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Nucleolin: Interactions, Gene & Clinical significance

Nucleolin is a protein that in humans is encoded by the NCL gene.

Language: English [EN]
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Nucleolin topic overview

The analysis highlights Interactions, Gene and Clinical significance as prominent areas in the source structure around Nucleolin.

Related topics
24
Source areas
5
Connected nodes
29
Extracted relationships
110
Concept neighborhoods
8
Bridge connections
29

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 12 topics
Clinical significance · 4 topics
Gene · 4 topics
Function · 2 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NCL, C23, nucleolin, Nsr1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FC8, 2FC9, 2KRR
Band
2q37.1 · 1 C5|1 43.94 cM
Bgee
ventricular zone · ganglionic eminence · appendix · body of pancreas · smooth muscle tissue
BioGPS
More reference expression data
Chr.
Chromosome 2 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nucleolin connects Entity context

The extracted context around Nucleolin shows recurring relationship patterns in the source. For example, Nucleolin → angiogenesis, cell cortex, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA binding, DNA topoisomerase binding, extracellular exosome, identical protein binding, membrane, mRNA 5'-UTR binding, negative regulation of translation, nucleic acid binding, nucleolus, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, protein binding Another extracted example is Nucleolin → Achilles tendon, appendix, body of pancreas, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left ovary, neural layer of retina, placenta, primary oocyte, right ovary, secondary oocyte, smooth muscle tissue, sural nerve, tail of embryo, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nucleolin

Top relations

Gene ontology · 24
Nucleolin → angiogenesis, cell cortex, cellular response to epidermal growth factor stimulus, cellular response to leukemia inhibitory factor, cytoplasm, cytoplasmic ribonucleoprotein granule, DNA binding, DNA topoisomerase binding, extracellular exosome, identical protein binding, membrane, mRNA 5'-UTR binding, negative regulation of translation, nucleic acid binding, nucleolus, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription of nucleolar large rRNA by RNA polymerase I, protein binding
Bgee · 19
Nucleolin → Achilles tendon, appendix, body of pancreas, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left ovary, neural layer of retina, placenta, primary oocyte, right ovary, secondary oocyte, smooth muscle tissue, sural nerve, tail of embryo, ventricular zone, yolk sac, zygote
RNA expression pattern · 19
Nucleolin → Achilles tendon, appendix, body of pancreas, epiblast, epithelium of colon, ganglionic eminence, genital tubercle, left ovary, neural layer of retina, placenta, primary oocyte, right ovary, secondary oocyte, smooth muscle tissue, sural nerve, tail of embryo, ventricular zone, yolk sac, zygote
related to Interactions · 10
Nucleolin → Centaurin, CSNK2A2, HuR, MTDH, NPM1, P53, PPP1CB, S100A11, Sjögren, TOP1
related to Function · 9
Nucleolin → Chicken Ovalbumin Upstream Promoter, COUP-TFII, DNA, H1, It, RNA, Transcription Factor II, TTAGGG-3, UUAGGG-3
related to Clinical significance · 5
Nucleolin → HIV, Interference, Midkine, RSV, This
Band · 2
Nucleolin → 1 C5|1 43.94 cM, 2q37.1
Chr. · 2
Nucleolin → Chromosome 1 (mouse), Chromosome 2 (human)
End · 2
Nucleolin → 231,483,641 bp, 86,287,122 bp
Aliases · 1
Nucleolin → NCL, C23, nucleolin, Nsr1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp human ncl chr band chromosome protein location mouse rna binding cell transcription nucleolar function search 483 641 end

