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Mutation

In biology, a mutation is an alteration in the nucleic acid sequence of the genome of an organism, virus, or extrachromosomal DNA. Mutations result from errors during replication, mitosis, meiosis, or damage to DNA, which then may trigger error-prone repair or cause an error during replication (translesion synthesis).

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Causes

MutagensRatsTautomersHydrogenBase pairing
45 related topics

Classification of types

Junk DNARegulatory sequencesIntronsPseudogenesRetrotransposons
66 related topics

Beneficial and conditional mutations

CCR5-Δ32AIDSEtiologyEuropeanBubonic plague
20 related topics

Overview

BiologyNucleic acid sequenceGenomeOrganismVirus
123 related topics

Topics to explore

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Overview

Causes

Classification of types

Mutation rates

Disease causation

Beneficial and conditional mutations

Application in human evolution and disease

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Map overview Semantic statistics

Mutation

Nodes281
Edges280
Triples257
Avg. degree1.99
Density0.007117
Components1

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Mutation

Top relations

related to By effect on function · 28
Mutation → Alzheimer's, An, ATM, Atopic, CEBPA, Dominant, Examples, Exceptions, FBN1, Gain-of-function, Gitelman, Huntington's, In, Intragenic, Lethal, Loss-of-function, Marfan, Muller's, Neomorphic, Null
related to External links · 23
Mutation → All About Mutations, BBC Radio, December, Education, February, Genetic Mutation, HOPES, Huntington's Disease Outreach Project, In Our Time, Jones, Leiden, Leiden University Medical Center, Liou, Locus Specific Mutation Databases, Mutalyzer, Netherlands, October, Partridge, Retrieved, Stanford
related to Nomenclature · 18
Mutation → Amino, D111E, D111X, DNA, For, HGVS, Human Genome Variation Society, If, In, N-terminus, Nonsense, Note, Nucleotide, Once, RNA, The, The Greek, This
related to Spontaneous mutation · 16
Mutation → AP, Deamination, Denaturation, Depurination, DNA, Examples, GC, HX, Hydrolysis, Loss, Naturally, Slipped, Spontaneous, Tautomerism, Theoretical, This
related to Beneficial and conditional mutations · 15
Mutation → AIDS, Although, CCR5, CCR5 Delta, CCR5-Δ32, Europe, European, Examples, HIV, In, One, People, Southern Africa, That, This
related to Evolutionary mechanism of compensation · 15
Mutation → Compensatory, CPD, CPDs, DePristo, Existence, Ferrer-Costa, For, However, In, Results, The, Thus, Under, Using, While
related to Special classes · 13
Mutation → Certain, Conditional, Cre-Lox, DNA, DNA Recombinase, Dual Recombinase, For, In, Replication, Steroid Binding Domain, The, These, This
related to Inherited disorders · 11
Mutation → An, Because DNA, DNA, Each, If, In, Individuals, OCA1, OCA2, Once DNA, This
related to Randomness of mutations · 10
Mutation → Additionally, Arabidopsis, DNA, Fluctuation Test, For, Monroe, Replica, There, They, This
related to Disease causation · 9
Mutation → Changes, DNA, Drosophila, Each, One, Some, Studies, The, When

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Important terminology

mutations dna gene protein sequence genetic fitness neutral also may acid different genome effect amino one change effects example cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mutationis aalteration in the nucleic acid sequence of the genome of an organism0.90text
Mutationis aultimate source of all genetic variation0.90text
Mutationis aalteration of the base sequence of the DNA0.90text
Mutationis apoint mutation in a sequence of DNA that results in a premature stop codon0.90text
Mutationis agene where the mutation occurs has a complete change in function.A reversion0.90text
Mutationis amutation of only one allele.A homozygous mutation is an identical mutation of both the paternal and maternal alleles.Compound heterozygous mutations or a genetic compound consis…0.90text
Mutationis amutation that has wild-type0.90text
natural selection can act.Mutation can result in many different types of change in sequencesinstance ofproviding the raw material on which evolutionary forces0.80text
8-hydroxydeoxyguanosineinstance ofa modified guanosine residue in DNA0.80text
or a polycyclic aromatic hydrocarbon adductinstance ofa modified guanosine residue in DNA0.80text
regulating gene expressioninstance ofand these sequences have now been recruited to perform functions0.80text
duplicationsinstance ofectopic intrachromosomal recombination and other chromosomal events0.80text

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