STAT6

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STAT6 topic overview

The analysis highlights Regions, Function and Interactions as prominent areas in the source structure around STAT6.

Related topics: 38
Source areas: 7
Connected nodes: 45
Extracted relationships: 159
Concept neighborhoods: 22
Bridge connections: 45

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 9 topics

Function · 8 topics

Interactions · 8 topics

Clinical significance · 5 topics

Gene · 3 topics

Structure · 3 topics

Regulation · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OJ5, 4Y5W, 4Y5U
Band: 12q13.3 · 10 D3|10 74.59 cM
Bgee: granulocyte · right ovary · left ovary · canal of the cervix · spleen
BioGPS: More reference expression data
Chr.: Chromosome 12 (human) · Chromosome 10 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Transcription factor
Signal Transducer and Activator of Transcription STAT protein
Proteins Protein
Receptor Receptor (biochemistry)
Gene expression
Growth factors Growth factor
Cytokines Cytokine
Interleukin-4 Interleukin 4
Interleukin-13 Interleukin 13

Gene

Structure

N-terminal domain N-terminus
DNA binding domain DNA-binding domain
SH2 domain

Regulation

Janus family (JAKs) Janus kinase
IL-4 receptor Interleukin-4 receptor

Function

IL-5 Interleukin 5
JAK1 Janus kinase 1
Knockout Knockout mouse
Immunoglobulins Antibody
Macrophage
Gata3
IL-9 Interleukin 9
T cells T cell

Clinical significance

IgE Immunoglobulin E
Polymorphisms Polymorphism (biology)
NGFI-A–binding protein 2
NAB2
Solitary fibrous tumors Solitary fibrous tumor

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How STAT6 connects Entity context

The extracted context around STAT6 shows recurring relationship patterns in the source. For example, STAT6 → cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, growth hormone receptor signaling pathway via JAK-STAT, identical protein binding, interleukin-4-mediated signaling pathway, mammary gland epithelial cell proliferation, mammary gland morphogenesis, membrane raft, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, nuclear membrane, nucleoplasm Another extracted example is STAT6 → Activation, BCL2L1/BCL-X, Expression, Gata3, IL-13, IL-4, IL-5, IL-9-secreting, IL4, It, JAK1, Knockout, M2, SH2, STAT, STAT6-deficient, STAT6-mediated, T-helper, Th2, Y641. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 40

STAT6 → cellular response to hydrogen peroxide, cellular response to reactive nitrogen species, cytokine-mediated signaling pathway, cytoplasm, cytosol, defense response, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, growth hormone receptor signaling pathway via JAK-STAT, identical protein binding, interleukin-4-mediated signaling pathway, mammary gland epithelial cell proliferation, mammary gland morphogenesis, membrane raft, negative regulation of transcription by RNA polymerase II, negative regulation of type 2 immune response, nuclear membrane, nucleoplasm

related to Function · 20

STAT6 → Activation, BCL2L1/BCL-X, Expression, Gata3, IL-13, IL-4, IL-5, IL-9-secreting, IL4, It, JAK1, Knockout, M2, SH2, STAT, STAT6-deficient, STAT6-mediated, T-helper, Th2, Y641

Bgee · 18

STAT6 → aortic valve, ascending aorta, body of uterus, canal of the cervix, esophagus, gastric mucosa, granulocyte, left ovary, left uterine tube, lip, lumbar spinal ganglion, mesenteric lymph nodes, right adrenal cortex, right ovary, right uterine tube, spleen, stroma of bone marrow, thymus

RNA expression pattern · 18

related to Clinical significance · 12

STAT6 → AmplificationSTAT6, Association, Gene, GT, IgE, IL-13, IL-4, NAB2, NGFI-A, Only, Th2, Th2-cell

related to Regulation · 9

STAT6 → DNA, DNA-binding, IL-13, IL-4, IL-4Rα, JAKs, Janus, STAT, Tyrosine

related to Interactions · 6

STAT6 → CREB-binding, EP300, IRF4, NFKB1, Nuclear, SND1

related to Structure · 6

STAT6 → DNA, N-terminal, SH2, SH3, STAT, TAD

related to External links · 5

STAT6 → Factor, Medicine Medical Subject Headings, MeSH, National Library, Transcription

Band · 2

STAT6 → 10 D3|10 74.59 cM, 12q13.3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene stat bp proteins human cytokines protein chr chromosome band transcription family receptor expression il-4 activated 12 also factor function

