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RELA: Measurement, Interactions & Structure

Transcription factor p65 also known as nuclear factor NF-kappa-B p65 subunit is a protein that in humans is encoded by the RELA gene.

Language: English [EN]
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RELA topic overview

The analysis highlights Measurement, Interactions and Structure as prominent areas in the source structure around RELA.

Related topics
81
Source areas
4
Connected nodes
85
Extracted relationships
334
Concept neighborhoods
9
Bridge connections
85

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 54 topics
Structure · 16 topics
Cancer · 7 topics
Overview · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22
Band
11q13.1 · 19 A|19 4.34 cM
Bgee
gastric mucosa · popliteal artery · tibial arteries · left uterine tube · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 11 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Interactions

Cancer

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How RELA connects Entity context

The extracted context around RELA shows recurring relationship patterns in the source. For example, RELA → acetaldehyde metabolic process, actinin binding, ageing, animal organ morphogenesis, ankyrin repeat binding, cellular defense response, cellular response to angiotensin, cellular response to hepatocyte growth factor stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to nicotine, cellular response to peptidoglycan, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, chromatin binding, chromatin DNA binding, chromatin organization Another extracted example is RELA → After IL-1or TNFα, AKT/phosphatidylinositol, CBP, CD40, Cell-type-specific, CKII, DNA, For, GSK3β, II, IKK1, IKK2, IKKs, In, IκB, LPS, LTβR, MSK1, Multiple-site, NAK. Use these groups to spot repeated connection types before inspecting the individual relationships.

RELA

Top relations

Gene ontology · 119
RELA → acetaldehyde metabolic process, actinin binding, ageing, animal organ morphogenesis, ankyrin repeat binding, cellular defense response, cellular response to angiotensin, cellular response to hepatocyte growth factor stimulus, cellular response to hydrogen peroxide, cellular response to interleukin-1, cellular response to interleukin-6, cellular response to lipopolysaccharide, cellular response to lipoteichoic acid, cellular response to nicotine, cellular response to peptidoglycan, cellular response to tumor necrosis factor, cellular response to vascular endothelial growth factor stimulus, chromatin binding, chromatin DNA binding, chromatin organization
related to Phosphorylation · 40
RELA → After IL-1or TNFα, AKT/phosphatidylinositol, CBP, CD40, Cell-type-specific, CKII, DNA, For, GSK3β, II, IKK1, IKK2, IKKs, In, IκB, LPS, LTβR, MSK1, Multiple-site, NAK
related to Interactions · 21
RELA → After NF-κB, Another, As, CDK9, CDKs, Gro-β, IL-8, In, IκBα, LPS, NF-κB, P-TEFb, Phosphorylation, Pol II, RELA-P-TEFb, RELA/p50, RELA/p65, T1, This, TNFIKK
Bgee · 19
RELA → ascending aorta, cartilage tissue, choroid plexus of fourth ventricle, Descending thoracic aorta, ectocervix, external carotid artery, gastric mucosa, gastrula, genital tubercle, granulocyte, internal carotid artery, lactiferous gland, left uterine tube, mesenteric lymph nodes, popliteal artery, right coronary artery, right lung, stroma of bone marrow, tibial arteries
RNA expression pattern · 19
RELA → ascending aorta, cartilage tissue, choroid plexus of fourth ventricle, Descending thoracic aorta, ectocervix, external carotid artery, gastric mucosa, gastrula, genital tubercle, granulocyte, internal carotid artery, lactiferous gland, left uterine tube, mesenteric lymph nodes, popliteal artery, right coronary artery, right lung, stroma of bone marrow, tibial arteries
related to Structure · 15
RELA → C-terminal, CREB-CBP, DNA, Like, N-terminal REL-homology, NF-κB, NF-κB/REL, On, REL, RELB, RHD, Seven, TAD, TBP, TFIIB
related to Acetylation · 13
RELA → CBP, DNA-binding, For, HDAC, HDAC3, Hypothesis, In, IκBα, Lysine, Lysines, PMF, TNFα, Unknown
related to Role in immune system · 11
RELA → Gene, IL-1, In, Lymphocyte, Mice, Mutations, NF-κB, REL-related, T-cell, The, TNFα
related to Breast · 9
RELA → AhR, Another, ER, ERE, ERα, It, NF-κB, The, There
related to Thyroid · 7
RELA → COX-2, GST-pi, IL-8, NF-κB, Other, PTC, Strong

