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YAP1

YAP1 (yes-associated protein 1), also known as YAP or YAP65, is a protein that acts as a transcription coregulator that promotes transcription of genes involved in cellular proliferation and suppressing apoptotic genes. YAP1 is a component in the hippo signaling pathway which regulates organ size, regeneration, and tumorigenesis. YAP1 was first…

Function, Structure & Regulation

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Aliases
YAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX
Band
11q22.1 · 9|9 A1
Bgee
saphenous vein · germinal epithelium · tail of epididymis · urethra · seminal vesicula
BioGPS
n/a
Chr.
Chromosome 11 (human) · Chromosome 9 (mouse)

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Structure

Function

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Clinical significance

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YAP1

Nodes61
Edges60
Triples200
Avg. degree1.97
Density0.032787
Components1

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YAP1

Top relations

Gene ontology · 60
YAP1 → bud elongation involved in lung branching, cardiac muscle tissue regeneration, cell morphogenesis, cell population proliferation, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to retinoic acid, chromatin binding, contact inhibition, cytoplasm, cytosol, embryonic heart tube morphogenesis, heart process, hippo signaling, keratinocyte differentiation, lateral mesoderm development, lung epithelial cell differentiation, membrane, negative regulation of epithelial cell differentiation, negative regulation of extrinsic apoptotic signaling pathway
related to Function · 23
YAP1 → AMOTs, AREG, Birc2, Birc5, CTGF, Cyr61, ErbB4, Hippo, Hoxa1, Hoxc13, It, LATS1/2, PTPN14, RUNX, Several, SMADs, TAZ, TEAD, TP53BP2, When
Bgee · 20
YAP1 → corpus epididymis, external carotid artery, germinal epithelium, hair follicle, human penis, internal carotid artery, parietal pleura, pericardium, primary oocyte, primitive streak, retinal pigment epithelium, saphenous vein, secondary oocyte, seminal vesicula, superficial temporal artery, tail of epididymis, urethra, utricle, vestibular membrane of cochlear duct, zygote
RNA expression pattern · 20
YAP1 → corpus epididymis, external carotid artery, germinal epithelium, hair follicle, human penis, internal carotid artery, parietal pleura, pericardium, primary oocyte, primitive streak, retinal pigment epithelium, saphenous vein, secondary oocyte, seminal vesicula, superficial temporal artery, tail of epididymis, urethra, utricle, vestibular membrane of cochlear duct, zygote
related to Structure · 16
YAP1 → Apart, Cloning, Figure, Following, Next, PDZ, PDZ-BM, SH3-BM, Src Homology, TAD, TEAD, TID, Two, WW, YAP1-1, YAP1-2
related to External links · 8
YAP1 → Human Transcriptional, Mouse Transcriptional, Overview, P46937, P46938, PDB, PDBe-KB, UniProt
related to As a drug target · 6
YAP1 → Small, The YAP1, These, WW, YAP, YAP1-TEAD
related to Cancer · 6
YAP1 → Dysregulation, Hence YAP1, TAZ, While YAP, YAP, YAP/TAZ-mediated
Band · 2
YAP1 → 11q22.1, 9|9 A1
Chr. · 2
YAP1 → Chromosome 11 (human), Chromosome 9 (mouse)

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Important terminology

yap pathway gene human taz hippo protein bp transcriptional signaling chr band identified domain nucleus cancer transcription also chromosome 11

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
YAP1AliasesYAP1, COB1, YAP, YAP2, YAP65, YKI, Yes associated protein 1, Yap, Yes1 associated transcriptional regulator, YAP-11.00infobox
YAP1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1JMQ, 1K5R, 1K9Q, 1K9R, 2LAW, 2LAX, 2LAY, 2LTV, 2LTW, 3KYS, 3MHR, 4RE1, 4REX1.00infobox
YAP1Band11q22.11.00infobox
YAP1Band9|9 A11.00infobox
YAP1Bgeesaphenous vein1.00infobox
YAP1Bgeegerminal epithelium1.00infobox
YAP1Bgeetail of epididymis1.00infobox
YAP1Bgeeurethra1.00infobox
YAP1Bgeeseminal vesicula1.00infobox
YAP1Bgeehuman penis1.00infobox
YAP1Bgeeparietal pleura1.00infobox
YAP1Bgeesuperficial temporal artery1.00infobox
YAP1Bgeepericardium1.00infobox
YAP1Bgeecorpus epididymis1.00infobox
YAP1Bgeezygote1.00infobox
YAP1Bgeesecondary oocyte1.00infobox
YAP1Bgeeprimary oocyte1.00infobox
YAP1Bgeeinternal carotid artery1.00infobox
YAP1Bgeeprimitive streak1.00infobox
YAP1Bgeevestibular membrane of cochlear duct1.00infobox
YAP1Bgeeexternal carotid artery1.00infobox
YAP1Bgeehair follicle1.00infobox
YAP1Bgeeretinal pigment epithelium1.00infobox
YAP1Bgeeutricle1.00infobox
YAP1BioGPSn/a1.00infobox
YAP1Chr.Chromosome 11 (human)1.00infobox
YAP1Chr.Chromosome 9 (mouse)1.00infobox
YAP1DatabasesNCBI: entry; OMA: entry1.00infobox
YAP1End102,233,424 bp1.00infobox
YAP1End8,004,597 bp1.00infobox

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