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STAT6

Signal transducer and activator of transcription 6 (STAT6) is a transcription factor that belongs to the Signal Transducer and Activator of Transcription (STAT) family of proteins. The proteins of STAT family transmit signals from a receptor complex to the nucleus and activate gene expression. Similarly as other STAT family proteins, STAT6 is also…

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Aliases
STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OJ5, 4Y5W, 4Y5U
Band
12q13.3 · 10 D3|10 74.59 cM
Bgee
granulocyte · right ovary · left ovary · canal of the cervix · spleen
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)

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Gene

Structure

Regulation

Function

Clinical significance

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STAT6

Nodes46
Edges45
Triples159
Avg. degree1.96
Density0.043478
Components1

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STAT6

Top relations

Gene ontology · 40
STAT6 → cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, growth hormone receptor signaling pathway via JAK-STAT, identical protein binding, interleukin-4-mediated signaling pathway, mammary gland epithelial cell proliferation, mammary gland morphogenesis, membrane raft, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, nuclear membrane, nucleoplasm
related to Function · 20
STAT6 → Activation, BCL2L1/BCL-X, Expression, Gata3, IL-13, IL-4, IL-5, IL-9-secreting, IL4, It, JAK1, Knockout, M2, SH2, STAT, STAT6-deficient, STAT6-mediated, T-helper, Th2, Y641
Bgee · 18
STAT6 → aortic valve, ascending aorta, body of uterus, canal of the cervix, esophagus, gastric mucosa, granulocyte, left ovary, left uterine tube, lip, lumbar spinal ganglion, mesenteric lymph nodes, right adrenal cortex, right ovary, right uterine tube, spleen, stroma of bone marrow, thymus
RNA expression pattern · 18
STAT6 → aortic valve, ascending aorta, body of uterus, canal of the cervix, esophagus, gastric mucosa, granulocyte, left ovary, left uterine tube, lip, lumbar spinal ganglion, mesenteric lymph nodes, right adrenal cortex, right ovary, right uterine tube, spleen, stroma of bone marrow, thymus
related to Clinical significance · 12
STAT6 → AmplificationSTAT6, Association, Gene, GT, IgE, IL-13, IL-4, NAB2, NGFI-A, Only, Th2, Th2-cell
related to Regulation · 9
STAT6 → DNA, DNA-binding, IL-13, IL-4, IL-4Rα, JAKs, Janus, STAT, Tyrosine
related to Interactions · 6
STAT6 → CREB-binding, EP300, IRF4, NFKB1, Nuclear, SND1
related to Structure · 6
STAT6 → DNA, N-terminal, SH2, SH3, STAT, TAD
related to External links · 5
STAT6 → Factor, Medicine Medical Subject Headings, MeSH, National Library, Transcription
Band · 2
STAT6 → 10 D3|10 74.59 cM, 12q13.3

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Important terminology

gene stat bp proteins human cytokines protein chr chromosome band transcription family receptor expression il-4 activated 12 also factor function

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
STAT6AliasesSTAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 61.00infobox
STAT6Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OJ5, 4Y5W, 4Y5U1.00infobox
STAT6Band12q13.31.00infobox
STAT6Band10 D3|10 74.59 cM1.00infobox
STAT6Bgeegranulocyte1.00infobox
STAT6Bgeeright ovary1.00infobox
STAT6Bgeeleft ovary1.00infobox
STAT6Bgeecanal of the cervix1.00infobox
STAT6Bgeespleen1.00infobox
STAT6Bgeegastric mucosa1.00infobox
STAT6Bgeeright adrenal cortex1.00infobox
STAT6Bgeeright uterine tube1.00infobox
STAT6Bgeeleft uterine tube1.00infobox
STAT6Bgeebody of uterus1.00infobox
STAT6Bgeelumbar spinal ganglion1.00infobox
STAT6Bgeemesenteric lymph nodes1.00infobox
STAT6Bgeeascending aorta1.00infobox
STAT6Bgeeaortic valve1.00infobox
STAT6Bgeethymus1.00infobox
STAT6Bgeelip1.00infobox
STAT6Bgeestroma of bone marrow1.00infobox
STAT6Bgeeesophagus1.00infobox
STAT6BioGPSMore reference expression data1.00infobox
STAT6Chr.Chromosome 12 (human)1.00infobox
STAT6Chr.Chromosome 10 (mouse)1.00infobox
STAT6DatabasesNCBI: entry; OMA: entry1.00infobox
STAT6End57,132,139 bp1.00infobox
STAT6End127,496,826 bp1.00infobox
STAT6EnsemblENSG000001668881.00infobox
STAT6Entrez67781.00infobox

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