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HIF1A: Measurement, Function & Regulation

Hypoxia-inducible factor 1-alpha, also known as HIF-1-alpha, is a subunit of a heterodimeric transcription factor hypoxia-inducible factor 1 (HIF-1) that is encoded by the HIF1A gene. The Nobel Prize in Physiology or Medicine 2019 was awarded for the discovery of HIF.

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HIF1A topic overview

The analysis highlights Measurement, Function and Regulation as prominent areas in the source structure around HIF1A.

Related topics
151
Source areas
10
Connected nodes
161
Extracted relationships
299
Concept neighborhoods
35
Bridge connections
161

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Role in cancer · 37 topics
Regulation · 23 topics
Function · 21 topics
Overview · 18 topics
Role in Fish · 18 topics
Interactions · 12 topics
Role in Stroke · 9 topics
Structure · 6 topics
Gene and expression · 4 topics
Role in Fetal Development · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J
Band
14q23.2 · 12 C3|12 31.99 cM
Bgee
pancreatic ductal cell · corpus epididymis · caput epididymis · tibia · cartilage tissue
BioGPS
More reference expression data
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Gene and expression

Function

Regulation

Role in cancer

Role in Stroke

Role in Fetal Development

Interactions

Role in Fish

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HIF1A connects Entity context

The extracted context around HIF1A shows recurring relationship patterns in the source. For example, HIF1A → angiogenesis, axon cytoplasm, axonal transport of mitochondrion, B-1 B cell homeostasis, blood vessel development, blood vessel morphogenesis, camera-type eye morphogenesis, cardiac ventricle morphogenesis, cartilage development, cell differentiation, cellular iron ion homeostasis, cellular response to hypoxia, cellular response to interleukin-1, cerebral cortex development, collagen metabolic process, connective tissue replacement involved in inflammatory response wound healing, cytokine-mediated signaling pathway, cytoplasm, cytosol, digestive tract morphogenesis Another extracted example is HIF1A → Enzymes, Function, HIF, HIF-1, HIF1B, Hippel-Lindau, HPH, HRE, In, Many, ODD, Once, P402, P564, PHD, The, This, Under, VEGF, VHL. Use these groups to spot repeated connection types before inspecting the individual relationships.

HIF1A

Top relations

Gene ontology · 125
HIF1A → angiogenesis, axon cytoplasm, axonal transport of mitochondrion, B-1 B cell homeostasis, blood vessel development, blood vessel morphogenesis, camera-type eye morphogenesis, cardiac ventricle morphogenesis, cartilage development, cell differentiation, cellular iron ion homeostasis, cellular response to hypoxia, cellular response to interleukin-1, cerebral cortex development, collagen metabolic process, connective tissue replacement involved in inflammatory response wound healing, cytokine-mediated signaling pathway, cytoplasm, cytosol, digestive tract morphogenesis
related to Function · 21
HIF1A → Enzymes, Function, HIF, HIF-1, HIF1B, Hippel-Lindau, HPH, HRE, In, Many, ODD, Once, P402, P564, PHD, The, This, Under, VEGF, VHL
Bgee · 20
HIF1A → abdominal wall, calvaria, caput epididymis, cartilage tissue, corpus epididymis, cumulus cell, epithelium of lens, epithelium of nasopharynx, gingival epithelium, Gonadal ridge, iris, pancreatic ductal cell, pineal gland, retina, seminal vesicula, stria vascularis, tail of epididymis, tibia, vestibular sensory epithelium, visceral pleura
RNA expression pattern · 20
HIF1A → abdominal wall, calvaria, caput epididymis, cartilage tissue, corpus epididymis, cumulus cell, epithelium of lens, epithelium of nasopharynx, gingival epithelium, Gonadal ridge, iris, pancreatic ductal cell, pineal gland, retina, seminal vesicula, stria vascularis, tail of epididymis, tibia, vestibular sensory epithelium, visceral pleura
related to Repair, regeneration and rejuvenation · 15
HIF1A → Additionally, Following, HIF, HIF-1A, In, In June, Medicine, Not, One, PHD, PHDs, Researchers, Stanford University School, The, VEGFA
related to Interactions · 14
HIF1A → ARNT, ARNTL, CREBB, EP300, GR, HIF1AN, Mdm2, NR3C1, NR4A, P53, PSMA7, STAT3, UBC, VH
related to Role in cancer · 12
HIF1A → Clinically, Elevated HIF1A, However, Hypoxia, In, LV-positive, Moreover, Significant HIF1A, Similar, Studies, This, VEGF
related to Structure · 12
HIF1A → Arnt, C-terminal, CTAD, HIF1, ID, NTAD, PAC, PAS, PAS-associated C-terminal, PER-ARNT-SIM, The HIF1A, There
related to Gene and expression · 7
HIF1A → GC-rich, HIF-1-alpha, HIF1, In, Its, The, Typically
related to Regulation · 6
HIF1A → DFO, HBO, Hyperbaric, In, NF-κB-dependent, PHDs

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

hif-1α hypoxia oxygen also expression may fish cell levels tumor gene angiogenesis protein hif-1a transcription hypoxic factor metabolism conditions genes

