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DNA topoisomerase 1 is an enzyme that in humans is encoded by the TOP1 gene. It is a DNA topoisomerase, an enzyme that catalyzes the transient breaking and rejoining of a single strand of DNA.
The analysis highlights Standards, Cancer and Mechanism as prominent areas in the source structure around TOP1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around TOP1 shows recurring relationship patterns in the source. For example, TOP1 → ATP binding, chromatin binding, chromatin remodeling, chromosome, chromosome segregation, circadian regulation of gene expression, circadian rhythm, core promoter sequence-specific DNA binding, cytoplasm, DNA binding, DNA replication, DNA topoisomerase activity, DNA topoisomerase type I (single strand cut, ATP-independent) activity, DNA topoisomerase type II (double strand cut, ATP-hydrolyzing) complex, DNA topological change, double-stranded DNA binding, embryonic cleavage, fibrillar center, isomerase activity, nuclear chromosome Another extracted example is TOP1 → ganglionic eminence, genital tubercle, human fetus, Ileal epithelium, mandibular prominence, maxillary prominence, monocyte, oocyte, pancreatic ductal cell, pericardium, pylorus, secondary oocyte, superior surface of tongue, tail of embryo, vena cava, ventricular zone, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
dna irinotecan gene topoisomerase enzyme expression repair strand human bp chromosome 20 cancer chr band patients end synthetic lethality domain
TTTA extracted 133 structured relationships around TOP1. Examples in this analysis include TOP1 → 5.6.2.1 → ↗ and TOP1 → Aliases → TOP1, TOPI, topoisomerase (DNA) I, DNA topoisomerase I. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| TOP1 | 5.6.2.1 | ↗ | 1.00 | infobox |
| TOP1 | Aliases | TOP1, TOPI, topoisomerase (DNA) I, DNA topoisomerase I | 1.00 | infobox |
| TOP1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A31, 1A35, 1A36, 1EJ9, 1K4S, 1K4T, 1LPQ, 1NH3, 1R49, 1RR8, 1RRJ, 1SC7, 1SEU, 1T8I, 1TL8 | 1.00 | infobox |
| TOP1 | Band | 20q12 | 1.00 | infobox |
| TOP1 | Band | 2 H2|2 80.96 cM | 1.00 | infobox |
| TOP1 | Bgee | oocyte | 1.00 | infobox |
| TOP1 | Bgee | ventricular zone | 1.00 | infobox |
| TOP1 | Bgee | ganglionic eminence | 1.00 | infobox |
| TOP1 | Bgee | secondary oocyte | 1.00 | infobox |
| TOP1 | Bgee | pericardium | 1.00 | infobox |
| TOP1 | Bgee | pylorus | 1.00 | infobox |
| TOP1 | Bgee | vena cava | 1.00 | infobox |
| TOP1 | Bgee | pancreatic ductal cell | 1.00 | infobox |
| TOP1 | Bgee | superior surface of tongue | 1.00 | infobox |
| TOP1 | Bgee | monocyte | 1.00 | infobox |
| TOP1 | Bgee | Ileal epithelium | 1.00 | infobox |
| TOP1 | Bgee | zygote | 1.00 | infobox |
| TOP1 | Bgee | maxillary prominence | 1.00 | infobox |
| TOP1 | Bgee | mandibular prominence | 1.00 | infobox |
| TOP1 | Bgee | tail of embryo | 1.00 | infobox |
| TOP1 | Bgee | human fetus | 1.00 | infobox |
| TOP1 | Bgee | genital tubercle | 1.00 | infobox |
| TOP1 | BioGPS | n/a | 1.00 | infobox |
| TOP1 | Chr. | Chromosome 20 (human) | 1.00 | infobox |
| TOP1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| TOP1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| TOP1 | End | 41,124,487 bp | 1.00 | infobox |
| TOP1 | End | 160,564,684 bp | 1.00 | infobox |
| TOP1 | Ensembl | ENSG00000198900 | 1.00 | infobox |
| TOP1 | Entrez | 7150 | 1.00 | infobox |
The concept neighborhoods around TOP1 bring nearby vocabulary together. In this analysis, examples include Irinotecan, Expression and Inactivation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For TOP1, one of the stronger structural bridges in this analysis connects TOP1 with Cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around TOP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Cancer & Mechanism, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — TOP1 · EN edition · Analysis: TopicsToTalkAbout