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Embryonic stem cell

Embryonic stem cells (ESCs) are pluripotent stem cells derived from the inner cell mass of a blastocyst, an early-stage pre-implantation embryo. Human embryos reach the blastocyst stage 4–5 days post fertilization, at which time they consist of 50–150 cells. Isolating the inner cell mass (embryoblast) using immunosurgery results in destruction of the…

History, Culture & Standards

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Techniques and conditions for derivation and culture

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Embryonic stem cell

Nodes159
Edges158
Triples242
Avg. degree1.99
Density0.012579
Components1

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Embryonic stem cell

Top relations

related to history · 71
Embryonic stem cell → Although, An, Anatomy, Barry Pierce Jr, Bush, Bush's ESC, California, Cambridge, Cappechi, December, Department, Derived From Human Blastocysts, DNA, Dolly, Drug Administration, EC, Edinburgh, Embryonic, Embryonic Stem Cell Lines, ES
has method · 15
Embryonic stem cell → Advanced Cell Technology, August, Dr, However, Human, In March, MA, Nature, On August, Robert Lanza, SCNT, The, This, US, Worcester
related to Growth · 15
Embryonic stem cell → Although, CDK2, Cyclin-dependent, Despite, E2F, ESCs, G1, G1/S, In ESCs, Nanog, Oct4, Pluripotency, Rapid, Retinoblastoma, These
related to Derivation from other animals · 14
Embryonic stem cell → After, Clonal, Embryonic, ES, Evans, Gail Martin, Kaufman, Martin, Martin Evans, Matthew Kaufman, She, The, These, This
related to Induced pluripotent stem cells · 14
Embryonic stem cell → He, In, Japan, Klf4, Kyoto, Myc, Nobel Prize, Oct3/4, Shinya Yamanaka's, Sir John Gurdon, Sox2, The, This, Utilizing
related to External links · 13
Embryonic stem cell → Alternatives, Archived, Embryonic Stem Cell ResearchA, ES, HealthUniversity, Issues, National Academies Archived, Oxford, Science, Understanding Stem Cells, View, Wayback MachineFact, Wayback MachineNational Institutes
related to Contamination by reagents used in cell culture · 12
Embryonic stem cell → After, California, However, It, January, Lancet Medical Journal, March, Nature Medicine, San Diego, The, These, University
related to Models of genetic disorder · 10
Embryonic stem cell → Cystic, Either, Fragile-X, In, PGD, Russian-American, Several, The, This, Yury Verlinsky
related to Uses · 9
Embryonic stem cell → AIDS, Aside, Due, ESCs, Ethical, However, In, Parkinson's, Pluripotent
related to Clinical potential · 8
Embryonic stem cell → An, ESCs, European Heart Journal, For, Harvard University, Parkinson's, Researchers, Studies

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Important terminology

cells cell stem embryonic human escs pluripotent es research embryos used clinical embryo derived tissue genetic trial potential inner mass

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
tumorsinstance ofadverse effects in the research and clinical processes0.80text
unwanted immune responses have also been reportedinstance ofadverse effects in the research and clinical processes0.80text
CDK2 that promote cell cycle progression are overactiveinstance ofCyclin-dependent kinases0.80text
in part due to downregulation of their inhibitorsinstance ofCyclin-dependent kinases0.80text
secretion of cytokinesinstance ofthe cells used must be able to perform specific biological functions0.80text
signaling moleculesinstance ofthe cells used must be able to perform specific biological functions0.80text
interacting with neighboring cellsinstance ofthe cells used must be able to perform specific biological functions0.80text
and producing an extracellular matrix in the correct organizationinstance ofthe cells used must be able to perform specific biological functions0.80text
torsades de pointes.ESC-derived hepatocytes are also useful models that could be used in the preclinical stages of drug discoveryinstance ofESC derived cardiomyocytes have been shown to respond to pharmacological stimuli and hence can be used to assess cardiotoxicity0.80text
Fragile-X syndromeinstance ofThis approach may very well prove valuable at studying disorders0.80text
Cystic fibrosisinstance ofThis approach may very well prove valuable at studying disorders0.80text
and other genetic maladies that have no reliable model system.Yury Verlinskyinstance ofThis approach may very well prove valuable at studying disorders0.80text

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