Mitogen-activated protein kinase

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

Mitogen-activated protein kinase topic overview

The analysis highlights Activation, Signaling cascades and As therapeutic targets as prominent areas in the source structure around Mitogen-activated protein kinase.

Related topics: 143
Source areas: 9
Connected nodes: 152
Extracted relationships: 43
Concept neighborhoods: 28
Bridge connections: 152

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Signaling cascades · 63 topics

Activation · 23 topics

As therapeutic targets · 13 topics

Overview · 12 topics

Evolutionary relationships · 9 topics

Scaffold proteins · 8 topics

Types · 7 topics

Substrate and partner recognition · 6 topics

Discovery · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA: enzyme data
CAS no.: 142243-02-5
EC no.: 2.7.11.24
ExPASy: NiceZyme view
Gene Ontology: AmiGO / QuickGO
KEGG: enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Serine/threonine-specific protein kinases Serine/threonine-specific protein kinase
Mitogens Mitogen
Osmotic stress
Heat shock
Proinflammatory cytokines Proinflammatory cytokine
Proliferation Cell proliferation
Gene expression
Differentiation Cellular differentiation
Mitosis
Apoptosis
Eukaryotes Eukaryote
Cyclin-dependent kinases Cyclin-dependent kinase

Discovery

ERK1 MAPK3
ERK2 MAPK1

Evolutionary relationships

Substrate and partner recognition

Substrates Enzyme substrate (biology)
Serine
Proline
Cyclin-dependent kinases
Cyclin
N-termini N-terminus

Scaffold proteins

MP1 MAP2K1IP1
KSR1
KSR2
JIP1 MAPK8IP1
JIP2 MAPK8IP2
JIP3 MAPK8IP3
Kinesin-dependent transport Kinesin
Drosophila melanogaster

As therapeutic targets

Antineoplastic
Receptor tyrosine kinases Receptor tyrosine kinase
Raf kinases Raf kinase
Sorafenib
Cobimetinib
PI3K pathway PI3K/AKT/mTOR pathway
Insulin resistance
Excitotoxicity
Sensorineural hearing loss
Autoimmune diseases Autoimmune disease
Hepatotoxic
ASK1
TNF-α

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Mitogen-activated protein kinase connects Entity context

The extracted context around Mitogen-activated protein kinase shows recurring relationship patterns in the source. For example, Mitogen-activated protein kinase → ERK1, ERK2, ERK5, In, JNKs, MAP, Mitogen-activated, STE, TDY, TEY, TGY, This, TPY, TxY Another extracted example is Mitogen-activated protein kinase → Because, DNA, ERK1, ERK1/2, ERK2, MAPK, MAPK1, MAPK3, MAPKs, Since ERK1, The, Thus, With. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Activation · 14

Mitogen-activated protein kinase → ERK1, ERK2, ERK5, In, JNKs, MAP, Mitogen-activated, STE, TDY, TEY, TGY, This, TPY, TxY

related to Discovery · 13

Mitogen-activated protein kinase → Because, DNA, ERK1, ERK1/2, ERK2, MAPK, MAPK1, MAPK3, MAPKs, Since ERK1, The, Thus, With

BRENDA · 1

Mitogen-activated protein kinase → enzyme data

CAS no. · 1

Mitogen-activated protein kinase → 142243-02-5

EC no. · 1

Mitogen-activated protein kinase → 2.7.11.24

ExPASy · 1

Mitogen-activated protein kinase → NiceZyme view

Gene Ontology · 1

Mitogen-activated protein kinase → AmiGO / QuickGO

KEGG · 1

Mitogen-activated protein kinase → enzyme entry

MetaCyc · 1

Mitogen-activated protein kinase → metabolic pathway

NCBI · 1

Mitogen-activated protein kinase → proteins

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinases mapk also mapks pathway kinase activation erk1 map proteins needed p38 protein citation classical jnk involved phosphorylation erk5 substrates

