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Nuclear receptor coactivator 2: Interactions, Function & Overview

The nuclear receptor coactivator 2 also known as NCoA-2 is a protein that in humans is encoded by the NCOA2 gene. NCoA-2 is also frequently called glucocorticoid receptor-interacting protein 1 (GRIP1), steroid receptor coactivator-2 (SRC-2), or transcriptional mediators/intermediary factor 2 (TIF2).

Language: English [EN]
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Nuclear receptor coactivator 2 topic overview

The analysis highlights Interactions, Function and Overview as prominent areas in the source structure around Nuclear receptor coactivator 2.

Related topics
16
Source areas
3
Connected nodes
19
Extracted relationships
119
Concept neighborhoods
8
Bridge connections
19

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 8 topics
Function · 6 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23,…
Band
8q13.3 · 1 A3|1 4.12 cM
Bgee
corpus epididymis · endothelial cell · secondary oocyte · seminal vesicula · jejunal mucosa
BioGPS
More reference expression data
Chr.
Chromosome 8 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

  • Interact Protein-protein interaction
  • AR Androgen receptor
  • ARNT Aryl hydrocarbon receptor nuclear translocator
  • BRCA1
  • ESR1 Estrogen receptor alpha
  • PPFIA4
  • RXRA Retinoid X receptor alpha
  • VDR Calcitriol receptor

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Nuclear receptor coactivator 2 connects Entity context

The extracted context around Nuclear receptor coactivator 2 shows recurring relationship patterns in the source. For example, Nuclear receptor coactivator 2 → aryl hydrocarbon receptor binding, bile acid and bile salt transport, cellular response to hormone stimulus, cellular response to Thyroglobulin triiodothyronine, chromatin binding, circadian regulation of gene expression, circadian rhythm, cytoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, intracellular receptor signaling pathway, locomotor rhythm, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nuclear body, nuclear receptor binding, nuclear receptor coactivator activity, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding Another extracted example is Nuclear receptor coactivator 2 → amniotic fluid, buccal mucosa cell, cerebellar vermis, ciliary body, corpus epididymis, endothelial cell, Epithelium of choroid plexus, habenula, jejunal mucosa, lacrimal gland, lateral geniculate nucleus, left lung lobe, lobe of cerebellum, median eminence, oral cavity, retinal pigment epithelium, secondary oocyte, seminal vesicula, substantia nigra, tibia. Use these groups to spot repeated connection types before inspecting the individual relationships.

Nuclear receptor coactivator 2

Top relations

Gene ontology · 35
Nuclear receptor coactivator 2 → aryl hydrocarbon receptor binding, bile acid and bile salt transport, cellular response to hormone stimulus, cellular response to Thyroglobulin triiodothyronine, chromatin binding, circadian regulation of gene expression, circadian rhythm, cytoplasm, DNA-binding transcription factor activity, RNA polymerase II-specific, intracellular receptor signaling pathway, locomotor rhythm, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nuclear body, nuclear receptor binding, nuclear receptor coactivator activity, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, protein binding
Bgee · 20
Nuclear receptor coactivator 2 → amniotic fluid, buccal mucosa cell, cerebellar vermis, ciliary body, corpus epididymis, endothelial cell, Epithelium of choroid plexus, habenula, jejunal mucosa, lacrimal gland, lateral geniculate nucleus, left lung lobe, lobe of cerebellum, median eminence, oral cavity, retinal pigment epithelium, secondary oocyte, seminal vesicula, substantia nigra, tibia
RNA expression pattern · 20
Nuclear receptor coactivator 2 → amniotic fluid, buccal mucosa cell, cerebellar vermis, ciliary body, corpus epididymis, endothelial cell, Epithelium of choroid plexus, habenula, jejunal mucosa, lacrimal gland, lateral geniculate nucleus, left lung lobe, lobe of cerebellum, median eminence, oral cavity, retinal pigment epithelium, secondary oocyte, seminal vesicula, substantia nigra, tibia
related to External links · 12
Nuclear receptor coactivator 2 → Human Nuclear, Medicine Medical Subject Headings, MeSH, Mouse Nuclear, National Library, NURSAC90Overview, Overview, PDB, PDBe-KB, Q15596, Q61026, UniProt
related to Interactions · 9
Nuclear receptor coactivator 2 → AR, ARNT, BRCA1, ESR1, NR3C1, Nuclear, PPFIA4, RXRA, VDR
Band · 2
Nuclear receptor coactivator 2 → 1 A3|1 4.12 cM, 8q13.3
Chr. · 2
Nuclear receptor coactivator 2 → Chromosome 1 (mouse), Chromosome 8 (human)
End · 2
Nuclear receptor coactivator 2 → 13,374,083 bp, 70,403,808 bp
Aliases · 1
Nuclear receptor coactivator 2 → NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2
Available structures · 1
Nuclear receptor coactivator 2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23,…

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor nuclear coactivator bp ncoa2 human chr band protein gene ncoa-2 chromosome mouse dna grip1 factor location pdb uniprot transcriptional

