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RUNX1

Runt-related transcription factor 1 (RUNX1) also known as acute myeloid leukemia 1 protein (AML1) or core-binding factor subunit alpha-2 (CBFA2) and it is a protein that is encoded by the RUNX1 gene, in humans.

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Gene and protein

20 related topics

Discovery and characterization of RUNX1

9 related topics

Mutations and acute myeloid leukemia

13 related topics

Participation in haematopoiesis

11 related topics

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Aliases
RUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1, RUNX family transcription factor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CMO, 1CO1, 1E50, 1H9D, 1LJM
Band
21q22.12 · 16 C4|16 53.7 cM
Bgee
olfactory zone of nasal mucosa · epithelium of bronchus · mucosa of paranasal sinus · bronchial epithelial cell · nasal epithelium
BioGPS
More reference expression data
Chr.
Chromosome 21 (human) · Chromosome 16 (mouse)

Topics to explore

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Overview

Gene and protein

Discovery and characterization of RUNX1

Participation in haematopoiesis

Mutations and acute myeloid leukemia

Participation in hair follicle development

RUNX1 in Pancreatic Cancer

Interactions

Inhibitors

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Map overview Semantic statistics

RUNX1

Nodes92
Edges91
Triples232
Avg. degree1.98
Density0.021739
Components1

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RUNX1

Top relations

Gene ontology · 47
RUNX1 → ATP binding, calcium ion binding, chondrocyte differentiation, core-binding factor complex, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, hemopoiesis, intracellular membrane-bounded organelle, myeloid cell differentiation, negative regulation of CD4-positive, alpha-beta T cell differentiation, negative regulation of gene expression, negative regulation of granulocyte differentiation, negative regulation of transcription by RNA polymerase II, neuron differentiation, nucleoplasm, nucleus
related to Discovery and characterization of RUNX1 · 25
RUNX1 → Although, CBFα, CBFβ, Christiane Nüsslein-Volhard, DNA, DNA-binding, DNAs, Drosophila, Eric, Following, Furthermore, Gergen, However, Ito, Leukemia, Moloney, Ohki, Purified, RUNX, RUNX1's
related to Participation in haematopoiesis · 23
RUNX1 → AGM, As, At, CBF, Elf-1, Embryonic, ETS, Fli-1, Gata2, HSCs, HSPCs, It, Ldb1, Lmo2, Mpl, P-Sp, PU, SCL, Smad6, The
Bgee · 20
RUNX1 → bronchial epithelial cell, cumulus cell, decidua, Dermatocranium, epithelium of bronchus, epithelium of nasopharynx, gastrula, granulocyte, lower jaw, lumbar spinal ganglion, mandible, maxilla, membranous bone, minor salivary glands, mucosa of paranasal sinus, nasal epithelium, olfactory zone of nasal mucosa, tendon of biceps brachii, trabecular bone, visceral pleura
RNA expression pattern · 20
RUNX1 → bronchial epithelial cell, cumulus cell, decidua, Dermatocranium, epithelium of bronchus, epithelium of nasopharynx, gastrula, granulocyte, lower jaw, lumbar spinal ganglion, mandible, maxilla, membranous bone, minor salivary glands, mucosa of paranasal sinus, nasal epithelium, olfactory zone of nasal mucosa, tendon of biceps brachii, trabecular bone, visceral pleura
related to Mutations and acute myeloid leukemia · 19
RUNX1 → AML, AML-ETO, As, At, Auer, DNA, ETO, Examples, Familial Platelet Disorder, In, M2, MTG8, Nervy, NHR, OGG1, Oncogenic, Other, RUNX1T1, This
related to Gene and protein · 18
RUNX1 → Among, As, C-terminus, CBFs, CBFβ, DNA, In, NNN, RHD, RUNX, Specificity, TAD, TCA, TF, TGTGGNNN, The, These, TTT
related to External links · 11
RUNX1 → Human Runt-related, Medicine Medical Subject Headings, MeSH, Mouse Runt-related, National Library, Overview, PDB, PDBe-KB, Q01196, Q03347, UniProt
related to Participation in hair follicle development · 6
RUNX1 → At, In, It, Lef1, Thus, Wnt
related to RUNX1 in Pancreatic Cancer · 5
RUNX1 → Genetic, High, NOXA, Pharmacological, The

Important terminology Word statistics

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Important terminology

transcription gene factor binding protein human dna mutations runt leukemia 21 bp also mouse myeloid cells cancer development chromosome role

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
RUNX1AliasesRUNX1, AML1, AML1-EVI-1, AMLCR1, CBF2alpha, CBFA2, EVI-1, PEBP2aB, PEBP2alpha, runt related transcription factor 1, RUNX family transcription factor 11.00infobox
RUNX1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1CMO, 1CO1, 1E50, 1H9D, 1LJM1.00infobox
RUNX1Band21q22.121.00infobox
RUNX1Band16 C4|16 53.7 cM1.00infobox
RUNX1Bgeeolfactory zone of nasal mucosa1.00infobox
RUNX1Bgeeepithelium of bronchus1.00infobox
RUNX1Bgeemucosa of paranasal sinus1.00infobox
RUNX1Bgeebronchial epithelial cell1.00infobox
RUNX1Bgeenasal epithelium1.00infobox
RUNX1Bgeevisceral pleura1.00infobox
RUNX1Bgeetendon of biceps brachii1.00infobox
RUNX1Bgeetrabecular bone1.00infobox
RUNX1Bgeeepithelium of nasopharynx1.00infobox
RUNX1Bgeeminor salivary glands1.00infobox
RUNX1Bgeelumbar spinal ganglion1.00infobox
RUNX1BgeeDermatocranium1.00infobox
RUNX1Bgeemembranous bone1.00infobox
RUNX1Bgeedecidua1.00infobox
RUNX1Bgeelower jaw1.00infobox
RUNX1Bgeegranulocyte1.00infobox
RUNX1Bgeemaxilla1.00infobox
RUNX1Bgeemandible1.00infobox
RUNX1Bgeegastrula1.00infobox
RUNX1Bgeecumulus cell1.00infobox
RUNX1BioGPSMore reference expression data1.00infobox
RUNX1Chr.Chromosome 21 (human)1.00infobox
RUNX1Chr.Chromosome 16 (mouse)1.00infobox
RUNX1DatabasesNCBI: entry; OMA: entry1.00infobox
RUNX1End36,004,667 bp1.00infobox
RUNX1End92,623,037 bp1.00infobox

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