Protein–protein interaction

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Protein–protein interaction topic overview

The analysis highlights Works, Examples and Structure as prominent areas in the source structure around Protein–protein interaction.

Related topics: 163
Source areas: 11
Connected nodes: 174
Extracted relationships: 123
Concept neighborhoods: 42
Bridge connections: 174

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 36 topics

Experimental methods · 29 topics

Examples · 25 topics

Overview · 18 topics

Types · 18 topics

Computational methods · 8 topics

Properties of the interface · 7 topics

As therapeutic targets · 6 topics

Databases · 6 topics

Interaction networks · 5 topics

Regulation · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Computational methods

Databases

Biological databases
Interactomes
DIP Database of Interacting Proteins
Biomolecular Interaction Network Database
BioGRID
Known and Predicted Protein–Protein Interactions (STRING-db) STRING

Interaction networks

Cytoscape
Connected Connectivity (graph theory)
Social networks Social network
Gene expression
Genome Wide association Studies Genome-wide association study

As therapeutic targets

FDA Food and Drug Administration
Arkin Michelle R. Arkin
Quaternary protein complexes Protein quaternary structure
Auxin
Ning Zheng
Molecular glues Molecular glue

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Protein–protein interaction connects Entity context

The extracted context around Protein–protein interaction shows recurring relationship patterns in the source. For example, Protein–protein interaction → BIND, BioGRID, Biological General Repository, Biomolecular Interaction Network Database, Database, DIP, Examples, HPRD, Human Protein Reference Database, IntAct Molecular Interaction Database, Interacting Proteins, Interaction Datasets, Large, MINT, MIPS Mammalian Protein, MIPS Protein Interaction Resource, MIPS-MPact, MIPS-MPPI, Molecular Interactions Database, PPIs Another extracted example is Protein–protein interaction → Currently, Diverse, In, LUMIER, Many, Membrane, Natural Language Processing, NLP, Of, Other, PPI, PPIs, Prediction, Publicly, Saccharomyces, Schizophrenia-associated, Some, Such, Text, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Databases · 24

Protein–protein interaction → BIND, BioGRID, Biological General Repository, Biomolecular Interaction Network Database, Database, DIP, Examples, HPRD, Human Protein Reference Database, IntAct Molecular Interaction Database, Interacting Proteins, Interaction Datasets, Large, MINT, MIPS Mammalian Protein, MIPS Protein Interaction Resource, MIPS-MPact, MIPS-MPPI, Molecular Interactions Database, PPIs

has method · 23

Protein–protein interaction → Currently, Diverse, In, LUMIER, Many, Membrane, Natural Language Processing, NLP, Of, Other, PPI, PPIs, Prediction, Publicly, Saccharomyces, Schizophrenia-associated, Some, Such, Text, The

related to Nucleic acid programmable protein array (NAPPA) · 16

Protein–protein interaction → Anti-GST, APTES, Biotinylated, BSA, By, DNA, GST, HA, LaBaer, New, RRL, The, They, This, Thus, To

related to As therapeutic targets · 9

Protein–protein interaction → Amit Jaiswal, Arkin, FDA-approved, In, Modulation, Nevertheless, PPI, PPIs, Several

related to Affinity purification coupled to mass spectrometry · 8

Protein–protein interaction → Affinity, Bertrand Seraphin, Furthermore, Matthias Mann, One, PPIs, SILAC, This

related to Electron transfer proteins · 8

Protein–protein interaction → After, Arg, Asp, Examples, In, More, P450, These

related to Signed interaction networks · 8

Protein–protein interaction → Although, Conversely, However, PPI, Protein, Signed, Such, Vinayagam

related to Examples · 6

Protein–protein interaction → CCR5-gp120, HIV, IIb/IIIa, Inhibitors, Tirofiban, VenetoclaxLifitegrastSotorasibAdagrasib

related to External links · 5

Protein–protein interaction → Modulators, PPI, Protein, Protein Interaction DatabasesLibrary, Protein Interactions

related to Types · 4

Protein–protein interaction → Another, In, PPIs, To

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

proteins protein interactions interaction ppis methods molecular two many ppi yeast interacting cell one using gene prediction databases networks system

