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Histone deacetylases (EC 3.5.1.98, HDAC) are a class of enzymes that remove acetyl groups (O=C-CH3) from an ε-N-acetyl lysine amino acid on both histone and non-histone proteins. HDACs allow histones to wrap the DNA more tightly. This is important because DNA is wrapped around histones, and DNA expression is regulated by acetylation and de-acetylation.…
The analysis highlights Function, HDAC inhibitors and Classes of HDACs in higher eukaryotes as prominent areas in the source structure around Histone deacetylase.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Histone deacetylase shows recurring relationship patterns in the source. For example, Histone deacetylase → ACTR, Also, CTCL, DNA, E2F1, EKLF, FDA, FEN, For, Function, GATA, HDAC, HDACs, HDI, HDIs, Histone, HIV, HNF-4, HSP90, In Another extracted example is Histone deacetylase → Class, Class II, Class III, Class IV, DNA, HDAC, HDAC11, HDACs, Homologues, II, IV, NAD, Rpd3, Sir2, The Class III, TSA, Zn2. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
histone hdacs proteins acetylation hdac class deacetylase dna non-histone function transcription hdis deacetylases gene enzymes lysine found activity histones expression
TTTA extracted 94 structured relationships around Histone deacetylase. Examples in this analysis include Histone deacetylase → BRENDA → enzyme data and Histone deacetylase → CAS no. → 9076-57-7. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Histone deacetylase | BRENDA | enzyme data | 1.00 | infobox |
| Histone deacetylase | CAS no. | 9076-57-7 | 1.00 | infobox |
| Histone deacetylase | EC no. | 3.5.1.98 | 1.00 | infobox |
| Histone deacetylase | ExPASy | NiceZyme view | 1.00 | infobox |
| Histone deacetylase | Gene Ontology | AmiGO / QuickGO | 1.00 | infobox |
| Histone deacetylase | KEGG | enzyme entry | 1.00 | infobox |
| Histone deacetylase | MetaCyc | metabolic pathway | 1.00 | infobox |
| Histone deacetylase | NCBI | proteins | 1.00 | infobox |
| Histone deacetylase | PDB structures | RCSB PDB PDBe PDBsum | 1.00 | infobox |
| Histone deacetylase | PMC | articles | 1.00 | infobox |
| Histone deacetylase | PubMed | articles | 1.00 | infobox |
| Histone deacetylase | Rhea | reactions | 1.00 | infobox |
| Histone deacetylase | Search | SearchPMCarticlesPubMedarticlesNCBIproteins | 1.00 | infobox |
The concept neighborhoods around Histone deacetylase bring nearby vocabulary together. In this analysis, examples include Deacetylase, Histone and Inhibitors. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Histone deacetylase, one of the stronger structural bridges in this analysis connects Histone deacetylase with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Histone deacetylase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, HDAC inhibitors & Classes of HDACs in higher eukaryotes, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Histone deacetylase · EN edition · Analysis: TopicsToTalkAbout