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Histone deacetylase: Function, HDAC inhibitors & Classes of HDACs in higher eukaryotes

Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation.…

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Histone deacetylase topic overview

The analysis highlights Function, HDAC inhibitors and Classes of HDACs in higher eukaryotes as prominent areas in the source structure around Histone deacetylase.

Related topics
82
Source areas
8
Connected nodes
90
Extracted relationships
94
Concept neighborhoods
30
Bridge connections
90

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 38 topics
HDAC inhibitors · 24 topics
Overview · 9 topics
Classes of HDACs in higher eukaryotes · 3 topics
Subcellular distribution · 3 topics
HDAC super family · 2 topics
Subtypes · 2 topics
Evolution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

BRENDA
enzyme data
CAS no.
9076-57-7
EC no.
3.5.1.98
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

HDAC super family

Classes of HDACs in higher eukaryotes

Subtypes

Evolution

Subcellular distribution

Function

HDAC inhibitors

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Histone deacetylase connects Entity context

The extracted context around Histone deacetylase shows recurring relationship patterns in the source. For example, Histone deacetylase → ACTR, Also, CTCL, DNA, E2F1, EKLF, FDA, FEN, For, Function, GATA, HDAC, HDACs, HDI, HDIs, Histone, HIV, HNF-4, HSP90, In Another extracted example is Histone deacetylase → Class, Class II, Class III, Class IV, DNA, HDAC, HDAC11, HDACs, Homologues, II, IV, NAD, Rpd3, Sir2, The Class III, TSA, Zn2. Use these groups to spot repeated connection types before inspecting the individual relationships.

Histone deacetylase

Top relations

related to HDAC inhibitors · 37
Histone deacetylase → ACTR, Also, CTCL, DNA, E2F1, EKLF, FDA, FEN, For, Function, GATA, HDAC, HDACs, HDI, HDIs, Histone, HIV, HNF-4, HSP90, In
related to Subtypes · 17
Histone deacetylase → Class, Class II, Class III, Class IV, DNA, HDAC, HDAC11, HDACs, Homologues, II, IV, NAD, Rpd3, Sir2, The Class III, TSA, Zn2
related to Histone modification · 11
Histone deacetylase → According, Acetylation, DNA, Genes, Genomes, Histone, KEGG, Kyoto Encyclopedia, The, These, This
related to Classes of HDACs in higher eukaryotes · 7
Histone deacetylase → HDAC, HDACs, III, NAD, Rossmann, They, Zn2
see also · 4
Histone deacetylase → HAT, Histone, Histone-modifying, HMT
BRENDA · 1
Histone deacetylase → enzyme data
CAS no. · 1
Histone deacetylase → 9076-57-7
EC no. · 1
Histone deacetylase → 3.5.1.98
ExPASy · 1
Histone deacetylase → NiceZyme view
Gene Ontology · 1
Histone deacetylase → AmiGO / QuickGO

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

histone hdacs proteins acetylation hdac class deacetylase dna non-histone function transcription hdis deacetylases gene enzymes lysine found activity histones expression

Histone deacetylase relationships Subject–Predicate–Object triples

TTTA extracted 94 structured relationships around Histone deacetylase. Examples in this analysis include Histone deacetylase → BRENDA → enzyme data and Histone deacetylase → CAS no. → 9076-57-7. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Histone deacetylaseBRENDAenzyme data1.00infobox
Histone deacetylaseCAS no.9076-57-71.00infobox
Histone deacetylaseEC no.3.5.1.981.00infobox
Histone deacetylaseExPASyNiceZyme view1.00infobox
Histone deacetylaseGene OntologyAmiGO / QuickGO1.00infobox
Histone deacetylaseKEGGenzyme entry1.00infobox
Histone deacetylaseMetaCycmetabolic pathway1.00infobox
Histone deacetylaseNCBIproteins1.00infobox
Histone deacetylasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Histone deacetylasePMCarticles1.00infobox
Histone deacetylasePubMedarticles1.00infobox
Histone deacetylaseRheareactions1.00infobox
Histone deacetylaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Histone deacetylase bring nearby vocabulary together. In this analysis, examples include Deacetylase, Histone and Inhibitors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Histone deacetylase
    • Deacetylase
    • Histone
    • Inhibitors
    • Dna
    • Shown
    • Acid
    • Inhibitor
    • Gene
    • Hdacs
    • Non-histone
    • Acetylation
    • Pdb
  • histone deacetylase
    • Deacetylase
    • Histone
    • Inhibitors
    • Inhibitor
    • Pdb
    • Dna
    • Shown
    • Acid
    • Gene
    • Activity
    • Hdacs
    • Non-histone
  • histone
    • Deacetylase
    • Inhibitors
    • Dna
    • Shown
    • Acid
    • Inhibitor
    • Gene
    • Hdacs
    • Non-histone
    • Acetylation
    • Pdb
    • Amino
  • histone acetyltransferase
    • Deacetylase
    • Inhibitors
    • Dna
    • Shown
    • Acid
    • Inhibitor
    • Gene
    • Hdacs
    • Non-histone
    • Acetylation
    • Pdb
    • Amino
  • classes of hdacs in higher eukaryotes
    • Four
    • Iii
    • Enzymes
    • Hdac
    • Function
    • Non-histone
    • Classes
    • Hdacs
    • Proteins
    • Found
    • Inhibitor
    • Histone
  • hdac inhibitors
    • Proteins
    • Non-histone
    • Function
    • Classes
    • Four
    • Hdacs
    • Hdis
    • Lysine
    • Class
    • Also
    • Inhibitor
    • Enzymes
  • hdac super family
    • Proteins
    • Non-histone
    • Function
    • Classes
    • Four
    • Hdacs
    • Lysine
    • Class
    • Also
    • Inhibitor
    • Enzymes
    • Inhibitors
  • dna
    • Histones
    • Acetylation
    • Transcriptional
    • Groups
    • Histone
    • Activity
    • Transcription
    • Classes
    • Four
    • Important
    • Involved
    • Cell

Connections between topic areas Semantic bridges

For Histone deacetylase, one of the stronger structural bridges in this analysis connects Histone deacetylase with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Histone deacetylaseFunction · splits 52 ⟂ 39
Histone deacetylaseHDAC inhibitors · splits 66 ⟂ 25
Histone deacetylaseOverview · splits 81 ⟂ 10
Histone deacetylaseClasses of HDACs in higher eukaryotes · splits 87 ⟂ 4
Histone deacetylaseSubcellular distribution · splits 87 ⟂ 4
Histone deacetylaseHDAC super family · splits 88 ⟂ 3
Histone deacetylaseSubtypes · splits 88 ⟂ 3

Map overview Semantic statistics

Histone deacetylase

Nodes91
Edges90
Triples94
Avg. degree1.98
Density0.021978
Components1

Source & methodology

TTTA analyzes the structure around Histone deacetylase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, HDAC inhibitors & Classes of HDACs in higher eukaryotes, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Histone deacetylase · EN edition · Analysis: TopicsToTalkAbout

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