GATA3

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Explore the main themes, entities and connections around GATA3. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

GATA family Fat cells Neural crest cells Lymphocytes Group 2 ILCs

13 related topics

Overview

Transcription factor Gene Inflammatory Humoral Endothelium

23 related topics

Protein

Linear Amino acids Isoform Zinc finger Structural motifs

10 related topics

Clinical significance

Hypoparathyroidism Sensorineural deafness Kidney malformations Birth defects Penetrance

10 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: GATA3, HDR, HDRS, GATA binding protein 3
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4HC7, 4HC9, 4HCA
Band: 10p14 · 2 A1|2 6.69 cM
Bgee: skin of thigh · skin of hip · nipple · skin of arm · lactiferous duct
BioGPS: More reference expression data
Chr.: Chromosome 10 (human) · Chromosome 2 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Transcription factor
Gene
Inflammatory Inflammation
Humoral Humoral immunity
Endothelium
Blood vessels
Haploinsufficiency
Congenital
Barakat syndrome
Breast cancers Breast cancer
Estrogen receptor alpha
Androgen receptor
Immuocytochemical Immunocytochemistry
Triple-negative breast cancers Triple-negative breast cancer
Urinary bladder Bladder cancer
Urethral cancers Urethral cancer
Parathyroid gland
Salivary gland tumors Salivary gland tumor
Salivary duct carcinomas Salivary duct carcinoma
Mammary analog secretory carcinomas Mammary analog secretory carcinoma
Brenner tumors Brenner tumor
Walthard cell rests Walthard cell rest
Paragangliomas Paraganglioma

Gene

Protein

Linear Biomolecular structure
Amino acids
Isoform Protein isoform
Zinc finger
Structural motifs Structural motif
C-terminus
Gene promoter Promoter (genetics)
N-terminus
Zinc finger protein 1 ZFPM1
ZFPM2

Pathophysiology

Function

GATA family GATA transcription factor
Fat cells Adipocyte
Neural crest cells Neural crest cell
Lymphocytes
Group 2 ILCs Innate lymphoid cell
Th2 cells T helper cell
IL-4 Interleukin 4
IL-5 Interleukin 5
IL-13 Interleukin 13
Maturation Cellular differentiation
Breast Breast development
Epithelial cells Epithelium
Thymus

Clinical significance

Hypoparathyroidism
Sensorineural deafness Sensorineural hearing loss
Kidney malformations Kidney disease
Birth defects
Penetrance
Embryogenesis
Phase IIA clinical study Phases of clinical research
Deoxyribozyme
Messenger RNA
Eosinophil

Interactions

Interact Protein-protein interaction
LMO1
FOXA1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes77

Edges76

Triples289

Avg. degree1.97

Density0.025974

Components1

How this topic connects Entity context

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GATA3

Top relations

Gene ontology · 151

GATA3 → anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, animal organ morphogenesis, aortic valve morphogenesis, axon guidance, blood coagulation, canonical Wnt signaling pathway involved in metanephric kidney development, cardiac right ventricle morphogenesis, cell activation, cell development, cell fate determination, cell maturation, cell morphogenesis, cellular response to BMP stimulus, cellular response to cytokine stimulus, cellular response to interferon-alpha, cellular response to interleukin-4, cellular response to tumor necrosis factor, chromatin binding, chromatin remodeling

Bgee · 19

GATA3 → adrenal medulla, corpus epididymis, hair follicle, lactiferous duct, lactiferous gland, lip, medullary collecting duct, nasal cavity, nipple, renal medulla, seminal vesicula, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, transitional epithelium of urinary bladder, vulva

RNA expression pattern · 19

related to Protein · 16

GATA3 → C-terminus, Differences, DNA, FOG-1, FOG-2, Friends, GATA1, GATA3's, N-terminus, The, With, ZFPM1, ZFPM2, Zinc, ZNF1, ZNF2

related to Allergy · 15

GATA3 → Deoxyribozyme ST010, For, Group, IIA, IL-13, IL-4, IL-5, ILCs, In, Mouse, Reduction, RNA, Th2, The, This

related to Function · 14

GATA3 → All, Comparable, GATA, Gene-deletion, Group, IL-13, IL-4, IL-5, ILCs, In, It, Studies, Th, Th2

related to Gene · 13

GATA3 → Barakat, DiGeorge, Expression, GATA3-AS1, It, Knockout, Large-scale, Mutations, RNA, The, The GATA3, They, Various

related to Mutations · 6

GATA3 → Barakat, DeGeorge, Inactivating, Mutations, The Barakat, This

related to Interactions · 5

GATA3 → FOXA1, LMO1, These, ZFPM1, ZFPM2

related to External links · 4

GATA3 → FactorBookGATA3, Medicine Medical Subject Headings, MeSH, National Library

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

development breast gene transcription protein cells studies humans also expression cancer genes various 10 types factor human syndrome allergic chromosome

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
GATA3	Aliases	GATA3, HDR, HDRS, GATA binding protein 3	1.00	infobox
GATA3	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4HC7, 4HC9, 4HCA	1.00	infobox
GATA3	Band	10p14	1.00	infobox
GATA3	Band	2 A1\|2 6.69 cM	1.00	infobox
GATA3	Bgee	skin of thigh	1.00	infobox
GATA3	Bgee	skin of hip	1.00	infobox
GATA3	Bgee	nipple	1.00	infobox
GATA3	Bgee	skin of arm	1.00	infobox
GATA3	Bgee	lactiferous duct	1.00	infobox
GATA3	Bgee	renal medulla	1.00	infobox
GATA3	Bgee	seminal vesicula	1.00	infobox
GATA3	Bgee	skin of abdomen	1.00	infobox
GATA3	Bgee	vulva	1.00	infobox
GATA3	Bgee	corpus epididymis	1.00	infobox
GATA3	Bgee	transitional epithelium of urinary bladder	1.00	infobox
GATA3	Bgee	hair follicle	1.00	infobox
GATA3	Bgee	medullary collecting duct	1.00	infobox
GATA3	Bgee	adrenal medulla	1.00	infobox
GATA3	Bgee	lactiferous gland	1.00	infobox
GATA3	Bgee	skin of back	1.00	infobox
GATA3	Bgee	nasal cavity	1.00	infobox
GATA3	Bgee	skin of external ear	1.00	infobox
GATA3	Bgee	lip	1.00	infobox
GATA3	BioGPS	More reference expression data	1.00	infobox
GATA3	Chr.	Chromosome 10 (human)	1.00	infobox
GATA3	Chr.	Chromosome 2 (mouse)	1.00	infobox
GATA3	Databases	NCBI: entry; OMA: entry	1.00	infobox
GATA3	End	8,075,198 bp	1.00	infobox
GATA3	End	9,894,845 bp	1.00	infobox
GATA3	Ensembl	ENSG00000107485	1.00	infobox

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