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Transcription factor

In molecular biology, a transcription factor (TF) (or sequence-specific DNA-binding factor) is a protein that controls the rate of transcription of genetic information from DNA to messenger RNA, by binding to DNA sequences. Specificity can be due to sequence motifs, or epigenetic modifications. The function of TFs is to regulate—turn on and off—genes in…

Regulation, Classes & Clinical significance

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Overview

Number

Mechanism

Function

Regulation

Structure

Clinical significance

Role in evolution

Role in biocontrol activity

Analysis

Classes

Transcription factor databases

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Transcription factor

Nodes254
Edges253
Triples405
Avg. degree1.99
Density0.007874
Components1

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Transcription factor

Top relations

related to Structural · 122
Transcription factor → ABI0, Achaete-Scute1, Activated T-cells, ANK, AP-1, AP2/B30, AP2/EREBP-related, AP20, ARF0, ARG80, Barrel, Basic Domains1, C/EBP-like, Cell-cycle, Class, Cold-shock, Copper, CREB1, Cys2His2, Cys4
related to Functional · 41
Transcription factor → AP-1, CCAATII, Cell, Constitutive, CREB, DAG, Developmental, Examples, Extracellular, GAPDH, GATA, HNF, Hox, II, Intracellular, IP3, Latent, Mef2II, Myf5, MyoD
related to Structure · 21
Transcription factor → Activation, AD, AFs, Also, An, C2H2, DBD, DBDs, DNA, DNA-binding, However, Necessary, Sometimes, SSD, TAD, TFs, These, Trans-activating, Transactivation, Transcription
related to Activation · 16
Transcription factor → Activation, BCL3, C2H2, COPS5, DBDs, DNA, DNA-binding, EP300, However, Many, NCOR1, Not, SIN3A, STAT, Transcription, TRIM24
related to Analysis · 14
Transcription factor → By, ChIP, ChIP-seq, DamID, DNA, DNA-sequencing, EMSA, If, On, TF, The, The DNA, There, This
related to Basal transcriptional regulation · 13
Transcription factor → DNA, GTFs, In, Many, RNA, TATA, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, The
related to Mechanistic · 13
Transcription factor → General, II, TFIIA, TFIIB, TFIID, TFIIE, TFIIF, TFIIH, The, There, These, They, Upstream
related to Transcription factor databases · 13
Transcription factor → An, BP, Database, DB, DNA, Examples, JASPAR, MethMotif, Plant, Some, TF, There, Yeast
related to Interaction with methylated cytosine · 11
Transcription factor → CpG, CpG-containing, CpGs, Demethylation, DNA, Methylation, Of, TET, The DNA, There, Transcription
related to Availability of other cofactors/transcription factors · 10
Transcription factor → Cofactors, DNA, For, Many, Most, NF-κB, RNA, TF, This, Thus

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Important terminology

transcription factors dna factor cell binding gene proteins nuclear protein genes bind dna-binding specific activation tfs domain ligand sequence sites

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
coactivatorsinstance ofOther proteins0.80text
chromatin remodelersinstance ofOther proteins0.80text
histone acetyltransferasesinstance ofOther proteins0.80text
histone deacetylasesinstance ofOther proteins0.80text
kinasesinstance ofOther proteins0.80text
and methylases are also essential to gene regulationinstance ofOther proteins0.80text
but lack DNA-binding domainsinstance ofOther proteins0.80text
and therefore are not TFs.TFs are of interest in medicine because TF mutations can cause specific diseasesinstance ofOther proteins0.80text
and medications can be potentially targeted toward theminstance ofOther proteins0.80text
the ovariesinstance ofEstrogen is secreted by tissues0.80text
placentainstance ofEstrogen is secreted by tissues0.80text
crosses the cell membrane of the recipient cellinstance ofEstrogen is secreted by tissues0.80text

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