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Histone acetyltransferase

Histone acetyltransferases (HATs) are enzymes that acetylate conserved lysine amino acids on histone proteins by transferring an acetyl group from acetyl-CoA to form ε-N-acetyllysine. DNA is wrapped around histones, and, by transferring an acetyl group to the histones, genes can be turned on and off. In general, histone acetylation increases gene expression.

HAT families, Clinical significance & Overview

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Key facts & relationships

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BRENDA
enzyme data
CAS no.
9054-51-7
EC no.
2.3.1.48
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Topics to explore

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Overview

HAT families

Overall structure

Catalytic mechanisms

Substrate binding and specificity

Biological role

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

Histone acetyltransferase

Nodes165
Edges164
Triples56
Avg. degree1.99
Density0.012121
Components1

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Histone acetyltransferase

Top relations

related to Chromatin remodeling · 16
Histone acetyltransferase → Acetylation, Chromatin, DNA, DNA-associated, H1, H2A, H2B, H3, H4, Histone, Histone H1, Histones, N-terminal, The, There, This
related to Clinical significance · 15
Histone acetyltransferase → CBP, DNA, For, H4, H4K16, HATs, Huntington's, Hutchinson Gilford, In, It, Mof, N-terminal, PCAF, Specifically, The
related to Interaction with HDACs · 5
Histone acetyltransferase → HATs, HDACs, Histone, These, They
BRENDA · 1
Histone acetyltransferase → enzyme data
CAS no. · 1
Histone acetyltransferase → 9054-51-7
EC no. · 1
Histone acetyltransferase → 2.3.1.48
ExPASy · 1
Histone acetyltransferase → NiceZyme view
Gene Ontology · 1
Histone acetyltransferase → AmiGO / QuickGO
KEGG · 1
Histone acetyltransferase → enzyme entry
MetaCyc · 1
Histone acetyltransferase → metabolic pathway

Important terminology Word statistics

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Important terminology

histone hat hats lysine acetylation proteins p300 transcription histones cbp also dna chromatin acetylate activity protein binding myst pcaf residues

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Histone acetyltransferaseBRENDAenzyme data1.00infobox
Histone acetyltransferaseCAS no.9054-51-71.00infobox
Histone acetyltransferaseEC no.2.3.1.481.00infobox
Histone acetyltransferaseExPASyNiceZyme view1.00infobox
Histone acetyltransferaseGene OntologyAmiGO / QuickGO1.00infobox
Histone acetyltransferaseKEGGenzyme entry1.00infobox
Histone acetyltransferaseMetaCycmetabolic pathway1.00infobox
Histone acetyltransferaseNCBIproteins1.00infobox
Histone acetyltransferasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Histone acetyltransferasePMCarticles1.00infobox
Histone acetyltransferasePubMedarticles1.00infobox
Histone acetyltransferaseRheareactions1.00infobox
Histone acetyltransferaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

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