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Ku70

Ku70 is a heterodimeric protein made up of Ku70 and Ku80, which together form Ku. In humans, is encoded by the XRCC6 gene. Ku70 plays a critical role in the DNA repair, maintenance and many other cellular processes.

Interactions, Function & Clinical

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Interactions

16 related topics

Function

10 related topics

Clinical

3 related topics

Aging

1 related topics

Key facts & relationships

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4.2.99.18
5.6.2.4
Aliases
XRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6, CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross complementing 6
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEQ, 1JEY, 1JJR, 3RZX
Band
22q13.2 · 15 E1|15 38.33 cM
Bgee
right testis · left testis · ventricular zone · islet of Langerhans · embryo

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Overview

Function

Aging

Clinical

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Ku70

Nodes38
Edges37
Triples163
Avg. degree1.95
Density0.052632
Components1

How this topic connects Entity context

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Ku70

Top relations

Gene ontology · 61
Ku70 → 5'-deoxyribose-5-phosphate lyase activity, activation of innate immune response, ATP binding, brain development, catalytic activity, cellular hyperosmotic salinity response, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to X-ray, chromosome, cyclin binding, cytoplasm, cytosol, damaged DNA binding, DNA binding, DNA duplex unwinding, DNA helicase activity, DNA ligation, DNA recombination, DNA repair
Bgee · 18
Ku70 → Achilles tendon, beta cell, embryo, epiblast, ganglionic eminence, genital tubercle, islet of Langerhans, left testis, neural layer of retina, otic placode, otic vesicle, right adrenal gland, right lobe of liver, right testis, saccule, tail of embryo, thymus, ventricular zone
RNA expression pattern · 18
Ku70 → Achilles tendon, beta cell, embryo, epiblast, ganglionic eminence, genital tubercle, islet of Langerhans, left testis, neural layer of retina, otic placode, otic vesicle, right adrenal gland, right lobe of liver, right testis, saccule, tail of embryo, thymus, ventricular zone
related to Function · 15
Ku70 → DNA, DSBs, It, Ku, Ku's, Ku70 N-terminal, Ku80, Lysine, NHEJ, The DNA, The Ku70, Then, These, Together, Within
related to Interactions · 14
Ku70 → CBX5, CHEK1, CREBBP, GCN5L2, HOXC4, Ku80, MRE11A, NCF4, NCOA6, PCNA, PTTG1, RPA2, TERF2, TERTVAV1
related to Aging · 6
Ku70 → Also, DNA, Mouse, Mutant, These, Using
related to Nomenclature · 4
Ku70 → Chinese, DNA, Lupus Ku, XRCC6
Band · 2
Ku70 → 15 E1|15 38.33 cM, 22q13.2
Chr. · 2
Ku70 → Chromosome 15 (mouse), Chromosome 22 (human)
End · 2
Ku70 → 41,664,048 bp, 81,924,286 bp

Important terminology Word statistics

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Important terminology

dna gene ku bp repair ku80 human chr chromosome band end protein xrcc6 22 aging role x-ray mouse maintenance location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ku704.2.99.181.00infobox
Ku705.6.2.41.00infobox
Ku70AliasesXRCC6, X-ray repair complementing defective repair in Chinese hamster cells 6, CTC75, CTCBF, G22P1, KU70, ML8, TLAA, X-ray repair cross complementing 61.00infobox
Ku70Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JEQ, 1JEY, 1JJR, 3RZX1.00infobox
Ku70Band22q13.21.00infobox
Ku70Band15 E1|15 38.33 cM1.00infobox
Ku70Bgeeright testis1.00infobox
Ku70Bgeeleft testis1.00infobox
Ku70Bgeeventricular zone1.00infobox
Ku70Bgeeislet of Langerhans1.00infobox
Ku70Bgeeembryo1.00infobox
Ku70Bgeeganglionic eminence1.00infobox
Ku70BgeeAchilles tendon1.00infobox
Ku70Bgeeright adrenal gland1.00infobox
Ku70Bgeethymus1.00infobox
Ku70Bgeebeta cell1.00infobox
Ku70Bgeeotic placode1.00infobox
Ku70Bgeesaccule1.00infobox
Ku70Bgeeotic vesicle1.00infobox
Ku70Bgeeneural layer of retina1.00infobox
Ku70Bgeetail of embryo1.00infobox
Ku70Bgeeepiblast1.00infobox
Ku70Bgeegenital tubercle1.00infobox
Ku70Bgeeright lobe of liver1.00infobox
Ku70BioGPSn/a1.00infobox
Ku70Chr.Chromosome 22 (human)1.00infobox
Ku70Chr.Chromosome 15 (mouse)1.00infobox
Ku70DatabasesNCBI: entry; OMA: entry1.00infobox
Ku70End41,664,048 bp1.00infobox
Ku70End81,924,286 bp1.00infobox

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