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ANKRD2: Regions, Structure & Function

Ankyrin Repeat, PEST sequence and Proline-rich region (ARPP), also known as Ankyrin repeat domain-containing protein 2, is a protein that in humans is encoded by the ANKRD2 gene. ARPP is a member of the muscle ankyrin repeat proteins (MARP), which also includes CARP and DARP, and is highly expressed in cardiac and skeletal muscle and in other tissues.…

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ANKRD2 topic overview

The analysis highlights Regions, Structure and Function as prominent areas in the source structure around ANKRD2.

Related topics
53
Source areas
5
Connected nodes
58
Extracted relationships
115
Related term clusters
16
Bridge connections
58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Structure · 19 topics
Function · 17 topics
Overview · 9 topics
Clinical Significance · 4 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
ANKRD2, ankyrin repeat domain 2 (stretch responsive muscle), ARPP, ankyrin repeat domain 2
Band
10q24.2 · 19|19 C3
Bgee
muscle of thigh · thoracic diaphragm · apex of heart · Skeletal muscle tissue of rectus abdominis · gastrocnemius muscle
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)
Databases
NCBI: entry; OMA: entry

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical Significance

Interactions

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How ANKRD2 connects Entity context

The extracted context around ANKRD2 shows recurring relationship patterns in the source. For example, ANKRD2 → chromatin binding, cytoplasm, cytosol, euchromatin, I band, intracellular membrane-bounded organelle, muscle contraction, muscle organ development, myoblast differentiation, myofibril, negative regulation of myoblast differentiation, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, nucleus, PML body, protein kinase B binding, regulation of cytokine production, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, regulation of myoblast proliferation, regulation of transcription by RNA polymerase II Another extracted example is ANKRD2 → ankle, apex of heart, deltoid muscle, digastric muscle, gastrocnemius muscle, glutes, intercostal muscle, left ventricle, muscle of thigh, plantaris muscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle. Use these groups to spot repeated connection types before inspecting the individual relationships.

ANKRD2

Top relations

Gene ontology · 28
ANKRD2 → chromatin binding, cytoplasm, cytosol, euchromatin, I band, intracellular membrane-bounded organelle, muscle contraction, muscle organ development, myoblast differentiation, myofibril, negative regulation of myoblast differentiation, negative regulation of myotube differentiation, negative regulation of transcription by RNA polymerase II, nucleus, PML body, protein kinase B binding, regulation of cytokine production, regulation of intrinsic apoptotic signaling pathway by p53 class mediator, regulation of myoblast proliferation, regulation of transcription by RNA polymerase II
Bgee · 18
ANKRD2 → ankle, apex of heart, deltoid muscle, digastric muscle, gastrocnemius muscle, glutes, intercostal muscle, left ventricle, muscle of thigh, plantaris muscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
RNA expression pattern · 18
ANKRD2 → ankle, apex of heart, deltoid muscle, digastric muscle, gastrocnemius muscle, glutes, intercostal muscle, left ventricle, muscle of thigh, plantaris muscle, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, soleus muscle, sternocleidomastoid muscle, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, vastus lateralis muscle
related to Function · 15
ANKRD2 → A/protein, ARPP, C2C12, CARP, DARP, Functional, I-bands, MARP, MARPs, MLP, MyoD, Nkx2, PML, Titin, WAFI/CIPI
related to Structure · 11
ANKRD2 → ARPP, C-terminal, CARP, I-bands, Lysine-rich, MARPs, N-terminal, PEST-like, Proline-rich, Though ARPP, Two
related to Interactions · 5
ANKRD2 → AAkt, Lamin, PML, TCAP, TitinYBX1
Band · 2
ANKRD2 → 10q24.2, 19|19 C3
Chr. · 2
ANKRD2 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
ANKRD2 → 42,033,549 bp, 97,583,884 bp
Aliases · 1
ANKRD2 → ANKRD2, ankyrin repeat domain 2 (stretch responsive muscle), ARPP, ankyrin repeat domain 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

arpp muscle also expression shown gene skeletal bp human role titin protein ankyrin carp chr band expressed repeat proteins chromosome