Nucleolin relationships Subject–Predicate–Object triples

TTTA extracted 110 structured relationships around Nucleolin. Examples in this analysis include Nucleolin → Aliases → NCL, C23, nucleolin, Nsr1 and Nucleolin → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FC8, 2FC9, 2KRR. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NucleolinAliasesNCL, C23, nucleolin, Nsr11.00infobox
NucleolinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2FC8, 2FC9, 2KRR1.00infobox
NucleolinBand2q37.11.00infobox
NucleolinBand1 C5|1 43.94 cM1.00infobox
NucleolinBgeeventricular zone1.00infobox
NucleolinBgeeganglionic eminence1.00infobox
NucleolinBgeeappendix1.00infobox
NucleolinBgeebody of pancreas1.00infobox
NucleolinBgeesmooth muscle tissue1.00infobox
NucleolinBgeeAchilles tendon1.00infobox
NucleolinBgeeleft ovary1.00infobox
NucleolinBgeeright ovary1.00infobox
NucleolinBgeeepithelium of colon1.00infobox
NucleolinBgeesural nerve1.00infobox
NucleolinBgeetail of embryo1.00infobox
NucleolinBgeeyolk sac1.00infobox
NucleolinBgeeepiblast1.00infobox
NucleolinBgeegenital tubercle1.00infobox
NucleolinBgeeneural layer of retina1.00infobox
NucleolinBgeeprimary oocyte1.00infobox
NucleolinBgeesecondary oocyte1.00infobox
NucleolinBgeezygote1.00infobox
NucleolinBgeeplacenta1.00infobox
NucleolinBioGPSMore reference expression data1.00infobox
NucleolinChr.Chromosome 2 (human)1.00infobox
NucleolinChr.Chromosome 1 (mouse)1.00infobox
NucleolinDatabasesNCBI: entry; OMA: entry1.00infobox
NucleolinEnd231,483,641 bp1.00infobox
NucleolinEnd86,287,122 bp1.00infobox
NucleolinEnsemblENSG000001150531.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nucleolin bring nearby vocabulary together. In this analysis, examples include Protein, Receptor and Rsv. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nucleolin
    • Protein
    • Receptor
    • Rsv
    • Cell
    • Ncl
    • Gene
    • Citation
    • Dna
    • Factor
    • Function
    • Ii
    • Infection
  • nucleolin
    • Protein
    • Receptor
    • Rsv
    • Cell
    • Ncl
    • Gene
    • Citation
    • Dna
    • Factor
    • Function
    • Ii
    • Infection
  • gene
    • Ncl
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • C5
    • End
    • Function
    • Mouse
    • Search
    • Nucleolar
  • function
    • Search
    • Location
    • Chromosome
    • Human
    • Ncl
    • Bp
    • Chr
    • Gene
    • C5
    • Dna
    • End
    • Factor
  • chromosome 2
    • Human
    • Bp
    • Location
    • Band
    • C5
    • End
    • Function
    • Gene
    • Mouse
    • Search
    • Ncl
    • Dna
  • small nucleolar rna
    • Process
    • Telomeric
    • Nucleolar
    • Rna
    • Transcription
    • Protein
    • Citation
    • Needed
    • Play
    • Role
    • Search
    • Nucleolin
  • protein
    • Rsv
    • Nucleolar
    • Infection
    • Process
    • Receptor
    • Search
    • Telomeric
    • Rna
    • Transcription
  • fusion protein
    • Rsv
    • Nucleolar
    • Infection
    • Process
    • Receptor
    • Search
    • Telomeric
    • Rna
    • Transcription

Connections between topic areas Semantic bridges

For Nucleolin, one of the stronger structural bridges in this analysis connects Nucleolin with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NucleolinInteractions · splits 17 ⟂ 13
NucleolinGene · splits 25 ⟂ 5
NucleolinClinical significance · splits 25 ⟂ 5
NucleolinOverview · splits 27 ⟂ 3
NucleolinFunction · splits 27 ⟂ 3

Map overview Semantic statistics

Nucleolin

Nodes30
Edges29
Triples110
Avg. degree1.93
Density0.066667
Components1

Source & methodology

TTTA analyzes the structure around Nucleolin to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Gene & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nucleolin · EN edition · Analysis: TopicsToTalkAbout

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