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Origin recognition complex

In molecular biology, origin recognition complex (ORC) is a multi-subunit DNA binding complex (6 subunits) that binds in all eukaryotes and archaea in an ATP-dependent manner to origins of replication. The subunits of this complex are encoded by the ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6 genes. ORC is a central component for eukaryotic DNA replication…

Measurement, Overview & Autonomously replicating sequences

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Overview

Molecular biologyDNAEukaryotesArchaeaATP
41 related topics

Autonomously replicating sequences

Budding yeastBpChromosomesConserved sequencesReplication origins
6 related topics

Origin binding activity

LysArgHelicaseCofactorsCdc45
6 related topics

Role in pre-RC assembly

Pre-RCCdt1Hydrolysis
3 related topics

Key facts & relationships

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AlphaFold
IPR007220 · PF04084
Available protein structures:
IPR007220 · PF04084
InterPro
IPR007220
PDB
IPR007220 PF04084 (ECOD; PDBsum)
Pfam
PF04084
Symbol
ORC2

Topics to explore

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Overview

Autonomously replicating sequences

Role in pre-RC assembly

Origin binding activity

Advanced semantic analysis

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Map overview Semantic statistics

Origin recognition complex

Nodes61
Edges60
Triples8
Avg. degree1.97
Density0.032787
Components1

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Origin recognition complex

Top relations

AlphaFold · 2
Origin recognition complex → IPR007220, PF04084
Available protein structures: · 2
Origin recognition complex → IPR007220, PF04084
InterPro · 1
Origin recognition complex → IPR007220
PDB · 1
Origin recognition complex → IPR007220 PF04084 (ECOD; PDBsum)
Pfam · 1
Origin recognition complex → PF04084
Symbol · 1
Origin recognition complex → ORC2

Important terminology Word statistics

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Important terminology

orc dna replication complex orc1 origin cdc6 pre-rc atp binding origins cell yeast subunits cdt1 activity required mcm2-7 budding assembly

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Origin recognition complexAlphaFoldIPR0072201.00infobox
Origin recognition complexAlphaFoldPF040841.00infobox
Origin recognition complexAvailable protein structures:IPR0072201.00infobox
Origin recognition complexAvailable protein structures:PF040841.00infobox
Origin recognition complexInterProIPR0072201.00infobox
Origin recognition complexPDBIPR007220 PF04084 (ECOD; PDBsum)1.00infobox
Origin recognition complexPfamPF040841.00infobox
Origin recognition complexSymbolORC21.00infobox

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