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GATA3: Products, Function & Overview

GATA3 is a transcription factor that in humans is encoded by the GATA3 gene. Studies in animal models and humans indicate that it controls the expression of a wide range of biologically and clinically important genes.

Language: English [EN]
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GATA3 topic overview

The analysis highlights Products, Function and Overview as prominent areas in the source structure around GATA3.

Related topics
69
Source areas
7
Connected nodes
76
Extracted relationships
289
Concept neighborhoods
24
Bridge connections
76

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 23 topics
Function · 13 topics
Clinical significance · 10 topics
Protein · 10 topics
Gene · 7 topics
Interactions · 3 topics
Pathophysiology · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GATA3, HDR, HDRS, GATA binding protein 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4HC7, 4HC9, 4HCA
Band
10p14 · 2 A1|2 6.69 cM
Bgee
skin of thigh · skin of hip · nipple · skin of arm · lactiferous duct
BioGPS
More reference expression data
Chr.
Chromosome 10 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Gene

Protein

Pathophysiology

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GATA3 connects Entity context

The extracted context around GATA3 shows recurring relationship patterns in the source. For example, GATA3 → anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, animal organ morphogenesis, aortic valve morphogenesis, axon guidance, blood coagulation, canonical Wnt signaling pathway involved in metanephric kidney development, cardiac right ventricle morphogenesis, cell activation, cell development, cell fate determination, cell maturation, cell morphogenesis, cellular response to BMP stimulus, cellular response to cytokine stimulus, cellular response to interferon-alpha, cellular response to interleukin-4, cellular response to tumor necrosis factor, chromatin binding, chromatin remodeling Another extracted example is GATA3 → adrenal medulla, corpus epididymis, hair follicle, lactiferous duct, lactiferous gland, lip, medullary collecting duct, nasal cavity, nipple, renal medulla, seminal vesicula, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, transitional epithelium of urinary bladder, vulva. Use these groups to spot repeated connection types before inspecting the individual relationships.

GATA3

Top relations

Gene ontology · 151
GATA3 → anatomical structure formation involved in morphogenesis, anatomical structure morphogenesis, animal organ morphogenesis, aortic valve morphogenesis, axon guidance, blood coagulation, canonical Wnt signaling pathway involved in metanephric kidney development, cardiac right ventricle morphogenesis, cell activation, cell development, cell fate determination, cell maturation, cell morphogenesis, cellular response to BMP stimulus, cellular response to cytokine stimulus, cellular response to interferon-alpha, cellular response to interleukin-4, cellular response to tumor necrosis factor, chromatin binding, chromatin remodeling
Bgee · 19
GATA3 → adrenal medulla, corpus epididymis, hair follicle, lactiferous duct, lactiferous gland, lip, medullary collecting duct, nasal cavity, nipple, renal medulla, seminal vesicula, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, transitional epithelium of urinary bladder, vulva
RNA expression pattern · 19
GATA3 → adrenal medulla, corpus epididymis, hair follicle, lactiferous duct, lactiferous gland, lip, medullary collecting duct, nasal cavity, nipple, renal medulla, seminal vesicula, skin of abdomen, skin of arm, skin of back, skin of external ear, skin of hip, skin of thigh, transitional epithelium of urinary bladder, vulva
related to Protein · 16
GATA3 → C-terminus, Differences, DNA, FOG-1, FOG-2, Friends, GATA1, GATA3's, N-terminus, The, With, ZFPM1, ZFPM2, Zinc, ZNF1, ZNF2
related to Allergy · 15
GATA3 → Deoxyribozyme ST010, For, Group, IIA, IL-13, IL-4, IL-5, ILCs, In, Mouse, Reduction, RNA, Th2, The, This
related to Function · 14
GATA3 → All, Comparable, GATA, Gene-deletion, Group, IL-13, IL-4, IL-5, ILCs, In, It, Studies, Th, Th2
related to Gene · 13
GATA3 → Barakat, DiGeorge, Expression, GATA3-AS1, It, Knockout, Large-scale, Mutations, RNA, The, The GATA3, They, Various
related to Mutations · 6
GATA3 → Barakat, DeGeorge, Inactivating, Mutations, The Barakat, This
related to Interactions · 5
GATA3 → FOXA1, LMO1, These, ZFPM1, ZFPM2
related to External links · 4
GATA3 → FactorBookGATA3, Medicine Medical Subject Headings, MeSH, National Library

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

development breast gene transcription protein cells studies humans also expression cancer genes various 10 types factor human syndrome allergic chromosome

