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In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to DNA sequences. Specificity can be due to sequence motifs, or epigenetic modifications. The function of TFs is to regulate—turn on and off—genes in…
Regulation, Classes & Clinical significance
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transcription factors dna factor cell binding gene proteins nuclear protein genes bind dna-binding specific activation tfs domain ligand sequence sites
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| coactivators | instance of | Other proteins | 0.80 | text |
| chromatin remodelers | instance of | Other proteins | 0.80 | text |
| histone acetyltransferases | instance of | Other proteins | 0.80 | text |
| histone deacetylases | instance of | Other proteins | 0.80 | text |
| kinases | instance of | Other proteins | 0.80 | text |
| and methylases are also essential to gene regulation | instance of | Other proteins | 0.80 | text |
| but lack DNA-binding domains | instance of | Other proteins | 0.80 | text |
| and therefore are not TFs.TFs are of interest in medicine because TF mutations can cause specific diseases | instance of | Other proteins | 0.80 | text |
| and medications can be potentially targeted toward them | instance of | Other proteins | 0.80 | text |
| the ovaries | instance of | Estrogen is secreted by tissues | 0.80 | text |
| placenta | instance of | Estrogen is secreted by tissues | 0.80 | text |
| crosses the cell membrane of the recipient cell | instance of | Estrogen is secreted by tissues | 0.80 | text |
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