Protein–protein interaction relationships Subject–Predicate–Object triples

TTTA extracted 123 structured relationships around Protein–protein interaction. Examples in this analysis include His3 → instance of → The Y2H is based on the functional reconstitution of the yeast transcription factor Gal4 and subsequent activation of a selective reporter and Genomic Context → instance of → some of the interactions in the STRING database are only predicted by computational methods. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
His3	instance of	The Y2H is based on the functional reconstitution of the yeast transcription factor Gal4 and subsequent activation of a selective reporter	0.80	text
Genomic Context	instance of	some of the interactions in the STRING database are only predicted by computational methods	0.80	text
not experimentally verified	instance of	some of the interactions in the STRING database are only predicted by computational methods	0.80	text
Jactive modules	instance of	There are some methods	0.80	text
MoBaS	instance of	There are some methods	0.80	text
yeast two-hybrid screens or 'affinity purification	instance of	protein interaction networks are often constructed as a result of lab experiments	0.80	text
subsequent mass spectrometry techniques	instance of	protein interaction networks are often constructed as a result of lab experiments	0.80	text
allosteric sites	instance of	Several properties of PPI	0.80	text
hotspots	instance of	Several properties of PPI	0.80	text
have been incorporated into drug-design strategies	instance of	Several properties of PPI	0.80	text
Protein–protein interaction	has method	Diverse	0.60	section
Protein–protein interaction	has method	PPIs	0.60	section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Protein–protein interaction bring nearby vocabulary together. In this analysis, examples include Interaction, Protein and Networks. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Protein–protein interaction
- Interaction
- Protein
- Networks
- Proteins
- Prediction
- Molecular
- Examples
- Result
- Cell
- Methods
- Interactions
- Complexes
protein–protein interaction
- Interaction
- Protein
- Networks
- Proteins
- Network
- Prediction
- One
- Molecular
- Examples
- Two
- Result
- Cell
protein
- Interaction
- Proteins
- Prediction
- Molecular
- Result
- Cell
- Methods
- Complexes
- Network
- Structure
- Databases
- Include
molecular machines
- Complexes
- Also
- Ppis
- Interaction
- Protein
- Examples
- Information
- Structure
- Networks
- Yeast
- Methods
- Result
many methods
- Molecular
- Cell
- Ppis
- Information
- Two-hybrid
- Used
- Databases
- Methods
- Yeast
- Different
- Protein
- Also
molecular dynamics
- Complexes
- Also
- Ppis
- Interaction
- Protein
- Examples
- Information
- Structure
- Networks
- Yeast
- Methods
- Result
molecular motors
- Complexes
- Also
- Ppis
- Interaction
- Protein
- Examples
- Information
- Structure
- Networks
- Yeast
- Methods
- Result
myeloid cell leukemia 1
- Many
- Molecular
- Protein
- Network
- Structure
- Complex
- Databases
- Prediction
- Ppi
- Interaction
- Proteins
- Examples

Connections between topic areas Semantic bridges

For Protein–protein interaction, one of the stronger structural bridges in this analysis connects Protein–protein interaction with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Protein–protein interaction — Structure · splits 138 ⟂ 37

Protein–protein interaction — Experimental methods · splits 145 ⟂ 30

Protein–protein interaction — Examples · splits 149 ⟂ 26

Protein–protein interaction — Overview · splits 156 ⟂ 19

Protein–protein interaction — Types · splits 156 ⟂ 19

Protein–protein interaction — Computational methods · splits 166 ⟂ 9

Protein–protein interaction — Properties of the interface · splits 167 ⟂ 8

Protein–protein interaction — Databases · splits 168 ⟂ 7

Protein–protein interaction — As therapeutic targets · splits 168 ⟂ 7

Protein–protein interaction — Regulation · splits 169 ⟂ 6

Protein–protein interaction — Interaction networks · splits 169 ⟂ 6

Map overview Semantic statistics

Protein–protein interaction

Nodes175

Edges174

Triples123

Avg. degree1.99

Density0.011429

Components1

Source & methodology

TTTA analyzes the structure around Protein–protein interaction to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Works, Examples & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Protein–protein interaction · EN edition · Analysis: TopicsToTalkAbout

Protein–protein interaction: Works, Examples & Structure

Protein–protein interaction topic overview

What this topic covers Research coverage

Key facts & relationships

Explore all related topics Closing gaps

Overview

Examples

Types

Structure

Properties of the interface

Regulation

Experimental methods

Computational methods

Databases

Interaction networks

As therapeutic targets

Advanced semantic analysis

How Protein–protein interaction connects Entity context

Protein–protein interaction

Top relations

Important terminology

Important terminology

Protein–protein interaction relationships Subject–Predicate–Object triples

Related concept clusters Concept neighborhoods

Connections between topic areas Semantic bridges

Map overview Semantic statistics

Protein–protein interaction

Source & methodology