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nf-κb activation also phosphorylation p50 protein nuclear complex transcription acetylation gene serine involved p65 bp kinase factor human tnfα cancer

RELA relationships Subject–Predicate–Object triples

TTTA extracted 334 structured relationships around RELA. Examples in this analysis include RELA → Aliases → RELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU and RELA → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N22. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
RELAAliasesRELA, NFKB3, p65, RELA proto-oncogene, NF-kB subunit, CMCU1.00infobox
RELAAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4KV4, 1NFI, 2LSP, 2O61, 3GUT, 3QXY, 3RC0, 4KV1, 2N221.00infobox
RELABand11q13.11.00infobox
RELABand19 A|19 4.34 cM1.00infobox
RELABgeegastric mucosa1.00infobox
RELABgeepopliteal artery1.00infobox
RELABgeetibial arteries1.00infobox
RELABgeeleft uterine tube1.00infobox
RELABgeecartilage tissue1.00infobox
RELABgeeright lung1.00infobox
RELABgeeascending aorta1.00infobox
RELABgeeDescending thoracic aorta1.00infobox
RELABgeeectocervix1.00infobox
RELABgeeright coronary artery1.00infobox
RELABgeelactiferous gland1.00infobox
RELABgeechoroid plexus of fourth ventricle1.00infobox
RELABgeegranulocyte1.00infobox
RELABgeeexternal carotid artery1.00infobox
RELABgeeinternal carotid artery1.00infobox
RELABgeegastrula1.00infobox
RELABgeegenital tubercle1.00infobox
RELABgeemesenteric lymph nodes1.00infobox
RELABgeestroma of bone marrow1.00infobox
RELABioGPSMore reference expression data1.00infobox
RELAChr.Chromosome 11 (human)1.00infobox
RELAChr.Chromosome 19 (mouse)1.00infobox
RELADatabasesNCBI: entry; OMA: entry1.00infobox
RELAEnd65,663,090 bp1.00infobox
RELAEnd5,698,158 bp1.00infobox
RELAEnsemblENSG000001730391.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around RELA bring nearby vocabulary together. In this analysis, examples include Nf-κb, Activation and Phosphorylation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • RELA
    • Nf-κb
    • Activation
    • Phosphorylation
    • P50
    • Acetylation
    • Complex
    • Cancer
    • Translocation
    • Found
    • Response
    • Transcription
    • Cell
  • rela
    • Nf-κb
    • Activation
    • Phosphorylation
    • P50
    • Acetylation
    • Complex
    • Cancer
    • Translocation
    • Found
    • Response
    • Transcription
    • Cell
  • protein
    • Kinase
    • Domain
    • Human
    • Gene
    • Involved
    • Rela
    • Transcription
    • Serine
    • Nf-κb
    • Phosphorylation
    • Band
    • Binding
  • gene
    • Bp
    • Chr
    • Chromosome
    • Human
    • P65
    • Band
    • Transcription
    • Immune
    • Receptor
    • Cancer
    • Role
    • Protein
  • nf-κb
    • Activation
    • Rela
    • Nuclear
    • P50
    • Translocation
    • Transcription
    • Role
    • Complex
    • Including
    • Genes
    • Via
    • Kinase
  • cancer
    • Immune
    • Types
    • Gene
    • Role
    • Found
    • Bp
    • Chr
    • Chromosome
    • Human
    • P65
    • Receptor
    • Rela
  • p50
    • Rela
    • Iκbα
    • P65
    • Receptor
    • Genes
    • Tnfα
    • Translocation
    • Transcription
    • Types
    • Found
    • Response
    • Via
  • iκbα
    • P50
    • Tnfα
    • Translocation
    • Via
    • Rela
    • Nuclear
    • Phosphorylation
    • Nf-κb

Connections between topic areas Semantic bridges

For RELA, one of the stronger structural bridges in this analysis connects RELA with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
RELAInteractions · splits 31 ⟂ 55
RELAStructure · splits 69 ⟂ 17
RELACancer · splits 78 ⟂ 8
RELAOverview · splits 81 ⟂ 5

Map overview Semantic statistics

RELA

Nodes86
Edges85
Triples334
Avg. degree1.98
Density0.023256
Components1

Source & methodology

TTTA analyzes the structure around RELA to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Interactions & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — RELA · EN edition · Analysis: TopicsToTalkAbout

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