Nuclear receptor coactivator 2 relationships Subject–Predicate–Object triples

TTTA extracted 119 structured relationships around Nuclear receptor coactivator 2. Examples in this analysis include Nuclear receptor coactivator 2 → Aliases → NCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 2 and Nuclear receptor coactivator 2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23,…. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Nuclear receptor coactivator 2AliasesNCOA2, GRIP1, KAT13C, NCoA-2, SRC2, TIF2, bHLHe75, nuclear receptor coactivator 21.00infobox
Nuclear receptor coactivator 2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1GWQ, 1GWR, 1M2Z, 1MV9, 1MVC, 1MZN, 1P93, 1T63, 1T65, 1UHL, 1YOK, 1ZDT, 1ZDU, 1ZKY, 2AO6, 2B1V, 2B1Z, 2B23,…1.00infobox
Nuclear receptor coactivator 2Band8q13.31.00infobox
Nuclear receptor coactivator 2Band1 A3|1 4.12 cM1.00infobox
Nuclear receptor coactivator 2Bgeecorpus epididymis1.00infobox
Nuclear receptor coactivator 2Bgeeendothelial cell1.00infobox
Nuclear receptor coactivator 2Bgeesecondary oocyte1.00infobox
Nuclear receptor coactivator 2Bgeeseminal vesicula1.00infobox
Nuclear receptor coactivator 2Bgeejejunal mucosa1.00infobox
Nuclear receptor coactivator 2Bgeeamniotic fluid1.00infobox
Nuclear receptor coactivator 2Bgeetibia1.00infobox
Nuclear receptor coactivator 2BgeeEpithelium of choroid plexus1.00infobox
Nuclear receptor coactivator 2Bgeebuccal mucosa cell1.00infobox
Nuclear receptor coactivator 2Bgeeoral cavity1.00infobox
Nuclear receptor coactivator 2Bgeesubstantia nigra1.00infobox
Nuclear receptor coactivator 2Bgeelacrimal gland1.00infobox
Nuclear receptor coactivator 2Bgeeciliary body1.00infobox
Nuclear receptor coactivator 2Bgeeleft lung lobe1.00infobox
Nuclear receptor coactivator 2Bgeeretinal pigment epithelium1.00infobox
Nuclear receptor coactivator 2Bgeelateral geniculate nucleus1.00infobox
Nuclear receptor coactivator 2Bgeehabenula1.00infobox
Nuclear receptor coactivator 2Bgeemedian eminence1.00infobox
Nuclear receptor coactivator 2Bgeelobe of cerebellum1.00infobox
Nuclear receptor coactivator 2Bgeecerebellar vermis1.00infobox
Nuclear receptor coactivator 2BioGPSMore reference expression data1.00infobox
Nuclear receptor coactivator 2Chr.Chromosome 8 (human)1.00infobox
Nuclear receptor coactivator 2Chr.Chromosome 1 (mouse)1.00infobox
Nuclear receptor coactivator 2DatabasesNCBI: entry; OMA: entry1.00infobox
Nuclear receptor coactivator 2End70,403,808 bp1.00infobox
Nuclear receptor coactivator 2End13,374,083 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Nuclear receptor coactivator 2 bring nearby vocabulary together. In this analysis, examples include Coactivator, Nuclear and Receptor. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Nuclear receptor coactivator 2
    • Coactivator
    • Nuclear
    • Receptor
    • Ncoa2
    • Available
    • Pdb
    • Transcriptional
    • Uniprot
    • Dna
    • Gene
    • Ncoa-2
    • Human
  • nuclear receptor coactivator 2
    • Coactivator
    • Nuclear
    • Receptor
    • Ncoa2
    • Available
    • Pdb
    • Uniprot
    • Gene
    • Ncoa-2
    • Human
    • Transcriptional
    • Dna
  • gene
    • Location
    • Chromosome
    • Ncoa-2
    • A3
    • Bp
    • Chr
    • End
    • Function
    • Human
    • Search
    • Ncoa2
    • Mouse
  • nuclear receptor
    • Coactivator
    • Receptor
    • Ncoa2
    • Available
    • Pdb
    • Transcriptional
    • Uniprot
    • Dna
    • Gene
    • Ncoa-2
    • Human
    • Expression
  • glucocorticoid receptor
    • Factor
    • Grip1
    • Transcriptional
    • Available
    • Pdb
    • Uniprot
    • Tif2
    • Human
    • Function
    • Pdbe-kb
    • Protein
    • Q15596
  • function
    • Search
    • Location
    • Activity
    • Chromosome
    • Gene
    • Ncoa-2
    • Bp
    • Chr
    • Human
    • A3
    • End
    • Expression
  • protein
    • Factor
    • Transcriptional
    • Receptor
    • Activity
    • A3
    • End
    • Expression
    • Function
    • Glucocorticoid
    • Q15596
    • Q61026
    • Search
  • transcriptional coregulatory
    • Uniprot

Connections between topic areas Semantic bridges

For Nuclear receptor coactivator 2, one of the stronger structural bridges in this analysis connects Nuclear receptor coactivator 2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Nuclear receptor coactivator 2Interactions · splits 11 ⟂ 9
Nuclear receptor coactivator 2Function · splits 13 ⟂ 7
Nuclear receptor coactivator 2Overview · splits 17 ⟂ 3

Map overview Semantic statistics

Nuclear receptor coactivator 2

Nodes20
Edges19
Triples119
Avg. degree1.9
Density0.1
Components1

Source & methodology

TTTA analyzes the structure around Nuclear receptor coactivator 2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Nuclear receptor coactivator 2 · EN edition · Analysis: TopicsToTalkAbout

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