YAP1

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Map view:

Zoom: 100%

More settings

Connection length 100% Label size 100% Node size 100% Line width 100% Label width 100%

Export map as:

YAP1 topic overview

The analysis highlights Function, Structure and Regulation as prominent areas in the source structure around YAP1.

Related topics: 55
Source areas: 5
Connected nodes: 60
Extracted relationships: 200
Concept neighborhoods: 16
Bridge connections: 60

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 25 topics

Overview · 10 topics

Structure · 9 topics

Regulation · 8 topics

Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX
Band: 11q22.1 · 9|9 A1
Bgee: saphenous vein · germinal epithelium · tail of epididymis · urethra · seminal vesicula
BioGPS: n/a
Chr.: Chromosome 11 (human) · Chromosome 9 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Transcription coregulator
Cellular proliferation
Apoptotic Apoptosis
Hippo signaling pathway
Tumorigenesis
SH3 domain
Yes YES1
Src Proto-oncogene tyrosine-protein kinase Src
Tyrosine kinases
Oncogene

Structure

Function

Regulation

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How YAP1 connects Entity context

The extracted context around YAP1 shows recurring relationship patterns in the source. For example, YAP1 → bud elongation involved in lung branching, cardiac muscle tissue regeneration, cell morphogenesis, cell population proliferation, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to retinoic acid, chromatin binding, contact inhibition, cytoplasm, cytosol, embryonic heart tube morphogenesis, heart process, hippo signaling, keratinocyte differentiation, lateral mesoderm development, lung epithelial cell differentiation, membrane, negative regulation of epithelial cell differentiation, negative regulation of extrinsic apoptotic signaling pathway Another extracted example is YAP1 → AMOTs, AREG, Birc2, Birc5, CTGF, Cyr61, ErbB4, Hippo, Hoxa1, Hoxc13, It, LATS1/2, PTPN14, RUNX, Several, SMADs, TAZ, TEAD, TP53BP2, When. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 60

YAP1 → bud elongation involved in lung branching, cardiac muscle tissue regeneration, cell morphogenesis, cell population proliferation, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to retinoic acid, chromatin binding, contact inhibition, cytoplasm, cytosol, embryonic heart tube morphogenesis, heart process, hippo signaling, keratinocyte differentiation, lateral mesoderm development, lung epithelial cell differentiation, membrane, negative regulation of epithelial cell differentiation, negative regulation of extrinsic apoptotic signaling pathway

related to Function · 23

YAP1 → AMOTs, AREG, Birc2, Birc5, CTGF, Cyr61, ErbB4, Hippo, Hoxa1, Hoxc13, It, LATS1/2, PTPN14, RUNX, Several, SMADs, TAZ, TEAD, TP53BP2, When

Bgee · 20

YAP1 → corpus epididymis, external carotid artery, germinal epithelium, hair follicle, human penis, internal carotid artery, parietal pleura, pericardium, primary oocyte, primitive streak, retinal pigment epithelium, saphenous vein, secondary oocyte, seminal vesicula, superficial temporal artery, tail of epididymis, urethra, utricle, vestibular membrane of cochlear duct, zygote

RNA expression pattern · 20

related to Structure · 16

YAP1 → Apart, Cloning, Figure, Following, Next, PDZ, PDZ-BM, SH3-BM, Src Homology, TAD, TEAD, TID, Two, WW, YAP1-1, YAP1-2

related to External links · 8

YAP1 → Human Transcriptional, Mouse Transcriptional, Overview, P46937, P46938, PDB, PDBe-KB, UniProt

related to As a drug target · 6

YAP1 → Small, The YAP1, These, WW, YAP, YAP1-TEAD

related to Cancer · 6

YAP1 → Dysregulation, Hence YAP1, TAZ, While YAP, YAP, YAP/TAZ-mediated

Band · 2

YAP1 → 11q22.1, 9|9 A1

Chr. · 2

YAP1 → Chromosome 11 (human), Chromosome 9 (mouse)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

yap pathway gene human taz hippo protein bp transcriptional signaling chr band identified domain nucleus cancer transcription also chromosome 11

