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CREB: Overview, Involvement in circadian rhythms & Function in the brain

CREB-TF (CREB, cAMP response element-binding protein) is a cellular transcription factor. It binds to certain DNA sequences called cAMP response elements (CRE), thereby increasing or decreasing the transcription of the genes. CREB was first described in 1987 as a cAMP-responsive transcription factor regulating the somatostatin gene.

Language: English [EN]
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CREB topic overview

The analysis highlights Overview, Involvement in circadian rhythms and Function in the brain as prominent areas in the source structure around CREB.

Related topics
66
Source areas
7
Connected nodes
73
Extracted relationships
61
Related term clusters
27
Bridge connections
73

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 24 topics
Involvement in circadian rhythms · 9 topics
Function in the brain · 8 topics
Mechanism of action · 7 topics
Structure · 7 topics
Disease linkage · 6 topics
Subtypes · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Subtypes

Structure

Mechanism of action

Function in the brain

Disease linkage

Involvement in circadian rhythms

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How CREB connects Entity context

The extracted context around CREB shows recurring relationship patterns in the source. For example, CREB → Ca2, Calcium, CK2, Entrainment, Excitation, Light, NMDA, PER, Per1, Per2, PKA, PKC, Response Element, RHT, SCN Another extracted example is CREB → ATF4, CREB-like, CREB1, CREB2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5. Use these groups to spot repeated connection types before inspecting the individual relationships.

CREB

Top relations

related to Involvement in circadian rhythms · 15
CREB → Ca2, Calcium, CK2, Entrainment, Excitation, Light, NMDA, PER, Per1, Per2, PKA, PKC, Response Element, RHT, SCN
related to Subtypes · 10
CREB → ATF4, CREB-like, CREB1, CREB2, CREB3, CREB3L1, CREB3L2, CREB3L3, CREB3L4, CREB5
related to Disease linkage · 8
CREB → Abnormalities, CBP, CREB-binding, Disturbance, Huntington's, KID, Rubinstein, Taybi
related to Mechanism of action · 7
CREB → Ca2, CBP, CRE, CREB-binding, Evidence, G-protein, The DNA
related to Discovery of CREB involvement in circadian rhythms · 6
CREB → Experiments, Furthermore, Gunther Schutz, Michael Greenberg, SCN, Ser142
related to Structure · 6
CREB → Ca2, CRE, DNA, Hydrophobic, PKA, Serine
related to Function in the brain · 5
CREB → Aplysia, CREM, Drosophila, Flies, If CREB
related to cAMP response element · 3
CREB → CRE, CREs, TGACGTCA-3

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

protein transcription response camp circadian genes also doi pmid brain cell light 10 clock long-term role element cre memory factor

CREB relationships Subject–Predicate–Object triples

TTTA extracted 61 structured relationships around CREB. Examples in this analysis include cAMP or Ca2 → instance of → which leads to the production of a second messenger and CREB → related to cAMP response element → CRE. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
cAMP or Ca2instance ofwhich leads to the production of a second messenger0.80text
CREBrelated to cAMP response elementCRE0.60section
CREBrelated to cAMP response elementTGACGTCA-30.60section
CREBrelated to cAMP response elementCREs0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsMichael Greenberg0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsSCN0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsExperiments0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsGunther Schutz0.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsSer1420.60section
CREBrelated to Discovery of CREB involvement in circadian rhythmsFurthermore0.60section
CREBrelated to Disease linkageDisturbance0.60section
CREBrelated to Disease linkageCREB-binding0.60section

Related concept clusters Related term clusters

The concept neighborhoods around CREB bring nearby vocabulary together. In this analysis, examples include Protein, Long-term and Role. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • CREB
    • Protein
    • Long-term
    • Role
    • Brain
    • Also
    • Circadian
    • Transcription
    • Response
    • Factor
    • Function
    • Proteins
    • Shown
  • creb
    • Protein
    • Long-term
    • Role
    • Brain
    • Also
    • Circadian
    • Transcription
    • Response
    • Factor
    • Function
    • Proteins
    • Shown
  • circadian clock
    • Mammalian
    • Clock
    • Light
    • Genes
    • Transcription
    • Per1
    • Per2
    • Induction
    • Phosphorylation
    • Via
    • Element
    • Response
  • camp response element modulator
    • Response
    • Element
    • Transcription
    • Genes
    • Function
    • Proteins
    • Factor
    • Cre
    • Phosphorylation
    • Circadian
    • Clock
    • Disease
  • ca2+/calmodulin-dependent protein kinases
    • Binding
    • Cell
    • Response
    • Disease
    • Induction
    • Cre
    • Element
    • Phosphorylation
    • Brain
    • Genes
    • Circadian
    • Light
  • protein kinase
    • Binding
    • Cell
    • Response
    • Disease
    • Induction
    • Cre
    • Element
    • Phosphorylation
    • Brain
    • Genes
    • Circadian
    • Light
  • response element
    • Element
    • Response
    • Transcription
    • Function
    • Proteins
    • Genes
    • Factor
    • Cre
    • Phosphorylation
    • Clock
    • Circadian
    • Disease
  • involvement in circadian rhythms
    • Clock
    • Mammalian
    • Genes
    • Light
    • Transcription
    • Per1
    • Per2
    • Induction
    • Element
    • Phosphorylation
    • Via
    • Response

Connections between topic areas Semantic bridges

For CREB, one of the stronger structural bridges in this analysis connects CREB with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
CREB — Overview · splits 49 ⟂ 25
CREB — Involvement in circadian rhythms · splits 64 ⟂ 10
CREB — Function in the brain · splits 65 ⟂ 9
CREB — Structure · splits 66 ⟂ 8
CREB — Mechanism of action · splits 66 ⟂ 8
CREB — Disease linkage · splits 67 ⟂ 7
CREB — Subtypes · splits 68 ⟂ 6

Map overview Semantic statistics

CREB

Nodes74
Edges73
Triples61
Avg. degree1.97
Density0.027027
Components1

Source & methodology

TTTA analyzes the structure around CREB to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Overview, Involvement in circadian rhythms & Function in the brain, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — CREB · EN edition · Analysis: TopicsToTalkAbout

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