Mitogen-activated protein kinase relationships Subject–Predicate–Object triples

TTTA extracted 43 structured relationships around Mitogen-activated protein kinase. Examples in this analysis include Mitogen-activated protein kinase → BRENDA → enzyme data and Mitogen-activated protein kinase → CAS no. → 142243-02-5. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Mitogen-activated protein kinase	BRENDA	enzyme data	1.00	infobox
Mitogen-activated protein kinase	CAS no.	142243-02-5	1.00	infobox
Mitogen-activated protein kinase	EC no.	2.7.11.24	1.00	infobox
Mitogen-activated protein kinase	ExPASy	NiceZyme view	1.00	infobox
Mitogen-activated protein kinase	Gene Ontology	AmiGO / QuickGO	1.00	infobox
Mitogen-activated protein kinase	KEGG	enzyme entry	1.00	infobox
Mitogen-activated protein kinase	MetaCyc	metabolic pathway	1.00	infobox
Mitogen-activated protein kinase	NCBI	proteins	1.00	infobox
Mitogen-activated protein kinase	PDB structures	RCSB PDB PDBe PDBsum	1.00	infobox
Mitogen-activated protein kinase	PMC	articles	1.00	infobox
Mitogen-activated protein kinase	PubMed	articles	1.00	infobox
Mitogen-activated protein kinase	Rhea	reactions	1.00	infobox
Mitogen-activated protein kinase	Search	SearchPMCarticlesPubMedarticlesNCBIproteins	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Mitogen-activated protein kinase bring nearby vocabulary together. In this analysis, examples include Protein, Family and Map3. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Mitogen-activated protein kinase
- Protein
- Family
- Map3
- Involved
- Citation
- Substrates
- Kinases
- Erk1
- Mapk
- Erk5
- Activation
- Also
mitogen-activated protein kinase
- Map
- Protein
- Kinases
- Citation
- Erk1
- Needed
- Mammals
- Family
- Map3
- Mammalian
- Mapk
- Also
serine/threonine-specific protein kinases
- Map
- Needed
- Classical
- Citation
- Mapk
- Erk1
- Map3
- Substrates
- Protein
- Family
- Mapks
- Atypical
cyclin-dependent kinases
- Map
- Needed
- Classical
- Citation
- Mapk
- Erk1
- Map3
- Substrates
- Protein
- Mapks
- Atypical
- P38
erk1
- Pathway
- Kinase
- Signaling
- Kinases
- P38
- Mammals
- Needed
- Cell
- Erk5
- Mammalian
- Involved
- Jnk
extracellular signal-regulated kinases
- Map
- Needed
- Classical
- Citation
- Mapk
- Erk1
- Map3
- Substrates
- Protein
- Mapks
- Atypical
- P38
c-jun n-terminal kinases
- Map
- Needed
- Classical
- Citation
- Mapk
- Erk1
- Map3
- Substrates
- Protein
- Mapks
- Atypical
- P38
p38 mitogen-activated protein kinases
- Jnk
- Protein
- Map
- Needed
- Classical
- Citation
- Mapk
- Erk1
- Map3
- Substrates
- Erk5
- Family

Connections between topic areas Semantic bridges

For Mitogen-activated protein kinase, one of the stronger structural bridges in this analysis connects Mitogen-activated protein kinase with Signaling cascades. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Mitogen-activated protein kinase — Signaling cascades · splits 89 ⟂ 64

Mitogen-activated protein kinase — Activation · splits 129 ⟂ 24

Mitogen-activated protein kinase — As therapeutic targets · splits 139 ⟂ 14

Mitogen-activated protein kinase — Overview · splits 140 ⟂ 13

Mitogen-activated protein kinase — Evolutionary relationships · splits 143 ⟂ 10

Mitogen-activated protein kinase — Scaffold proteins · splits 144 ⟂ 9

Mitogen-activated protein kinase — Types · splits 145 ⟂ 8

Mitogen-activated protein kinase — Substrate and partner recognition · splits 146 ⟂ 7

Mitogen-activated protein kinase — Discovery · splits 150 ⟂ 3

Map overview Semantic statistics

Mitogen-activated protein kinase

Nodes153

Edges152

Triples43

Avg. degree1.99

Density0.013072

Components1

Source & methodology

TTTA analyzes the structure around Mitogen-activated protein kinase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Activation, Signaling cascades & As therapeutic targets, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Mitogen-activated protein kinase · EN edition · Analysis: TopicsToTalkAbout