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RELA

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

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Interactions

54 related topics

Structure

16 related topics

Cancer

7 related topics

Overview

4 related topics

Key facts & relationships

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Aliases
RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22
Band
11q13.1 · 19 A|19 4.34 cM
Bgee
gastric mucosa · popliteal artery · tibial arteries · left uterine tube · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)

Topics to explore

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Overview

Structure

Interactions

Cancer

Advanced semantic analysis

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Map overview Semantic statistics

RELA

Nodes86
Edges85
Triples334
Avg. degree1.98
Density0.023256
Components1

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RELA

Top relations

Gene ontology · 119
RELA → acetaldehyde metabolic process, actinin binding, ageing, animal organ morphogenesis, ankyrin repeat binding, cellular defense response, cellular response to angiotensin, cellular response to hepatocyte growth factor stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to nicotine, cellular response to peptidoglycan, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, chromatin binding, chromatin DNA binding, chromatin organization
related to Phosphorylation · 40
RELA → After IL-1or TNFα, AKT/phosphatidylinositol, CBP, CD40, Cell-type-specific, CKII, DNA, For, GSK3β, II, IKK1, IKK2, IKKs, In, IκB, LPS, LTβR, MSK1, Multiple-site, NAK
related to Interactions · 21
RELA → After NF-κB, Another, As, CDK9, CDKs, Gro-β, IL-8, In, IκBα, LPS, NF-κB, P-TEFb, Phosphorylation, Pol II, RELA-P-TEFb, RELA/p50, RELA/p65, T1, This, TNFIKK
Bgee · 19
RELA → ascending aorta, cartilage tissue, choroid plexus of fourth ventricle, Descending thoracic aorta, ectocervix, external carotid artery, gastric mucosa, gastrula, genital tubercle, granulocyte, internal carotid artery, lactiferous gland, left uterine tube, mesenteric lymph nodes, popliteal artery, right coronary artery, right lung, stroma of bone marrow, tibial arteries
RNA expression pattern · 19
RELA → ascending aorta, cartilage tissue, choroid plexus of fourth ventricle, Descending thoracic aorta, ectocervix, external carotid artery, gastric mucosa, gastrula, genital tubercle, granulocyte, internal carotid artery, lactiferous gland, left uterine tube, mesenteric lymph nodes, popliteal artery, right coronary artery, right lung, stroma of bone marrow, tibial arteries
related to Structure · 15
RELA → C-terminal, CREB-CBP, DNA, Like, N-terminal REL-homology, NF-κB, NF-κB/REL, On, REL, RELB, RHD, Seven, TAD, TBP, TFIIB
related to Acetylation · 13
RELA → CBP, DNA-binding, For, HDAC, HDAC3, Hypothesis, In, IκBα, Lysine, Lysines, PMF, TNFα, Unknown
related to Role in immune system · 11
RELA → Gene, IL-1, In, Lymphocyte, Mice, Mutations, NF-κB, REL-related, T-cell, The, TNFα
related to Breast · 9
RELA → AhR, Another, ER, ERE, ERα, It, NF-κB, The, There
related to Thyroid · 7
RELA → COX-2, GST-pi, IL-8, NF-κB, Other, PTC, Strong

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Important terminology

nf-κb activation also phosphorylation p50 protein nuclear complex transcription acetylation gene serine involved p65 bp kinase factor human tnfα cancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RELAAliasesRELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU1.00infobox
RELAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N221.00infobox
RELABand11q13.11.00infobox
RELABand19 A|19 4.34 cM1.00infobox
RELABgeegastric mucosa1.00infobox
RELABgeepopliteal artery1.00infobox
RELABgeetibial arteries1.00infobox
RELABgeeleft uterine tube1.00infobox
RELABgeecartilage tissue1.00infobox
RELABgeeright lung1.00infobox
RELABgeeascending aorta1.00infobox
RELABgeeDescending thoracic aorta1.00infobox
RELABgeeectocervix1.00infobox
RELABgeeright coronary artery1.00infobox
RELABgeelactiferous gland1.00infobox
RELABgeechoroid plexus of fourth ventricle1.00infobox
RELABgeegranulocyte1.00infobox
RELABgeeexternal carotid artery1.00infobox
RELABgeeinternal carotid artery1.00infobox
RELABgeegastrula1.00infobox
RELABgeegenital tubercle1.00infobox
RELABgeemesenteric lymph nodes1.00infobox
RELABgeestroma of bone marrow1.00infobox
RELABioGPSMore reference expression data1.00infobox
RELAChr.Chromosome 11 (human)1.00infobox
RELAChr.Chromosome 19 (mouse)1.00infobox
RELADatabasesNCBI: entry; OMA: entry1.00infobox
RELAEnd65,663,090 bp1.00infobox
RELAEnd5,698,158 bp1.00infobox
RELAEnsemblENSG000001730391.00infobox

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