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Post-translational modifications (PTMs) are the covalent processes of changing proteins following their synthesis, and release from ribosomes. PTMs are reversible editing events used and carried out in the overall process of post-translational regulation – the control of the levels of active protein; an irreversible event is proteolysis (protein…
The analysis highlights PTMs involving addition of functional groups, Structural changes and Overview as prominent areas in the source structure around Post-translational modification.
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Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
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The extracted context around Post-translational modification shows recurring relationship patterns in the source. For example, Post-translational modification → Consensus, O-GlcNAc, O-GlcNAcylation, PhosphoSitePlus, Protein Reference Database, PTM, PTM's, PTMs, The O-GlcNAc Database Another extracted example is Post-translational modification → Swiss-Prot. Use these groups to spot repeated connection types before inspecting the individual relationships.
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protein addition post-translational ptms residues proteins group acid lysine modifications modification covalent amino n-terminus formation cysteine one attachment chains serine
TTTA extracted 18 structured relationships around Post-translational modification. Examples in this analysis include phosphate → instance of → They can expand the chemical set of the 22 amino acids by changing an existing functional group or adding a new one and signal transduction → instance of → influencing cellular processes. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| phosphate | instance of | They can expand the chemical set of the 22 amino acids by changing an existing functional group or adding a new one | 0.80 | text |
| signal transduction | instance of | influencing cellular processes | 0.80 | text |
| gene expression | instance of | influencing cellular processes | 0.80 | text |
| with dysregulated interactions implicated in diseases like cancer | instance of | influencing cellular processes | 0.80 | text |
| neurodegenerative disorders.Sites that often undergo post-translational modification are those that have a functional group that can serve as a nucleophile in the reaction | instance of | influencing cellular processes | 0.80 | text |
| ADP-ribosylationpersulfidation | instance of | nucleotide addition | 0.80 | text |
| the addition of a sulfhydryl group onto a thiol group of a cysteine residue to form a hydropersulfidephosphate ester | instance of | nucleotide addition | 0.80 | text |
| Post-translational modification | related to Common PTMs by frequency | Swiss-Prot | 0.60 | section |
| Post-translational modification | related to Common PTMs by residue | Modifications | 0.60 | section |
| Post-translational modification | related to List of resources | PhosphoSitePlus | 0.60 | section |
| Post-translational modification | related to List of resources | Protein Reference Database | 0.60 | section |
| Post-translational modification | related to List of resources | Consensus | 0.60 | section |
The concept neighborhoods around Post-translational modification bring nearby vocabulary together. In this analysis, examples include Modification, Post-translational and Database. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Post-translational modification, one of the stronger structural bridges in this analysis connects Post-translational modification with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Post-translational modification to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as PTMs involving addition of functional groups, Structural changes & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Post-translational modification · EN edition · Analysis: TopicsToTalkAbout