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HMGB2: Function & Overview

High-mobility group protein B2 also known as high-mobility group protein 2 (HMG-2) is a protein that in humans is encoded by the HMGB2 gene.

Language: English [EN]
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HMGB2 topic overview

The analysis highlights Function and Overview as prominent areas in the source structure around HMGB2.

Related topics
7
Source areas
2
Connected nodes
9
Extracted relationships
126
Concept neighborhoods
9
Bridge connections
9

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
HMGB2, HMG2, high mobility group box 2
Band
4q34.1 · 8 B2|8 29.9 cM
Bgee
ventricular zone · secondary oocyte · amniotic fluid · embryo · trabecular bone
BioGPS
More reference expression data
Chr.
Chromosome 4 (human) · Chromosome 8 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How HMGB2 connects Entity context

The extracted context around HMGB2 shows recurring relationship patterns in the source. For example, HMGB2 → apoptotic DNA fragmentation, cell chemotaxis, cellular response to lipopolysaccharide, chemoattractant activity, chemotaxis, chromatin organization, chromatin remodeling, chromosome, cis-regulatory region sequence-specific DNA binding, condensed chromosome, cytoplasm, damaged DNA binding, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, DNA binding, DNA binding, bending, DNA geometric change, DNA ligation involved in DNA repair, DNA recombination, DNA topological change Another extracted example is HMGB2 → amniotic fluid, blastocyst, bone marrow, embryo, ganglionic eminence, genital tubercle, germinal epithelium, granulocyte, morula, secondary oocyte, tail of embryo, thymus, tibia, trabecular bone, ventricular zone, yolk sac, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.

HMGB2

Top relations

Gene ontology · 69
HMGB2 → apoptotic DNA fragmentation, cell chemotaxis, cellular response to lipopolysaccharide, chemoattractant activity, chemotaxis, chromatin organization, chromatin remodeling, chromosome, cis-regulatory region sequence-specific DNA binding, condensed chromosome, cytoplasm, damaged DNA binding, defense response to Gram-negative bacterium, defense response to Gram-positive bacterium, DNA binding, DNA binding, bending, DNA geometric change, DNA ligation involved in DNA repair, DNA recombination, DNA topological change
Bgee · 17
HMGB2 → amniotic fluid, blastocyst, bone marrow, embryo, ganglionic eminence, genital tubercle, germinal epithelium, granulocyte, morula, secondary oocyte, tail of embryo, thymus, tibia, trabecular bone, ventricular zone, yolk sac, zygote
RNA expression pattern · 17
HMGB2 → amniotic fluid, blastocyst, bone marrow, embryo, ganglionic eminence, genital tubercle, germinal epithelium, granulocyte, morula, secondary oocyte, tail of embryo, thymus, tibia, trabecular bone, ventricular zone, yolk sac, zygote
related to External links · 3
HMGB2 → Medicine Medical Subject Headings, MeSH, National Library
Band · 2
HMGB2 → 4q34.1, 8 B2|8 29.9 cM
Chr. · 2
HMGB2 → Chromosome 4 (human), Chromosome 8 (mouse)
End · 2
HMGB2 → 173,334,432 bp, 57,969,033 bp
Aliases · 1
HMGB2 → HMGB2, HMG2, high mobility group box 2
BioGPS · 1
HMGB2 → More reference expression data
Databases · 1
HMGB2 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp human protein gene chr chromosome band b2 dna group location mouse function external high-mobility also 334 432 end 173

HMGB2 relationships Subject–Predicate–Object triples

TTTA extracted 126 structured relationships around HMGB2. Examples in this analysis include HMGB2 → Aliases → HMGB2, HMG2, high mobility group box 2 and HMGB2 → Band → 4q34.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
HMGB2AliasesHMGB2, HMG2, high mobility group box 21.00infobox
HMGB2Band4q34.11.00infobox
HMGB2Band8 B2|8 29.9 cM1.00infobox
HMGB2Bgeeventricular zone1.00infobox
HMGB2Bgeesecondary oocyte1.00infobox
HMGB2Bgeeamniotic fluid1.00infobox
HMGB2Bgeeembryo1.00infobox
HMGB2Bgeetrabecular bone1.00infobox
HMGB2Bgeeganglionic eminence1.00infobox
HMGB2Bgeebone marrow1.00infobox
HMGB2Bgeetibia1.00infobox
HMGB2Bgeethymus1.00infobox
HMGB2Bgeegerminal epithelium1.00infobox
HMGB2Bgeetail of embryo1.00infobox
HMGB2Bgeegenital tubercle1.00infobox
HMGB2Bgeegranulocyte1.00infobox
HMGB2Bgeeyolk sac1.00infobox
HMGB2Bgeezygote1.00infobox
HMGB2Bgeeblastocyst1.00infobox
HMGB2Bgeemorula1.00infobox
HMGB2BioGPSMore reference expression data1.00infobox
HMGB2Chr.Chromosome 4 (human)1.00infobox
HMGB2Chr.Chromosome 8 (mouse)1.00infobox
HMGB2DatabasesNCBI: entry; OMA: entry1.00infobox
HMGB2End173,334,432 bp1.00infobox
HMGB2End57,969,033 bp1.00infobox
HMGB2EnsemblENSG000001641041.00infobox
HMGB2Entrez31481.00infobox
HMGB2External IDsOMIM: 163906; MGI: 96157; GeneCards: HMGB21.00infobox
HMGB2Gene location (Human)Gene location (Human)Chr.Chromosome 4 (human)Band4q34.1Start173,331,376 bpEnd173,334,432 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around HMGB2 bring nearby vocabulary together. In this analysis, examples include Function, Human and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Group
    • Location
    • Chromosome
    • Hmgb2
    • Bp
    • Chr
    • End
    • Function
    • High-mobility
    • Human
    • Mouse
    • Band
  • high-mobility group
    • Gene
    • Hmgb2
    • B2
    • Function
    • High-mobility
    • Encoded
    • Hmg-2
    • Humans
    • Known
    • Location
    • Chromosome
    • Protein
  • dna double-strand breaks repair
    • Involved
    • Ligation
    • Recombination
    • Dna
    • Protein
    • Repair
    • Studies
    • Also
    • End
    • Family
    • Function
    • High-mobility
  • function
    • Group
    • Location
    • Chromosome
    • External
    • Gene
    • Hmgb2
    • Links
    • Reading
    • References
    • Bp
    • Chr
    • Human
  • HMGB2
    • Function
    • Human
    • Protein
    • Location
    • Chromosome
    • Bp
    • Chr
    • External
    • Humans
    • Known
    • Links
    • Reading
  • hmgb2
    • Function
    • Human
    • Protein
    • Location
    • Chromosome
    • Bp
    • Chr
    • External
    • Humans
    • Known
    • Links
    • Reading
  • ligation
    • Involved
    • Recombination
    • Repair
    • Protein
    • Family
    • Mouse
    • Nucleus
    • Location
  • protein
    • Recombination
    • Repair
    • Studies

Connections between topic areas Semantic bridges

For HMGB2, one of the stronger structural bridges in this analysis connects HMGB2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
HMGB2Function · splits 4 ⟂ 6
HMGB2Overview · splits 7 ⟂ 3

Map overview Semantic statistics

HMGB2

Nodes10
Edges9
Triples126
Avg. degree1.8
Density0.2
Components1

Source & methodology

TTTA analyzes the structure around HMGB2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — HMGB2 · EN edition · Analysis: TopicsToTalkAbout

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