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HMGA1: Function, Interactions & Overview

High-mobility group protein HMG-I/HMG-Y is a protein that in humans is encoded by the HMGA1 gene.

Language: English [EN]
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HMGA1 topic overview

The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around HMGA1.

Related topics
17
Source areas
3
Connected nodes
20
Extracted relationships
130
Concept neighborhoods
7
Bridge connections
20

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HMGA1, HMG-R, HMGA1A, HMGIY, high mobility group AT-hook 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EZD, 2EZE, 2EZF, 2EZG
Band
6p21.31 · 17 A3.3|17 14.5 cM
Bgee
cartilage tissue · embryo · mucosa of pharynx · ganglionic eminence · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 6 (human) · Chromosome 17 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HMGA1 connects Entity context

The extracted context around HMGA1 shows recurring relationship patterns in the source. For example, HMGA1 → 5'-deoxyribose-5-phosphate lyase activity, base-excision repair, chromatin, chromatin binding, chromosome, cis-regulatory region sequence-specific DNA binding, cytosol, DNA binding, DNA unwinding involved in DNA replication, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme binding, establishment of integrated proviral latency, focal adhesion, minor groove of adenine-thymine-rich DNA binding, negative regulation of cell population proliferation, negative regulation of transcription, DNA-templated, nuclear receptor coactivator activity Another extracted example is HMGA1 → appendix, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, lip, mucosa of pharynx, mucosa of transverse colon, nipple, secondary oocyte, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

HMGA1

Top relations

Gene ontology · 44
HMGA1 → 5'-deoxyribose-5-phosphate lyase activity, base-excision repair, chromatin, chromatin binding, chromosome, cis-regulatory region sequence-specific DNA binding, cytosol, DNA binding, DNA unwinding involved in DNA replication, DNA-(apurinic or apyrimidinic site) endonuclease activity, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, enzyme binding, establishment of integrated proviral latency, focal adhesion, minor groove of adenine-thymine-rich DNA binding, negative regulation of cell population proliferation, negative regulation of transcription, DNA-templated, nuclear receptor coactivator activity
Bgee · 18
HMGA1 → appendix, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, lip, mucosa of pharynx, mucosa of transverse colon, nipple, secondary oocyte, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, yolk sac, zygote
RNA expression pattern · 18
HMGA1 → appendix, cartilage tissue, embryo, epiblast, ganglionic eminence, genital tubercle, lip, mucosa of pharynx, mucosa of transverse colon, nipple, secondary oocyte, skin of abdomen, skin of leg, tail of embryo, thymus, ventricular zone, yolk sac, zygote
related to External links · 13
HMGA1 → High, HMG-I/HMG-Y, Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, P17096, PDB, PDBe-KB, This, UniProt, United States National Library
related to Function · 11
HMGA1 → Arg-Gly-Arg-Pro, AT-hook, AT-hooks, C-terminal, DNA, HMG, HMGA, HMGB, HMGN, RGRP, This
Band · 2
HMGA1 → 17 A3.3|17 14.5 cM, 6p21.31
Chr. · 2
HMGA1 → Chromosome 17 (mouse), Chromosome 6 (human)
End · 2
HMGA1 → 27,782,648 bp, 34,246,231 bp
related to Interactions · 2
HMGA1 → CEBPB, Sp1
Aliases · 1
HMGA1 → HMGA1, HMG-R, HMGA1A, HMGIY, high mobility group AT-hook 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene human chr chromosome band protein dna heterochromatin proteins group location at-hook hmga chromatin also mouse hmga1a high tail

HMGA1 relationships Subject–Predicate–Object triples

TTTA extracted 130 structured relationships around HMGA1. Examples in this analysis include HMGA1 → Aliases → HMGA1, HMG-R, HMGA1A, HMGIY, high mobility group AT-hook 1 and HMGA1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EZD, 2EZE, 2EZF, 2EZG. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HMGA1AliasesHMGA1, HMG-R, HMGA1A, HMGIY, high mobility group AT-hook 11.00infobox
HMGA1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2EZD, 2EZE, 2EZF, 2EZG1.00infobox
HMGA1Band6p21.311.00infobox
HMGA1Band17 A3.3|17 14.5 cM1.00infobox
HMGA1Bgeecartilage tissue1.00infobox
HMGA1Bgeeembryo1.00infobox
HMGA1Bgeemucosa of pharynx1.00infobox
HMGA1Bgeeganglionic eminence1.00infobox
HMGA1Bgeeskin of abdomen1.00infobox
HMGA1Bgeethymus1.00infobox
HMGA1Bgeemucosa of transverse colon1.00infobox
HMGA1Bgeeskin of leg1.00infobox
HMGA1Bgeenipple1.00infobox
HMGA1Bgeeappendix1.00infobox
HMGA1Bgeeepiblast1.00infobox
HMGA1Bgeetail of embryo1.00infobox
HMGA1Bgeeyolk sac1.00infobox
HMGA1Bgeegenital tubercle1.00infobox
HMGA1Bgeesecondary oocyte1.00infobox
HMGA1Bgeezygote1.00infobox
HMGA1Bgeelip1.00infobox
HMGA1Bgeeventricular zone1.00infobox
HMGA1BioGPSMore reference expression data1.00infobox
HMGA1Chr.Chromosome 6 (human)1.00infobox
HMGA1Chr.Chromosome 17 (mouse)1.00infobox
HMGA1DatabasesNCBI: entry; OMA: entry1.00infobox
HMGA1End34,246,231 bp1.00infobox
HMGA1End27,782,648 bp1.00infobox
HMGA1EnsemblENSG000001373091.00infobox
HMGA1Entrez31591.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HMGA1 bring nearby vocabulary together. In this analysis, examples include At-hook, Heterochromatin and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • HMGA1
    • At-hook
    • Heterochromatin
    • Protein
    • Dna
    • Human
    • Proteins
    • Chromatin
    • Function
    • Search
    • Transcription
    • Also
    • High
  • hmga1
    • At-hook
    • Heterochromatin
    • Protein
    • Dna
    • Human
    • Proteins
    • Chromatin
    • Function
    • Search
    • Transcription
    • Also
    • High
  • gene
    • Location
    • Chromosome
    • Bp
    • Chr
    • Human
    • A3
    • End
    • Function
    • Mouse
    • Search
    • Group
    • Hmga1a
  • function
    • Search
    • Location
    • Chromosome
    • Bp
    • Chr
    • Gene
    • Human
    • A3
    • Chromatin
    • End
    • Mouse
    • P17096
  • heterochromatin
    • Structural
    • Proteins
    • Hmga1
    • Mouse
    • P17096
    • Search
    • Transcription
    • Uniprot
    • High
    • Hmga1a
    • Location
    • Tail
  • protein
    • P17096
    • Uniprot
    • Structural
    • Search
    • Transcription
    • Hmga
    • Tail
  • sp1 transcription factor
    • Uniprot

Connections between topic areas Semantic bridges

For HMGA1, one of the stronger structural bridges in this analysis connects HMGA1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HMGA1Function · splits 8 ⟂ 13
HMGA1Interactions · splits 17 ⟂ 4
HMGA1Overview · splits 18 ⟂ 3

Map overview Semantic statistics

HMGA1

Nodes21
Edges20
Triples130
Avg. degree1.9
Density0.095238
Components1

Source & methodology

TTTA analyzes the structure around HMGA1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HMGA1 · EN edition · Analysis: TopicsToTalkAbout

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