YAP1 relationships Subject–Predicate–Object triples

TTTA extracted 200 structured relationships around YAP1. Examples in this analysis include YAP1 → Aliases → YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1 and YAP1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
YAP1	Aliases	YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1	1.00	infobox
YAP1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX	1.00	infobox
YAP1	Band	11q22.1	1.00	infobox
YAP1	Band	9\|9 A1	1.00	infobox
YAP1	Bgee	saphenous vein	1.00	infobox
YAP1	Bgee	germinal epithelium	1.00	infobox
YAP1	Bgee	tail of epididymis	1.00	infobox
YAP1	Bgee	urethra	1.00	infobox
YAP1	Bgee	seminal vesicula	1.00	infobox
YAP1	Bgee	human penis	1.00	infobox
YAP1	Bgee	parietal pleura	1.00	infobox
YAP1	Bgee	superficial temporal artery	1.00	infobox
YAP1	Bgee	pericardium	1.00	infobox
YAP1	Bgee	corpus epididymis	1.00	infobox
YAP1	Bgee	zygote	1.00	infobox
YAP1	Bgee	secondary oocyte	1.00	infobox
YAP1	Bgee	primary oocyte	1.00	infobox
YAP1	Bgee	internal carotid artery	1.00	infobox
YAP1	Bgee	primitive streak	1.00	infobox
YAP1	Bgee	vestibular membrane of cochlear duct	1.00	infobox
YAP1	Bgee	external carotid artery	1.00	infobox
YAP1	Bgee	hair follicle	1.00	infobox
YAP1	Bgee	retinal pigment epithelium	1.00	infobox
YAP1	Bgee	utricle	1.00	infobox
YAP1	BioGPS	n/a	1.00	infobox
YAP1	Chr.	Chromosome 11 (human)	1.00	infobox
YAP1	Chr.	Chromosome 9 (mouse)	1.00	infobox
YAP1	Databases	NCBI: entry; OMA: entry	1.00	infobox
YAP1	End	102,233,424 bp	1.00	infobox
YAP1	End	8,004,597 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around YAP1 bring nearby vocabulary together. In this analysis, examples include Gene, Pathway and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

YAP1
- Gene
- Pathway
- Protein
- Transcription
- Domain
- Human
- Identified
- Hippo
- Transcriptional
- Pdb
- Uniprot
- Growth
yap1
- Gene
- Pathway
- Protein
- Transcription
- Domain
- Human
- Identified
- Hippo
- Transcriptional
- Pdb
- Uniprot
- Growth
transcription coregulator
- Cellular
- Proliferation
- Expression
- Growth
- Cell
- Ww
- Domain
- Nucleus
- Yap1
- Gene
- Hippo
- Transcriptional
cellular proliferation
- Proliferation
- Protein
- Transcription
- External
- Function
- Location
- Uniprot
- Band
- Binding
- Chromosome
- Development
- Expression
hippo signaling pathway
- Pathway
- Signaling
- Nucleus
- Taz
- Expression
- Gene
- Cell
- Yap1
- Transcription
- External
- Yap
- Function
sh3 domain
- Ww
- Binding
- Two
- Protein
- Transcription
- Identified
- Yap1
- Gene
- External
- Function
- Location
- Proliferation
protein domain
- Ww
- External
- Cellular
- Function
- Location
- Proliferation
- Chromosome
- Binding
- Bp
- Chr
- Transcription
- Two
ww domain
- Ww
- Two
- Binding
- Protein
- Transcription
- Identified
- Yap1
- Gene
- External
- Function
- Location
- Proliferation

Connections between topic areas Semantic bridges

For YAP1, one of the stronger structural bridges in this analysis connects YAP1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

YAP1 — Function · splits 35 ⟂ 26

YAP1 — Overview · splits 50 ⟂ 11

YAP1 — Structure · splits 51 ⟂ 10

YAP1 — Regulation · splits 52 ⟂ 9

YAP1 — Clinical significance · splits 57 ⟂ 4

Map overview Semantic statistics

YAP1

Nodes61

Edges60

Triples200

Avg. degree1.97

Density0.032787

Components1

Source & methodology

TTTA analyzes the structure around YAP1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Structure & Regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — YAP1 · EN edition · Analysis: TopicsToTalkAbout