HIF1A relationships Subject–Predicate–Object triples

TTTA extracted 299 structured relationships around HIF1A. Examples in this analysis include HIF1A → Aliases → HIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α and HIF1A → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HIF1AAliasesHIF1A, HIF-1-alpha, HIF-1A, HIF-1alpha, HIF1, HIF1-ALPHA, MOP1, PASD8, bHLHe78, hypoxia inducible factor 1 alpha subunit, hypoxia inducible factor 1 subunit alpha, HIF-1α1.00infobox
HIF1AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1H2K, 1H2L, 1H2M, 1L3E, 1L8C, 1LM8, 1LQB, 2ILM, 3HQR, 3HQU, 4AJY, 4H6J1.00infobox
HIF1ABand14q23.21.00infobox
HIF1ABand12 C3|12 31.99 cM1.00infobox
HIF1ABgeepancreatic ductal cell1.00infobox
HIF1ABgeecorpus epididymis1.00infobox
HIF1ABgeecaput epididymis1.00infobox
HIF1ABgeetibia1.00infobox
HIF1ABgeecartilage tissue1.00infobox
HIF1ABgeegingival epithelium1.00infobox
HIF1ABgeevisceral pleura1.00infobox
HIF1ABgeetail of epididymis1.00infobox
HIF1ABgeeseminal vesicula1.00infobox
HIF1ABgeeepithelium of nasopharynx1.00infobox
HIF1ABgeepineal gland1.00infobox
HIF1ABgeeretina1.00infobox
HIF1ABgeestria vascularis1.00infobox
HIF1ABgeecumulus cell1.00infobox
HIF1ABgeeepithelium of lens1.00infobox
HIF1ABgeeiris1.00infobox
HIF1ABgeeGonadal ridge1.00infobox
HIF1ABgeecalvaria1.00infobox
HIF1ABgeeabdominal wall1.00infobox
HIF1ABgeevestibular sensory epithelium1.00infobox
HIF1ABioGPSMore reference expression data1.00infobox
HIF1AChr.Chromosome 14 (human)1.00infobox
HIF1AChr.Chromosome 12 (mouse)1.00infobox
HIF1ADatabasesNCBI: entry; OMA: entry1.00infobox
HIF1AEnd61,748,259 bp1.00infobox
HIF1AEnd73,994,304 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HIF1A bring nearby vocabulary together. In this analysis, examples include Tumor, Expression and Gene. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HIF1A
    • Tumor
    • Expression
    • Gene
    • Levels
    • Overexpression
    • Hypoxia
    • Cancer
    • Activity
    • Transcription
    • Protein
    • Development
    • Vegf
  • hif1a
    • Tumor
    • Expression
    • Gene
    • Levels
    • Overexpression
    • Hypoxia
    • Cancer
    • Activity
    • Transcription
    • Protein
    • Development
    • Vegf
  • transcription factor
    • Human
    • Transcription
    • Gene
    • Expression
    • Development
    • Hypoxia
    • Involved
    • Response
    • Vegf
    • Role
    • Angiogenesis
    • Oxygen
  • gene
    • Human
    • Transcription
    • Expression
    • Levels
    • Hif1a
    • Development
    • Hypoxia
    • Pathway
    • Role
    • Study
    • Oxygen
    • Fish
  • protein
    • Mrna
    • Levels
    • Pathway
    • Using
    • Hypoxia
    • Activity
    • Involved
    • Hif
    • Response
    • Expression
    • Found
    • Hif-1α
  • hypoxia
    • Response
    • Hif-1α
    • Cell
    • Metabolism
    • Overexpression
    • Fish
    • Pathway
    • Angiogenesis
    • Transcription
    • Protein
    • Hif-1a
    • Tumor
  • angiogenesis
    • Vegf
    • Blood
    • Metabolism
    • Cell
    • Tumor
    • Role
    • Hypoxia
    • Cancer
    • Involved
    • Overexpression
    • Response
    • Cells
  • placental development
    • Human
    • Factor
    • Gene
    • Hypoxia
    • Hif1a
    • Mrna
    • Expression
    • Activity
    • Blood
    • Involved
    • Overexpression
    • Response

Connections between topic areas Semantic bridges

For HIF1A, one of the stronger structural bridges in this analysis connects HIF1A with Role in cancer. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HIF1A — Role in cancer · splits 124 ⟂ 38
HIF1A — Regulation · splits 138 ⟂ 24
HIF1A — Function · splits 140 ⟂ 22
HIF1A — Overview · splits 143 ⟂ 19
HIF1A — Role in Fish · splits 143 ⟂ 19
HIF1A — Interactions · splits 149 ⟂ 13
HIF1A — Role in Stroke · splits 152 ⟂ 10
HIF1A — Structure · splits 155 ⟂ 7
HIF1A — Gene and expression · splits 157 ⟂ 5
HIF1A — Role in Fetal Development · splits 158 ⟂ 4

Map overview Semantic statistics

HIF1A

Nodes162
Edges161
Triples299
Avg. degree1.99
Density0.012346
Components1

Source & methodology

TTTA analyzes the structure around HIF1A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Measurement, Function & Regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HIF1A · EN edition · Analysis: TopicsToTalkAbout

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