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Flap endonuclease 1 is an enzyme that in humans is encoded by the FEN1 gene.
The analysis highlights Interactions, Therapeutic target for human cancer and Over expression of FEN1 in cancers as prominent areas in the source structure around Flap structure-specific endonuclease 1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Flap structure-specific endonuclease 1 shows recurring relationship patterns in the source. For example, Flap structure-specific endonuclease 1 → 5'-3' exonuclease activity, 5'-flap endonuclease activity, apoptotic DNA fragmentation, base-excision repair, catalytic activity, cellular response to DNA damage stimulus, damaged DNA binding, DNA binding, DNA repair, DNA replication, DNA replication, removal of RNA primer, double-strand break repair, double-strand break repair via homologous recombination, double-stranded DNA binding, double-stranded DNA exodeoxyribonuclease activity, endonuclease activity, exonuclease activity, flap endonuclease activity, hydrolase activity, hydrolase activity, acting on ester bonds Another extracted example is Flap structure-specific endonuclease 1 → amniotic fluid, bone marrow, ciliary body, cumulus cell, embryo, endothelial cell of lymphatic vessel, fetal liver hematopoietic progenitor cell, gingival epithelium, gonad, iris, maxillary prominence, motor neuron, oocyte, Paneth cell, paraflocculus of cerebellum, primitive streak, retinal pigment epithelium, secondary oocyte, tendon of biceps brachii, trabecular bone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
fen1 repair dna gene human bp cancer protein endonuclease cancers chr band expression pathway end flap mmej chromosome 11 enzyme
TTTA extracted 109 structured relationships around Flap structure-specific endonuclease 1. Examples in this analysis include Flap structure-specific endonuclease 1 → Aliases → FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2 and Flap structure-specific endonuclease 1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Flap structure-specific endonuclease 1 | Aliases | FEN1, Flap endonuclease 1, flap structure-specific endonuclease 1, FEN-1, MF1, RAD2 | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1U7B, 1UL1, 3Q8K, 3Q8L, 3Q8M, 3UVU, 5E0V | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Band | 11q12.2 | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Band | 19|19 A | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | oocyte | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | amniotic fluid | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | paraflocculus of cerebellum | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | gingival epithelium | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | secondary oocyte | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | tendon of biceps brachii | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | gonad | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | trabecular bone | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | bone marrow | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | embryo | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | Paneth cell | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | ciliary body | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | primitive streak | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | retinal pigment epithelium | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | iris | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | cumulus cell | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | endothelial cell of lymphatic vessel | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | maxillary prominence | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Bgee | motor neuron | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | BioGPS | More reference expression data | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Chr. | Chromosome 11 (human) | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Chr. | Chromosome 19 (mouse) | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | End | 61,797,238 bp | 1.00 | infobox |
| Flap structure-specific endonuclease 1 | End | 10,181,533 bp | 1.00 | infobox |
The concept neighborhoods around Flap structure-specific endonuclease 1 bring nearby vocabulary together. In this analysis, examples include Flap, Gene and Binding. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Flap structure-specific endonuclease 1, one of the stronger structural bridges in this analysis connects Flap structure-specific endonuclease 1 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Flap structure-specific endonuclease 1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Therapeutic target for human cancer & Over expression of FEN1 in cancers, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Flap structure-specific endonuclease 1 · EN edition · Analysis: TopicsToTalkAbout