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Post-translational modification

Post-translational modifications (PTMs) are the covalent processes of changing proteins following their synthesis, and release from ribosomes. PTMs are reversible editing events used and carried out in the overall process of post-translational regulation – the control of the levels of active protein; an irreversible event is proteolysis (protein…

PTMs involving addition of functional groups, Structural changes & Overview

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Overview

PTMs involving addition of functional groups

Conjugation with other proteins or peptides

Chemical modification of amino acids

Structural changes

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Post-translational modification

Nodes220
Edges219
Triples25
Avg. degree1.99
Density0.009091
Components1

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Post-translational modification

Top relations

related to List of resources · 9
Post-translational modification → Consensus, O-GlcNAc, O-GlcNAcylation, PhosphoSitePlus, Protein Reference Database, PTM, PTM's, PTMs, The O-GlcNAc Database
related to External links · 4
Post-translational modification → Controlled, ExPASyBrowse SCOP, PTM, UniprotList
related to Common PTMs by frequency · 3
Post-translational modification → In, Swiss-Prot, The
related to Common PTMs by residue · 2
Post-translational modification → Modifications, Some

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Important terminology

protein addition post-translational ptms residues proteins group acid lysine modifications modification covalent amino n-terminus formation cysteine one attachment chains serine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
phosphateinstance ofThey can expand the chemical set of the 22 amino acids by changing an existing functional group or adding a new one0.80text
signal transductioninstance ofinfluencing cellular processes0.80text
gene expressioninstance ofinfluencing cellular processes0.80text
with dysregulated interactions implicated in diseases like cancerinstance ofinfluencing cellular processes0.80text
neurodegenerative disorders.Sites that often undergo post-translational modification are those that have a functional group that can serve as a nucleophile in the reactioninstance ofinfluencing cellular processes0.80text
ADP-ribosylationpersulfidationinstance ofnucleotide addition0.80text
the addition of a sulfhydryl group onto a thiol group of a cysteine residue to form a hydropersulfidephosphate esterinstance ofnucleotide addition0.80text
Post-translational modificationrelated to Common PTMs by frequencyIn0.60section
Post-translational modificationrelated to Common PTMs by frequencySwiss-Prot0.60section
Post-translational modificationrelated to Common PTMs by frequencyThe0.60section
Post-translational modificationrelated to Common PTMs by residueSome0.60section
Post-translational modificationrelated to Common PTMs by residueModifications0.60section

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