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DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.
Standards, Cancer & Mechanism
Explore the main themes, entities and connections around TOP1. Start with the topic map, then use the sections below for research and deeper semantic analysis.
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dna irinotecan gene topoisomerase enzyme expression repair strand human bp chromosome 20 cancer chr band patients end synthetic lethality domain
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TOP1 | 5.6.2.1 | ↗ | 1.00 | infobox |
| TOP1 | Aliases | TOP1, TOPI, topoisomerase (DNA) I, DNA topoisomerase I | 1.00 | infobox |
| TOP1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8 | 1.00 | infobox |
| TOP1 | Band | 20q12 | 1.00 | infobox |
| TOP1 | Band | 2 H2|2 80.96 cM | 1.00 | infobox |
| TOP1 | Bgee | oocyte | 1.00 | infobox |
| TOP1 | Bgee | ventricular zone | 1.00 | infobox |
| TOP1 | Bgee | ganglionic eminence | 1.00 | infobox |
| TOP1 | Bgee | secondary oocyte | 1.00 | infobox |
| TOP1 | Bgee | pericardium | 1.00 | infobox |
| TOP1 | Bgee | pylorus | 1.00 | infobox |
| TOP1 | Bgee | vena cava | 1.00 | infobox |
| TOP1 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| TOP1 | Bgee | superior surface of tongue | 1.00 | infobox |
| TOP1 | Bgee | monocyte | 1.00 | infobox |
| TOP1 | Bgee | Ileal epithelium | 1.00 | infobox |
| TOP1 | Bgee | zygote | 1.00 | infobox |
| TOP1 | Bgee | maxillary prominence | 1.00 | infobox |
| TOP1 | Bgee | mandibular prominence | 1.00 | infobox |
| TOP1 | Bgee | tail of embryo | 1.00 | infobox |
| TOP1 | Bgee | human fetus | 1.00 | infobox |
| TOP1 | Bgee | genital tubercle | 1.00 | infobox |
| TOP1 | BioGPS | n/a | 1.00 | infobox |
| TOP1 | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| TOP1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| TOP1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TOP1 | End | 41,124,487 bp | 1.00 | infobox |
| TOP1 | End | 160,564,684 bp | 1.00 | infobox |
| TOP1 | Ensembl | ENSG00000198900 | 1.00 | infobox |
| TOP1 | Entrez | 7150 | 1.00 | infobox |
These clusters group vocabulary that occurs around closely connected concepts in the source material.
Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.