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Histone acetyltransferase: HAT families, Clinical significance & Overview

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

Language: English [EN]
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Histone acetyltransferase topic overview

The analysis highlights HAT families, Clinical significance and Overview as prominent areas in the source structure around Histone acetyltransferase.

Related topics
157
Source areas
7
Connected nodes
164
Extracted relationships
56
Concept neighborhoods
32
Bridge connections
164

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 80 topics
HAT families · 37 topics
Clinical significance · 18 topics
Biological role · 8 topics
Substrate binding and specificity · 6 topics
Catalytic mechanisms · 4 topics
Overall structure · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
9054-51-7
EC no.
2.3.1.48
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

HAT families

Overall structure

Catalytic mechanisms

Substrate binding and specificity

Biological role

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Histone acetyltransferase connects Entity context

The extracted context around Histone acetyltransferase shows recurring relationship patterns in the source. For example, Histone acetyltransferase → Acetylation, Chromatin, DNA, DNA-associated, H1, H2A, H2B, H3, H4, Histone, Histone H1, Histones, N-terminal, The, There, This Another extracted example is Histone acetyltransferase → CBP, DNA, For, H4, H4K16, HATs, Huntington's, Hutchinson Gilford, In, It, Mof, N-terminal, PCAF, Specifically, The. Use these groups to spot repeated connection types before inspecting the individual relationships.

Histone acetyltransferase

Top relations

related to Chromatin remodeling · 16
Histone acetyltransferase → Acetylation, Chromatin, DNA, DNA-associated, H1, H2A, H2B, H3, H4, Histone, Histone H1, Histones, N-terminal, The, There, This
related to Clinical significance · 15
Histone acetyltransferase → CBP, DNA, For, H4, H4K16, HATs, Huntington's, Hutchinson Gilford, In, It, Mof, N-terminal, PCAF, Specifically, The
related to Interaction with HDACs · 5
Histone acetyltransferase → HATs, HDACs, Histone, These, They
BRENDA · 1
Histone acetyltransferase → enzyme data
CAS no. · 1
Histone acetyltransferase → 9054-51-7
EC no. · 1
Histone acetyltransferase → 2.3.1.48
ExPASy · 1
Histone acetyltransferase → NiceZyme view
Gene Ontology · 1
Histone acetyltransferase → AmiGO / QuickGO
KEGG · 1
Histone acetyltransferase → enzyme entry
MetaCyc · 1
Histone acetyltransferase → metabolic pathway

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

histone hat hats lysine acetylation proteins p300 transcription histones cbp also dna chromatin acetylate activity protein binding myst pcaf residues

Histone acetyltransferase relationships Subject–Predicate–Object triples

TTTA extracted 56 structured relationships around Histone acetyltransferase. Examples in this analysis include Histone acetyltransferase → BRENDA → enzyme data and Histone acetyltransferase → CAS no. → 9054-51-7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Histone acetyltransferaseBRENDAenzyme data1.00infobox
Histone acetyltransferaseCAS no.9054-51-71.00infobox
Histone acetyltransferaseEC no.2.3.1.481.00infobox
Histone acetyltransferaseExPASyNiceZyme view1.00infobox
Histone acetyltransferaseGene OntologyAmiGO / QuickGO1.00infobox
Histone acetyltransferaseKEGGenzyme entry1.00infobox
Histone acetyltransferaseMetaCycmetabolic pathway1.00infobox
Histone acetyltransferaseNCBIproteins1.00infobox
Histone acetyltransferasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Histone acetyltransferasePMCarticles1.00infobox
Histone acetyltransferasePubMedarticles1.00infobox
Histone acetyltransferaseRheareactions1.00infobox
Histone acetyltransferaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Histone acetyltransferase bring nearby vocabulary together. In this analysis, examples include Substrates, Lysine and Acetylation. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Histone acetyltransferase
    • Substrates
    • Lysine
    • Acetylation
    • Acetyl-coa
    • Substrate
    • Different
    • Binding
    • Proteins
    • H4
    • May
    • Complex
    • Chromatin
  • histone acetyltransferase
    • Substrates
    • Lysine
    • Acetylation
    • Acetyl-coa
    • Substrate
    • Different
    • Binding
    • Proteins
    • H4
    • May
    • Complex
    • Chromatin
  • acetylation
    • Also
    • Histone
    • Chromatin
    • Activity
    • Histones
    • Transcriptional
    • Transcription
    • Protein
    • Lysine
    • Proteins
    • General
    • May
  • lysine
    • Residues
    • Bromodomain
    • Family
    • H4
    • Histones
    • Gnat
    • Complexes
    • Myst
    • Substrates
    • Substrate
    • Domain
    • Hat
  • histone
    • Substrates
    • Lysine
    • Acetylation
    • Acetyl-coa
    • Substrate
    • Different
    • Binding
    • Proteins
    • H4
    • May
    • Complex
    • Chromatin
  • transcriptional
    • Transcription
    • Factors
    • General
    • Activity
    • Bromodomain
    • Cbp
    • P300
    • Hat
    • Complex
    • Pcaf
    • Acetylation
    • Dna
  • transcription factors
    • Transcription
    • Transcriptional
    • General
    • Chromatin
    • Bromodomain
    • Proteins
    • Cbp
    • P300
    • Also
    • Substrates
    • Protein
    • Pcaf
  • bromodomain
    • Lysine
    • Residues
    • Domain
    • Transcription
    • Factors
    • Substrates
    • Transcriptional
    • Hat
    • Also
    • Cbp
    • Histones
    • P300

Connections between topic areas Semantic bridges

For Histone acetyltransferase, one of the stronger structural bridges in this analysis connects Histone acetyltransferase with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Histone acetyltransferase — Overview · splits 84 ⟂ 81
Histone acetyltransferase — HAT families · splits 127 ⟂ 38
Histone acetyltransferase — Clinical significance · splits 146 ⟂ 19
Histone acetyltransferase — Biological role · splits 156 ⟂ 9
Histone acetyltransferase — Substrate binding and specificity · splits 158 ⟂ 7
Histone acetyltransferase — Overall structure · splits 160 ⟂ 5
Histone acetyltransferase — Catalytic mechanisms · splits 160 ⟂ 5

Map overview Semantic statistics

Histone acetyltransferase

Nodes165
Edges164
Triples56
Avg. degree1.99
Density0.012121
Components1

Source & methodology

TTTA analyzes the structure around Histone acetyltransferase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as HAT families, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Histone acetyltransferase · EN edition · Analysis: TopicsToTalkAbout

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