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Intrinsically disordered proteins

In molecular biology, an intrinsically disordered protein (IDP) is a protein that lacks a fixed or ordered three-dimensional structure, typically in the absence of its macromolecular interaction partners, such as other proteins or RNA. IDPs range from fully unstructured to partially structured and include random coil, molten globule-like aggregates, or…

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History

Abundance

Biological roles

Structural aspects

Experimental validation

Computer simulations

Disorder annotation

Disorder and disease

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Intrinsically disordered proteins

Nodes108
Edges107
Triples44
Avg. degree1.98
Density0.018519
Components1

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Intrinsically disordered proteins

Top relations

related to External links · 12
Intrinsically disordered proteins → Archived, Disordered Protein PredictionsGallery, Extensive Annotations, IDP, IDPsIDP, Intrinsically, Intrinsically Disordered, JournalDatabase, Literature Archived, ProteopediaMobiDB, Wayback Machine, Wayback MachineD2P2 Database
related to Structural aspects · 7
Intrinsically disordered proteins → Disorder, Few, IDP, IDRs, Intrinsically, The, Their
related to Disorder in the bound state (fuzzy complexes) · 6
Intrinsically disordered proteins → DNA, In, Intrinsically, Some, Specificity, The

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Important terminology

proteins disordered idps protein disorder regions structure binding many structural also large methods flexible idp intrinsically different nmr conformational interactions

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
allosteric regulationinstance ofBiological rolesHighly dynamic disordered regions of proteins have been linked to functionally important phenomena0.80text
enzyme catalysisinstance ofBiological rolesHighly dynamic disordered regions of proteins have been linked to functionally important phenomena0.80text
phosphorylation tune the affinityinstance ofpost-translational modifications0.80text
Hendra virusinstance ofDisordered proteins and short linear motifs are particularly abundant in many RNA viruses0.80text
HCVinstance ofDisordered proteins and short linear motifs are particularly abundant in many RNA viruses0.80text
HIV-1instance ofDisordered proteins and short linear motifs are particularly abundant in many RNA viruses0.80text
human papillomavirusesinstance ofDisordered proteins and short linear motifs are particularly abundant in many RNA viruses0.80text
accelerated-MD simulationsinstance ofother computational techniques0.80text
replica exchange simulationsinstance ofother computational techniques0.80text
metadynamicsinstance ofother computational techniques0.80text
multicanonical MD simulationsinstance ofother computational techniques0.80text
or methods using coarse-grained representation with implicitinstance ofother computational techniques0.80text

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