GATA3 relationships Subject–Predicate–Object triples

TTTA extracted 289 structured relationships around GATA3. Examples in this analysis include GATA3 → Aliases → GATA3, HDR, HDRS, GATA binding protein 3 and GATA3 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4HC7, 4HC9, 4HCA. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GATA3AliasesGATA3, HDR, HDRS, GATA binding protein 31.00infobox
GATA3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4HC7, 4HC9, 4HCA1.00infobox
GATA3Band10p141.00infobox
GATA3Band2 A1|2 6.69 cM1.00infobox
GATA3Bgeeskin of thigh1.00infobox
GATA3Bgeeskin of hip1.00infobox
GATA3Bgeenipple1.00infobox
GATA3Bgeeskin of arm1.00infobox
GATA3Bgeelactiferous duct1.00infobox
GATA3Bgeerenal medulla1.00infobox
GATA3Bgeeseminal vesicula1.00infobox
GATA3Bgeeskin of abdomen1.00infobox
GATA3Bgeevulva1.00infobox
GATA3Bgeecorpus epididymis1.00infobox
GATA3Bgeetransitional epithelium of urinary bladder1.00infobox
GATA3Bgeehair follicle1.00infobox
GATA3Bgeemedullary collecting duct1.00infobox
GATA3Bgeeadrenal medulla1.00infobox
GATA3Bgeelactiferous gland1.00infobox
GATA3Bgeeskin of back1.00infobox
GATA3Bgeenasal cavity1.00infobox
GATA3Bgeeskin of external ear1.00infobox
GATA3Bgeelip1.00infobox
GATA3BioGPSMore reference expression data1.00infobox
GATA3Chr.Chromosome 10 (human)1.00infobox
GATA3Chr.Chromosome 2 (mouse)1.00infobox
GATA3DatabasesNCBI: entry; OMA: entry1.00infobox
GATA3End8,075,198 bp1.00infobox
GATA3End9,894,845 bp1.00infobox
GATA3EnsemblENSG000001074851.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GATA3 bring nearby vocabulary together. In this analysis, examples include Development, Cells and Studies. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GATA3
    • Development
    • Cells
    • Studies
    • Transcription
    • Breast
    • Factor
    • Expression
    • Humans
    • Protein
    • Responses
    • Tissues
    • Allergic
  • gata3
    • Development
    • Cells
    • Studies
    • Transcription
    • Breast
    • Factor
    • Expression
    • Humans
    • Protein
    • Responses
    • Tissues
    • Allergic
  • transcription factor
    • Transcription
    • Inflammatory
    • Humoral
    • Tissues
    • Development
    • Immune
    • Gata3
    • Responses
    • Well
    • Various
    • Expression
    • Gene
  • gene
    • Chromosome
    • Bp
    • Chr
    • Function
    • Mouse
    • Human
    • Types
    • Expression
    • Transcription
    • Band
    • Cells
    • Critical
  • breast cancers
    • Cancer
    • Types
    • Studies
    • Cancers
    • Gata3
    • Cells
    • Role
    • Human
    • Development
    • Humans
    • Protein
    • Gene
  • triple-negative breast cancers
    • Cancer
    • Types
    • Studies
    • Cancers
    • Gata3
    • Cells
    • Role
    • Human
    • Development
    • Humans
    • Protein
    • Gene
  • gene promoter
    • Chromosome
    • Bp
    • Chr
    • Function
    • Mouse
    • Human
    • Types
    • Expression
    • Transcription
    • Band
    • Cells
    • Critical
  • fat cells
    • Function
    • Development
    • Humans
    • Critical
    • Mouse
    • Gata3
    • Responses
    • Gene
    • Humoral
    • Immune
    • Tissues
    • Various

Connections between topic areas Semantic bridges

For GATA3, one of the stronger structural bridges in this analysis connects GATA3 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GATA3Overview · splits 53 ⟂ 24
GATA3Function · splits 63 ⟂ 14
GATA3Protein · splits 66 ⟂ 11
GATA3Clinical significance · splits 66 ⟂ 11
GATA3Gene · splits 69 ⟂ 8
GATA3Pathophysiology · splits 73 ⟂ 4
GATA3Interactions · splits 73 ⟂ 4

Map overview Semantic statistics

GATA3

Nodes77
Edges76
Triples289
Avg. degree1.97
Density0.025974
Components1

Source & methodology

TTTA analyzes the structure around GATA3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Products, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GATA3 · EN edition · Analysis: TopicsToTalkAbout

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