16p13.2 · 16|16 A1
Bgee
Brodmann area 23 · middle temporal gyrus · Achilles tendon · epithelium of colon · ventricular zone
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Association with herpesviruses

Binding partners

Interactions

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How USP7 connects Entity context

The extracted context around USP7 shows recurring relationship patterns in the source. For example, USP7 → cellular response to DNA damage stimulus, chromosome, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytosol, deubiquitinase activity, DNA repair, histone H2B conserved C-terminal lysine deubiquitination, hydrolase activity, Lys48-specific deubiquitinase activity, maintenance of DNA methylation, monoubiquitinated protein deubiquitination, multicellular organism development, negative regulation of NF-kappaB transcription factor activity, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, nuclear body, nucleoplasm, nucleus, p53 binding Another extracted example is USP7 → Achilles tendon, Brodmann area 23, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, human fetus, medullary collecting duct, mesenteric lymph nodes, middle temporal gyrus, Paneth cell, primary oocyte, rectum, renal corpuscle, secondary oocyte, skin of abdomen, skin of leg, substantia nigra, ureter, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

USP7

Top relations

Gene ontology · 42
USP7 → cellular response to DNA damage stimulus, chromosome, cysteine-type endopeptidase activity, cysteine-type peptidase activity, cytoplasm, cytosol, deubiquitinase activity, DNA repair, histone H2B conserved C-terminal lysine deubiquitination, hydrolase activity, Lys48-specific deubiquitinase activity, maintenance of DNA methylation, monoubiquitinated protein deubiquitination, multicellular organism development, negative regulation of NF-kappaB transcription factor activity, negative regulation of proteasomal ubiquitin-dependent protein catabolic process, nuclear body, nucleoplasm, nucleus, p53 binding
Bgee · 19
USP7 → Achilles tendon, Brodmann area 23, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, human fetus, medullary collecting duct, mesenteric lymph nodes, middle temporal gyrus, Paneth cell, primary oocyte, rectum, renal corpuscle, secondary oocyte, skin of abdomen, skin of leg, substantia nigra, ureter, ventricular zone
RNA expression pattern · 19
USP7 → Achilles tendon, Brodmann area 23, epithelium of colon, fetal liver hematopoietic progenitor cell, ganglionic eminence, human fetus, medullary collecting duct, mesenteric lymph nodes, middle temporal gyrus, Paneth cell, primary oocyte, rectum, renal corpuscle, secondary oocyte, skin of abdomen, skin of leg, substantia nigra, ureter, ventricular zone
related to Association with herpesviruses · 18
USP7 → Additionally, Barr, Compromising, E3-ubiquitin, EBNA1, EBV, Epstein, GMPS, H2B, HAUSP, Herpesvirus Associated USP, HSV, ICP0, In, More, Stabilization, This, Thus USP7
related to Role in transcriptional regulation · 9
USP7 → Drosophila, GMP, GMPS, H2A, H2AK119ub1, H2B, Pc, Polycomb-repressive, The USP7-GMPS
related to Regulation of the p53 tumor suppressor · 7
USP7 → E3, HAUSP, In, Mdm2, Mdm2-mediated, Normally, Since
related to Interactions · 6
USP7 → Ataxin, CLSPN, DUBs, H2A, MAGED1, P53
related to Role in drug addiction · 5
USP7 → Furthermore, H2A, Maged1, These, This
related to Binding partners · 3
USP7 → MdmXFOXO4DaxxPTENMarch7UVSSA, The, USP7/HAUSP
related to Clinical significance · 3
USP7 → Hao-Fountain Syndrome, Loss-of-function, MRIs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

p53 hausp human gene ubiquitin bp function chr chromosome band also activity histone oncogenic binding associated degradation 16 enzyme tumor

