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MHC class II transactivator

MHC class II transactivator is a major histocompatability complex protein encoded in the human by the gene CIITA. Mutations in this gene are responsible for the bare lymphocyte syndrome in which the immune system is severely compromised and cannot effectively fight infection. Chromosomal rearrangement of CIITA is involved in the pathogenesis of Hodgkin…

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2.7.11.1
Aliases
CIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator
Band
16p13.13 · 16|16 A1
Bgee
monocyte · granulocyte · appendix · spleen · lymph node
BioGPS
More reference expression data
Chr.
Chromosome 16 (human) · Chromosome 16 (mouse)

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MHC class II transactivator

Nodes29
Edges28
Triples88
Avg. degree1.93
Density0.068966
Components1

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MHC class II transactivator

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Gene ontology · 29
MHC class II transactivator → acyltransferase activity, ATP binding, DNA binding, GTP binding, immune response, inflammatory response, interferon-gamma-mediated signaling pathway, kinase activity, negative regulation of collagen biosynthetic process, negative regulation of transcription by RNA polymerase II, negative regulation of transcription, DNA-templated, nucleoplasm, nucleotide binding, nucleus, phosphorylation, PML body, positive regulation of MHC class I biosynthetic process, positive regulation of MHC class II biosynthetic process, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated
Bgee · 18
MHC class II transactivator → apex of heart, appendix, blood, duodenum, gallbladder, granulocyte, lip, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, morula, right kidney, spleen, subcutaneous adipose tissue, sural nerve, thymus, upper lobe of left lung
RNA expression pattern · 18
MHC class II transactivator → apex of heart, appendix, blood, duodenum, gallbladder, granulocyte, lip, lumbar subsegment of spinal cord, lymph node, mesenteric lymph nodes, monocyte, morula, right kidney, spleen, subcutaneous adipose tissue, sural nerve, thymus, upper lobe of left lung
Band · 2
MHC class II transactivator → 16p13.13, 16|16 A1
Chr. · 2
MHC class II transactivator → Chromosome 16 (human), Chromosome 16 (mouse)
End · 2
MHC class II transactivator → 10,346,282 bp, 10,943,021 bp
2.7.11.1 · 1
MHC class II transactivator → ↗
Aliases · 1
MHC class II transactivator → CIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator
BioGPS · 1
MHC class II transactivator → More reference expression data
Databases · 1
MHC class II transactivator → NCBI: entry; OMA: entry

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Important terminology

ciita human gene class ii bp protein chr band complex chromosome 16 expression mhc location transactivator major coactivator gtp nucleus

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MHC class II transactivator2.7.11.11.00infobox
MHC class II transactivatorAliasesCIITA, C2TA, CIITAIV, MHC2TA, NLRA, class II, major histocompatibility complex, transactivator, class II major histocompatibility complex transactivator1.00infobox
MHC class II transactivatorBand16p13.131.00infobox
MHC class II transactivatorBand16|16 A11.00infobox
MHC class II transactivatorBgeemonocyte1.00infobox
MHC class II transactivatorBgeegranulocyte1.00infobox
MHC class II transactivatorBgeeappendix1.00infobox
MHC class II transactivatorBgeespleen1.00infobox
MHC class II transactivatorBgeelymph node1.00infobox
MHC class II transactivatorBgeesural nerve1.00infobox
MHC class II transactivatorBgeegallbladder1.00infobox
MHC class II transactivatorBgeeupper lobe of left lung1.00infobox
MHC class II transactivatorBgeeblood1.00infobox
MHC class II transactivatorBgeeapex of heart1.00infobox
MHC class II transactivatorBgeemesenteric lymph nodes1.00infobox
MHC class II transactivatorBgeethymus1.00infobox
MHC class II transactivatorBgeelumbar subsegment of spinal cord1.00infobox
MHC class II transactivatorBgeesubcutaneous adipose tissue1.00infobox
MHC class II transactivatorBgeeduodenum1.00infobox
MHC class II transactivatorBgeemorula1.00infobox
MHC class II transactivatorBgeeright kidney1.00infobox
MHC class II transactivatorBgeelip1.00infobox
MHC class II transactivatorBioGPSMore reference expression data1.00infobox
MHC class II transactivatorChr.Chromosome 16 (human)1.00infobox
MHC class II transactivatorChr.Chromosome 16 (mouse)1.00infobox
MHC class II transactivatorDatabasesNCBI: entry; OMA: entry1.00infobox
MHC class II transactivatorEnd10,943,021 bp1.00infobox
MHC class II transactivatorEnd10,346,282 bp1.00infobox
MHC class II transactivatorEnsemblENSG000001795831.00infobox
MHC class II transactivatorEntrez42611.00infobox

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