ANKRD2 relationships Subject–Predicate–Object triples

TTTA extracted 115 structured relationships around ANKRD2. Examples in this analysis include ANKRD2 → Aliases → ANKRD2, ankyrin repeat domain 2 (stretch responsive muscle), ARPP, ankyrin repeat domain 2 and ANKRD2 → Band → 10q24.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
ANKRD2AliasesANKRD2, ankyrin repeat domain 2 (stretch responsive muscle), ARPP, ankyrin repeat domain 21.00infobox
ANKRD2Band10q24.21.00infobox
ANKRD2Band19|19 C31.00infobox
ANKRD2Bgeemuscle of thigh1.00infobox
ANKRD2Bgeethoracic diaphragm1.00infobox
ANKRD2Bgeeapex of heart1.00infobox
ANKRD2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
ANKRD2Bgeegastrocnemius muscle1.00infobox
ANKRD2Bgeeleft ventricle1.00infobox
ANKRD2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
ANKRD2Bgeetriceps brachii muscle1.00infobox
ANKRD2Bgeeglutes1.00infobox
ANKRD2Bgeedeltoid muscle1.00infobox
ANKRD2Bgeesoleus muscle1.00infobox
ANKRD2Bgeeankle1.00infobox
ANKRD2Bgeeintercostal muscle1.00infobox
ANKRD2Bgeedigastric muscle1.00infobox
ANKRD2Bgeesternocleidomastoid muscle1.00infobox
ANKRD2Bgeetibialis anterior muscle1.00infobox
ANKRD2Bgeevastus lateralis muscle1.00infobox
ANKRD2Bgeeplantaris muscle1.00infobox
ANKRD2BioGPSMore reference expression data1.00infobox
ANKRD2Chr.Chromosome 10 (human)1.00infobox
ANKRD2Chr.Chromosome 19 (mouse)1.00infobox
ANKRD2DatabasesNCBI: entry; OMA: entry1.00infobox
ANKRD2End97,583,884 bp1.00infobox
ANKRD2End42,033,549 bp1.00infobox
ANKRD2EnsemblENSG000001658871.00infobox
ANKRD2Entrez262871.00infobox
ANKRD2External IDsOMIM: 610734; MGI: 1861447; GeneCards: ANKRD21.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around ANKRD2 bring nearby vocabulary together. In this analysis, examples include Gene, Location and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • ANKRD2
    • Gene
    • Location
    • Protein
    • Shown
    • Ankyrin
    • Human
    • Titin
    • Role
    • Differentiation
    • P53
    • Pml
    • Chromosome
  • ankrd2
    • Gene
    • Location
    • Protein
    • Shown
    • Ankyrin
    • Human
    • Titin
    • Role
    • Differentiation
    • P53
    • Pml
    • Chromosome
  • gene
    • Location
    • Human
    • Chromosome
    • Bp
    • Chr
    • Role
    • Muscle
    • P53
    • Pml
    • Band
    • Function
    • May
  • skeletal muscle
    • Skeletal
    • Expression
    • Proteins
    • Following
    • Carp
    • Expressed
    • Titin
    • Cardiac
    • Development
    • Nuclei
    • Function
    • Mrna
  • titin
    • Sarcomere
    • Pml
    • Mouse
    • Mrna
    • Protein
    • Skeletal
    • Carp
    • Ankrd2
    • Expression
    • Arpp
    • Muscle
    • Darp
  • protein
    • Sarcomere
    • Titin
    • Gene
    • Development
    • Differentiation
    • P53
    • Pml
    • Band
    • Chromosome
    • Function
    • Location
    • Mouse
  • protein kinase a
    • Sarcomere
    • Titin
    • Gene
    • Development
    • Differentiation
    • P53
    • Pml
    • Band
    • Chromosome
    • Function
    • Location
    • Mouse
  • protein kinase c
    • Sarcomere
    • Titin
    • Gene
    • Development
    • Differentiation
    • P53
    • Pml
    • Band
    • Chromosome
    • Function
    • Location
    • Mouse

Connections between topic areas Semantic bridges

For ANKRD2, one of the stronger structural bridges in this analysis connects ANKRD2 with Structure. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
ANKRD2 — Structure · splits 39 ⟂ 20
ANKRD2 — Function · splits 41 ⟂ 18
ANKRD2 — Overview · splits 49 ⟂ 10
ANKRD2 — Clinical Significance · splits 54 ⟂ 5
ANKRD2 — Interactions · splits 54 ⟂ 5

Map overview Semantic statistics

ANKRD2

Nodes59
Edges58
Triples115
Avg. degree1.97
Density0.033898
Components1

Source & methodology

TTTA analyzes the structure around ANKRD2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Structure & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — ANKRD2 · EN edition · Analysis: TopicsToTalkAbout

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