STAT6 relationships Subject–Predicate–Object triples

TTTA extracted 159 structured relationships around STAT6. Examples in this analysis include STAT6 → Aliases → STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6 and STAT6 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OJ5, 4Y5W, 4Y5U. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
STAT6	Aliases	STAT6, D12S1644, IL-4-STAT, STAT6B, STAT6C, signal transducer and activator of transcription 6	1.00	infobox
STAT6	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1OJ5, 4Y5W, 4Y5U	1.00	infobox
STAT6	Band	12q13.3	1.00	infobox
STAT6	Band	10 D3\|10 74.59 cM	1.00	infobox
STAT6	Bgee	granulocyte	1.00	infobox
STAT6	Bgee	right ovary	1.00	infobox
STAT6	Bgee	left ovary	1.00	infobox
STAT6	Bgee	canal of the cervix	1.00	infobox
STAT6	Bgee	spleen	1.00	infobox
STAT6	Bgee	gastric mucosa	1.00	infobox
STAT6	Bgee	right adrenal cortex	1.00	infobox
STAT6	Bgee	right uterine tube	1.00	infobox
STAT6	Bgee	left uterine tube	1.00	infobox
STAT6	Bgee	body of uterus	1.00	infobox
STAT6	Bgee	lumbar spinal ganglion	1.00	infobox
STAT6	Bgee	mesenteric lymph nodes	1.00	infobox
STAT6	Bgee	ascending aorta	1.00	infobox
STAT6	Bgee	aortic valve	1.00	infobox
STAT6	Bgee	thymus	1.00	infobox
STAT6	Bgee	lip	1.00	infobox
STAT6	Bgee	stroma of bone marrow	1.00	infobox
STAT6	Bgee	esophagus	1.00	infobox
STAT6	BioGPS	More reference expression data	1.00	infobox
STAT6	Chr.	Chromosome 12 (human)	1.00	infobox
STAT6	Chr.	Chromosome 10 (mouse)	1.00	infobox
STAT6	Databases	NCBI: entry; OMA: entry	1.00	infobox
STAT6	End	57,132,139 bp	1.00	infobox
STAT6	End	127,496,826 bp	1.00	infobox
STAT6	Ensembl	ENSG00000166888	1.00	infobox
STAT6	Entrez	6778	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around STAT6 bring nearby vocabulary together. In this analysis, examples include Transcription, Protein and Also. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

STAT6
- Transcription
- Protein
- Also
- Binding
- Function
- Receptor
- Dna
- Nuclear
- Region
- 12q13
- Activated
- Cytokines
stat6
- Transcription
- Protein
- Also
- Binding
- Function
- Receptor
- Dna
- Nuclear
- Region
- 12q13
- Activated
- Cytokines
transcription factor
- Transcription
- Signal
- Transducer
- Location
- Also
- Chromosome
- Function
- Human
- Bp
- Chr
- Protein
- Stat6
signal transducer and activator of transcription
- Activator
- Signal
- Transducer
- Transcription
- Location
- Chromosome
- Factor
- Function
- Human
- Bp
- Chr
- Also
receptor
- Nuclear
- Il-4
- Protein
- Stat6
- Growth
- Interleukin-4
- Mouse
- Dna
- Ige
- Il-13
- Location
- Pathway
gene expression
- Location
- Nucleus
- 12q13
- Chromosome
- Human
- Bp
- Chr
- Expression
- Gene
- Mouse
- Receptor
- Region
growth factors
- Mouse
- Nucleus
- Dna
- Ige
- Location
- Nuclear
- Pathway
- Region
- Signal
- Signaling
- 12q13
- Band
chromosome
- Human
- Bp
- Location
- Band
- Mouse
- Signal
- Gene
- 12q13
- Function
- Transcription
- Growth
- Nucleus

Connections between topic areas Semantic bridges

For STAT6, one of the stronger structural bridges in this analysis connects STAT6 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

STAT6 — Overview · splits 36 ⟂ 10

STAT6 — Function · splits 37 ⟂ 9

STAT6 — Interactions · splits 37 ⟂ 9

STAT6 — Clinical significance · splits 40 ⟂ 6

STAT6 — Gene · splits 42 ⟂ 4

STAT6 — Structure · splits 42 ⟂ 4

STAT6 — Regulation · splits 43 ⟂ 3

Map overview Semantic statistics

STAT6

Nodes46

Edges45

Triples159

Avg. degree1.96

Density0.043478

Components1

Source & methodology

TTTA analyzes the structure around STAT6 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Function & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — STAT6 · EN edition · Analysis: TopicsToTalkAbout