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MECOM

MDS1 and EVI1 complex locus protein (MECOM) also known as ecotropic virus integration site 1 protein homolog (EVI-1) or positive regulatory domain zinc finger protein 3 (PRDM3) is a protein that in humans is encoded by the MECOM gene. MECOM was first identified as a common retroviral integration site in AKXD murine myeloid tumors. It has since been…

Research, Association with cancer & Gene structure

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2.1.1.367
Aliases
MECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E
Band
3q26.2 · 3 A3|3 12.66 cM
Bgee
cardia · renal medulla · pylorus · nasal epithelium · mucosa of paranasal sinus
BioGPS
More reference expression data
Chr.
Chromosome 3 (human) · Chromosome 3 (mouse)

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Overview

Gene structure

Biological role

Association with cancer

Future and current research

Interactions

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Map overview Semantic statistics

MECOM

Nodes62
Edges61
Triples197
Avg. degree1.97
Density0.032258
Components1

How this topic connects Entity context

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MECOM

Top relations

Gene ontology · 34
MECOM → apoptotic process, cell differentiation, cytoplasm, cytosol, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hematopoietic stem cell proliferation, heterochromatin organization, histone deacetylase complex, histone H3-K9 methylation, histone lysine methylation, histone methyltransferase activity (H3-K9 specific), histone-lysine N-methyltransferase activity, metal ion binding, methylation, methyltransferase activity, multicellular organism development, negative regulation of JNK cascade, negative regulation of programmed cell death
Bgee · 20
MECOM → bronchial epithelial cell, cardia, ciliary body, endocardial cushion, epithelium of stomach, lacrimal gland, left colon, left lung lobe, lower lobe of lung, medullary collecting duct, mucosa of paranasal sinus, mucosa of sigmoid colon, mucosa of urinary bladder, nasal epithelium, Paneth cell, pylorus, renal corpuscle, renal medulla, transitional epithelium of urinary bladder, visceral pleura
RNA expression pattern · 20
MECOM → bronchial epithelial cell, cardia, ciliary body, endocardial cushion, epithelium of stomach, lacrimal gland, left colon, left lung lobe, lower lobe of lung, medullary collecting duct, mucosa of paranasal sinus, mucosa of sigmoid colon, mucosa of urinary bladder, nasal epithelium, Paneth cell, pylorus, renal corpuscle, renal medulla, transitional epithelium of urinary bladder, visceral pleura
has treatment · 11
MECOM → AML1/MDS1/MECOM, Arsenic, As, ATO, However, If, II, It, One, Phase, Very
related to Epigenetics · 9
MECOM → C-terminal-binding, CtBP, CtBP-binding, DNA, HDACs, Smad3, TGF-β, The, This
related to mRNA · 9
MECOM → AME, AML1/MDS1/MECOM, C-terminus, ETV6/MDS1/MECOM, Fusion, MDS1/MECOM, ME, Rp9, Some
related to Association with cancer · 8
MECOM → All, AML, CML, It, Its, MDS, N-terminal DNA, Overexpression
related to Chromosome instability · 8
MECOM → DNA, Nucifora, One, Ribophorin, RPN1, Since, The, This
related to Oncogenesis and induced proliferation of HSCs · 7
MECOM → Among, GATA-2, However, HSC, HSCs, It, The
related to External links · 6
MECOM → Histone-lysine N-methyltransferase MECOM, Overview, PDB, PDBe-KB, Q03112, UniProt

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Important terminology

transcription cell human shown gene protein binding cells tgf-β role chromosome expression factor signaling nucleus development proliferation cycle also many

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MECOM2.1.1.3671.00infobox
MECOMAliasesMECOM, AML1-EVI-1, EVI1, MDS1, MDS1-EVI1, PRDM3, RUSAT2, MDS1 and EVI1 complex locus, KMT8E1.00infobox
MECOMBand3q26.21.00infobox
MECOMBand3 A3|3 12.66 cM1.00infobox
MECOMBgeecardia1.00infobox
MECOMBgeerenal medulla1.00infobox
MECOMBgeepylorus1.00infobox
MECOMBgeenasal epithelium1.00infobox
MECOMBgeemucosa of paranasal sinus1.00infobox
MECOMBgeebronchial epithelial cell1.00infobox
MECOMBgeevisceral pleura1.00infobox
MECOMBgeemucosa of urinary bladder1.00infobox
MECOMBgeemucosa of sigmoid colon1.00infobox
MECOMBgeelower lobe of lung1.00infobox
MECOMBgeetransitional epithelium of urinary bladder1.00infobox
MECOMBgeeepithelium of stomach1.00infobox
MECOMBgeePaneth cell1.00infobox
MECOMBgeeleft lung lobe1.00infobox
MECOMBgeerenal corpuscle1.00infobox
MECOMBgeemedullary collecting duct1.00infobox
MECOMBgeeendocardial cushion1.00infobox
MECOMBgeeleft colon1.00infobox
MECOMBgeelacrimal gland1.00infobox
MECOMBgeeciliary body1.00infobox
MECOMBioGPSMore reference expression data1.00infobox
MECOMChr.Chromosome 3 (human)1.00infobox
MECOMChr.Chromosome 3 (mouse)1.00infobox
MECOMDatabasesNCBI: entry; OMA: entry1.00infobox
MECOMEnd169,663,775 bp1.00infobox
MECOMEnd30,602,157 bp1.00infobox

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