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Post-translational modification: PTMs involving addition of functional groups, Structural changes & Overview

Post-translational modifications (PTMs) are the covalent processes of changing proteins following their synthesis, and release from ribosomes. PTMs are reversible editing events used and carried out in the overall process of post-translational regulation – the control of the levels of active protein; an irreversible event is proteolysis (protein…

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Post-translational modification topic overview

The analysis highlights PTMs involving addition of functional groups, Structural changes and Overview as prominent areas in the source structure around Post-translational modification.

Related topics
212
Source areas
7
Connected nodes
219
Extracted relationships
25
Concept neighborhoods
39
Bridge connections
219

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 157 topics
PTMs involving addition of functional groups · 13 topics
Structural changes · 12 topics
Chemical modification of amino acids · 10 topics
Conjugation with other proteins or peptides · 8 topics
Databases and tools · 8 topics
Case examples · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

PTMs involving addition of functional groups

Conjugation with other proteins or peptides

Chemical modification of amino acids

Structural changes

Databases and tools

Case examples

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Post-translational modification connects Entity context

The extracted context around Post-translational modification shows recurring relationship patterns in the source. For example, Post-translational modification → Consensus, O-GlcNAc, O-GlcNAcylation, PhosphoSitePlus, Protein Reference Database, PTM, PTM's, PTMs, The O-GlcNAc Database Another extracted example is Post-translational modification → Controlled, ExPASyBrowse SCOP, PTM, UniprotList. Use these groups to spot repeated connection types before inspecting the individual relationships.

Post-translational modification

Top relations

related to List of resources · 9
Post-translational modification → Consensus, O-GlcNAc, O-GlcNAcylation, PhosphoSitePlus, Protein Reference Database, PTM, PTM's, PTMs, The O-GlcNAc Database
related to External links · 4
Post-translational modification → Controlled, ExPASyBrowse SCOP, PTM, UniprotList
related to Common PTMs by frequency · 3
Post-translational modification → In, Swiss-Prot, The
related to Common PTMs by residue · 2
Post-translational modification → Modifications, Some

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein addition post-translational ptms residues proteins group acid lysine modifications modification covalent amino n-terminus formation cysteine one attachment chains serine

Post-translational modification relationships Subject–Predicate–Object triples

TTTA extracted 25 structured relationships around Post-translational modification. Examples in this analysis include phosphate → instance of → They can expand the chemical set of the 22 amino acids by changing an existing functional group or adding a new one and signal transduction → instance of → influencing cellular processes. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
phosphateinstance ofThey can expand the chemical set of the 22 amino acids by changing an existing functional group or adding a new one0.80text
signal transductioninstance ofinfluencing cellular processes0.80text
gene expressioninstance ofinfluencing cellular processes0.80text
with dysregulated interactions implicated in diseases like cancerinstance ofinfluencing cellular processes0.80text
neurodegenerative disorders.Sites that often undergo post-translational modification are those that have a functional group that can serve as a nucleophile in the reactioninstance ofinfluencing cellular processes0.80text
ADP-ribosylationpersulfidationinstance ofnucleotide addition0.80text
the addition of a sulfhydryl group onto a thiol group of a cysteine residue to form a hydropersulfidephosphate esterinstance ofnucleotide addition0.80text
Post-translational modificationrelated to Common PTMs by frequencyIn0.60section
Post-translational modificationrelated to Common PTMs by frequencySwiss-Prot0.60section
Post-translational modificationrelated to Common PTMs by frequencyThe0.60section
Post-translational modificationrelated to Common PTMs by residueSome0.60section
Post-translational modificationrelated to Common PTMs by residueModifications0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around Post-translational modification bring nearby vocabulary together. In this analysis, examples include Modification, Post-translational and Database. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Post-translational modification
    • Modification
    • Post-translational
    • Database
    • Proteins
    • Cysteine
    • Disulfide
    • Ptms
    • Histidine
    • Amino
    • Modifications
    • Groups
    • Residue
  • post-translational modification
    • Modification
    • Post-translational
    • Formation
    • Database
    • Bonds
    • Cysteine
    • Disulfide
    • Proteins
    • Ptms
    • Histidine
    • Lysine
    • Amino
  • covalent
    • Linkage
    • Asparagine
    • Residues
    • Serine
    • Threonine
    • Acid
    • Formation
    • Cysteine
    • N-terminus
    • One
    • Attachment
    • Tyrosine
  • proteins
    • Ptms
    • Acid
    • See
    • Modification
    • May
    • Protein
    • Amino
    • Formation
    • Addition
    • Group
    • Database
    • Groups
  • amino acid
    • Acid
    • Amino
    • Asparagine
    • Covalent
    • Formation
    • Linkage
    • Residue
    • Serine
    • Threonine
    • Addition
    • Lysine
    • Modifications
  • amino acids
    • Acid
    • Modifications
    • Functional
    • Modification
    • Database
    • Information
    • Linkage
    • Residue
    • See
    • Serine
    • Threonine
    • Group
  • functional group
    • Addition
    • Lysine
    • Histidine
    • Residues
    • Groups
    • Arginine
    • N-terminus
    • One
    • Group
    • Tyrosine
    • Residue
    • Serine
  • protein folding
    • Database
    • Proteins
    • Ptms
    • Formation
    • Lysine
    • Used
    • Residues
    • Chains
    • Disulfide
    • N-terminus
    • Ptm
    • Acid

Connections between topic areas Semantic bridges

For Post-translational modification, one of the stronger structural bridges in this analysis connects Post-translational modification with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Post-translational modificationOverview · splits 62 ⟂ 158
Post-translational modificationPTMs involving addition of functional groups · splits 206 ⟂ 14
Post-translational modificationStructural changes · splits 207 ⟂ 13
Post-translational modificationChemical modification of amino acids · splits 209 ⟂ 11
Post-translational modificationConjugation with other proteins or peptides · splits 211 ⟂ 9
Post-translational modificationDatabases and tools · splits 211 ⟂ 9
Post-translational modificationCase examples · splits 215 ⟂ 5

Map overview Semantic statistics

Post-translational modification

Nodes220
Edges219
Triples25
Avg. degree1.99
Density0.009091
Components1

Source & methodology

TTTA analyzes the structure around Post-translational modification to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as PTMs involving addition of functional groups, Structural changes & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Post-translational modification · EN edition · Analysis: TopicsToTalkAbout

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