USP7 relationships Subject–Predicate–Object triples

TTTA extracted 158 structured relationships around USP7. Examples in this analysis include USP7 → 3.4.19.12 → ↗ and USP7 → Aliases → USP7, HAUSP, TEF1, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific peptidase 7, HAFOUS. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
USP73.4.19.121.00infobox
USP7AliasesUSP7, HAUSP, TEF1, ubiquitin specific peptidase 7 (herpes virus-associated), ubiquitin specific peptidase 7, HAFOUS1.00infobox
USP7Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1NB8, 1NBF, 1YY6, 1YZE, 2F1W, 2F1X, 2F1Y, 2F1Z, 2FOJ, 2FOO, 2FOP, 2KVR, 2XXN, 2YLM, 3MQR, 3MQS, 4JJQ, 4KG9,…1.00infobox
USP7Band16p13.21.00infobox
USP7Band16|16 A11.00infobox
USP7BgeeBrodmann area 231.00infobox
USP7Bgeemiddle temporal gyrus1.00infobox
USP7BgeeAchilles tendon1.00infobox
USP7Bgeeepithelium of colon1.00infobox
USP7Bgeeventricular zone1.00infobox
USP7Bgeerectum1.00infobox
USP7Bgeeskin of leg1.00infobox
USP7Bgeeskin of abdomen1.00infobox
USP7Bgeesecondary oocyte1.00infobox
USP7Bgeeganglionic eminence1.00infobox
USP7Bgeerenal corpuscle1.00infobox
USP7Bgeemedullary collecting duct1.00infobox
USP7Bgeeureter1.00infobox
USP7Bgeefetal liver hematopoietic progenitor cell1.00infobox
USP7Bgeeprimary oocyte1.00infobox
USP7BgeePaneth cell1.00infobox
USP7Bgeehuman fetus1.00infobox
USP7Bgeemesenteric lymph nodes1.00infobox
USP7Bgeesubstantia nigra1.00infobox
USP7BioGPSMore reference expression data1.00infobox
USP7Chr.Chromosome 16 (human)1.00infobox
USP7Chr.Chromosome 16 (mouse)1.00infobox
USP7DatabasesNCBI: entry; OMA: entry1.00infobox
USP7End8,975,328 bp1.00infobox
USP7End8,610,172 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around USP7 bring nearby vocabulary together. In this analysis, examples include P53, Histone and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • USP7
    • P53
    • Histone
    • Gene
    • Binding
    • Activity
    • Also
    • Function
    • Human
    • Hausp
    • Ebna1
    • Enzyme
    • H2b
  • usp7
    • P53
    • Histone
    • Gene
    • Binding
    • Activity
    • Also
    • Function
    • Human
    • Hausp
    • Ebna1
    • Enzyme
    • H2b
  • enzyme
    • Ubiquitin
    • Activity
    • Hydrolase
    • Location
    • Regulation
    • Gene
    • Chromosome
    • H2b
    • Binding
    • Bp
    • Chr
    • Hausp
  • gene
    • Location
    • Regulation
    • Chromosome
    • Bp
    • Chr
    • Ubiquitin
    • Activity
    • Histone
    • Human
    • Hydrolase
    • Usp7
    • Band
  • ubiquitin
    • Hydrolase
    • Enzyme
    • Hausp
    • Gene
    • Location
    • Regulation
    • Chromosome
    • Suppressor
    • Binding
    • Bp
    • Chr
    • Protein
  • e3 ubiquitin ligase
    • Hydrolase
    • Enzyme
    • Hausp
    • Gene
    • Location
    • Regulation
    • Chromosome
    • Suppressor
    • Binding
    • Bp
    • Chr
    • Protein
  • p53
    • Stabilization
    • Suppressor
    • Tumor
    • Usp7
    • Mdm2
    • Ebna1
    • Oncogenic
    • Ubiquitin
    • Degradation
    • Location
    • Regulation
    • Ubiquitination
  • function
    • P53
    • Stabilization
    • Hausp
    • Suppressor
    • Binding
    • Oncogenic
    • Tumor
    • Location
    • Regulation
    • Chromosome
    • Complex
    • Response

Connections between topic areas Semantic bridges

For USP7, one of the stronger structural bridges in this analysis connects USP7 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
USP7Function · splits 28 ⟂ 12
USP7Binding partners · splits 33 ⟂ 7
USP7Clinical significance · splits 33 ⟂ 7
USP7Association with herpesviruses · splits 34 ⟂ 6
USP7Interactions · splits 36 ⟂ 4
USP7Overview · splits 37 ⟂ 3

Map overview Semantic statistics

USP7

Nodes40
Edges39
Triples158
Avg. degree1.95
Density0.05
Components1

Source & methodology

TTTA analyzes the structure around USP7 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications, Function & Binding partners, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — USP7 · EN edition · Analysis: TopicsToTalkAbout

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